RU99118890A - Водорастворимая фармацевтическая композиция в виде ионного комплекса и ее применение - Google Patents
Водорастворимая фармацевтическая композиция в виде ионного комплекса и ее применениеInfo
- Publication number
- RU99118890A RU99118890A RU99118890/14A RU99118890A RU99118890A RU 99118890 A RU99118890 A RU 99118890A RU 99118890/14 A RU99118890/14 A RU 99118890/14A RU 99118890 A RU99118890 A RU 99118890A RU 99118890 A RU99118890 A RU 99118890A
- Authority
- RU
- Russia
- Prior art keywords
- polypeptide
- composition according
- complex
- amphiphilic compound
- composition
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 150000002500 ions Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 claims 11
- 229920001184 polypeptide Polymers 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 5
- 102000003693 Hedgehog Proteins Human genes 0.000 claims 4
- 108090000031 Hedgehog Proteins Proteins 0.000 claims 4
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 2
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 2
- 229940112869 Bone morphogenetic proteins Drugs 0.000 claims 2
- 102000003951 Erythropoietin Human genes 0.000 claims 2
- 108090000394 Erythropoietin Proteins 0.000 claims 2
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 2
- 229940047124 Interferons Drugs 0.000 claims 2
- 102000014150 Interferons Human genes 0.000 claims 2
- 108010050904 Interferons Proteins 0.000 claims 2
- 102000015696 Interleukins Human genes 0.000 claims 2
- 229940047122 Interleukins Drugs 0.000 claims 2
- 108010063738 Interleukins Proteins 0.000 claims 2
- 102000036902 Thrombopoietin Human genes 0.000 claims 2
- 108010041111 Thrombopoietin Proteins 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 229940105423 erythropoietin Drugs 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- 229940009976 Deoxycholate Drugs 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000010668 complexation reaction Methods 0.000 claims 1
- KXGVEGMKQFWNSR-LLQZFEROSA-M deoxycholate Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-M 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000005755 formation reaction Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 102000006240 membrane receptors Human genes 0.000 claims 1
- 108020004084 membrane receptors Proteins 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 230000002459 sustained Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Claims (11)
1. Водная композиция, содержащая фармацевтически эффективный полипептид, выбранный из группы, включающей hedgehog-протеины, костные морфогенетические протеины, факторы роста, эритропоэтин, тромбопоэтин, G-CSF, интерлейкины и интерфероны, отличающаяся тем, что эта композиция дополнительно содержит амфифильное соединение, при эотом полипептид и амфифильное соединение образуют ионный комплекс, причем образование комплекса не увеличивает растворимость полипептида.
2. Композиция по п.1 в лиофилизированной форме.
3. Композиция по п.2, отличающаяся тем, что комплекс иммобилизован на биологически совместимом носителе.
4. Композиция по п.3, отличающаяся тем, что комплекс присутствует в виде смеси растворенной и осажденной формы.
5. Композиция по любому из пп.1 - 4, отличающаяся тем, что композиция имеет значение рН в водном растворе, которое отличается по крайней мере на 0,5 единиц рН от значений рК полипептида и поверхностно-активного вещества.
6. Композиция по любому из пп.1 - 5, отличающаяся тем, что полипептид представляет собой hedgehog-протеин.
7. Композиция по любому из пп.1 - 6, отличающаяся тем, что амфифильное соединение представляет собой дезоксихолат.
8. Композиция по любому из пп.1 - 7, предназначенная для замедленного высвобождения или для локального введения hedgehog-протеина в организм человека.
9. Способ приготовления фармацевтической композиции для локального введения людям, отличающийся тем, что образующийся в результате ионного взаимодействия комплекс фармацевтически эффективного полипептида, выбранного из группы, включающей hedgehog-протеины, костные морфогенетические протеины, факторы роста, эритропоэтин, тромбопоэтин, G-CSF, интерлейкины и интерфероны, с амфифильным соединением применяют в качестве основного компонента, в которой вспомогательное вещество присутствует в концентрации, которая не увеличивает водорастворимость полипептида.
10. Способ по п.9, отличающийся тем, что комплекс иммобилизуют на биологически совместимом носителе.
