SK280831B6 - Spôsob výroby 5,6-dihydro-(s)-4(alkylamino)-(s)-6-alkyl-4h- -tieno[2,3-b]tiopyrán-2-sulfónamid-7,7-dioxidu - Google Patents

Spôsob výroby 5,6-dihydro-(s)-4(alkylamino)-(s)-6-alkyl-4h- -tieno[2,3-b]tiopyrán-2-sulfónamid-7,7-dioxidu Download PDF

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Publication number
SK280831B6
SK280831B6 SK1169-95A SK116995A SK280831B6 SK 280831 B6 SK280831 B6 SK 280831B6 SK 116995 A SK116995 A SK 116995A SK 280831 B6 SK280831 B6 SK 280831B6
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SK
Slovakia
Prior art keywords
formula
compound
acid
mixture
process according
Prior art date
Application number
SK1169-95A
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English (en)
Slovak (sk)
Other versions
SK116995A3 (en
Inventor
Paul Sohar
David J. Mathre
Thomas J. Blacklock
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of SK116995A3 publication Critical patent/SK116995A3/sk
Publication of SK280831B6 publication Critical patent/SK280831B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
SK1169-95A 1993-03-22 1994-03-16 Spôsob výroby 5,6-dihydro-(s)-4(alkylamino)-(s)-6-alkyl-4h- -tieno[2,3-b]tiopyrán-2-sulfónamid-7,7-dioxidu SK280831B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3552393A 1993-03-22 1993-03-22
US19588694A 1994-02-10 1994-02-10
PCT/US1994/002852 WO1994021645A1 (en) 1993-03-22 1994-03-16 ENANTIOSELECTIVE SYNTHESIS OF 5,6-DIHYDRO-(S)-4-(ETHYLAMINO)-(S)-6-METHYL-4H-THIENO[2,3-b]THIOPYRAN-2-SULFONAMIDE 7,7-DIOXIDE AND RELATED COMPOUNDS

Publications (2)

Publication Number Publication Date
SK116995A3 SK116995A3 (en) 1997-06-04
SK280831B6 true SK280831B6 (sk) 2000-08-14

Family

ID=26712200

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1169-95A SK280831B6 (sk) 1993-03-22 1994-03-16 Spôsob výroby 5,6-dihydro-(s)-4(alkylamino)-(s)-6-alkyl-4h- -tieno[2,3-b]tiopyrán-2-sulfónamid-7,7-dioxidu

Country Status (29)

Country Link
US (1) US5688968A (xx)
EP (1) EP0617037B1 (xx)
JP (1) JP3273096B2 (xx)
KR (1) KR0157162B1 (xx)
CN (1) CN1046732C (xx)
AT (1) ATE163291T1 (xx)
AU (1) AU673409B2 (xx)
BR (1) BR9406017A (xx)
CA (1) CA2119218C (xx)
CY (1) CY2108B1 (xx)
CZ (1) CZ281390B6 (xx)
DE (1) DE69408550T2 (xx)
DK (1) DK0617037T3 (xx)
ES (1) ES2112482T3 (xx)
FI (1) FI107384B (xx)
GR (1) GR3026178T3 (xx)
HK (1) HK1009063A1 (xx)
HR (1) HRP940182B1 (xx)
HU (1) HU217363B (xx)
NO (1) NO313240B1 (xx)
NZ (1) NZ263092A (xx)
PL (1) PL176373B1 (xx)
RO (1) RO115264B1 (xx)
SI (1) SI9420016B (xx)
SK (1) SK280831B6 (xx)
TW (1) TW265343B (xx)
UA (1) UA41921C2 (xx)
WO (1) WO1994021645A1 (xx)
YU (1) YU48951B (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760249A (en) * 1995-08-29 1998-06-02 Merck & Co., Inc. Synthesis of hydroxysulfone and related compounds
ES2177415B1 (es) * 2000-09-04 2004-10-16 Ragactives, S.L. Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios.
ES2204306B1 (es) * 2002-08-16 2005-08-01 Ragactives, S.L. Formas polimorficas de clorhidrato de dorzolamida, su obtencion y composiciones farmaceuticas que las contienen.
EP1611138A1 (en) * 2003-04-07 2006-01-04 Hetero Drugs Limited A novel crystalline form of dorzolamide hydrochloride
WO2006038222A1 (en) * 2004-07-09 2006-04-13 Fdc Ltd AN IMPROVED PROCESS FOR THE PREPARATION OF 5,6 -DIHYDRO -4H-4(S)-ETHYLAMINO-6(S)-METHYLTHIENO[2,3-b] THIOPYRAN-2-SULFONAMIDE- 7,7 -DIOXIDE AND ITS SALT
ES2253112B1 (es) * 2004-11-05 2007-03-16 Ragactives, S.L. Procedimiento para la obtencion de derivados de 4-(n-alquilamino)-5, 6-dihidro-4h-tieno-(2,3-b)-tiopirano.
WO2006070387A1 (en) * 2004-12-28 2006-07-06 Council Of Scientific And Industrial Research PROCESS FOR PREPARING 5,6-DIHYDRO-4-(S)-(ETHYLAMINO)-6-(S) METHYL-4H-THIENO[2,3b]THIOPYRAN-2-SULPHONAMIDE-7,7-DIOXIDE HCI
US7109353B2 (en) 2004-12-28 2006-09-19 Council Of Scientific And Industrial Research Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCl
WO2006074230A2 (en) * 2005-01-06 2006-07-13 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method of making dorzolamide hydrochloride
JP2008526780A (ja) * 2005-01-18 2008-07-24 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ ドルゾルアミド塩酸塩の非晶質および結晶質の形態およびそれらを製造する方法
JP2010526127A (ja) 2007-05-07 2010-07-29 シプラ・リミテッド ドルゾラミドの製造方法
US8927740B2 (en) 2011-03-10 2015-01-06 Zach System S.P.A. Asymmetric reduction process
ITMI20121165A1 (it) * 2012-07-03 2014-01-04 Zach System Spa Processo di riduzione asimmetrica
MX2016004940A (es) * 2013-10-17 2016-06-28 Dow Agrosciences Llc Proceso para la preparacion de compuestos plaguicidas.
US9102655B2 (en) * 2013-10-17 2015-08-11 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
CN103497202B (zh) * 2013-10-23 2015-12-02 武汉武药科技有限公司 盐酸多佐胺中间体的合成方法
CN108822127B (zh) * 2018-05-30 2020-05-15 沈阳药科大学 4-羟亚胺基噻吩并[2,3-b]噻喃-2-甲酰胺类化合物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863922A (en) * 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4797413A (en) * 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
US4968814A (en) * 1990-04-18 1990-11-06 Merck & Co., Inc. (S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs and synthesis thereof
US5091409A (en) * 1990-05-17 1992-02-25 Merck & Co., Inc. 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides

