SK119194A3 - Fharmaceuticaly active bicyclic-heterocyclic amines - Google Patents

Fharmaceuticaly active bicyclic-heterocyclic amines Download PDF

Info

Publication number
SK119194A3
SK119194A3 SK1191-94A SK119194A SK119194A3 SK 119194 A3 SK119194 A3 SK 119194A3 SK 119194 A SK119194 A SK 119194A SK 119194 A3 SK119194 A3 SK 119194A3
Authority
SK
Slovakia
Prior art keywords
pyrrolo
pyrrolidinyl
methyl
pyrimidine
defined above
Prior art date
Application number
SK1191-94A
Other languages
English (en)
Slovak (sk)
Inventor
Donald E Ayer
Gordon L Bundy
Eric J Jacobsen
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of SK119194A3 publication Critical patent/SK119194A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
SK1191-94A 1992-04-03 1993-03-16 Fharmaceuticaly active bicyclic-heterocyclic amines SK119194A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86364692A 1992-04-03 1992-04-03
PCT/US1993/002188 WO1993020078A1 (en) 1992-04-03 1993-03-16 Pharmaceutically active bicyclic-heterocyclic amines

Publications (1)

Publication Number Publication Date
SK119194A3 true SK119194A3 (en) 1995-05-10

Family

ID=25341481

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1191-94A SK119194A3 (en) 1992-04-03 1993-03-16 Fharmaceuticaly active bicyclic-heterocyclic amines

Country Status (21)