11. Способ увеличения активности полипептида, который распознается и связывается рецептором клеточной поверхности, отличающийся образованием ионного комплекса полипептида с амфифильным соединением.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98116494.0 | 1998-09-01 | ||
| EP98116494 | 1998-09-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU99118890A true RU99118890A (ru) | 2001-05-20 |
| RU2180855C2 RU2180855C2 (ru) | 2002-03-27 |
Family
ID=8232558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU99118890/14A RU2180855C2 (ru) | 1998-09-01 | 1999-08-31 | Водорастворимая фармацевтическая композиция в виде ионного комплекса и ее применение |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US6867182B2 (ru) |
| EP (1) | EP1002547B1 (ru) |
| JP (1) | JP3664373B2 (ru) |
| KR (1) | KR100403075B1 (ru) |
| CN (1) | CN1325118C (ru) |
| AR (1) | AR023044A1 (ru) |
| AT (1) | ATE318616T1 (ru) |
| AU (1) | AU755930B2 (ru) |
| BR (1) | BR9903984B1 (ru) |
| CA (1) | CA2281049C (ru) |
| CO (1) | CO5271726A1 (ru) |
| DE (1) | DE69930033T2 (ru) |
| ES (1) | ES2258830T3 (ru) |
| GC (1) | GC0000107A (ru) |
| HR (1) | HRP990272B1 (ru) |
| HU (1) | HUP9902952A1 (ru) |
| ID (1) | ID22964A (ru) |
| IL (1) | IL131626A0 (ru) |
| MA (1) | MA26682A1 (ru) |
| MY (1) | MY127935A (ru) |
| NO (1) | NO994214L (ru) |
| NZ (1) | NZ337527A (ru) |
| PE (1) | PE20001027A1 (ru) |
| PL (1) | PL194218B1 (ru) |
| RU (1) | RU2180855C2 (ru) |
| SG (1) | SG85670A1 (ru) |
| TR (1) | TR199902103A2 (ru) |
| TW (1) | TW570805B (ru) |
| YU (1) | YU42399A (ru) |
| ZA (1) | ZA995601B (ru) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050112087A1 (en) * | 2003-04-29 | 2005-05-26 | Musso Gary F. | Pharmaceutical formulations for sustained drug delivery |
| US20060193825A1 (en) * | 2003-04-29 | 2006-08-31 | Praecis Phamaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
| BRPI0411114B8 (pt) * | 2003-06-10 | 2021-05-25 | Lg Chemical Ltd | solução aquosa estável de eritropoetina humana, não contendo albumina de soro |
| US20060127468A1 (en) | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
| US7754230B2 (en) * | 2004-05-19 | 2010-07-13 | The Regents Of The University Of California | Methods and related compositions for reduction of fat |
| ATE521355T1 (de) * | 2004-05-19 | 2011-09-15 | Los Angeles Biomed Res Inst | Verwendung eines detergens zur nicht- chirurgischen entfernung von fett |
| WO2007010900A1 (ja) * | 2005-07-15 | 2007-01-25 | Transcu Ltd. | 貼付位置表示機能付き経皮吸収用パッチ及びイオントフォレーシス装置 |
| JP2007037868A (ja) * | 2005-08-05 | 2007-02-15 | Transcutaneous Technologies Inc | 経皮投与装置及びその制御方法 |
| US20070042041A1 (en) * | 2005-08-17 | 2007-02-22 | Board Of Trustees Of The University Of Arkansas | Drug-surfactant complexes for sustained release |
| NZ566628A (en) * | 2005-09-16 | 2010-02-26 | Tti Ellebeau Inc | Catheter type iontophoresis apparatus using alternating layers of electrolytes and ion exchange membranes |
| CN101277737A (zh) * | 2005-09-30 | 2008-10-01 | Tti优而美株式会社 | 将多种活性剂输送至生物界面的离子电渗装置 |
| US20080033338A1 (en) * | 2005-12-28 | 2008-02-07 | Smith Gregory A | Electroosmotic pump apparatus and method to deliver active agents to biological interfaces |
