ATE203016T1 - Cryptophycine - Google Patents

Cryptophycine

Info

Publication number
ATE203016T1
ATE203016T1 AT95906059T AT95906059T ATE203016T1 AT E203016 T1 ATE203016 T1 AT E203016T1 AT 95906059 T AT95906059 T AT 95906059T AT 95906059 T AT95906059 T AT 95906059T AT E203016 T1 ATE203016 T1 AT E203016T1
Authority
AT
Austria
Prior art keywords
cryptophycins
methods
pharmaceuticals
proliferation
inhibit
Prior art date
Application number
AT95906059T
Other languages
English (en)
Inventor
Richard E Moore
Charles D Smith
Gregory M L Patterson
Susan L Mooberry
Thomas H Corbett
Frederick A Valeriote
Trimurtulu Golakoti
Original Assignee
Univ Hawaii
Univ Wayne State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Hawaii, Univ Wayne State filed Critical Univ Hawaii
Application granted granted Critical
Publication of ATE203016T1 publication Critical patent/ATE203016T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT95906059T 1993-12-21 1994-12-21 Cryptophycine ATE203016T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17263293A 1993-12-21 1993-12-21
US24995594A 1994-05-27 1994-05-27
PCT/US1994/014740 WO1995017093A1 (en) 1993-12-21 1994-12-21 New cryptophycins

Publications (1)

Publication Number Publication Date
ATE203016T1 true ATE203016T1 (de) 2001-07-15

Family

ID=26868303

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95906059T ATE203016T1 (de) 1993-12-21 1994-12-21 Cryptophycine

Country Status (8)

Country Link
US (2) US6013626A (de)
EP (1) EP0735819B1 (de)
JP (1) JPH09510436A (de)
AT (1) ATE203016T1 (de)
AU (1) AU695873B2 (de)
CA (1) CA2179490A1 (de)
DE (1) DE69427706T2 (de)
WO (1) WO1995017093A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE203016T1 (de) * 1993-12-21 2001-07-15 Univ Hawaii Cryptophycine
PL185949B1 (pl) * 1995-03-07 2003-09-30 Univ Hawaii Nowe związki kryptoficynowe, sposób wytwarzania nowych związków kryptoficynowych, zawierająca je kompozycja farmaceutyczna i ich zastosowanie
MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US6372780B2 (en) 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
JP2000502351A (ja) * 1995-12-22 2000-02-29 イーライ・リリー・アンド・カンパニー 医薬化合物
WO1997031632A1 (en) * 1996-02-27 1997-09-04 Eli Lilly And Company Pharmaceutical compounds
EP0934065B1 (de) * 1996-08-30 2006-06-07 University Of Hawaii Neue cryptophycin-derivate als antineoplastika
CA2263420A1 (en) * 1996-08-30 1998-03-05 James Edward Ray Pharmaceutical compounds
US6680311B1 (en) 1996-08-30 2004-01-20 Eli Lilly And Company Cryptophycin compounds
CA2264294A1 (en) * 1996-08-30 1998-03-05 University Of Hawai'i Process for preparing pharmaceutical compounds
EP0934250A4 (de) * 1996-09-06 2004-08-11 Lilly Co Eli Verfahren zum herstellen pharmazeutischer verbindungen
JP2001500496A (ja) * 1996-09-06 2001-01-16 イーライ・リリー・アンド・カンパニー 医薬化合物の製造方法
WO1998009955A1 (en) * 1996-09-06 1998-03-12 Eli Lilly And Company Process and novel intermediates
AU6667198A (en) * 1997-02-26 1998-09-18 Eli Lilly And Company Process for preparing pharmaceutical compounds
US6180679B1 (en) * 1998-04-07 2001-01-30 Eli Lilly And Company Method for treating fungal infections
US6376230B1 (en) 1998-10-16 2002-04-23 Eli Lilly And Company Stereoselective process for producing intermediates of cryptophycins
US6103913A (en) * 1998-10-16 2000-08-15 Eli Lilly And Company Process for preparing enollactone derivatives
IT1307320B1 (it) * 1999-06-29 2001-10-30 Univ Firenze Ceppo cianobatterico del genere nostoc, nonche' colture, biomasse,estratti, molocole bioattive derivate da tale ceppo e loro uso in
EP2266607A3 (de) 1999-10-01 2011-04-20 Immunogen, Inc. Immunokonjugate für Krebsbehandlung
US6747021B2 (en) 2000-10-02 2004-06-08 Eli Lilly And Company Cryptophycin compound
AU2002246542A1 (en) * 2000-10-31 2002-07-30 Chemgenex Therapeutics, Inc. Antiproliferative colchicine compositions and uses thereof
US20050170015A1 (en) * 2000-10-31 2005-08-04 Brown Dennis M. Antiproliferative colchicine compositions and uses thereof
US6743598B2 (en) * 2001-08-10 2004-06-01 Mycologics, Inc. Methods for the identification of fungal glucose utilization inhibitors and antifungal agents
US7625885B2 (en) * 2004-02-17 2009-12-01 University Of South Florida Cytotoxin compound and method of isolation
US7229814B2 (en) * 2004-05-05 2007-06-12 Regents Of The University Of Minnesota Nucleic acids and polypeptides involved in the production of cryptophycin
US7566558B2 (en) * 2006-07-28 2009-07-28 Regents Of The University Of Michigan Nucleic acids and polypeptides involved in the production of cryptophycin
US20110269698A1 (en) * 2009-01-02 2011-11-03 Chung-Ang University Industry-Academy Cooperation Foundation Novel Cyclic Pentadepsipeptide Derivative and Fusarium Strain Producing The Same
TWI714661B (zh) * 2015-11-05 2021-01-01 法商賽諾菲公司 新穎念珠藻素化合物及接合物、其製備與其治療用途
BR112018016757A2 (pt) * 2016-02-16 2020-05-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. análogos de fenilalanina não-proteícos para inibir crescimento de cianobacteria e de plantas.
EP4038085A1 (de) * 2019-09-30 2022-08-10 The Regents of The University of Michigan Biokatalytische synthese von cryptophycin-antikrebsmitteln

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946835A (en) * 1988-07-15 1990-08-07 Merck & Co., Inc. Antifungal fermentation product and method
US4868208A (en) * 1988-07-15 1989-09-19 Merck & Co., Inc. Antifungal agent and method
US4845085A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
US4845086A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
ATE203016T1 (de) * 1993-12-21 2001-07-15 Univ Hawaii Cryptophycine

Also Published As

Publication number Publication date
JPH09510436A (ja) 1997-10-21
AU695873B2 (en) 1998-08-27
EP0735819A1 (de) 1996-10-09
EP0735819A4 (de) 1997-03-19
WO1995017093A1 (en) 1995-06-29
CA2179490A1 (en) 1995-06-29
EP0735819B1 (de) 2001-07-11
US6013626A (en) 2000-01-11
US5945315A (en) 1999-08-31
DE69427706D1 (en) 2001-08-16
AU1442395A (en) 1995-07-10
DE69427706T2 (de) 2001-10-25

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee