DK0633886T3 - Farmaceutisk aktive bicyclisk-heterocycliske aminer - Google Patents
Farmaceutisk aktive bicyclisk-heterocycliske aminerInfo
- Publication number
- DK0633886T3 DK0633886T3 DK93908303T DK93908303T DK0633886T3 DK 0633886 T3 DK0633886 T3 DK 0633886T3 DK 93908303 T DK93908303 T DK 93908303T DK 93908303 T DK93908303 T DK 93908303T DK 0633886 T3 DK0633886 T3 DK 0633886T3
- Authority
- DK
- Denmark
- Prior art keywords
- pharmaceutically active
- heterocyclic amines
- active bicyclic
- bicyclic
- xxx
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86364692A | 1992-04-03 | 1992-04-03 | |
PCT/US1993/002188 WO1993020078A1 (en) | 1992-04-03 | 1993-03-16 | Pharmaceutically active bicyclic-heterocyclic amines |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0633886T3 true DK0633886T3 (da) | 2000-12-18 |
Family
ID=25341481
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93908303T DK0633886T3 (da) | 1992-04-03 | 1993-03-16 | Farmaceutisk aktive bicyclisk-heterocycliske aminer |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0633886B1 (da) |
JP (1) | JPH08502721A (da) |
KR (1) | KR100284473B1 (da) |
AT (1) | ATE197051T1 (da) |
AU (1) | AU675932B2 (da) |
CA (1) | CA2130937A1 (da) |
CZ (1) | CZ236494A3 (da) |
DE (1) | DE69329574T2 (da) |
DK (1) | DK0633886T3 (da) |
ES (1) | ES2150941T3 (da) |
FI (1) | FI944602A0 (da) |
GR (1) | GR3035188T3 (da) |
HU (1) | HUT70954A (da) |
LV (1) | LV12794B (da) |
MX (1) | MX9301847A (da) |
NO (1) | NO303542B1 (da) |
PL (2) | PL175347B1 (da) |
PT (1) | PT633886E (da) |
RU (1) | RU2103272C1 (da) |
SK (1) | SK119194A3 (da) |
WO (1) | WO1993020078A1 (da) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU694853B2 (en) * | 1995-03-02 | 1998-07-30 | Pharmacia & Upjohn Company | Pyrimido{4,5-b}indoles |
EP0948495B1 (en) | 1996-11-19 | 2004-04-14 | Amgen Inc., | Aryl and heteroaryl substituted fused pyrrole antiinflammatory agents |
WO1998024453A1 (fr) * | 1996-12-05 | 1998-06-11 | Nippon Shinyaku Co., Ltd. | Medicaments pour la myelopathie |
JP2002511061A (ja) * | 1997-01-08 | 2002-04-09 | ファルマシア・アンド・アップジョン・カンパニー | 医薬上活性な三環式アミン |
GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
GB2331988B (en) * | 1997-12-04 | 2003-04-16 | Imperial College | Polycyclic sulphamate inhibitors or oestrone sulphatase |
GB9803226D0 (en) | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
EP1082120A1 (en) * | 1998-06-02 | 2001-03-14 | OSI Pharmaceuticals, Inc. | PYRROLO[2,3d]PYRIMIDINE COMPOSITIONS AND THEIR USE |
US6878716B1 (en) | 1998-06-02 | 2005-04-12 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptor and uses thereof |
US6686366B1 (en) | 1998-06-02 | 2004-02-03 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
PA8474101A1 (es) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
AU5625499A (en) * | 1998-09-04 | 2000-03-27 | Altana Pharma Ag | Novel pyranoses |
GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902453D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902455D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902452D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902459D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9918035D0 (en) | 1999-07-30 | 1999-09-29 | Novartis Ag | Organic compounds |