| JP2009522011A (ja) * | 2005-12-30 | 2009-06-11 | Ｔｔｉ・エルビュー株式会社 | 活性物質を生体界面に送達するイオントフォレーシスシステム、装置及び方法 |
| WO2007123707A1 (en) * | 2006-03-30 | 2007-11-01 | Tti Ellebeau, Inc. | Controlled release membrane and methods of use |
| KR20090027755A (ko) * | 2006-07-05 | 2009-03-17 | 티티아이 엘뷰 가부시키가이샤 | 자기-조립형 수지상 중합체를 함유하는 전달 장치 및 이의 사용 방법 |
| EP2049149B1 (en) | 2006-07-31 | 2015-04-15 | Novo Nordisk A/S | Pegylated extended insulins |
| HUE029512T2 (en) | 2006-09-22 | 2017-03-28 | Novo Nordisk As | Protease Resistant Insulin Analogs |
| US20080193514A1 (en) * | 2006-11-02 | 2008-08-14 | Transcu Ltd. | Compostions and methods for iontophoresis delivery of active ingredients through hair follicles |
| FR2908414B1 (fr) | 2006-11-13 | 2012-01-20 | Centre Nat Rech Scient | Immobilisation de proteines membranaires sur un support par l'intermediaire d'une molecule amphiphile |
| EP2123259A1 (en) * | 2007-01-16 | 2009-11-25 | Hokkaido University | Liposome preparation for iontophoresis having antioxidant component encapsulated therein |
| JP5496082B2 (ja) | 2007-04-30 | 2014-05-21 | ノボ・ノルデイスク・エー／エス | タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物 |
| EP2164458A1 (en) * | 2007-06-01 | 2010-03-24 | Novo Nordisk A/S | Stable non-aqueous pharmaceutical compositions |
| JP2010187707A (ja) * | 2007-06-12 | 2010-09-02 | Hokkaido Univ | インスリンを封入したイオントフォレーシス用リポソーム製剤 |
| WO2009112583A2 (en) | 2008-03-14 | 2009-09-17 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
| WO2009115469A1 (en) | 2008-03-18 | 2009-09-24 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
| CA2736495A1 (en) * | 2008-09-10 | 2010-03-18 | Gregory A. Smith | Apparatus and method to dispense hpc-based viscous liquids into porous substrates, e.g., continuous web-based process |
| WO2012134540A2 (en) * | 2010-10-22 | 2012-10-04 | Vanderbilt University | Injectable synthetic pur composite |
| US8101593B2 (en) | 2009-03-03 | 2012-01-24 | Kythera Biopharmaceuticals, Inc. | Formulations of deoxycholic acid and salts thereof |
| CN107412754A (zh) * | 2009-12-22 | 2017-12-01 | 塞尔德克斯医疗公司 | 疫苗组合物 |
| CA2827643C (en) | 2011-02-18 | 2019-05-07 | Kythera Biopharmaceuticals, Inc. | Treatment of submental fat |
| US8653058B2 (en) | 2011-04-05 | 2014-02-18 | Kythera Biopharmaceuticals, Inc. | Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits |
| CA2867903C (en) | 2012-03-23 | 2023-02-14 | Amicrobe, Inc. | Compositions and uses of antimicrobial materials with tissue-compatible properties |
| CA2870313A1 (en) | 2012-04-11 | 2013-10-17 | Novo Nordisk A/S | Insulin formulations |
| WO2015052088A1 (en) | 2013-10-07 | 2015-04-16 | Novo Nordisk A/S | Novel derivative of an insulin analogue |
| JP6776360B2 (ja) * | 2015-11-04 | 2020-10-28 | ポステック・アカデミー‐インダストリー・ファウンデーションＰｏｓｔｅｃｈ Ａｃａｄｅｍｙ‐Ｉｎｄｕｓｔｒｙ Ｆｏｕｎｄａｔｉｏｎ | カチオン性分子輸送体およびタンパク質を含む、皮膚浸透用組成物 |
| HRP20221324T1 (hr) | 2016-12-16 | 2022-12-23 | Novo Nordisk A/S | Farmaceutski pripravci koji sadrže inzulin |
| AU2018249552A1 (en) | 2017-04-06 | 2019-10-31 | Amicrobe, Inc. | Compositions and uses of locally-applied antimicrobial synthetic cationic polypeptide(s) with enhanced performance and safety |
