SI9300677A - Combination of a cholesterol biosynthesis inhibitor and a beta-lactam cholesterol absorption inhibitor - Google Patents
Combination of a cholesterol biosynthesis inhibitor and a beta-lactam cholesterol absorption inhibitor Download PDFInfo
- Publication number
- SI9300677A SI9300677A SI9300677A SI9300677A SI9300677A SI 9300677 A SI9300677 A SI 9300677A SI 9300677 A SI9300677 A SI 9300677A SI 9300677 A SI9300677 A SI 9300677A SI 9300677 A SI9300677 A SI 9300677A
- Authority
- SI
- Slovenia
- Prior art keywords
- lower alkyl
- cholesterol
- phenyl
- inhibitor
- group
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99548892A | 1992-12-23 | 1992-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
SI9300677A true SI9300677A (en) | 1994-09-30 |
Family
ID=25541876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9300677A SI9300677A (en) | 1992-12-23 | 1993-12-22 | Combination of a cholesterol biosynthesis inhibitor and a beta-lactam cholesterol absorption inhibitor |
Country Status (32)
Country | Link |
---|---|
US (1) | US5661145A (lv) |
EP (1) | EP0675714B1 (lv) |
JP (1) | JP3992728B2 (lv) |
KR (1) | KR100306936B1 (lv) |
CN (1) | CN1090479C (lv) |
AT (1) | ATE175872T1 (lv) |
AU (1) | AU680864B2 (lv) |
CA (1) | CA2152351C (lv) |
CZ (1) | CZ287125B6 (lv) |
DE (1) | DE69323213T2 (lv) |
DK (1) | DK0675714T3 (lv) |
EE (1) | EE03383B1 (lv) |
ES (1) | ES2128552T3 (lv) |
FI (1) | FI952916A0 (lv) |
GR (1) | GR3029405T3 (lv) |
HR (1) | HRP931515B1 (lv) |
HU (1) | HU221724B1 (lv) |
IL (1) | IL108112A (lv) |
LT (1) | LT3300B (lv) |
LV (1) | LV10919B (lv) |
MX (1) | MX9308053A (lv) |
MY (1) | MY109538A (lv) |
NO (1) | NO311325B1 (lv) |
NZ (1) | NZ259790A (lv) |
PL (1) | PL174128B1 (lv) |
SG (1) | SG45147A1 (lv) |
SI (1) | SI9300677A (lv) |
SK (1) | SK281173B6 (lv) |
TW (1) | TW319698B (lv) |
WO (1) | WO1994014433A1 (lv) |
YU (1) | YU49060B (lv) |
ZA (1) | ZA939552B (lv) |
Families Citing this family (81)
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US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
JPH09511753A (ja) * | 1994-09-20 | 1997-11-25 | ファイザー・インコーポレーテッド | コレステロール吸収阻害薬とコレステロール合成阻害薬の併用 |
US5624920A (en) * | 1994-11-18 | 1997-04-29 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
US5633246A (en) * | 1994-11-18 | 1997-05-27 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
US5656624A (en) * | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
EA000514B1 (ru) | 1995-11-02 | 1999-10-28 | Варнер-Ламберт Компани | Способ нормализации липопротеидного профиля плазмы крови у млекопитающего и фармацевтическая композиция для его осуществления |
US20030153541A1 (en) * | 1997-10-31 | 2003-08-14 | Robert Dudley | Novel anticholesterol compositions and method for using same |
SI20109A (sl) * | 1998-12-16 | 2000-06-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Stabilna farmacevtska formulacija |
AU4343500A (en) * | 1999-04-16 | 2000-11-02 | Schering Corporation | Use of azetidinone compounds |
JP4945876B2 (ja) * | 2000-04-05 | 2012-06-06 | 東レ株式会社 | ハイモビリティーグループタンパクの吸着材および体液浄化カラム |
US6979462B1 (en) * | 2000-10-03 | 2005-12-27 | Mutual Pharmaceutical Co., Inc. | Stabilization of solid drug formulations |
US6584357B1 (en) * | 2000-10-17 | 2003-06-24 | Sony Corporation | Method and system for forming an acoustic signal from neural timing difference data |
US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
EP1911462A3 (en) | 2001-01-26 | 2011-11-30 | Schering Corporation | Compositions comprising a sterol absorption inhibitor |
CN101297969B (zh) * | 2001-01-26 | 2011-03-09 | 先灵公司 | 过氧化物酶体增殖物激活受体(ppar)活化剂和甾醇吸收抑制剂的组合药 |
CA2442219C (en) | 2001-03-28 | 2007-09-11 | Schering Corporation | Enantioselective synthesis of azetidinone intermediate compounds |
