MX9700026A - Analogos de 7-eter-taxol, su uso antineoplastico y composiciones farmaceuticas que los contienen. - Google Patents

Analogos de 7-eter-taxol, su uso antineoplastico y composiciones farmaceuticas que los contienen.

Info

Publication number
MX9700026A
MX9700026A MX9700026A MX9700026A MX9700026A MX 9700026 A MX9700026 A MX 9700026A MX 9700026 A MX9700026 A MX 9700026A MX 9700026 A MX9700026 A MX 9700026A MX 9700026 A MX9700026 A MX 9700026A
Authority
MX
Mexico
Prior art keywords
ether
cancer
pharmaceutical compositions
compositions containing
taxol analogs
Prior art date
Application number
MX9700026A
Other languages
English (en)
Inventor
Robert C Kelly
Ilse Gebhard
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of MX9700026A publication Critical patent/MX9700026A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)

Abstract

La invencion proporciona análogos de 7-eter-taxol de la formula (1). Los compuestos de la formula 1 son utiles para el tratamiento de los mismos tipos de cáncer paralos que el taxol ha mostrado ser activo, incluyendo cáncer de ovario, de mama y melanoma maligno en humanos, así como cáncer de pulmon, cáncer gástrico, cáncer de colon, cáncer de cabeza y cuello y leucemia.
MX9700026A 1994-06-28 1995-06-07 Analogos de 7-eter-taxol, su uso antineoplastico y composiciones farmaceuticas que los contienen. MX9700026A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26817994A 1994-06-28 1994-06-28
PCT/US1995/006595 WO1996000724A1 (en) 1994-06-28 1995-06-07 7-ether-taxol analogs, antineoplastic use and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
MX9700026A true MX9700026A (es) 1997-04-30

Family

ID=23021820

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9700026A MX9700026A (es) 1994-06-28 1995-06-07 Analogos de 7-eter-taxol, su uso antineoplastico y composiciones farmaceuticas que los contienen.

Country Status (12)

Country Link
EP (1) EP0767786B1 (es)
JP (1) JPH10502077A (es)
CN (1) CN1151740A (es)
AT (1) ATE171170T1 (es)
AU (1) AU2814595A (es)
CA (1) CA2191224A1 (es)
DE (1) DE69504843T2 (es)
DK (1) DK0767786T3 (es)
ES (1) ES2123996T3 (es)
MX (1) MX9700026A (es)
NZ (1) NZ288802A (es)
WO (1) WO1996000724A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
US6040466A (en) * 1996-03-25 2000-03-21 Rhone Poulenc Rorer Sa Taxoids, their preparation and pharmaceutical compositions containing them
US6232477B1 (en) 1996-03-25 2001-05-15 Aventis Pharma S.A. Methods of preparing new taxoids and pharmaceutical compositions containing them
US6593482B2 (en) 1993-02-01 2003-07-15 Aventis Pharma S.A. Methods for preparing new taxoids and pharmaceutical compositions containing them
US6372780B2 (en) 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
US5847170A (en) * 1995-03-27 1998-12-08 Rhone-Poulenc Rorer, S.A. Taxoids, their preparation and pharmaceutical compositions containing them
MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
DE19605024A1 (de) * 1996-01-31 1997-08-07 Schering Ag Neue selektive Taxane, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
CA2253443A1 (en) * 1996-05-16 1997-11-20 Bristol-Myers Squibb Company 7-o-methoxymethyl paclitaxel
US5977386A (en) * 1996-12-24 1999-11-02 Bristol-Myers Squibb Company 6-thio-substituted paclitaxels
US5902822A (en) * 1997-02-28 1999-05-11 Bristol-Myers Squibb Company 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
CA2410632A1 (en) 2000-06-22 2001-12-27 David S. Garvey Nitrosated and nitrosylated taxanes, compositions and methods of use
HUP0302599A3 (en) 2000-09-22 2005-05-30 Bristol Myers Squibb Co Method for reducing toxicity of combined chemotherapic compositions
TW200300416A (en) * 2001-11-27 2003-06-01 Bristol Myers Squibb Co Method of synthesizing a paclitaxel derivative
EP2717699B1 (en) * 2011-06-06 2020-06-03 Veiled Therapeutics LLC Acid-labile lipophilic prodrugs of chemo-therapeutic anti-cancer agents
CN102408397B (zh) * 2011-10-19 2014-08-20 上海贝美医药科技有限公司 紫杉烷类衍生物及其制备方法
CN103980232A (zh) * 2014-06-05 2014-08-13 北京诺普德医药科技有限公司 10-乙酰基多西紫杉醇及其用途
CN104086514A (zh) * 2014-06-19 2014-10-08 上海应用技术学院 紫杉醇衍生物及其制备方法
CN107021943B (zh) * 2016-02-02 2020-12-29 中国科学院上海药物研究所 一类7-epi-巴卡亭III衍生物，及其制备方法和用途
CN113698369A (zh) * 2021-08-31 2021-11-26 无锡紫杉药业有限公司 一种除去卡巴他赛中特定单杂的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
IL112412A (en) * 1994-01-28 2000-02-29 Upjohn Co Delta 12,13-iso-taxol analogs and antineoplastic pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DE69504843D1 (de) 1998-10-22
CA2191224A1 (en) 1996-01-11
AU2814595A (en) 1996-01-25
NZ288802A (en) 1998-05-27
WO1996000724A1 (en) 1996-01-11
JPH10502077A (ja) 1998-02-24
EP0767786A1 (en) 1997-04-16
DK0767786T3 (da) 1999-06-14
ES2123996T3 (es) 1999-01-16
DE69504843T2 (de) 1999-02-11
CN1151740A (zh) 1997-06-11
ATE171170T1 (de) 1998-10-15
EP0767786B1 (en) 1998-09-16

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