| US11198831B2 (en) | 2019-01-31 | 2021-12-14 | Kvi Llc | Lubricant for a device |
| AU2020254582A1 (en) * | 2019-04-01 | 2021-09-30 | Genentech, Inc. | Compositions and methods for stabilizing protein-containing formulations |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985004328A1 (en) * | 1984-03-28 | 1985-10-10 | Cetus Corporation | Pharmaceutical compositions of microbially produced interleukin-2 |
| US4604377A (en) | 1984-03-28 | 1986-08-05 | Cetus Corporation | Pharmaceutical compositions of microbially produced interleukin-2 |
| EP0179583A1 (en) * | 1984-10-04 | 1986-04-30 | Merck & Co. Inc. | A system for enhancing the water dissolution rate and solubility of poorly soluble drugs |
| LU85971A1 (fr) | 1985-06-25 | 1987-01-13 | Oreal | Nouveaux composes lipidiques amphiphiles, leur procede de preparation et leurs applications,notamnent en cosmetique et en dermopharmacie |
| JPS62207226A (ja) | 1986-03-07 | 1987-09-11 | Sumitomo Pharmaceut Co Ltd | 経鼻投与用製剤 |
| FR2615194B1 (fr) | 1987-05-11 | 1991-06-14 | Rhone Poulenc Chimie | Particules de polymere comportant, implantees a leur surface des molecules amphiphiles portant des groupes ionogenes ou reactifs, leur procede de preparation et leur application en biologie |
| ATE145337T1 (de) | 1988-05-02 | 1996-12-15 | Phanos Tech Inc | Verbindungen, zusammensetzungen und verfahren zum binden von bio-affektions-substanzen an oberflächenmembranen von bioteilchen |
| US5688761A (en) | 1991-04-19 | 1997-11-18 | Lds Technologies, Inc. | Convertible microemulsion formulations |
| FR2694559B1 (fr) | 1992-08-06 | 1994-10-28 | Atta | Nouveaux dérivés amphiphiles d'aminoacides ou de peptides, leur procédé de préparation et leur utilisation dans des préparations à usage biomédical. |
| AU5171293A (en) * | 1992-10-14 | 1994-05-09 | Regents Of The University Of Colorado, The | Ion-pairing of drugs for improved efficacy and delivery |
| JP3290745B2 (ja) | 1993-03-31 | 2002-06-10 | 藤平 正道 | 単分子膜のパターン形成方法 |
| IS1796B (is) | 1993-06-24 | 2001-12-31 | Ab Astra | Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband |
| US5789543A (en) * | 1993-12-30 | 1998-08-04 | President And Fellows Of Harvard College | Vertebrate embryonic pattern-inducing proteins and uses related thereto |
| AU704178B2 (en) * | 1993-12-30 | 1999-04-15 | Imperial Cancer Research Technology Ltd | Vertebrate embryonic pattern-inducing hedgehog-like proteins |
| US20030186357A1 (en) * | 1993-12-30 | 2003-10-02 | Philip W. Ingham | Vertebrate embryonic pattern-inducing proteins, and uses related thereto |
| FR2714621B1 (fr) | 1994-01-06 | 1996-02-23 | Centre Nat Rech Scient | Procédé de préparation de liposomes sans utilisation de solvant organique. |
| GB9417524D0 (en) | 1994-08-31 | 1994-10-19 | Cortecs Ltd | Pharmaceutical compositions |
| US5653987A (en) * | 1995-05-16 | 1997-08-05 | Modi; Pankaj | Liquid formulations for proteinic pharmaceuticals |
| US5750123A (en) * | 1996-06-28 | 1998-05-12 | Chesebrough-Pond's Co., Division Of Conopco, Inc. | Vitamin C delivery system |