Also Published As

Publication number Publication date
HRP940182B1 (en) 2000-02-29
JP3273096B2 (ja) 2002-04-08
NO953733D0 (no) 1995-09-21
DK0617037T3 (da) 1998-03-16
PL176373B1 (pl) 1999-05-31
BR9406017A (pt) 1995-12-19
CY2108B1 (en) 2002-04-26
RO115264B1 (ro) 1999-12-30
KR0157162B1 (ko) 1998-11-16
NZ263092A (en) 1997-12-19
TW265343B (xx) 1995-12-11
ATE163291T1 (de) 1998-03-15
CA2119218C (en) 2000-02-15
EP0617037B1 (en) 1998-02-18
CA2119218A1 (en) 1994-09-23
FI954438A0 (fi) 1995-09-20
AU673409B2 (en) 1996-11-07
CN1046732C (zh) 1999-11-24
SK116995A3 (en) 1997-06-04
NO953733L (no) 1995-09-21
AU5787194A (en) 1994-09-29
HU217363B (hu) 2000-01-28
FI107384B (fi) 2001-07-31
YU48951B (sh) 2003-01-31
PL310633A1 (en) 1995-12-27
HK1009063A1 (en) 1999-05-21
YU13194A (sh) 1997-01-08
DE69408550T2 (de) 1998-08-27
FI954438A (fi) 1995-09-20
HRP940182A2 (en) 1996-08-31
UA41921C2 (uk) 2001-10-15
HU9502772D0 (en) 1995-11-28
SI9420016A (en) 1996-06-30
CZ281390B6 (cs) 1996-09-11
NO313240B1 (no) 2002-09-02
GR3026178T3 (en) 1998-05-29
HUT72676A (en) 1996-05-28
ES2112482T3 (es) 1998-04-01
CZ241895A3 (en) 1996-01-17
EP0617037A1 (en) 1994-09-28
US5688968A (en) 1997-11-18
JPH06298767A (ja) 1994-10-25
WO1994021645A1 (en) 1994-09-29
CN1119866A (zh) 1996-04-03
DE69408550D1 (de) 1998-03-26
SI9420016B (sl) 2002-12-31

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TC4A Change of owner's name

Owner name: MERCK SHARP & DOHME CORP., RAHWAY, NJ, US

Effective date: 20100204

PC4A Assignment and transfer of rights

Owner name: SCHERING CORPORATION, KENILWORTH, NEW JERSEY, US

Free format text: FORMER OWNER: MERCK SHARP & DOHME CORP., RAHWAY, NJ, US

Effective date: 20121122

TC4A Change of owner's name

Owner name: MERCK SHARP & DOHME CORP., RAHWAY, NJ, US

Effective date: 20121122

MK4A Patent expired

Expiry date: 20140316