US6680322B2 (en) | 1999-12-02 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
PT1246623E (pt) * | 1999-12-02 | 2006-12-29 | Osi Pharm Inc | Compostos específicos para o receptor de adenosina a1,a2a e a3 e as suas utilizações |
US6664252B2 (en) | 1999-12-02 | 2003-12-16 | Osi Pharmaceuticals, Inc. | 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof |
US7160890B2 (en) | 1999-12-02 | 2007-01-09 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
JP2003518123A (ja) | 1999-12-21 | 2003-06-03 | スージェン・インコーポレーテッド | 4−置換7−アザ−インドリン−2−オンおよびその蛋白質キナーゼ阻害剤としての使用 |
GB0000625D0 (en) | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
WO2001058869A2 (en) | 2000-02-11 | 2001-08-16 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases |
US20020061897A1 (en) | 2000-03-30 | 2002-05-23 | Elliott Richard L. | Neuropeptide Y antagonists |
ATE362468T1 (de) | 2000-07-25 | 2007-06-15 | Merck & Co Inc | N-substituierte indole mit anwendung in der behandlung von diabetes |
SE0003795D0 (sv) | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Pharmaceutically useful compounds |
US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
US6673802B2 (en) | 2000-12-01 | 2004-01-06 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
GB0100622D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds V111 |
GB0117396D0 (en) | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
AU2002360436A1 (en) | 2001-11-30 | 2003-06-17 | Osi Pharmaceuticals, Inc. | 2-aryl pyrrologpyrimidines for a1 and a3 receptors |
DE60236458D1 (de) | 2001-12-20 | 2010-07-01 | Osi Pharm Inc | Pyrrolopyrimidin a2b selektive antagonistische verbindungen, deren synthese und verwendung |
WO2003053366A2 (en) | 2001-12-20 | 2003-07-03 | Osi Pharmaceuticals, Inc. | Pyrimidine a2b selective antagonist compounds, their synthesis and use |
GB0308208D0 (en) | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
US7285550B2 (en) | 2003-04-09 | 2007-10-23 | Biogen Idec Ma Inc. | Triazolotriazines and pyrazolotriazines and methods of making and using the same |
US7674791B2 (en) | 2003-04-09 | 2010-03-09 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
US7834014B2 (en) | 2003-04-09 | 2010-11-16 | Biogen Idec Ma Inc. | A2a adenosine receptor antagonists |
WO2005063665A1 (en) * | 2003-12-23 | 2005-07-14 | Abraxis Bioscience, Inc | Propofol analogs, process for their preparation, and methods of use |
ZA200606792B (en) * | 2004-03-04 | 2007-12-27 | Kissei Pharmaceutical | Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof |
US7696210B2 (en) | 2004-06-17 | 2010-04-13 | Wyeth | Gonadotropin releasing hormone receptor antagonists |
AU2005264998A1 (en) | 2004-06-17 | 2006-01-26 | Wyeth | The present invention relates to methods of making Gonadotropin Releasing Hormone ('GnRH') (also known as Leutinizing Hormone Releasing Hormone) receptor antagonists |
CN101006053A (zh) | 2004-06-18 | 2007-07-25 | 比奥里波克斯公司 | 用于治疗炎症的吲哚 |
FR2880626B1 (fr) * | 2005-01-13 | 2008-04-18 | Aventis Pharma Sa | Derives de la purine, compositions les contenant et utilisation |
ATE501119T1 (de) | 2005-01-19 | 2011-03-15 | Biolipox Ab | Entzündungshemmende indol-derivate |
US7538113B2 (en) | 2005-02-18 | 2009-05-26 | Wyeth | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
US7582634B2 (en) | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
