IL117636A - Taxoids, their preparation and pharmaceutical compositions containing them - Google Patents

Taxoids, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL117636A
IL117636A IL11763696A IL11763696A IL117636A IL 117636 A IL117636 A IL 117636A IL 11763696 A IL11763696 A IL 11763696A IL 11763696 A IL11763696 A IL 11763696A IL 117636 A IL117636 A IL 117636A
Authority
IL
Israel
Prior art keywords
carbon atoms
radical
formula
alkyl
radical containing
Prior art date
Application number
IL11763696A
Other languages
English (en)
Other versions
IL117636A0 (en
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9503545A external-priority patent/FR2732340B1/fr
Priority claimed from FR9515381A external-priority patent/FR2742754B1/fr
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Priority to IL15937896A priority Critical patent/IL159378A/xx
Publication of IL117636A0 publication Critical patent/IL117636A0/xx
Priority to IL15937803A priority patent/IL159378A0/xx
Publication of IL117636A publication Critical patent/IL117636A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL11763696A 1995-03-27 1996-03-24 Taxoids, their preparation and pharmaceutical compositions containing them IL117636A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL15937896A IL159378A (en) 1995-03-27 1996-03-24 Intermediate in the preparation of taxoids
IL15937803A IL159378A0 (en) 1995-03-27 2003-12-15 Intermediate in the preparation of taxoids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9503545A FR2732340B1 (fr) 1995-03-27 1995-03-27 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR9515381A FR2742754B1 (fr) 1995-12-22 1995-12-22 Procede de preparation de taxoides

Publications (2)

Publication Number Publication Date
IL117636A0 IL117636A0 (en) 1996-07-23
IL117636A true IL117636A (en) 2004-08-31

Family

ID=26231838

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11763696A IL117636A (en) 1995-03-27 1996-03-24 Taxoids, their preparation and pharmaceutical compositions containing them

Country Status (41)

Country Link
US (3) US5889043A (el)
EP (2) EP0817780B1 (el)
JP (2) JP3790826B2 (el)
KR (2) KR100485309B1 (el)
CN (2) CN1213042C (el)
AP (2) AP753A (el)
AR (1) AR001440A1 (el)
AT (2) ATE185562T1 (el)
AU (2) AU703278B2 (el)
BG (2) BG63121B1 (el)
BR (2) BR9607930A (el)
CA (2) CA2214319C (el)
CO (1) CO4700576A1 (el)
CZ (2) CZ287326B6 (el)
DE (2) DE69606028T2 (el)
DK (2) DK0817780T3 (el)
DZ (1) DZ2009A1 (el)
EA (2) EA000567B1 (el)
EE (2) EE03609B1 (el)
ES (2) ES2143187T3 (el)
GE (2) GEP20002211B (el)
GR (2) GR3031526T3 (el)
HU (2) HU223732B1 (el)
IL (1) IL117636A (el)
IS (2) IS2058B (el)
MA (1) MA23823A1 (el)
MY (1) MY121225A (el)
NO (2) NO316379B1 (el)
NZ (2) NZ304900A (el)
OA (2) OA10514A (el)
PE (1) PE51097A1 (el)
PL (2) PL188284B1 (el)
PT (1) PT817779E (el)
RO (2) RO115878B1 (el)
SK (2) SK281928B6 (el)
TN (1) TNSN96043A1 (el)
TR (2) TR199701040T1 (el)
TW (1) TW394765B (el)
UY (2) UY24192A1 (el)
WO (2) WO1996030356A1 (el)
ZA (1) ZA962399B (el)

Families Citing this family (77)