| IL129295A0 (en) * | 1996-10-07 | 2000-02-17 | Univ Johns Hopkins Med | Novel hedgehog-derived polypeptides |
| AU713591B2 (en) | 1996-10-15 | 1999-12-09 | Seikagaku Corporation | Polypeptide transition metal salts and method of enhancing anti-HIV activity of polypeptide |
| WO1998020298A1 (en) * | 1996-11-08 | 1998-05-14 | Northern Magnetics, Inc. | Sensing and controlling the location of elements of a linear motor |
| US5759811A (en) * | 1996-11-13 | 1998-06-02 | The Regents Of The University Of California | Mutant human hedgehog gene |
| JPH10194987A (ja) * | 1997-01-14 | 1998-07-28 | Youtai Iwamoto | 骨・軟骨形成用組成物 |
| JPH114695A (ja) * | 1997-04-25 | 1999-01-12 | Hayashibara Biochem Lab Inc | ヘッジホッグ蛋白質 |
| US6639051B2 (en) * | 1997-10-20 | 2003-10-28 | Curis, Inc. | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
| ATE220558T1 (de) | 1997-11-22 | 2002-08-15 | Roche Diagnostics Gmbh | Verbessertes verfahren zur stabilisierung von proteinen |
| EP0919618A1 (de) | 1997-11-28 | 1999-06-02 | Boehringer Mannheim Gmbh | Aktive Hedgehog-Protein-Mutante, Verfahren zur Herstellung und Verwendung |
| DE69830192T2 (de) | 1997-12-03 | 2006-01-12 | Biogen Idec Ma Inc., Cambridge | Hydrophobisch-modifizierte Hedgehog Protein Zusammensetzungen und Verfahren |
| JP3648051B2 (ja) * | 1998-02-02 | 2005-05-18 | 富士通株式会社 | 関連情報検索装置及びプログラム記録媒体 |
| CA2260423C (en) | 1998-02-04 | 2006-06-20 | Kurt Lang | Pharmaceutical composition of hedgehog proteins and use thereof |
| EP0947201B1 (en) * | 1998-02-04 | 2006-06-28 | Curis, Inc. | Pharmaceutical composition of hedgehog proteins and use thereof |
| ES2252886T3 (es) * | 1998-04-30 | 2006-05-16 | Curis, Inc. | Conjugado de proteinas de erizo activo, proceso para su produccion y uso. |
| US20050021440A1 (en) * | 2003-04-04 | 2005-01-27 | Scott Dresden | Integrated dynamic pricing and procurement support for e-commerce advertising channels |
| WO2005029362A1 (en) * | 2003-09-22 | 2005-03-31 | Eurekster, Inc. | Enhanced search engine |
| US20050114319A1 (en) * | 2003-11-21 | 2005-05-26 | Microsoft Corporation | System and method for checking a content site for efficacy |
| US10515374B2 (en) * | 2005-03-10 | 2019-12-24 | Adobe Inc. | Keyword generation method and apparatus |
-
1999
- 1999-08-18 TW TW088114073A patent/TW570805B/zh not_active IP Right Cessation
- 1999-08-24 ES ES99116537T patent/ES2258830T3/es not_active Expired - Lifetime
- 1999-08-24 DE DE69930033T patent/DE69930033T2/de not_active Expired - Lifetime
- 1999-08-24 EP EP99116537A patent/EP1002547B1/en not_active Expired - Lifetime
- 1999-08-24 AT AT99116537T patent/ATE318616T1/de active
- 1999-08-27 SG SG9904209A patent/SG85670A1/en unknown
- 1999-08-27 NZ NZ337527A patent/NZ337527A/xx unknown
- 1999-08-27 ID IDP990812D patent/ID22964A/id unknown
- 1999-08-27 MY MYPI99003715A patent/MY127935A/en unknown
- 1999-08-27 CN CNB991192451A patent/CN1325118C/zh not_active Expired - Fee Related
- 1999-08-27 CO CO99054477A patent/CO5271726A1/es not_active Application Discontinuation
- 1999-08-27 IL IL13162699A patent/IL131626A0/xx unknown
- 1999-08-28 KR KR10-1999-0036053A patent/KR100403075B1/ko not_active IP Right Cessation
