SK10802003A3 - Kondenzovaná heterocyklická zlúčenina, jej použitie a jej farmaceutický prípravok - Google Patents
Kondenzovaná heterocyklická zlúčenina, jej použitie a jej farmaceutický prípravok Download PDFInfo
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- SK10802003A3 SK10802003A3 SK1080-2003A SK10802003A SK10802003A3 SK 10802003 A3 SK10802003 A3 SK 10802003A3 SK 10802003 A SK10802003 A SK 10802003A SK 10802003 A3 SK10802003 A3 SK 10802003A3
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- 150000002391 heterocyclic compounds Chemical class 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 289
- 150000003839 salts Chemical class 0.000 claims abstract description 89
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 67
- 125000003118 aryl group Chemical group 0.000 claims abstract description 54
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 41
- 238000011282 treatment Methods 0.000 claims abstract description 30
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 29
- 238000011321 prophylaxis Methods 0.000 claims abstract description 23
- 125000001183 hydrocarbyl group Chemical group 0.000 claims abstract 32
- -1 cyano, amino Chemical group 0.000 claims description 335
- 125000004432 carbon atom Chemical group C* 0.000 claims description 121
- 238000000034 method Methods 0.000 claims description 106
- 125000001424 substituent group Chemical group 0.000 claims description 79
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 56
- 239000013078 crystal Substances 0.000 claims description 54
- 125000005843 halogen group Chemical group 0.000 claims description 52
- 150000002430 hydrocarbons Chemical group 0.000 claims description 48
- 125000000217 alkyl group Chemical group 0.000 claims description 43
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 37
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 37
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims description 35
- 125000003277 amino group Chemical group 0.000 claims description 32
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 32
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 23
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- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims description 7
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- 125000005236 alkanoylamino group Chemical group 0.000 claims description 6
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- ZEIBESNNLHERGM-UHFFFAOYSA-N ethyl 2-[3-(aminomethyl)-4-butoxy-2-(2-methylpropyl)-1-oxoisoquinolin-6-yl]-1,3-thiazole-4-carboxylate Chemical compound C1=C2C(OCCCC)=C(CN)N(CC(C)C)C(=O)C2=CC=C1C1=NC(C(=O)OCC)=CS1 ZEIBESNNLHERGM-UHFFFAOYSA-N 0.000 claims description 2
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- HMVYYTRDXNKRBQ-UHFFFAOYSA-N 1,3-thiazole-4-carboxylic acid Chemical compound OC(=O)C1=CSC=N1 HMVYYTRDXNKRBQ-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- FBWHFOSIHPOUBP-UHFFFAOYSA-N 3-(aminomethyl)-2,6,7-trimethyl-4-phenylisoquinolin-1-one Chemical compound NCC=1N(C)C(=O)C=2C=C(C)C(C)=CC=2C=1C1=CC=CC=C1 FBWHFOSIHPOUBP-UHFFFAOYSA-N 0.000 abstract description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Applications Claiming Priority (4)
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JP2001027349 | 2001-02-02 | ||
JP2001292388 | 2001-09-25 | ||
JP2001382232 | 2001-12-14 | ||
PCT/JP2002/000831 WO2002062764A1 (en) | 2001-02-02 | 2002-02-01 | Fused heterocyclic compounds |
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SK10802003A3 true SK10802003A3 (sk) | 2004-05-04 |
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SK1080-2003A SK10802003A3 (sk) | 2001-02-02 | 2002-02-01 | Kondenzovaná heterocyklická zlúčenina, jej použitie a jej farmaceutický prípravok |
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US (1) | US7034039B2 (ko) |
EP (1) | EP1355886B1 (ko) |
KR (1) | KR20030074774A (ko) |
CN (1) | CN1500080A (ko) |
AT (1) | ATE366724T1 (ko) |
BR (1) | BR0206831A (ko) |
CA (1) | CA2437492A1 (ko) |
CZ (1) | CZ20032321A3 (ko) |
DE (1) | DE60221098T2 (ko) |
HU (1) | HUP0400058A2 (ko) |
IL (1) | IL157179A0 (ko) |
MX (1) | MXPA03006918A (ko) |
NO (1) | NO20033385L (ko) |
PE (1) | PE20021002A1 (ko) |
PL (1) | PL364221A1 (ko) |
SK (1) | SK10802003A3 (ko) |
WO (1) | WO2002062764A1 (ko) |
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CA2450722A1 (en) | 2001-06-27 | 2003-01-09 | Smithkline Beecham Corporation | Fluoropyrrolidines as dipeptidyl peptidase inhibitors |
EP1484320A1 (en) * | 2002-02-13 | 2004-12-08 | Takeda Chemical Industries, Ltd. | Jnk inhibitor |