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US6500858B2 (en) 1994-10-28 2002-12-31 The Research Foundation Of The State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US5811452A (en) * 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
FR2771092B1 (fr) * 1997-11-18 1999-12-17 Rhone Poulenc Rorer Sa Procede de preparation de derives de la classe des taxoides
EP0982027A1 (en) * 1998-08-17 2000-03-01 Aventis Pharma S.A. Taxoid derivatives for treating abnormal cell proliferation of the brain
US6346543B1 (en) * 1998-08-17 2002-02-12 Aventis Pharma S.A. Use of a taxoid to treat abnormal cell proliferation in the brain
EP0982028A1 (en) * 1998-08-20 2000-03-01 Aventis Pharma S.A. New use of taxoid derivatives
JP2002523364A (ja) * 1998-08-20 2002-07-30 アベンテイス・フアルマ・ソシエテ・アノニム タキソイド誘導体の新規な使用
EP1020188A1 (en) * 1999-01-13 2000-07-19 Aventis Pharma S.A. New use of taxoid derivatives
CN1362876A (zh) * 2000-02-02 2002-08-07 佛罗里达州立大学研究基金有限公司 C10杂取代的乙酸基紫衫烷抗肿瘤剂
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
US8147816B2 (en) * 2000-08-16 2012-04-03 Encore Health, Llc Presbyopia treatment by lens alteration
AU2001290636A1 (en) * 2000-09-22 2002-04-02 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
AU2001288805A1 (en) * 2000-09-22 2002-04-02 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
US6593334B1 (en) 2002-05-02 2003-07-15 The University Of North Carolina At Chapel Hill Camptothecin-taxoid conjugates as antimitotic and antitumor agents
PT1534340E (pt) 2002-09-06 2012-03-13 Cerulean Pharma Inc Polímeros à base de ciclodextrina para a administração de medicamentos ligados por ligação covalente
AU2003291458A1 (en) * 2002-11-08 2004-06-03 Bristol-Myers Squibb Company Pharmaceutical compositions and methods of using taxane derivatives
CA2526278A1 (en) * 2003-05-20 2004-12-02 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising a liposomal platinum complex
US7064980B2 (en) * 2003-09-17 2006-06-20 Sandisk Corporation Non-volatile memory and method with bit line coupled compensation
FR2859996B1 (fr) * 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
GT200500025A (es) * 2004-02-13 2005-09-30 Taxanos sustituidos con esteres de ciclopentilo en c10
HN2005000054A (es) * 2004-02-13 2009-02-18 Florida State University Foundation Inc Taxanos sustituidos con esteres de ciclopentilo en c10
AU2006214498A1 (en) * 2005-02-14 2006-08-24 Florida State University Research Foundation, Inc. C10 cyclopropyl ester substituted taxane compositions
PL1871753T3 (pl) * 2005-03-31 2012-12-31 Accord Healthcare Inc Wytwarzanie taksanów z 9-dihydro-13-acetylobakatyny iii
US8207358B2 (en) * 2005-11-04 2012-06-26 Accord Healthcare Ltd. Methods for the preparation of taxanes using chiral auxiliaries
