SI9420048B - Farmacevtske formulacije živčnega rastnega faktorja - Google Patents
Farmacevtske formulacije živčnega rastnega faktorja Download PDFInfo
- Publication number
- SI9420048B SI9420048B SI9420048A SI9420048A SI9420048B SI 9420048 B SI9420048 B SI 9420048B SI 9420048 A SI9420048 A SI 9420048A SI 9420048 A SI9420048 A SI 9420048A SI 9420048 B SI9420048 B SI 9420048B
- Authority
- SI
- Slovenia
- Prior art keywords
- formulation
- water
- growth factor
- aqueous
- nerve growth
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/839—Nerves; brain
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (13)
- PATENTNI ZAHTEVKI 1. Vodna farmacevtska formulacija, ki obsega: (a) živčni rastni faktor; (b) biološko sprejemljivo sol v količini, ki zadostuje za vzdrževanje izoto-ničnosti; (c) pufer v količini, ki zadostuje za vzdrževanje pH formulacije od 4,5 do 6,0; in (d) vodo in s pridržkom, da navedena formulacija ne vsebuje vodotopnega polisaharida.
- 2. Formulacija po zahtevku 1, označena s tem, da nadalje obsega biološko sprejemljiv vodotopen nosilec.
- 3. Formulacija po zahtevku 1 ali 2, označena s tem, da: (a) živčni rastni faktor obsega 0,0001 do 0,125 % glede na maso vodne formulacije; (b) nosilec obsega 0,1 do 1,25 % glede na maso vodne formulacije; (c) sol obsega 0,5 do 1,0 % glede na maso vodne formulacije; in (d) je pufer prisoten v količini, ki zadostuje za vzdrževanje pH vodne formulacije od 4,5 do 6,0.
- 4. Formulacija po kateremkoli od prejšnjih zahtevkov, označena s tem, da je pH od 5,0 do 5,4.
- 5. Vodna formulacija po kateremkoli od zahtevkov 2 do 4, označena s tem, da obsega 10 do 500 μg NGF, 5 mg/ml HSA, 8,7 mg/ml NaCl, 2,1 mg/ml citronske kisline in vodo, pri čemer je pH formulacije naravnan na 5,2.
- 6. Vodna farmacevtska formulacija živčnega rastnega faktorja, prikladna za liofilizacijo, označena s tem, da obsega: (a) od 1 do 1250 /ig/ml živčnega rastnega faktorja; (b) od 30 do 90 mg/ml biološko sprejemljivega pomožnega sredstva; (c) pufer v količini, ki zadostuje za vzdrževanje pH formulacije pri 5,5 do 6,5; in (d) vodo; s pridržkom, da navedena formulacija ne vsebuje vodotopnega polisaharida.
- 7. Formulacija po zahtevku 6, označena s tem, da je pomožno sredstvo sladkor.
- 8. Formulacija po kateremkoli od zahtevkov 6-7, označena s tem, da pomožno sredstvo obsega zmes saharoze in manitola, pufer je citrat, pH formulacije pa je od 5,8 do 6,2.
- 9. Formulacija po kateremkoli od zahtevkov 6-8, označena s tem, da je liofilizirana, da se zniža vsebnost vlage na manj kot 2 %.
- 10. Liofiliziran farmacevtski sestavek, označen s tem, da obsega 0,001 do 1,25 delov živčnega rastnega faktorja, 30 do 90 delov sladkorja in manj kot 1 del vode, s pridržkom, da naveden sestavek ne vsebuje vodotopnega polisaharida.
- 11. Formulacija ali sestavek po kateremkoli od zahtevkov 6-10, označen s tem, da nadalje obsega biološko sprejemljiv vodotopen nosilec.
- 12. Formulacija ali sestavek po kateremkoli od prejšnjih zahtevkov za uporabo pri zdravljenju nevronskih disfunkcij pri ljudeh.