- 1999-08-30 AR ARP990104345A patent/AR023044A1/es not_active Application Discontinuation
- 1999-08-30 CA CA2281049A patent/CA2281049C/en not_active Expired - Fee Related
- 1999-08-30 YU YU42399A patent/YU42399A/sh unknown
- 1999-08-30 GC GCP1999255 patent/GC0000107A/xx active
- 1999-08-31 MA MA25748A patent/MA26682A1/fr unknown
- 1999-08-31 NO NO994214A patent/NO994214L/no not_active Application Discontinuation
- 1999-08-31 HR HR990272A patent/HRP990272B1/xx not_active IP Right Cessation
- 1999-08-31 RU RU99118890/14A patent/RU2180855C2/ru active
- 1999-08-31 PE PE1999000871A patent/PE20001027A1/es not_active Application Discontinuation
- 1999-08-31 TR TR1999/02103A patent/TR199902103A2/xx unknown
- 1999-08-31 ZA ZA9905601A patent/ZA995601B/xx unknown
- 1999-08-31 AU AU44866/99A patent/AU755930B2/en not_active Ceased
- 1999-09-01 HU HU9902952A patent/HUP9902952A1/hu unknown
- 1999-09-01 PL PL335203A patent/PL194218B1/pl unknown
- 1999-09-01 BR BRPI9903984-2A patent/BR9903984B1/pt not_active IP Right Cessation
- 1999-09-01 JP JP24801399A patent/JP3664373B2/ja not_active Expired - Lifetime
-
2001
- 2001-09-17 US US09/953,721 patent/US6867182B2/en not_active Expired - Lifetime
-
2005
- 2005-01-10 US US11/032,492 patent/US20050123610A1/en not_active Abandoned
-
2007
- 2007-10-31 US US11/931,118 patent/US8519098B2/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU99118890A (ru) | Водорастворимая фармацевтическая композиция в виде ионного комплекса и ее применение | |
| CA2281049A1 (en) | Water-soluble pharmaceutical composition in an ionic complex and the use thereof | |
| DE69430251T2 (de) | Verbesserte interferon-polymerkonjugate | |
| DE69532970T2 (de) | Sprühgetrocknetes erythropoietin | |
| EP0301639A3 (en) | Analogues of the bradykinin potentiating peptide bpp 5a and methods for their preparation | |
| SI9420048B (sl) | Farmacevtske formulacije živčnega rastnega faktorja | |
| JP2005527470A5 (ru) | ||
| EP1025840A3 (en) | Oral drug compositions and methods | |
| CA2087087C (en) | Molecules for iontophoretic delivery | |
| CA2140347A1 (en) | Injection and injection kit containing omeprazole and its analogs | |
| WO1997033622A3 (en) | Delivery of nucleic acids by porphyrins | |
| DE69925820T2 (de) | Zubereitungen zur stabilisierung von peg-interferon alpha konjugaten | |
| EP1061904A1 (de) | Nanopartikel, verfahren zu ihrer herstellung und ihre verwendung | |
| WO2000040269A3 (en) | Pharmaceutical compositions for treatment of diseased tissues | |
| WO1996024370B1 (en) | Pharmaceutical non inorganic saline solutions for endonasal administration of a calcitonin | |
| JP3544180B2 (ja) | 安定化した顆粒球コロニー刺激因子 | |
| DE69227276T2 (de) | Konjugate von Calcitonin und Polyethylenglycol | |
| KR910002899A (ko) | 혈조절 펩타이드 | |
| WO2002058589A3 (en) | Agents and methods for promoting bone growth | |
| RU2002135669A (ru) | Олигопептиды | |
| RU2239457C2 (ru) | Фармацевтическая композиция пролонгированного действия и способ ее получения | |
| JP2548822B2 (ja) | マカラスムギ由来の糖タンパク質、その製造法及びそれを含有する免疫調節剤 | |
| JP2000169391A5 (ru) | ||
| IE840977L (en) | Pharmaceutical preparations | |
| MY101266A (en) | Pharmaceutical formulations |