US7847111B2 (en) * 2006-06-19 2010-12-07 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
JP2010516625A (ja) 2007-01-24 2010-05-20 インサート セラピューティクス， インコーポレイテッド 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート
EP2173732A4 (en) * 2007-07-04 2011-09-07 Reddys Lab Ltd Dr PROCESSES FOR THE PREPARATION OF DOCETAXEL AND POLYMORPHIC
FR2926551A1 (fr) 2008-01-17 2009-07-24 Aventis Pharma Sa Formes cristallines du dimethoxy docetaxel et leurs procedes de preparation
JP2011517455A (ja) 2008-03-31 2011-06-09 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド Ｃ（１０）エチルエステルおよびｃ（１０）シクロプロピルエステル置換タキサン
CA2732508C (en) 2008-08-11 2016-03-15 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates
FR2945211A1 (fr) 2009-05-06 2010-11-12 Sanofi Aventis Combinaison antitumorale comprenant la cabazitaxel et la capecitabine
CA2779009A1 (en) 2009-10-29 2011-05-05 Aventis Pharma S.A. Novel antitumoral use of cabazitaxel
JP6220126B2 (ja) * 2009-11-23 2017-10-25 セルリアン・ファーマ・インコーポレイテッド 治療的送達のためのシクロデキストリンに基づく重合体
US8791279B2 (en) * 2010-12-13 2014-07-29 Yung Shin Pharm. Ind. Co., Ltd. Process for preparing taxoids from baccatin derivatives using lewis acid catalyst
WO2012088422A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
WO2012088445A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
US20130338216A1 (en) 2010-12-22 2013-12-19 Nektar Therapeutics Deuterated and/or fluorinated taxane derivatives
CN102060815B (zh) * 2010-12-24 2012-09-26 重庆泰濠制药有限公司 一种紫杉烷类化合物的制备方法
WO2012113897A1 (en) 2011-02-25 2012-08-30 Aventis Pharma S.A. Antitumoral combination comprising cabazitaxel and cisplatin
EP2620148A1 (en) 2012-01-27 2013-07-31 Aventis Pharma S.A. Antitumoral combination comprising cabazitaxel and cisplatin
EP2491925A1 (en) 2011-02-25 2012-08-29 Aventis Pharma S.A. Antitumoral combination comprising cabazitaxel and cisplatin
JP2014514306A (ja) * 2011-04-12 2014-06-19 プラス・ケミカルス・エスアー 固体形態のカバジタキセル及びその製造方法
EP2740477A1 (en) 2011-08-02 2014-06-11 Astellas Pharma Inc. Method for treating cancer by combined use of medicinal agents
TWI526437B (zh) 2011-09-09 2016-03-21 台灣神隆股份有限公司 卡巴他賽之結晶型
EP2760848B1 (en) * 2011-09-26 2018-11-28 Fresenius Kabi Oncology Limited Processes for the preparation of cabazitaxel involving c(7)-oh and c(13)-oh silylation or just c(7)-oh silylation
CN102336726B (zh) * 2011-09-30 2014-11-26 重庆泰濠制药有限公司 一种卡巴他赛的制备方法
US20130090484A1 (en) * 2011-10-11 2013-04-11 Scinopharm Taiwan Ltd. Process for making an intermediate of cabazitaxel
CN102408397B (zh) * 2011-10-19 2014-08-20 上海贝美医药科技有限公司 紫杉烷类衍生物及其制备方法
CN102516281B (zh) * 2011-10-20 2015-02-04 江苏红豆杉生物科技股份有限公司 一种10-脱乙酰基巴卡丁iii及其衍生物甲氧基化的方法
CN102424672A (zh) * 2011-10-20 2012-04-25 江苏红豆杉生物科技有限公司 脱保护基制备二甲氧基紫杉烷类化合物的方法
CN102603724B (zh) * 2011-10-20 2014-02-26 江苏红豆杉生物科技股份有限公司 二甲氧基紫杉烷类化合物纯化精制的方法