Country Link
EP (1) EP0633886B1 (da)
JP (1) JPH08502721A (da)
KR (1) KR100284473B1 (da)
AT (1) ATE197051T1 (da)
AU (1) AU675932B2 (da)
CA (1) CA2130937A1 (da)
CZ (1) CZ236494A3 (da)
DE (1) DE69329574T2 (da)
DK (1) DK0633886T3 (da)
ES (1) ES2150941T3 (da)
FI (1) FI944602A (da)
GR (1) GR3035188T3 (da)
HU (1) HUT70954A (da)
LV (1) LV12794B (da)
MX (1) MX9301847A (da)
NO (1) NO303542B1 (da)
PL (2) PL175327B1 (da)
PT (1) PT633886E (da)
RU (1) RU2103272C1 (da)
SK (1) SK119194A3 (da)
WO (1) WO1993020078A1 (da)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026941A1 (en) * 1995-03-02 1996-09-06 Pharmacia & Upjohn Company PYRIMIDO[4,5-b]INDOLES
US6180643B1 (en) 1996-11-19 2001-01-30 Amgen Inc. Aryl and heteroaryl substituted fused pyrrole antiinflammatory agents
WO1998024453A1 (fr) * 1996-12-05 1998-06-11 Nippon Shinyaku Co., Ltd. Medicaments pour la myelopathie
AU723709B2 (en) * 1997-01-08 2000-09-07 Pharmacia & Upjohn Company Pharmaceutically active tricyclic amines
GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB2331988B (en) 1997-12-04 2003-04-16 Imperial College Polycyclic sulphamate inhibitors or oestrone sulphatase
GB9803226D0 (en) 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
NZ508314A (en) * 1998-06-02 2004-03-26 Osi Pharm Inc Pyrrolo[2,3d]pyrimidine compositions and their use
US6686366B1 (en) 1998-06-02 2004-02-03 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6878716B1 (en) 1998-06-02 2005-04-12 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptor and uses thereof
PA8474101A1 (es) * 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
JP2003524598A (ja) * 1998-09-04 2003-08-19 アルタナ ファルマ アクチエンゲゼルシャフト 新規ピラノセン
GB9902452D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902461D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902453D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902455D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902459D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9918035D0 (en) 1999-07-30 1999-09-29 Novartis Ag Organic compounds
US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US7160890B2 (en) 1999-12-02 2007-01-09 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
PT1246623E (pt) * 1999-12-02 2006-12-29 Osi Pharm Inc Compostos específicos para o receptor de adenosina a1,a2a e a3 e as suas utilizações
US6664252B2 (en) 1999-12-02 2003-12-16 Osi Pharmaceuticals, Inc. 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
JP2003518123A (ja) * 1999-12-21 2003-06-03 スージェン・インコーポレーテッド ４−置換７−アザ−インドリン−２−オンおよびその蛋白質キナーゼ阻害剤としての使用
GB0000625D0 (en) 2000-01-13 2000-03-01 Zeneca Ltd Chemical compounds
US6653304B2 (en) 2000-02-11 2003-11-25 Bristol-Myers Squibb Co. Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases
US20020061897A1 (en) 2000-03-30 2002-05-23 Elliott Richard L. Neuropeptide Y antagonists
WO2002008188A1 (en) 2000-07-25 2002-01-31 Merck & Co., Inc. N-substituted indoles useful in the treatment of diabetes
SE0003795D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Pharmaceutically useful compounds
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6673802B2 (en) 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
GB0100622D0 (en) 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds V111
GB0117396D0 (en) 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
ATE446298T1 (de) 2001-11-30 2009-11-15 Osi Pharm Inc Verbindungen, die für adenosin a1 und a3 rezeptoren spezifisch sind, und deren anwendungen
CN101973998A (zh) 2001-12-20 2011-02-16 Osi药物公司 吡咯并嘧啶A2b选择性拮抗剂化合物
AU2002366811B2 (en) 2001-12-20 2009-01-15 Osi Pharmaceuticals, Inc. Pyrimidine A2B selective antagonist compounds, their synthesis and use
EP1615931A1 (en) 2003-04-09 2006-01-18 Biogen Idec MA Inc. Triazolopyrazines and methods of making and using the same
EP1615930A2 (en) 2003-04-09 2006-01-18 Biogen Idec MA, Inc. Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagonists
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
DE602004018637D1 (de) 2003-04-09 2009-02-05 Biogen Idec Inc A2a-adenosinrezeptorantagonisten
WO2005063665A1 (en) 2003-12-23 2005-07-14 Abraxis Bioscience, Inc Propofol analogs, process for their preparation, and methods of use
AU2005219777B2 (en) 2004-03-04 2011-02-03 Kissei Pharmaceutical Co., Ltd. Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof
