RO115877B1 - Taxoide, procedee pentru prepararea acestora şi compoziţie farmaceutică care le conţine - Google Patents

Taxoide, procedee pentru prepararea acestora şi compoziţie farmaceutică care le conţine

Info

Publication number
RO115877B1
RO115877B1 RO97-01793A RO9701793A RO115877B1 RO 115877 B1 RO115877 B1 RO 115877B1 RO 9701793 A RO9701793 A RO 9701793A RO 115877 B1 RO115877 B1 RO 115877B1
Authority
RO
Romania
Prior art keywords
radical
optionally substituted
processes
preparation
same
Prior art date
Application number
RO97-01793A
Other languages
English (en)
Inventor
Herve Bouchard
Jean Dominique Bourzat
Alain Commercon
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9503545A external-priority patent/FR2732340B1/fr
Priority claimed from FR9515381A external-priority patent/FR2742754B1/fr
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of RO115877B1 publication Critical patent/RO115877B1/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Invenţia se referă la noi taxoide cu formula generală (I):în care Z este hidrogen sau un radical cu formula generală (II):în care Rreprezintă un radical benzoil, eventual substituit sau un radical tenoil sau furoil, un radical R-O-CO- în care Reste alchil, alchenil, alchinil, cicloalchil, cicloalchenil, bicicloalchil, fenil eventual substituit sau heterociclil, Reste alchil, alchenil, alchinil, cicloalchil, fenil, naftil sau heterociclu aromatic, Reste un alcoxi, alcheniloxi, alchiniloxi, eventual substituit sau un radical cicloalcoxi sau cicloalcheniloxi, şi Reste un radical alcoxi, alcheniloxi, alchiniloxi, eventual substituit, sau un radical cicloalcoxi sau cicloalcheniloxi, compuşi cu proprietăţi antitumorale, la procedee pentru prepararea acestora şi compoziţii farmaceutice care îi conţin.
RO97-01793A 1995-03-27 1996-03-25 Taxoide, procedee pentru prepararea acestora şi compoziţie farmaceutică care le conţine RO115877B1 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9503545A FR2732340B1 (fr) 1995-03-27 1995-03-27 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR9515381A FR2742754B1 (fr) 1995-12-22 1995-12-22 Procede de preparation de taxoides
PCT/FR1996/000440 WO1996030355A1 (fr) 1995-03-27 1996-03-25 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
RO115877B1 true RO115877B1 (ro) 2000-07-28

Family

ID=26231838

Family Applications (2)

Application Number Title Priority Date Filing Date
RO97-01794A RO115878B1 (ro) 1995-03-27 1996-03-25 Taxoide, procedee pentru prepararea lor si compozitie farmaceutica care le contine
RO97-01793A RO115877B1 (ro) 1995-03-27 1996-03-25 Taxoide, procedee pentru prepararea acestora şi compoziţie farmaceutică care le conţine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RO97-01794A RO115878B1 (ro) 1995-03-27 1996-03-25 Taxoide, procedee pentru prepararea lor si compozitie farmaceutica care le contine

Country Status (41)

Country Link
US (3) US5889043A (ro)
EP (2) EP0817779B1 (ro)
JP (2) JP2941951B2 (ro)
KR (2) KR100485309B1 (ro)
CN (2) CN1152870C (ro)
AP (2) AP753A (ro)
AR (1) AR001440A1 (ro)
AT (2) ATE185562T1 (ro)
AU (2) AU711227B2 (ro)
BG (2) BG63009B1 (ro)
BR (2) BR9607930A (ro)
CA (2) CA2214321C (ro)
CO (1) CO4700576A1 (ro)
CZ (2) CZ287326B6 (ro)
DE (2) DE69604653T2 (ro)
DK (2) DK0817780T3 (ro)
DZ (1) DZ2009A1 (ro)
EA (2) EA000567B1 (ro)
EE (2) EE03609B1 (ro)
ES (2) ES2143187T3 (ro)
GE (2) GEP20002188B (ro)
GR (2) GR3031526T3 (ro)
HU (2) HU223732B1 (ro)
IL (1) IL117636A (ro)
IS (2) IS2058B (ro)
MA (1) MA23823A1 (ro)
MY (1) MY121225A (ro)
NO (2) NO316607B1 (ro)
NZ (2) NZ304901A (ro)
OA (2) OA10513A (ro)
PE (1) PE51097A1 (ro)
PL (2) PL188284B1 (ro)
PT (1) PT817779E (ro)
RO (2) RO115878B1 (ro)
SK (2) SK281928B6 (ro)
TN (1) TNSN96043A1 (ro)
TR (2) TR199701042T1 (ro)
TW (1) TW394765B (ro)
UY (2) UY24192A1 (ro)
WO (2) WO1996030355A1 (ro)
ZA (1) ZA962399B (ro)

