MX9704050A - P-amidinobencilamidas de dipeptido novedosas con radicales sulfonilo o aminosulfonilo en terminal n. - Google Patents

P-amidinobencilamidas de dipeptido novedosas con radicales sulfonilo o aminosulfonilo en terminal n.

Info

Publication number
MX9704050A
MX9704050A MX9704050A MX9704050A MX9704050A MX 9704050 A MX9704050 A MX 9704050A MX 9704050 A MX9704050 A MX 9704050A MX 9704050 A MX9704050 A MX 9704050A MX 9704050 A MX9704050 A MX 9704050A
Authority
MX
Mexico
Prior art keywords
amidinobenzylamides
aminosulfonyl radicals
terminal sulfonyl
new dipeptide
new
Prior art date
Application number
MX9704050A
Other languages
English (en)
Other versions
MXPA97004050A (es
Inventor
Hans-Joachim Boehm
Stefan Koser
Helmut Mack
Thomas Pfeiffer
Werner Seitz
Hans Wolfgang Hoffken
Wilfried Hornberger
Thomas Zierke
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of MXPA97004050A publication Critical patent/MXPA97004050A/es
Publication of MX9704050A publication Critical patent/MX9704050A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Se describen compuestos de la formula I (Ver Formula) en donde R1; A y B tiene los significados establecidos en la descripcion, así como la preparacion de los mismos. Los compuestos novedosos son adecuados para controlar enfermedades.
MX9704050A 1994-12-06 1995-11-25 P-amidinobencilamidas de dipeptido novedosas con radicales sulfonilo o aminosulfonilo en terminal n. MX9704050A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4443390A DE4443390A1 (de) 1994-12-06 1994-12-06 Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten
DEP4443390.5 1994-12-06
PCT/EP1995/004646 WO1996017860A1 (de) 1994-12-06 1995-11-25 Neue dipeptidische p-amidinobenzylamide mit n-terminalen sulfonyl- bzw. aminosulfonylresten

Publications (2)

Publication Number Publication Date
MXPA97004050A MXPA97004050A (es) 1997-08-01
MX9704050A true MX9704050A (es) 1997-08-30

Family

ID=6535046

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9704050A MX9704050A (es) 1994-12-06 1995-11-25 P-amidinobencilamidas de dipeptido novedosas con radicales sulfonilo o aminosulfonilo en terminal n.

Country Status (20)

Country Link
US (1) US5852051A (es)
EP (1) EP0796271B1 (es)
JP (1) JPH10509727A (es)
CN (1) CN1168673A (es)
AT (1) ATE189458T1 (es)
AU (1) AU699579B2 (es)
BR (1) BR9509970A (es)
CA (1) CA2207874A1 (es)
CZ (1) CZ153797A3 (es)
DE (2) DE4443390A1 (es)
ES (1) ES2143666T3 (es)
FI (1) FI972384A0 (es)
HU (1) HU222353B1 (es)
IL (1) IL116231A (es)
MX (1) MX9704050A (es)
NO (1) NO972559L (es)
RU (1) RU2152953C1 (es)
TW (1) TW336222B (es)
WO (1) WO1996017860A1 (es)
ZA (1) ZA9510295B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9900043D0 (sv) * 1999-01-11 1999-01-11 Astra Ab New use
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
US6200967B1 (en) 1996-06-25 2001-03-13 Eli Lilly And Company Anticoagulant agents
US5863929A (en) 1996-06-25 1999-01-26 Eli Lilly And Company Anticoagulant agents
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
BR0009678A (pt) 1999-04-09 2002-01-22 Basf Ag Compostos, composição farmacêutica, e, uso de compostos
NZ518195A (en) * 2000-08-11 2005-04-29 Corvas Int Inc Non-covalent inhibitors of urokinase and blood vessel formation
EP1182207B1 (en) * 2000-08-11 2007-04-18 Dendreon Corporation Non-covalent inhibitors of urokinase and blood vessel formation
DE10049937A1 (de) * 2000-10-06 2002-04-11 Knoll Ag Niedermolekulare Inhibitoren von Serinproteasen mit Polyhydroxyalkyl- und Polyhydroxycycloalkylresten
CH695999A5 (de) 2002-02-28 2006-11-15 Wilex Ag Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
DE102004029812A1 (de) * 2004-06-19 2006-05-24 Clariant Gmbh Verfahren zur Herstellung von Nitrilen aus Aldehydoximen durch Umsetzung mit Alkylphosphonsäureanhydriden

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
CA2140598C (en) * 1994-01-27 2010-03-09 Masahiro Ohshima Prolineamide derivatives
ZA951617B (en) * 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.