- 13. Formulacija ali sestavek po zahtevku 13 v intracerebroventrikularni infuzijski obliki za uporabo pri zdravljenju Alzheimerjeve bolezni pri ljudeh.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/109,798 US6277828B1 (en) | 1993-08-20 | 1993-08-20 | Pharmaceutical formulations of nerve growth factor |
PCT/US1994/009245 WO1995005845A1 (en) | 1993-08-20 | 1994-08-16 | Pharmaceutical formulations of nerve growth factor |
Publications (2)
Publication Number | Publication Date |
---|---|
SI9420048A SI9420048A (en) | 1996-10-31 |
SI9420048B true SI9420048B (sl) | 2003-12-31 |
Family
ID=22329623
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9420048A SI9420048B (sl) | 1993-08-20 | 1994-08-16 | Farmacevtske formulacije živčnega rastnega faktorja |
Country Status (32)
Country | Link |
---|---|
US (2) | US6277828B1 (sl) |
EP (1) | EP0721343B1 (sl) |
JP (2) | JP4592830B2 (sl) |
KR (1) | KR100341193B1 (sl) |
CN (1) | CN1163265C (sl) |
AT (1) | ATE226085T1 (sl) |
AU (1) | AU677699B2 (sl) |
BG (1) | BG62951B1 (sl) |
BR (1) | BR9407278A (sl) |
CA (1) | CA2169834C (sl) |
CZ (1) | CZ292422B6 (sl) |
DE (1) | DE69431562T2 (sl) |
DK (1) | DK0721343T3 (sl) |
ES (1) | ES2181723T3 (sl) |
FI (1) | FI113241B (sl) |
HK (1) | HK1012990A1 (sl) |
HU (1) | HU228152B1 (sl) |
IL (3) | IL110725A (sl) |
LT (1) | LT4051B (sl) |
LV (1) | LV11279B (sl) |
NO (1) | NO317627B1 (sl) |
NZ (1) | NZ271873A (sl) |
PL (1) | PL176387B1 (sl) |
PT (1) | PT721343E (sl) |
RO (1) | RO114742B1 (sl) |
RU (1) | RU2126265C1 (sl) |
SI (1) | SI9420048B (sl) |
SK (1) | SK284064B6 (sl) |
TW (1) | TW427905B (sl) |
UA (1) | UA43348C2 (sl) |
WO (1) | WO1995005845A1 (sl) |
ZA (1) | ZA946333B (sl) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5981485A (en) | 1997-07-14 | 1999-11-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
CA2220897A1 (en) * | 1995-05-12 | 1996-11-14 | The Rockefeller University | Treatment of alzheimer disease by modulation of synapsins |
IL124004A (en) * | 1995-11-07 | 2003-10-31 | Genentech Inc | Stable pharmaceutical composition comprising ngf |
US6964947B1 (en) * | 1995-11-07 | 2005-11-15 | Genentech, Inc. | Stabilizing formulation for NGF |
US6090781A (en) * | 1996-11-06 | 2000-07-18 | Genentech, Inc. | Stabilizing formulation for NGF |
WO1997045009A2 (en) * | 1996-05-29 | 1997-12-04 | Universal Preservation Technologies, Inc. | Long-term shelf preservation by vitrification |
CN1059597C (zh) * | 1996-08-08 | 2000-12-20 | 陈素兰 | 神经损伤修复制剂 |
WO1998048832A1 (en) * | 1997-05-01 | 1998-11-05 | Protechtion Unlimited, Inc. | Nerve growth factor as a vaccine adjuvant |
US6313089B1 (en) | 1997-08-20 | 2001-11-06 | Duke University | Complexes of apolipoprotein E and ciliary neurotrophic factor (CNTF) and methods of use |
JP2001518449A (ja) * | 1997-09-30 | 2001-10-16 | デューク・ユニバーシティー | アポリポタンパク質e/成長因子複合体およびその使用法 |
US6979442B1 (en) | 1998-08-17 | 2005-12-27 | Pfizer Inc. | Stabilized protein compositions |
IL162239A0 (en) | 2001-12-21 | 2005-11-20 | Novo Nordisk Healthcare Ag | Liquid composition of factor vii polypeptides |
KR20040065278A (ko) * | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
ES2523655T5 (es) | 2002-06-21 | 2018-04-23 | Novo Nordisk Health Care Ag | Composiciones sólidas estabilizadas de polipéptidos del Factor VIIa |
EP1605968A2 (en) * | 2003-03-18 | 2005-12-21 | Novo Nordisk Health Care AG | Liquid, aqueous, pharmaceutical compositions of factor vii polypeptides |