AU2002336609B2 (en) * | 2001-09-21 | 2006-08-24 | Merck Sharp & Dohme Corp. | Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors |
CN101785772A (zh) * | 2001-09-21 | 2010-07-28 | 先灵公司 | 使用甾醇吸收抑制剂治疗或预防脉管炎的方法 |
WO2003043624A1 (en) | 2001-11-16 | 2003-05-30 | Bristol-Myers Squibb Company | Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein |
US20030204096A1 (en) * | 2002-03-25 | 2003-10-30 | Schering Corporation | Enantioselective synthesis of azetidinone intermediate compounds |
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US7135556B2 (en) * | 2002-07-19 | 2006-11-14 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
AR040588A1 (es) * | 2002-07-26 | 2005-04-13 | Schering Corp | Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa |
AU2003291227A1 (en) | 2002-11-05 | 2004-06-07 | Smithkline Beecham Corporation | Antibacterial agents |
JP4589919B2 (ja) * | 2003-03-07 | 2010-12-01 | シェーリング コーポレイション | 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用 |
CN1756755A (zh) * | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
EP1810971B1 (en) * | 2003-03-07 | 2013-12-25 | Merck Sharp & Dohme Corp. | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
US7235543B2 (en) * | 2003-03-07 | 2007-06-26 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
JP2005015434A (ja) * | 2003-06-27 | 2005-01-20 | Kotobuki Seiyaku Kk | 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤 |
US20060089374A1 (en) * | 2003-07-17 | 2006-04-27 | Glenn Cornett | Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease |
US20050113314A1 (en) * | 2003-08-29 | 2005-05-26 | Fong Benson M. | Cicletanine in combination with oral antidiabetic and/or blood lipid-lowering agents as a combination therapy for diabetes and metabolic syndrome |
US7371759B2 (en) | 2003-09-25 | 2008-05-13 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
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US7420059B2 (en) | 2003-11-20 | 2008-09-02 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
AU2004308332B2 (en) * | 2003-12-23 | 2008-04-10 | Merck Sharp & Dohme Corp. | Anti-hypercholesterolemic compounds |
GB0329778D0 (en) * | 2003-12-23 | 2004-01-28 | Astrazeneca Ab | Chemical compounds |
AU2004303742B2 (en) | 2003-12-23 | 2008-06-19 | Astrazeneca Ab | Diphenylazetidinone derivatives possessing cholesterol absorption inhibitory activity |
EP1723414A4 (en) * | 2004-01-16 | 2008-03-26 | Merck & Co Inc | NPC1L1 (NPC3) AND METHOD FOR IDENTIFYING ITS LIGANDS |
RU2408591C9 (ru) * | 2004-07-01 | 2011-04-27 | Шеринг Корпорейшн | Производные пиперидина, фармацевтическая композиция на их основе и их применение |
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US20060046996A1 (en) | 2004-08-31 | 2006-03-02 | Kowa Co., Ltd. | Method for treating hyperlipidemia |
US20060154959A1 (en) * | 2005-01-13 | 2006-07-13 | Navitas Pharma | Combination therapies of cicletanine and carvedilol |
WO2006039334A1 (en) * | 2004-09-29 | 2006-04-13 | Schering Corporation | Combinations of substituted azetidonones and cb1 antagonists |
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US7314882B2 (en) | 2005-01-12 | 2008-01-01 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid receptor modulators |
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US7368458B2 (en) | 2005-01-12 | 2008-05-06 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid receptor modulators |
US20080096915A1 (en) * | 2005-01-13 | 2008-04-24 | Greenberg Traurig LLP | Compositions for the treatment of metabolic disorders |
US20070141174A1 (en) * | 2005-01-13 | 2007-06-21 | Navitas Pharma, Inc. | Enantiomeric compositions of cicletanine, in combination with other agents, for the treatment of hypertension |