Also Published As

Publication number Publication date
TW336222B (en) 1998-07-11
EP0796271A1 (de) 1997-09-24
WO1996017860A1 (de) 1996-06-13
CN1168673A (zh) 1997-12-24
DE59507755D1 (de) 2000-03-09
FI972384A (fi) 1997-06-05
AU4255996A (en) 1996-06-26
US5852051A (en) 1998-12-22
NO972559D0 (no) 1997-06-05
EP0796271B1 (de) 2000-02-02
CA2207874A1 (en) 1996-06-13
ZA9510295B (en) 1997-06-05
IL116231A0 (en) 1996-03-31
NO972559L (no) 1997-08-05
DE4443390A1 (de) 1996-06-13
HUT77289A (hu) 1998-03-30
BR9509970A (pt) 1997-11-25
JPH10509727A (ja) 1998-09-22
IL116231A (en) 2001-01-28
CZ153797A3 (cs) 1998-02-18
FI972384A0 (fi) 1997-06-05
ATE189458T1 (de) 2000-02-15
ES2143666T3 (es) 2000-05-16
RU2152953C1 (ru) 2000-07-20
HU222353B1 (hu) 2003-06-28
AU699579B2 (en) 1998-12-10

Similar Documents

Publication Publication Date Title
MX9704050A (es) P-amidinobencilamidas de dipeptido novedosas con radicales sulfonilo o aminosulfonilo en terminal n.
BG101112A (en) The use of heterocyclic compounds
MX9700886A (es) Nuevas oxazolidinonas sustituidas.
BG102616A (en) Substituted aza- and diazacycloheptane and cyclooctane derivatives and their application
ZA988158B (en) Sulfinic acid derivatives and their preparation and use
BG103096A (en) Thrombin inhibitors
BG102425A (en) (methylsulphonyl)phenyl-2-(5h)-furanons as cyclooxygenase-2-inhibitors
DE69530403T2 (de) Analogen des keratinozytenwachstumfaktors
GB9406857D0 (en) Improvements in or relating to organic compounds
DK0944643T3 (da) Oxyiminopregnancarbolactoner.
ES2140565T3 (es) Nuevos derivados de pirazina-carboxamida, su preparacion y su utilizacion en medicamentos.
BG103399A (en) New heterocycle-substituted benzamides and their application for the treatment of diseases
MY117090A (en) Substituted benzamidines, their preparation and their use as pharmaceutical compounds
FI972308A0 (fi) 2-substituoituja 1,2,5-tiadiatsolidin-3-oni-1,1-dioksideja ja niitä sisältäviä koostumuksia ja menetelmiä niiden käyttämiseksi
BG103558A (en) Sulphonic acid or sulphonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds
MX9700807A (es) Derivados de 3-azabiciclo (3.2.0)heptano n-sustituidos utiles como neurolepticos.
AR241022A2 (es) "fosfatidos de eteres de glicerina y procedimiento para su preparacion"
ATE45739T1 (de) Indolophenanthridine, ihre herstellung und verwendung.
FI891473A (fi) Menetelmä terapeuttisesti käyttökelpoisten 4-aryyli-4-piperidiinikarbinolien valmistamiseksi
ES2128313T3 (es) Naftalimidas n-substituidas, su obtencion y empleo.
IL89325A0 (en) Optically active rhodium complexes of 3,4-bis(diarylphosphino)pyrrolidines and their use for the preparation of phosphinothricin by asymmetric hydrogenation
MX9701764A (es) Derivados de imidoacidos.
DE69409961T2 (de) Triarylethylenderivate zur therapeutischen verwendung
MX9603722A (es) Nuevos pseudopeptidos sustituidos con heterociclos.
MX9704796A (es) Peptidos novedosos, su preparacion y uso.

Legal Events

Date Code Title Description
FG Grant or registration
PD Change of proprietorship

Owner name: ABBOTT GMBH & CO. KG

MM Annulment or lapse due to non-payment of fees