CN103906747A (zh) * 2011-10-31 2014-07-02 台湾神隆股份有限公司 卡巴他赛及其中间体的制备方法
CN102417491B (zh) * 2011-10-31 2013-11-06 江苏红豆杉生物科技有限公司 以10-去乙酰基-巴卡丁iii为原料制备卡巴他赛的方法
DE112012004569T5 (de) * 2011-11-01 2014-08-14 Fresenius Kabi Oncology Ltd. Amorphe Form von Cabazitaxel und Verfahren zum Herstellen davon
CN103159705B (zh) * 2011-12-12 2015-05-27 福建南方制药股份有限公司 卡巴他赛中间体的制备方法
CN102532064B (zh) * 2011-12-13 2015-06-17 重庆泰濠制药有限公司 二甲氧基多西他赛的合成方法
WO2013088335A1 (en) 2011-12-13 2013-06-20 Aventis Pharma S.A. Crystalline form of cabazitaxel and process for preparing the same
CN104583189A (zh) * 2012-07-31 2015-04-29 永信药品工业股份有限公司 非晶型的卡巴利他索
CN102775435B (zh) * 2012-08-21 2015-04-08 江苏红豆杉生物科技股份有限公司 一种用于制备7,10-甲氧基多西他赛的中间体的合成方法
CN102775434B (zh) * 2012-08-21 2015-04-08 江苏红豆杉生物科技股份有限公司 一种7,10-二甲氧基紫杉烷化合物中间体的合成方法
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CN103804323A (zh) * 2012-11-14 2014-05-21 上海希迈医药科技有限公司 一种卡巴他赛溶剂化物及其制备方法和应用
KR101407353B1 (ko) * 2012-12-04 2014-06-17 주식회사 삼양바이오팜 10-디아세틸바카틴 iii으로부터 카바지탁셀을 고수율로 제조하는 새로운 방법 및 이를 위한 신규 중간체
EP2743264A1 (en) 2012-12-13 2014-06-18 INDENA S.p.A. New crystalline form of cabazitaxel, process for the preparation and pharmaceutical compositions thereof
EP2815749A1 (en) 2013-06-20 2014-12-24 IP Gesellschaft für Management mbH Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern
EP2865674A1 (en) 2013-10-23 2015-04-29 INDENA S.p.A. Crystalline solvate forms of Cabazitaxel
EP2865675A1 (en) 2013-10-23 2015-04-29 INDENA S.p.A. A crystalline anhydrous form of Cabazitaxel, process for the preparation and pharmaceutical compositions thereof
CN104650012A (zh) * 2013-11-22 2015-05-27 天士力控股集团有限公司 一种紫杉烷类化合物
CN104086514A (zh) * 2014-06-19 2014-10-08 上海应用技术学院 紫杉醇衍生物及其制备方法
PL3258931T3 (pl) 2015-02-17 2020-12-28 Erasmus University Medical Center Rotterdam Zastosowanie kabazitakselu w leczeniu nowotworu złośliwego prostaty
EP3093014A1 (en) 2015-05-13 2016-11-16 Aventis Pharma S.A. Cabazitaxel and its use for treating cancer
WO2020249507A1 (en) 2019-06-11 2020-12-17 Indena S.P.A. Anhydrous crystalline form of cabazitaxel, a process for its preparation and pharmaceutical compositions containing it
JP2022543679A (ja) 2019-08-08 2022-10-13 ラークナ・リミテッド 癌を処置する方法
EP3797834A1 (en) 2019-09-25 2021-03-31 Sanofi Mature IP Cabazitaxel in mcrpc patients previously treated with docetaxel and who failed a prior androgen signaling targeted inhibitor agent
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FR2629819B1 (fr) 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
MX9102128A (es) 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
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US5489601A (en) 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
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Also Published As