US7897734B2 (en) * | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
ATE454900T1 (de) * | 2003-05-23 | 2010-01-15 | Novo Nordisk Healthcare Ag | Stabilisierung von proteinen in lösung |
CN1318087C (zh) * | 2003-06-06 | 2007-05-30 | 北京三诺佳邑生物技术有限责任公司 | 去白蛋白神经生长因子制剂 |
EP1641487B1 (en) * | 2003-06-25 | 2012-02-29 | Novo Nordisk Health Care AG | Liquid composition of factor vii polypeptides |
DE602004023848D1 (de) * | 2003-07-01 | 2009-12-10 | Novo Nordisk Healthcare Ag | Von factor vii polypeptiden |
ES2574581T3 (es) | 2003-08-14 | 2016-06-20 | Novo Nordisk Health Care Ag | Composición farmacéutica líquida acuosa de polipéptidos de tipo Factor VII |
PL2298287T3 (pl) * | 2003-12-19 | 2019-02-28 | Novo Nordisk Health Care Ag | Stabilizowane kompozycje polipeptydów czynnika VII |
US8168222B2 (en) | 2004-09-07 | 2012-05-01 | Board Of Regents Of The University Of Nebraska | Amphiphilic polymer-protein conjugates and methods of use thereof |
US8017151B2 (en) * | 2004-09-07 | 2011-09-13 | Board Of Regents Of The University Of Nebraska By And Behalf Of The University Of Nebraska Medical Center | Amphiphilic polymer-protein conjugates and methods of use thereof |
JPWO2008020584A1 (ja) * | 2006-08-14 | 2010-01-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 安定な凍結乾燥製剤 |
ES2407413T3 (es) * | 2006-11-08 | 2013-06-12 | P Mind Co., Ltd | Aparato para acelerar la producción de factor neurotrófico |
EP1958618A1 (de) | 2007-02-15 | 2008-08-20 | Octapharma AG | Verfahren zur Gefriertrocknung mit optimierter Rekonstitution von Biopolymeren |
KR20110061639A (ko) * | 2008-09-26 | 2011-06-09 | 아도시아 | 폴리사카라이드 및 hpb로 구성된 복합체 |
CN102232932B (zh) * | 2010-04-27 | 2013-06-05 | 重庆莱美药业股份有限公司 | 果胶-阿霉素轭合物的冻干制剂及制备方法 |
KR102017905B1 (ko) | 2011-04-07 | 2019-09-03 | 니오베크스 | Ifn 알파 관련 질환을 치료하는 방법 |
BR112014019576A8 (pt) * | 2012-02-08 | 2017-07-11 | Agronomique Inst Nat Rech | Fator de crescimento de nervos beta, composição farmacêutica e método para induzir a ovulação |
ES2893239T3 (es) * | 2015-04-21 | 2022-02-08 | Staidson Beijing Biopharmaceuticals Co Ltd | Composición de factor de crecimiento nervioso y polvo de inyección |
DK3287140T3 (da) * | 2015-04-21 | 2021-07-19 | Beijing Staidson Medical Tech Co Ltd | Nervevækstfaktorsammensætning og pulverinjektion |
WO2016169455A1 (zh) * | 2015-04-21 | 2016-10-27 | 舒泰神(北京)生物制药股份有限公司 | 神经生长因子组合物和注射粉剂 |
US9868828B2 (en) * | 2015-06-23 | 2018-01-16 | Amolifescience Co., Ltd. | Defined three-dimensional microenvironment for stem cell |
US20200299371A1 (en) | 2016-03-25 | 2020-09-24 | Astellas Pharma Inc. | Pharmaceutical composition comprising pegylated fab' fragment of anti-human ngf antibody |
LT3463308T (lt) * | 2016-06-01 | 2022-02-10 | Servier IP UK Limited | Polialkilenoksido-asparaginazės vaisto formos ir jų gamybos būdai bei panaudojimas |
CN109260147B (zh) * | 2018-10-15 | 2019-09-13 | 珠海亿胜生物制药有限公司 | 一种用于治疗或预防神经损伤的重组人碱性成纤维细胞生长因子注射剂 |
US11767504B2 (en) | 2020-08-14 | 2023-09-26 | Albcura Corporation | Albumin compositions and methods of producing and using same |
IL302317A (en) | 2020-10-28 | 2023-06-01 | Dompe Farm Spa | Pharmaceutical packaging including polypropylene containers and aqueous formulations of NGF packed in them |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