US20060160850A1 (en) | 2005-01-18 | 2006-07-20 | Chongqing Sun | Bicyclic heterocycles as cannabinoid receptor modulators |
EP1846410B1 (en) | 2005-02-10 | 2009-01-21 | Bristol-Myers Squibb Company | Dihydroquinazolinones as 5ht modulators |
US7572808B2 (en) | 2005-06-17 | 2009-08-11 | Bristol-Myers Squibb Company | Triazolopyridine cannabinoid receptor 1 antagonists |
US7629342B2 (en) | 2005-06-17 | 2009-12-08 | Bristol-Myers Squibb Company | Azabicyclic heterocycles as cannabinoid receptor modulators |
US7317012B2 (en) | 2005-06-17 | 2008-01-08 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoind-1 receptor modulators |
US7452892B2 (en) | 2005-06-17 | 2008-11-18 | Bristol-Myers Squibb Company | Triazolopyrimidine cannabinoid receptor 1 antagonists |
US7632837B2 (en) | 2005-06-17 | 2009-12-15 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid-1 receptor modulators |
CN101243072A (zh) * | 2005-06-20 | 2008-08-13 | 先灵公司 | 用作组胺h3拮抗剂的哌啶衍生物 |
UY29607A1 (es) * | 2005-06-20 | 2007-01-31 | Astrazeneca Ab | Compuestos quimicos |
AR057383A1 (es) * | 2005-06-22 | 2007-12-05 | Astrazeneca Ab | Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto |
SA06270191B1 (ar) * | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
AR057072A1 (es) * | 2005-06-22 | 2007-11-14 | Astrazeneca Ab | Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto |
AR054482A1 (es) * | 2005-06-22 | 2007-06-27 | Astrazeneca Ab | Derivados de azetidinona para el tratamiento de hiperlipidemias |
AR057380A1 (es) * | 2005-06-22 | 2007-11-28 | Astrazeneca Ab | Compuestos quimicos derivados de 2-azetidinona y uso terapeutico de los mismos |
US7795436B2 (en) | 2005-08-24 | 2010-09-14 | Bristol-Myers Squibb Company | Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists |
AR056155A1 (es) | 2005-10-26 | 2007-09-19 | Bristol Myers Squibb Co | Antagonistas del receptor 1 de la hormona de concentracion de melanina no basica |
US20070105817A1 (en) * | 2005-11-09 | 2007-05-10 | Jim Page | Use of cicletanine and other furopyridines for treatment of systolic-predominant hypertension, isolated systolic hypertension, elevated pulse pressure, and general hypertension |
JP2009521452A (ja) * | 2005-12-21 | 2009-06-04 | シェーリング コーポレイション | コレステロール降下剤およびh3受容体アンタゴニスト/逆アゴニストを使用する非アルコール性脂肪性肝疾患の処置 |
US7553836B2 (en) | 2006-02-06 | 2009-06-30 | Bristol-Myers Squibb Company | Melanin concentrating hormone receptor-1 antagonists |
WO2007100807A2 (en) | 2006-02-24 | 2007-09-07 | Schering Corporation | Npc1l1 orthologues |
AR060623A1 (es) * | 2006-04-27 | 2008-07-02 | Astrazeneca Ab | Compuestos derivados de 2-azetidinona y un metodo de preparacion |
US20070275052A1 (en) * | 2006-05-24 | 2007-11-29 | Glenmark Pharmaceuticals Limited | Pharmaceutical compositions containing sterol inhibitors |
CA2661404A1 (en) * | 2006-09-05 | 2008-03-13 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
JP2010514841A (ja) * | 2007-01-03 | 2010-05-06 | グレン ブイ. コルネット, | 肺疾患および心疾患の処置におけるシクレタニンおよびpkc阻害剤 |
US20090011994A1 (en) | 2007-07-06 | 2009-01-08 | Bristol-Myers Squibb Company | Non-basic melanin concentrating hormone receptor-1 antagonists and methods |
PE20091928A1 (es) | 2008-05-29 | 2009-12-31 | Bristol Myers Squibb Co | Tienopirimidinas hidroxisustituidas como antagonistas de receptor-1 de hormona concentradora de melanina no basicos |
US20100092479A1 (en) * | 2008-08-18 | 2010-04-15 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
MX2011009852A (es) | 2009-03-27 | 2011-09-29 | Bristol Myers Squibb Co | Metodos para prevenir episodios cardiovasculares adversos mayores con inhibidores de dipeptidil peptidasa iv. |