Publication number Publication date
IL117636A0 (en) 1996-07-23
ZA962399B (en) 1996-10-01
BG101917A (en) 1998-10-30
NO316607B1 (no) 2004-03-08
EA000567B1 (ru) 1999-12-29
MA23823A1 (fr) 1996-10-01
AU711227B2 (en) 1999-10-07
DE69604653T2 (de) 2000-05-31
WO1996030355A1 (fr) 1996-10-03
EA199700269A1 (ru) 1998-04-30
AU5278096A (en) 1996-10-16
UY24192A1 (es) 1996-06-14
AP9701093A0 (en) 1997-10-31
US6331635B1 (en) 2001-12-18
AP9701090A0 (en) 1997-10-31
RO115878B1 (ro) 2000-07-28
PL322465A1 (en) 1998-02-02
IS2056B (is) 2005-10-14
ATE185562T1 (de) 1999-10-15
KR100297196B1 (ko) 2001-11-22
EP0817779B1 (fr) 2000-01-05
DE69604653D1 (de) 1999-11-18
TR199701042T1 (xx) 1998-01-21
AR001440A1 (es) 1997-10-22
KR19980703287A (ko) 1998-10-15
NZ304901A (en) 1998-12-23
CA2214319A1 (fr) 1996-10-03
GEP20002211B (en) 2000-08-25
AP753A (en) 1999-07-21
EP0817780B1 (fr) 1999-10-13
AP785A (en) 1999-11-26
GEP20002188B (en) 2000-07-25
CZ287468B6 (en) 2000-12-13
UY24370A1 (es) 2001-10-25
NO316379B1 (no) 2004-01-19
CO4700576A1 (es) 1998-12-29
NO973923L (no) 1997-08-26
JPH11500141A (ja) 1999-01-06
DK0817780T3 (da) 2000-03-27
OA10514A (fr) 2002-04-22
CZ303297A3 (cs) 1998-01-14
MX9706568A (es) 1997-11-29
IS4567A (is) 1997-09-23
AU5278196A (en) 1996-10-16
DE69606028D1 (de) 2000-02-10
CA2214321C (fr) 2008-01-22
CZ303097A3 (cs) 1998-01-14
DE69606028T2 (de) 2000-08-10
CA2214321A1 (fr) 1996-10-03
KR19980703357A (ko) 1998-10-15
BG101918A (en) 1998-10-30
TR199701040T1 (xx) 1998-01-21
SK281928B6 (sk) 2001-09-11
HUP9801201A3 (en) 2000-12-28
TW394765B (en) 2000-06-21
HU223732B1 (hu) 2004-12-28
AU703278B2 (en) 1999-03-25
DK0817779T3 (da) 2000-06-19
CN1179775A (zh) 1998-04-22
TNSN96043A1 (fr) 2005-03-15
HUP9801204A3 (en) 2000-12-28
CN1213042C (zh) 2005-08-03
RO115877B1 (ro) 2000-07-28
HU223666B1 (hu) 2004-11-29
PL188284B1 (pl) 2005-01-31
KR100485309B1 (ko) 2005-10-12
EA199700270A1 (ru) 1998-02-26
OA10513A (fr) 2002-04-22
GR3031526T3 (en) 2000-01-31
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BG63121B1 (bg) 2001-04-30
US5889043A (en) 1999-03-30
CN1152870C (zh) 2004-06-09
MY121225A (en) 2006-01-28
PT817779E (pt) 2000-04-28
CA2214319C (fr) 2004-02-17
US6387946B1 (en) 2002-05-14
EE03609B1 (et) 2002-02-15
BG63009B1 (bg) 2001-01-31
PL322499A1 (en) 1998-02-02
EP0817779A1 (fr) 1998-01-14
EE9700323A (et) 1998-06-15
JP2941951B2 (ja) 1999-08-30
IS2058B (is) 2005-10-14
HUP9801201A2 (hu) 2000-05-28
EE9700315A (et) 1998-06-15
EE03608B1 (et) 2002-02-15
EP0817780A1 (fr) 1998-01-14
NO973923D0 (no) 1997-08-26
DZ2009A1 (fr) 2002-10-23
ATE188471T1 (de) 2000-01-15
HUP9801204A1 (hu) 2000-05-28
SK130297A3 (en) 1998-03-04
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NZ304900A (en) 1998-09-24
BR9607930A (pt) 1998-06-02
WO1996030356A1 (fr) 1996-10-03
ES2143187T3 (es) 2000-05-01
JP3790826B2 (ja) 2006-06-28
BR9607929A (pt) 1998-06-02
ES2140075T3 (es) 2000-02-16
MX9706278A (es) 1997-10-31
NO973922D0 (no) 1997-08-26
CZ287326B6 (en) 2000-10-11
SK130197A3 (en) 1998-04-08
US20020038038A1 (en) 2002-03-28
NO973922L (no) 1997-08-26
CN1179776A (zh) 1998-04-22
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IS4536A (is) 1997-07-31
PL188987B1 (pl) 2005-05-31

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