DE69121464T2 - Verfahren zur Verhütung, Stabilisierung oder Verursachung des Zurückgangs von Atherosklerose durch Anwendung einer Mischung von einem Cholesterol-vermindernden Arzneimittel mit einem ACE-Inhibitor - Google Patents

Verfahren zur Verhütung, Stabilisierung oder Verursachung des Zurückgangs von Atherosklerose durch Anwendung einer Mischung von einem Cholesterol-vermindernden Arzneimittel mit einem ACE-Inhibitor

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Publication number
DE69121464T2
DE69121464T2 DE69121464T DE69121464T DE69121464T2 DE 69121464 T2 DE69121464 T2 DE 69121464T2 DE 69121464 T DE69121464 T DE 69121464T DE 69121464 T DE69121464 T DE 69121464T DE 69121464 T2 DE69121464 T2 DE 69121464T2
Authority
DE
Germany
Prior art keywords
atherosclerosis
cholesterol
ace inhibitor
decline
stabilizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69121464T
Other languages
English (en)
Other versions
DE69121464D1 (de
Inventor
James L Bergey
James C Kawano
Werner Tschollar
Cary S Yonce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of DE69121464D1 publication Critical patent/DE69121464D1/de
Application granted granted Critical
Publication of DE69121464T2 publication Critical patent/DE69121464T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69121464T 1990-05-15 1991-05-10 Verfahren zur Verhütung, Stabilisierung oder Verursachung des Zurückgangs von Atherosklerose durch Anwendung einer Mischung von einem Cholesterol-vermindernden Arzneimittel mit einem ACE-Inhibitor Expired - Lifetime DE69121464T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52426690A 1990-05-15 1990-05-15

Publications (2)

Publication Number Publication Date
DE69121464D1 DE69121464D1 (de) 1996-09-26
DE69121464T2 true DE69121464T2 (de) 1997-03-27

Family

ID=24088484

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69121464T Expired - Lifetime DE69121464T2 (de) 1990-05-15 1991-05-10 Verfahren zur Verhütung, Stabilisierung oder Verursachung des Zurückgangs von Atherosklerose durch Anwendung einer Mischung von einem Cholesterol-vermindernden Arzneimittel mit einem ACE-Inhibitor

Country Status (15)

Country Link
EP (1) EP0457514B1 (de)
JP (1) JPH04226921A (de)
KR (1) KR100200467B1 (de)
AT (1) ATE141514T1 (de)
AU (1) AU651579B2 (de)
CA (1) CA2040865C (de)
DE (1) DE69121464T2 (de)
DK (1) DK0457514T3 (de)
ES (1) ES2090244T3 (de)
GR (1) GR3021703T3 (de)
HU (1) HU212102B (de)
IE (1) IE77637B1 (de)
NZ (1) NZ237929A (de)
PT (1) PT97660B (de)
ZA (1) ZA913509B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5157025A (en) * 1991-04-01 1992-10-20 E. R. Squibb & Sons, Inc. Method for lowering serum cholesterol employing a phosphorus containing ace inhibitor alone or in combination with a cholesterol lowering drug
WO1993013801A1 (en) * 1992-01-17 1993-07-22 The Procter & Gamble Company Treatment for atherosclerosis
WO1995013063A1 (en) * 1993-11-09 1995-05-18 Merck & Co., Inc. HMG-CoA REDUCTASE INHIBITORS IN THE NORMALIZATION OF VASCULAR ENDOTHELIAL DYSFUNCTION
DE4402379C2 (de) * 1994-01-27 1997-09-25 Lohmann Therapie Syst Lts Orale Arzneiform mit sauren Wirkstoffen und Verfahren zu ihrer Herstellung
JP3883205B2 (ja) * 1994-03-29 2007-02-21 メルク エンド カンパニー インコーポレーテッド アンギオテンシン▲ii▼レセプタ遮断イミダゾールによるアテローム性動脈硬化症の治療
SI1009400T1 (en) 1997-08-29 2005-04-30 Pfizer Inc. Combination therapy comprising atorvastatin and an antihypertensive agent
SI20305A (sl) 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
AU2007200367B2 (en) * 1999-02-06 2010-04-08 Astrazeneca Ab Use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors for the manufacture of a medicament for the treatment of diabetic neuropathy
GB0001662D0 (en) 1999-02-06 2000-03-15 Zeneca Ltd Pharmaceutical compositions
US6172441B1 (en) 1999-06-28 2001-01-09 Visteon Global Technologies, Inc. Rotor assembly
UA77151C2 (en) 1999-08-30 2006-11-15 Sanofi Aventis Deutschland Use of ramipril for prevention of cardiovascular events
US6576256B2 (en) 2001-08-28 2003-06-10 The Brigham And Women's Hospital, Inc. Treatment of patients at elevated cardiovascular risk with a combination of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin
US6669955B2 (en) * 2001-08-28 2003-12-30 Longwood Pharmaceutical Research, Inc. Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
EP1501546B1 (de) * 2002-05-03 2012-10-10 Hexal AG Stabile pharmazeutische formulierung für eine kombination aus einem statin mit einem ace-hemmer
AR040588A1 (es) 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
US7208486B2 (en) 2003-03-07 2007-04-24 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7235543B2 (en) 2003-03-07 2007-06-26 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
WO2004085448A2 (en) * 2003-03-19 2004-10-07 Genzyme Corporation Unsaturated phosphinyl-phosphonate phosphate transport inhibitors
GB0322552D0 (en) 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
CN1903364B (zh) * 2005-07-26 2011-06-22 安徽省现代中药研究中心 含有血管紧张素转化酶抑制剂和苯氧酸类化合物的药物组合物
JP2012510511A (ja) * 2008-12-01 2012-05-10 インヴアスク セラピューテイックス インコーポレイテッド レニン−アンジオテンシン−アルドステロン系阻害剤及びリポ酸化合物を含有する組成物、並びに、レニン−アンジオテンシン−アルドステロン系に関連した疾患の治療のためのそれらの使用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3536687A1 (de) * 1985-10-15 1987-04-16 Hoechst Ag Verfahren zur behandlung von atherosklerose, thrombose und der peripheren gefaesskrankheit

Also Published As

Publication number Publication date
AU7627091A (en) 1991-11-21
ATE141514T1 (de) 1996-09-15
CA2040865C (en) 2002-07-23
KR910019614A (ko) 1991-12-19
ES2090244T3 (es) 1996-10-16
IE911431A1 (en) 1991-11-20
IE77637B1 (en) 1997-12-31
PT97660A (pt) 1992-02-28
KR100200467B1 (ko) 1999-06-15
HUT57993A (en) 1992-01-28
DE69121464D1 (de) 1996-09-26
GR3021703T3 (en) 1997-02-28
NZ237929A (en) 1997-06-24
DK0457514T3 (da) 1996-09-16
HU212102B (en) 1996-02-28
PT97660B (pt) 1998-09-30
EP0457514A1 (de) 1991-11-21
EP0457514B1 (de) 1996-08-21
HU911620D0 (en) 1991-11-28
AU651579B2 (en) 1994-07-28
CA2040865A1 (en) 1991-11-16
JPH04226921A (ja) 1992-08-17
ZA913509B (en) 1992-02-26

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