US9586900B2 (en) | 2012-09-05 | 2017-03-07 | Bristol-Myers Squibb Company | Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists |
WO2014039412A1 (en) | 2012-09-05 | 2014-03-13 | Bristol-Myers Squibb Company | Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists |
SG11202100417RA (en) | 2018-07-19 | 2021-02-25 | Astrazeneca Ab | Methods of treating hfpef employing dapagliflozin and compositions comprising the same |
MX2023014197A (es) | 2021-06-16 | 2024-01-18 | Celgene Corp | Compuestos de azetidinilo que comprenden un grupo de acido carboxilico para el tratamiento de enfermedades neurodegenerativas. |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4680391A (en) * | 1983-12-01 | 1987-07-14 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
US4983597A (en) * | 1989-08-31 | 1991-01-08 | Merck & Co., Inc. | Beta-lactams as anticholesterolemic agents |
US5120729A (en) * | 1990-06-20 | 1992-06-09 | Merck & Co., Inc. | Beta-lactams as antihypercholesterolemics |
US5085473A (en) * | 1990-10-09 | 1992-02-04 | Yuhe Yang | Air actuated car curtain device |
MY131273A (en) | 1991-07-23 | 2007-07-31 | Schering Corp | Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof |
ES2613245T3 (es) | 2012-01-26 | 2017-05-23 | Intralot S.A. - Integrated Lottery Systems And Services | Métodos y sistemas para dispensar |
-
1993
- 1993-12-03 LT LTIP1514A patent/LT3300B/lt not_active IP Right Cessation
- 1993-12-13 MX MX9308053A patent/MX9308053A/es unknown
- 1993-12-21 CA CA002152351A patent/CA2152351C/en not_active Expired - Fee Related
- 1993-12-21 ES ES94904854T patent/ES2128552T3/es not_active Expired - Lifetime
- 1993-12-21 ZA ZA939552A patent/ZA939552B/xx unknown
- 1993-12-21 US US08/454,348 patent/US5661145A/en not_active Expired - Lifetime
- 1993-12-21 CZ CZ19951643A patent/CZ287125B6/cs not_active IP Right Cessation
- 1993-12-21 MY MYPI93002792A patent/MY109538A/en unknown
- 1993-12-21 JP JP51530594A patent/JP3992728B2/ja not_active Expired - Fee Related
- 1993-12-21 PL PL93309636A patent/PL174128B1/pl not_active IP Right Cessation
- 1993-12-21 HU HU9501854A patent/HU221724B1/hu not_active IP Right Cessation
- 1993-12-21 EP EP94904854A patent/EP0675714B1/en not_active Expired - Lifetime
- 1993-12-21 NZ NZ259790A patent/NZ259790A/en not_active IP Right Cessation
- 1993-12-21 SG SG1996000543A patent/SG45147A1/en unknown
- 1993-12-21 YU YU80293A patent/YU49060B/sh unknown
- 1993-12-21 AT AT94904854T patent/ATE175872T1/de active
- 1993-12-21 DE DE69323213T patent/DE69323213T2/de not_active Expired - Lifetime
- 1993-12-21 KR KR1019950702608A patent/KR100306936B1/ko not_active IP Right Cessation
- 1993-12-21 TW TW082110824A patent/TW319698B/zh not_active IP Right Cessation
- 1993-12-21 WO PCT/US1993/012291 patent/WO1994014433A1/en active IP Right Grant
- 1993-12-21 AU AU58720/94A patent/AU680864B2/en not_active Ceased
- 1993-12-21 IL IL10811293A patent/IL108112A/en not_active IP Right Cessation
- 1993-12-21 SK SK783-95A patent/SK281173B6/sk not_active IP Right Cessation
- 1993-12-21 DK DK94904854T patent/DK0675714T3/da active
- 1993-12-22 CN CN93112663A patent/CN1090479C/zh not_active Expired - Fee Related
- 1993-12-22 SI SI9300677A patent/SI9300677A/sl not_active IP Right Cessation
- 1993-12-22 HR HR07/995,488A patent/HRP931515B1/xx not_active IP Right Cessation
-
1994
- 1994-11-23 EE EE9400341A patent/EE03383B1/xx not_active IP Right Cessation
-
1995
- 1995-06-14 FI FI952916A patent/FI952916A0/fi unknown
- 1995-06-22 LV LVP-95-189A patent/LV10919B/en unknown
- 1995-06-23 NO NO19952529A patent/NO311325B1/no not_active IP Right Cessation
-
1999
- 1999-02-16 GR GR990400487T patent/GR3029405T3/el unknown
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