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NZ235556A (en) | 1986-11-05 | 1991-06-25 | Ethicon Inc | Breast milk substitute containing recombinant human egf |
NZ226170A (en) * | 1987-09-18 | 1990-07-26 | Ethicon Inc | Stable freeze-dried pharmaceutical composition containing epidermal growth factor |
IT1219874B (it) * | 1988-03-18 | 1990-05-24 | Fidia Farmaceutici | Utilizzazione del fattore di crescita nervoso umano e sue composizioni farmaceutiche |
US5096885A (en) | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
JPH0418031A (ja) * | 1989-02-16 | 1992-01-22 | Hiroshi Saito | 損傷治癒促進剤 |
JP3283288B2 (ja) * | 1991-03-08 | 2002-05-20 | 電気化学工業株式会社 | 生理活性ペプチド製剤 |
JP2818834B2 (ja) * | 1991-08-12 | 1998-10-30 | 大塚製薬株式会社 | IL−1α安定化医薬製剤 |
-
1993
- 1993-08-20 US US08/109,798 patent/US6277828B1/en not_active Expired - Lifetime
-
1994
- 1994-08-16 RU RU96105951A patent/RU2126265C1/ru active
- 1994-08-16 CN CNB94193148XA patent/CN1163265C/zh not_active Expired - Lifetime
- 1994-08-16 WO PCT/US1994/009245 patent/WO1995005845A1/en active IP Right Grant
- 1994-08-16 CA CA002169834A patent/CA2169834C/en not_active Expired - Lifetime
- 1994-08-16 SK SK183-96A patent/SK284064B6/sk not_active IP Right Cessation
- 1994-08-16 EP EP94925903A patent/EP0721343B1/en not_active Expired - Lifetime
- 1994-08-16 DE DE69431562T patent/DE69431562T2/de not_active Expired - Lifetime
- 1994-08-16 PT PT94925903T patent/PT721343E/pt unknown
- 1994-08-16 CZ CZ1996424A patent/CZ292422B6/cs not_active IP Right Cessation
- 1994-08-16 DK DK94925903T patent/DK0721343T3/da active
- 1994-08-16 NZ NZ271873A patent/NZ271873A/en not_active IP Right Cessation
- 1994-08-16 AT AT94925903T patent/ATE226085T1/de active
- 1994-08-16 HU HU9600371A patent/HU228152B1/hu unknown
- 1994-08-16 UA UA96020622A patent/UA43348C2/uk unknown
- 1994-08-16 JP JP50764495A patent/JP4592830B2/ja not_active Expired - Lifetime
- 1994-08-16 PL PL94313084A patent/PL176387B1/pl unknown
- 1994-08-16 KR KR1020017005635A patent/KR100341193B1/ko not_active IP Right Cessation
- 1994-08-16 RO RO96-00301A patent/RO114742B1/ro unknown
- 1994-08-16 BR BR9407278A patent/BR9407278A/pt not_active Application Discontinuation
- 1994-08-16 AU AU75668/94A patent/AU677699B2/en not_active Expired
- 1994-08-16 SI SI9420048A patent/SI9420048B/sl unknown
- 1994-08-16 ES ES94925903T patent/ES2181723T3/es not_active Expired - Lifetime
- 1994-08-19 ZA ZA946333A patent/ZA946333B/xx unknown
- 1994-08-19 IL IL11072594A patent/IL110725A/en not_active IP Right Cessation
- 1994-08-19 IL IL124941A patent/IL124941A/en not_active IP Right Cessation
- 1994-08-30 TW TW083107604A patent/TW427905B/zh not_active IP Right Cessation
-
1996
- 1996-02-19 LT LT96-011A patent/LT4051B/lt not_active IP Right Cessation
- 1996-02-19 NO NO19960651A patent/NO317627B1/no not_active IP Right Cessation
- 1996-02-19 FI FI960750A patent/FI113241B/fi not_active IP Right Cessation
- 1996-02-19 BG BG100371A patent/BG62951B1/bg unknown
- 1996-02-19 LV LVP-96-48A patent/LV11279B/en unknown
-
1998
- 1998-06-16 IL IL12494198A patent/IL124941A0/xx active IP Right Grant
- 1998-12-19 HK HK98114132A patent/HK1012990A1/xx not_active IP Right Cessation
-
2001
- 2001-02-20 US US09/789,855 patent/US7074763B2/en not_active Expired - Fee Related
-
2007
- 2007-08-08 JP JP2007206876A patent/JP2007314572A/ja active Pending
Also Published As
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