US7534796B2 (en) | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
FR2884824B1 (fr) | 2005-04-20 | 2007-07-13 | Sanofi Aventis Sa | Derives de 1h-pyrimido[4,5-b]indole, leur preparation et leur application en therapeutique |
US7531542B2 (en) | 2005-05-18 | 2009-05-12 | Wyeth | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor |
US7582636B2 (en) | 2005-05-26 | 2009-09-01 | Wyeth | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor |
UA95788C2 (en) | 2005-12-15 | 2011-09-12 | Ф. Хоффманн-Ля Рош Аг | Fused pyrrole derivatives |
KR100749216B1 (ko) * | 2006-08-30 | 2007-08-13 | 위아 주식회사 | 4륜구동차량용 부변속기 |
MX2009004898A (es) | 2006-11-09 | 2009-05-19 | Hoffmann La Roche | Derivados de indol y de benzofurano-2-carboxamida. |
EP2188292B1 (en) * | 2007-08-08 | 2013-05-29 | GlaxoSmithKline Intellectual Property Development Limited | 2- [ (2-{phenylamino}-1h-pyrrolo [2, 3-d]pyrimidin-4-yl) amino]benzamide derivatives as igf-1r inhibitors for the treatment of cancer |
US8436038B2 (en) * | 2007-08-17 | 2013-05-07 | Lg Life Sciences Ltd. | Indole and indazole compounds as an inhibitor of cellular necrosis |
AR070127A1 (es) | 2008-01-11 | 2010-03-17 | Novartis Ag | Pirrolo - pirimidinas y pirrolo -piridinas |
JP5727793B2 (ja) | 2008-01-31 | 2015-06-03 | サノフイ | 環状アザインドール−3−カルボキサミド、その製造および医薬としてのその使用 |
TW200938201A (en) * | 2008-02-07 | 2009-09-16 | Chugai Pharmaceutical Co Ltd | Pyrrolopyrimidine derivative as PI3K inhibitor and use thereof |
ES2539478T3 (es) | 2008-11-11 | 2015-07-01 | Xcovery Holding Company Llc | Inhibidores de PI3K/mTOR cinasa |
US20130196990A1 (en) | 2010-10-06 | 2013-08-01 | Junya Qu | Benzimidazole Derivatives As PI3 Kinase Inhibitors |
UY33883A (es) | 2011-01-31 | 2012-08-31 | Novartis Ag | Novedosos derivados heterocíclicos |
MX345780B (es) | 2011-03-15 | 2017-02-15 | Trius Therapeutics Inc | Inhibidores triciclicos de girasa. |
JP6059731B2 (ja) | 2011-10-28 | 2017-01-11 | ノバルティス アーゲー | 新規プリン誘導体および疾患の処置におけるその使用 |
EP2807165B1 (en) | 2012-01-27 | 2019-05-15 | Université de Montréal | Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells |
EP2867236B1 (en) | 2012-06-29 | 2017-06-14 | Pfizer Inc | Novel 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrimidines as lrrk2 inhibitors |
WO2015092592A1 (en) | 2013-12-17 | 2015-06-25 | Pfizer Inc. | Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors |
EP3116876A4 (en) | 2014-03-13 | 2017-10-25 | Agency For Science, Technology And Research | Fused pyrimidine-based hydroxamate derivatives |
RU2704008C2 (ru) * | 2014-09-22 | 2019-10-23 | Нэшнл Хелс Ресерч Инститьютс | Гетероциклические соединения и их применение |
CN107922926B (zh) | 2015-06-05 | 2021-09-10 | 赫马魁北克公司 | 培养和/或使造血干细胞分化为祖细胞的方法及其用途 |
AU2016322813B2 (en) | 2015-09-14 | 2021-04-01 | Pfizer Inc. | Novel imidazo (4,5-c) quinoline and imidazo (4,5-c)(1,5) naphthyridine derivatives as LRRK2 inhibitors |
US9630968B1 (en) | 2015-12-23 | 2017-04-25 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
JP2019530650A (ja) | 2016-08-24 | 2019-10-24 | アークル インコーポレイテッド | アミノ−ピロロピリミジノン化合物およびその使用方法 |
TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
WO2019158731A1 (en) * | 2018-02-16 | 2019-08-22 | Ucb Biopharma Sprl | Pharmaceutical 6,5 heterobicyclic ring derivatives |