EP1338595B1 (en) | 2002-02-25 | 2006-05-03 | Eisai Co., Ltd. | Xanthine derivatives as DPP-IV inhibitors |
US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
US7547710B2 (en) | 2002-08-08 | 2009-06-16 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds as peptidase inhibitors |
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
WO2004024184A1 (ja) * | 2002-09-11 | 2004-03-25 | Takeda Pharmaceutical Company Limited | 徐放性製剤 |
WO2004054979A1 (ja) * | 2002-12-18 | 2004-07-01 | Takeda Pharmaceutical Company Limited | Jnk阻害剤 |
EP1572660B1 (en) | 2002-12-20 | 2011-01-26 | X-Ceptor Therapeutics, Inc. | Isoquinolinone derivatives and their use as therapeutic agents |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
WO2004083184A1 (ja) * | 2003-03-17 | 2004-09-30 | Takeda Pharmaceutical Company Limited | 受容体拮抗剤 |
JP4887139B2 (ja) * | 2003-03-25 | 2012-02-29 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼインヒビター |
ES2465624T3 (es) * | 2003-07-11 | 2014-06-06 | Merck Patent Gmbh | Benzimidazol carboxamidas como inhibidores de RAF quinasa |
US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
RU2006107553A (ru) * | 2003-08-13 | 2007-09-20 | Такеда Фармасьютикал Компани Лимитед (Jp) | Производные 4-пиримидона и их применение в качестве ингибиторов пептидилпептидаз |
US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
EP1699777B1 (en) * | 2003-09-08 | 2012-12-12 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US20050065144A1 (en) * | 2003-09-08 | 2005-03-24 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
WO2005028438A1 (ja) | 2003-09-22 | 2005-03-31 | Banyu Pharmaceutical Co., Ltd. | 新規ピペリジン誘導体 |
EP1667978B1 (en) * | 2003-09-23 | 2013-09-04 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
JP4719152B2 (ja) * | 2003-09-23 | 2011-07-06 | メルク・シャープ・エンド・ドーム・コーポレイション | イソキノリノンカリウムチャネル阻害剤 |
WO2005030729A1 (en) * | 2003-09-23 | 2005-04-07 | Merck & Co., Inc. | Isoquinoline potassium channel inhibitors |
KR20180050427A (ko) | 2003-11-17 | 2018-05-14 | 노파르티스 아게 | 디펩티딜 펩티다제 ⅳ 억제제의 용도 |
RS57561B1 (sr) | 2004-01-20 | 2018-10-31 | Novartis Ag | Formulacija dobijena direktnom kompresijom i proces za njeno dobijanje |
NZ548440A (en) * | 2004-02-05 | 2009-07-31 | Kyorin Seiyaku Kk | Bicycloester derivative inhibitng DPP-IV for treatment of diabetes or similar |
KR20060129021A (ko) * | 2004-02-18 | 2006-12-14 | 교린 세이야꾸 가부시키 가이샤 | 비시클로아미드 유도체 |
EP1719757B1 (en) * | 2004-02-27 | 2013-10-09 | Kyorin Pharmaceutical Co., Ltd. | Bicyclo derivative |
US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
NZ549716A (en) * | 2004-03-15 | 2010-04-30 | Takeda Pharmaceutical | Pyrimidin-dione derivatives as dipeptidyl peptidase inhibitors |
US20080255216A1 (en) | 2004-03-29 | 2008-10-16 | Aster Susan D | Diaryltriazoles as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 |
EP2305352A1 (en) | 2004-04-02 | 2011-04-06 | Merck Sharp & Dohme Corp. | 5-alpha-reductase inhibitors for use in the treatment of men with metabolic and anthropometric disorders |
WO2005118555A1 (en) * | 2004-06-04 | 2005-12-15 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
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2002
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- 2002-02-01 KR KR10-2003-7010229A patent/KR20030074774A/ko not_active Application Discontinuation
- 2002-02-01 CN CNA028074297A patent/CN1500080A/zh active Pending
- 2002-02-01 IL IL15717902A patent/IL157179A0/xx unknown
- 2002-02-01 WO PCT/JP2002/000831 patent/WO2002062764A1/en active IP Right Grant
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- 2002-02-01 MX MXPA03006918A patent/MXPA03006918A/es unknown
- 2002-02-01 SK SK1080-2003A patent/SK10802003A3/sk unknown
- 2002-02-01 EP EP02711278A patent/EP1355886B1/en not_active Expired - Lifetime
- 2002-02-01 PE PE2002000076A patent/PE20021002A1/es not_active Application Discontinuation
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CN1500080A (zh) | 2004-05-26 |
IL157179A0 (en) | 2004-02-08 |
BR0206831A (pt) | 2004-07-06 |
US20040082607A1 (en) | 2004-04-29 |
DE60221098T2 (de) | 2008-01-24 |
MXPA03006918A (es) | 2004-05-24 |
DE60221098D1 (de) | 2007-08-23 |
WO2002062764A9 (en) | 2002-10-10 |
CZ20032321A3 (en) | 2004-03-17 |
EP1355886A1 (en) | 2003-10-29 |
EP1355886B1 (en) | 2007-07-11 |
WO2002062764A1 (en) | 2002-08-15 |
KR20030074774A (ko) | 2003-09-19 |
HUP0400058A2 (hu) | 2004-04-28 |
PL364221A1 (en) | 2004-12-13 |
NO20033385L (no) | 2003-09-30 |
NO20033385D0 (no) | 2003-07-29 |
PE20021002A1 (es) | 2002-12-06 |
CA2437492A1 (en) | 2002-08-15 |
ATE366724T1 (de) | 2007-08-15 |
US7034039B2 (en) | 2006-04-25 |
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