EP1756093A1 (en) 2004-06-17 2007-02-28 Wyeth Processes for preparing gonadotropin releasing hormone receptor antagonists
KR20070027584A (ko) 2004-06-17 2007-03-09 와이어쓰 고나도트로핀 방출 호르몬 수용체 길항제
KR20070028553A (ko) 2004-06-18 2007-03-12 바이올리폭스 에이비 염증 치료에 유용한 인돌
FR2880626B1 (fr) * 2005-01-13 2008-04-18 Aventis Pharma Sa Derives de la purine, compositions les contenant et utilisation
WO2006077366A1 (en) 2005-01-19 2006-07-27 Biolipox Ab Indoles useful in the treatment of inflammation
US7534796B2 (en) 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en) 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7538113B2 (en) 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
FR2884824B1 (fr) 2005-04-20 2007-07-13 Sanofi Aventis Sa Derives de 1h-pyrimido[4,5-b]indole, leur preparation et leur application en therapeutique
US7531542B2 (en) 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
UA95788C2 (en) 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
KR100749216B1 (ko) * 2006-08-30 2007-08-13 위아 주식회사 4륜구동차량용 부변속기
JP2010509259A (ja) 2006-11-09 2010-03-25 エフ．ホフマン−ラ ロシュ アーゲー インドール及びベンゾフラン２−カルボキサミド誘導体
ES2424977T3 (es) * 2007-08-08 2013-10-10 Glaxosmithkline Intellectual Property Development Limited Derivados de 2-[(2-{fenilamino}-1H-pirrolo[2,3-D]pirimidin-4-il)amino]benzamida como inhibidores de IGF-1R para el tratamiento del cáncer
RU2437883C1 (ru) * 2007-08-17 2011-12-27 Эл Джи Лайф Сайенсиз Лтд. Соединения индола и индазола в качестве ингибитора некроза клетки
AR070127A1 (es) 2008-01-11 2010-03-17 Novartis Ag Pirrolo - pirimidinas y pirrolo -piridinas
WO2009095162A1 (en) 2008-01-31 2009-08-06 Sanofi-Aventis Cyclic azaindole-3-carboxamides, their preparation and their use as pharmaceuticals
CL2009000241A1 (es) * 2008-02-07 2010-09-03 Chugai Pharmaceutical Co Ltd Compuestos derivados de 5-(2-morfolin-4-il-7h-pirrolo[2,3-d]pirimidin-4-il)pirimidin-2-ilamina; proceso de preparacion; composicion farmaceutica; y uso de los compuestos para tratar o prevenir una enfermedad proliferativa tal como el cancer.
CA2743015A1 (en) * 2008-11-11 2010-05-20 Xcovery Holding Company Llc Pi3k/mtor kinase inhibitors
US20130196990A1 (en) 2010-10-06 2013-08-01 Junya Qu Benzimidazole Derivatives As PI3 Kinase Inhibitors
AU2012213080B2 (en) 2011-01-31 2014-03-27 Novartis Ag Novel heterocyclic derivatives
AU2012229997B2 (en) 2011-03-15 2016-04-14 Lawrence Livermore National Security, Llc Tricyclic gyrase inhibitors
CN104039790B (zh) 2011-10-28 2016-04-13 诺华股份有限公司 嘌呤衍生物及它们在治疗疾病中的应用
AU2013212457B2 (en) 2012-01-27 2017-02-16 Universite De Montreal Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells
MD20140130A2 (ro) 2012-06-29 2015-04-30 Pfizer Inc. 4-(amino-substituite)-7H-pirolo[2,3-d]pirimidine noi ca inhibitori de LRRK2
JP6487921B2 (ja) 2013-12-17 2019-03-20 ファイザー・インク ＬＲＲＫ２阻害薬としての新規の３，４−二置換−１Ｈ−ピロロ［２，３−ｂ］ピリジンおよび４，５−二置換−７Ｈ−ピロロ［２，３−ｃ］ピリダジン
US9957270B2 (en) 2014-03-13 2018-05-01 Agency For Science, Technology And Research Fused pyrimidine-based hydroxamate derivatives
ES2849998T3 (es) 2014-09-22 2021-08-24 National Health Res Inst Compuestos heterocíclicos y su uso
JP6954844B2 (ja) 2015-06-05 2021-10-27 エマ−ケベック 造血幹細胞を培養するため及び／又は造血幹細胞を前駆体へ分化させるための方法及びその使用
WO2017046675A1 (en) 2015-09-14 2017-03-23 Pfizer Inc. Novel imidazo [4,5-c] quinoline and imidazo [4,5-c][1,5] naphthyridine derivatives as lrrk2 inhibitors
US9630968B1 (en) 2015-12-23 2017-04-25 Arqule, Inc. Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof
SG11201901197PA (en) 2016-08-24 2019-03-28 Arqule Inc Amino-pyrrolopyrimidinone compounds and methods of use thereof
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
WO2019158731A1 (en) * 2018-02-16 2019-08-22 Ucb Biopharma Sprl Pharmaceutical 6,5 heterobicyclic ring derivatives
US20230234943A1 (en) * 2020-06-26 2023-07-27 Tempest Therapeutics, Inc. Trex1 inhibitors and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB864145A (en) * 1959-06-02 1961-03-29 Thomae Gmbh Dr K Novel purines and a process for their manufacture
GB1268772A (en) * 1968-03-15 1972-03-29 Glaxo Lab Ltd NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME
CA2065434C (en) * 1989-09-19 1999-11-30 Yasuji Sakuma Pyrrolo[2,3-d]pyrimidine derivatives, process for producing the same and pharmaceutical preparation comprising the same as active ingredient