TW202216693A (zh) * | 2020-06-26 | 2022-05-01 | 美商坦帕斯醫療公司 | Trex1抑制劑及其用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB864145A (en) * | 1959-06-02 | 1961-03-29 | Thomae Gmbh Dr K | Novel purines and a process for their manufacture |
GB1268772A (en) * | 1968-03-15 | 1972-03-29 | Glaxo Lab Ltd | NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME |
CA2065434C (en) * | 1989-09-19 | 1999-11-30 | Yasuji Sakuma | Pyrrolo[2,3-d]pyrimidine derivatives, process for producing the same and pharmaceutical preparation comprising the same as active ingredient |
-
1993
- 1993-03-16 RU RU94042466A patent/RU2103272C1/ru not_active IP Right Cessation
- 1993-03-16 PL PL93305430A patent/PL175347B1/pl not_active IP Right Cessation
- 1993-03-16 PT PT93908303T patent/PT633886E/pt unknown
- 1993-03-16 WO PCT/US1993/002188 patent/WO1993020078A1/en not_active Application Discontinuation
- 1993-03-16 DK DK93908303T patent/DK0633886T3/da active
- 1993-03-16 AT AT93908303T patent/ATE197051T1/de not_active IP Right Cessation
- 1993-03-16 SK SK1191-94A patent/SK119194A3/sk unknown
- 1993-03-16 KR KR1019940703452A patent/KR100284473B1/ko not_active IP Right Cessation
- 1993-03-16 EP EP93908303A patent/EP0633886B1/en not_active Expired - Lifetime
- 1993-03-16 ES ES93908303T patent/ES2150941T3/es not_active Expired - Lifetime
- 1993-03-16 AU AU39174/93A patent/AU675932B2/en not_active Ceased
- 1993-03-16 HU HU9402829A patent/HUT70954A/hu unknown
- 1993-03-16 DE DE69329574T patent/DE69329574T2/de not_active Expired - Fee Related
- 1993-03-16 JP JP5517457A patent/JPH08502721A/ja active Pending
- 1993-03-16 CA CA002130937A patent/CA2130937A1/en not_active Abandoned
- 1993-03-16 CZ CZ942364A patent/CZ236494A3/cs unknown
- 1993-03-16 PL PL93317810A patent/PL175327B1/pl not_active IP Right Cessation
- 1993-03-31 MX MX9301847A patent/MX9301847A/es not_active IP Right Cessation
-
1994
- 1994-09-30 NO NO943655A patent/NO303542B1/no unknown
- 1994-10-03 FI FI944602A patent/FI944602A0/fi not_active Application Discontinuation
-
2001
- 2001-01-04 GR GR20010400006T patent/GR3035188T3/el not_active IP Right Cessation
- 2001-10-18 LV LVP-01-150A patent/LV12794B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DE69329574D1 (de) | 2000-11-23 |
CZ236494A3 (en) | 1994-12-15 |
EP0633886B1 (en) | 2000-10-18 |
KR100284473B1 (ko) | 2001-04-02 |
PL175327B1 (pl) | 1998-12-31 |
KR950700912A (ko) | 1995-02-20 |
RU2103272C1 (ru) | 1998-01-27 |
WO1993020078A1 (en) | 1993-10-14 |
PT633886E (pt) | 2001-03-30 |
NO943655D0 (no) | 1994-09-30 |
NO943655L (no) | 1994-12-05 |
JPH08502721A (ja) | 1996-03-26 |
AU675932B2 (en) | 1997-02-27 |
SK119194A3 (en) | 1995-05-10 |
ES2150941T3 (es) | 2000-12-16 |
FI944602A (fi) | 1994-10-03 |
HU9402829D0 (en) | 1995-02-28 |
AU3917493A (en) | 1993-11-08 |
GR3035188T3 (en) | 2001-04-30 |
NO303542B1 (no) | 1998-07-27 |
ATE197051T1 (de) | 2000-11-15 |
FI944602A0 (fi) | 1994-10-03 |
CA2130937A1 (en) | 1993-10-14 |
MX9301847A (es) | 1993-10-01 |
HUT70954A (en) | 1995-11-28 |
LV12794A (en) | 2002-02-20 |
DE69329574T2 (de) | 2001-05-31 |
EP0633886A1 (en) | 1995-01-18 |
LV12794B (en) | 2002-06-20 |
PL175347B1 (pl) | 1998-12-31 |
RU94042466A (ru) | 1996-07-20 |
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