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Also Published As

Publication number Publication date
EA199700269A1 (ru) 1998-04-30
GR3032316T3 (en) 2000-04-27
JPH11502531A (ja) 1999-03-02
HUP9801204A1 (hu) 2000-05-28
IS2056B (is) 2005-10-14
CZ287326B6 (en) 2000-10-11
IL117636A (en) 2004-08-31
RO115878B1 (ro) 2000-07-28
NO973923D0 (no) 1997-08-26
TR199701042T1 (xx) 1998-01-21
EA000567B1 (ru) 1999-12-29
GEP20002188B (en) 2000-07-25
CN1179775A (zh) 1998-04-22
OA10513A (fr) 2002-04-22
BR9607930A (pt) 1998-06-02
ATE188471T1 (de) 2000-01-15
KR19980703287A (ko) 1998-10-15
WO1996030355A1 (fr) 1996-10-03
BG101918A (en) 1998-10-30
KR19980703357A (ko) 1998-10-15
BG63121B1 (bg) 2001-04-30
ES2140075T3 (es) 2000-02-16
ES2143187T3 (es) 2000-05-01
PL188284B1 (pl) 2005-01-31
MX9706568A (es) 1997-11-29
EP0817780A1 (fr) 1998-01-14
NO316379B1 (no) 2004-01-19
EE03609B1 (et) 2002-02-15
EP0817780B1 (fr) 1999-10-13
OA10514A (fr) 2002-04-22
CN1152870C (zh) 2004-06-09
DE69604653T2 (de) 2000-05-31
EP0817779B1 (fr) 2000-01-05
PL322499A1 (en) 1998-02-02
WO1996030356A1 (fr) 1996-10-03
BG101917A (en) 1998-10-30
JPH11500141A (ja) 1999-01-06
HU223666B1 (hu) 2004-11-29
JP3790826B2 (ja) 2006-06-28
KR100485309B1 (ko) 2005-10-12
NO973922L (no) 1997-08-26
EE9700315A (et) 1998-06-15
KR100297196B1 (ko) 2001-11-22
CZ303097A3 (cs) 1998-01-14
CO4700576A1 (es) 1998-12-29
SK281927B6 (sk) 2001-09-11
TNSN96043A1 (fr) 2005-03-15
HU223732B1 (hu) 2004-12-28
ATE185562T1 (de) 1999-10-15
AU5278196A (en) 1996-10-16
ZA962399B (en) 1996-10-01
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AP9701093A0 (en) 1997-10-31
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DZ2009A1 (fr) 2002-10-23
TW394765B (en) 2000-06-21
EE9700323A (et) 1998-06-15
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AP753A (en) 1999-07-21
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CA2214321A1 (fr) 1996-10-03
CA2214321C (fr) 2008-01-22
HUP9801201A3 (en) 2000-12-28
CN1213042C (zh) 2005-08-03
AU5278096A (en) 1996-10-16
US6387946B1 (en) 2002-05-14
NO316607B1 (no) 2004-03-08
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IS4567A (is) 1997-09-23
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EP0817779A1 (fr) 1998-01-14
IS2058B (is) 2005-10-14
EA199700270A1 (ru) 1998-02-26
US20020038038A1 (en) 2002-03-28
GR3031526T3 (en) 2000-01-31
MA23823A1 (fr) 1996-10-01
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AU703278B2 (en) 1999-03-25
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IS4536A (is) 1997-07-31
UY24192A1 (es) 1996-06-14
US5889043A (en) 1999-03-30
UY24370A1 (es) 2001-10-25
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JP2941951B2 (ja) 1999-08-30
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SK130197A3 (en) 1998-04-08
NO973923L (no) 1997-08-26
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DK0817780T3 (da) 2000-03-27
DE69606028D1 (de) 2000-02-10
CA2214319A1 (fr) 1996-10-03
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AU711227B2 (en) 1999-10-07
US6331635B1 (en) 2001-12-18
DE69604653D1 (de) 1999-11-18
BR9607929A (pt) 1998-06-02
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