Also Published As

Publication number Publication date
PT633886E (pt) 2001-03-30
HU9402829D0 (en) 1995-02-28
ES2150941T3 (es) 2000-12-16
DE69329574T2 (de) 2001-05-31
NO303542B1 (no) 1998-07-27
AU3917493A (en) 1993-11-08
AU675932B2 (en) 1997-02-27
GR3035188T3 (en) 2001-04-30
ATE197051T1 (de) 2000-11-15
KR950700912A (ko) 1995-02-20
RU2103272C1 (ru) 1998-01-27
WO1993020078A1 (en) 1993-10-14
DE69329574D1 (de) 2000-11-23
RU94042466A (ru) 1996-07-20
PL175347B1 (pl) 1998-12-31
NO943655D0 (no) 1994-09-30
NO943655L (no) 1994-12-05
FI944602A0 (fi) 1994-10-03
LV12794B (en) 2002-06-20
FI944602A (fi) 1994-10-03
MX9301847A (es) 1993-10-01
LV12794A (en) 2002-02-20
EP0633886A1 (en) 1995-01-18
HUT70954A (en) 1995-11-28
JPH08502721A (ja) 1996-03-26
KR100284473B1 (ko) 2001-04-02
EP0633886B1 (en) 2000-10-18
PL175327B1 (pl) 1998-12-31
CZ236494A3 (en) 1994-12-15
CA2130937A1 (en) 1993-10-14
DK0633886T3 (da) 2000-12-18

Similar Documents

Publication Publication Date Title
SK119194A3 (en) Fharmaceuticaly active bicyclic-heterocyclic amines
US5502187A (en) Pharmaceutically active bicyclic-heterocyclic amines
EP2734205B1 (en) Heterocyclic protein kinase inhibitors
KR100883289B1 (ko) 암 치료용5-아미노-2,4,7-트리옥소-3,4,7,8-테트라히드로-2ｈ-피리도[2,3-ｄ]피리미딘 유도체 및 관련 화합물
US4923872A (en) Analogues of pyrrolo[3,2d]pyrimidin-4-ones
US20030008872A1 (en) 2,3-Diaryl-pyrazolo[1,5-B]pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (COX-2) inhibitors
WO2007126128A1 (ja) ジヒドロピラゾロピリミジノン誘導体
US20110046127A1 (en) Imidazopyridazines for Use as Protein Kinase Inhibitors
EP3545956B1 (en) 3,5-(un)substituted-1h-pyrrolo[2,3-b]pyridine, 1h-pyrazolo[3,4-b]pyridine and 5h- pyrrolo[2,3-b]pyrazine dual itk and jak3 kinase inhibitors
JP2008505084A (ja) フラノピリミジン
US7279473B2 (en) Pyrazolopyridazine derivatives
AU1036300A (en) Bicyclic nitrogen heterocycles
CA2556946A1 (en) Pyrrolopyrimidine derivatives
CA2713324A1 (en) Pyrrolopyrazine kinase inhibitors
KR20010040426A (ko) 아졸로 트리아진 및 피리미딘
US5663339A (en) Process for preparing 5-substituted pyrrolo-[2,3-D] pyrimidines
CZ20032539A3 (en) Imidazo-pyrimidine derivatives as ligands for gaba receptors
JP4484524B2 (ja) １−［アルキル］、１−［（ヘテロアリール）アルキル］および１−［（アリール）アルキル］−７−（ピリミジン−４−イル）−イミダゾ［１，２−ａ］ピリミジン−５（１Ｈ）−オン誘導体
KR900005836B1 (ko) 1,2,4-트리아조로[4,3-c]피리미딘
CA2212195A1 (en) Pyrimido 4,5- indoles
WO2004111053A1 (en) Imidazotriazinone derivatives as pde 7 (phosphodiesterase 7) inhibitors
Reisch et al. Acetylenic chemistry: Part 15 [1]. Reactions of 1, 2, 3, 4‐Tetrahydro‐2, 4‐dioxopyrido [2, 3‐d] pyrimidine with 3‐bromoprop‐1‐yne
CN116854709A (zh) Bruton′s酪氨酸激酶可逆抑制剂及其应用
US20240158391A1 (en) Derivatives of 4-(imidazo[1,2-a]pyridin-3-yl)-n-(pyridin-3-yl) pyrimidin-2- amine for treating proliferative diseases and conditions
US4996319A (en) -2-Amino-4,6-dichloro-5-(2-cyanomethyl-2-amino-5(cyanomethyl)-4,6-dichloro pyrimidine