SI3064511T1 - Medicinska uporaba humanih protiteles z visoko afiniteto za humani receptor il-4 - Google Patents
Medicinska uporaba humanih protiteles z visoko afiniteto za humani receptor il-4 Download PDFInfo
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- SI3064511T1 SI3064511T1 SI200931856T SI200931856T SI3064511T1 SI 3064511 T1 SI3064511 T1 SI 3064511T1 SI 200931856 T SI200931856 T SI 200931856T SI 200931856 T SI200931856 T SI 200931856T SI 3064511 T1 SI3064511 T1 SI 3064511T1
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/02—Immunomodulators
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C07—ORGANIC CHEMISTRY
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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Claims (10)
- MEDICINSKA UPORABA HUMANIH PROTITELES Z VISOKO AFINITETO ZA HUMANI RECEPTOR IL-4 PATENTNI ZAHTEVKI1. Uporaba protitelesa ali fragmenta z vezavo antigena, ki specifično veže humani receptor interlevkina-4 (hlL-4R) (SEQ ID ŠT.:274), pri proizvodnji zdravila za zdravljenje bolezni ali motnje, značilne po tem, da je bolezen ali motnja izbrana iz skupine, ki jo sestavljajo bolezni pljuč, vnetne bolezni in alergijske reakcije, značilne po tem, da protitelo ali njegov fragment vsebuje variabilno regijo težke verige (HCVR), ki vsebuje aminokislinsko zaporedje, prikazano v SEQ ID ŠT.: 162, in variabilno regijo lahke verige (LCVR), ki vsebuje aminokislinsko zaporedje, prikazano v SEQ ID ŠT.:164.
- 2. Uporaba protitelesa ali fragmenta z vezavo antigena, ki specifično veže humani receptor interlevkina-4 (hlL-4R) (SEQ ID ŠT.:274), pri proizvodnji zdravila za zdravljenje bolezni ali motnje, značilne po tem, da je bolezen ali motnja izbrana iz skupine, ki jo sestavljajo bolezni pljuč, vnetne bolezni in alergijske reakcije, značilne po tem, da protitelo ali njegov fragment vsebuje tri zaporedja težkoverižne regije za določanje komplementarnosti (HCDR), ki vsebujejo SEQ ID ŠT.:148, 150 in 152, in tri zaporedja lahkoverižne regije za določanje komplementarnosti (LCDR), ki vsebujejo SEQ ID ŠT.: 156, 158 in 160.
- 3. Uporaba protitelesa ali fragmenta z vezavo antigena po zahtevku 2, značilne po tem, da protitelo ali njegov fragment z vezavo antigena vsebuje variabilno regijo težke verige (HCVR), ki vsebuje aminokislinsko zaporedje SEQ ID ŠT.:162.
- 4. Uporaba protitelesa ali fragmenta z vezavo antigena po zahtevku 2, značilne po tem, da protitelo ali njegov fragment z vezavo antigena vsebuje variabilno regijo lahke verige (LCVR), ki vsebuje aminokislinsko zaporedje SEQ ID ŠT.:164.
- 5. Uporaba protitelesa ali fragmenta z vezavo antigena po katerem koli od predhodnih zahtevkov, značilne po tem, da se protitelo ali njegov fragment daje v kombinaciji z drugim terapevtskim sredstvom, izbranim iz montelukasta, pranlukasta, zafirlukasta in rilonacepta.
- 6. Protitelo ali fragment z vezavo antigena, ki specifično veže humani receptor interlevkina-4 (hlL-4R) (SEQ ID ŠT.:274), za uporabo v metodi zdravljenja bolezni ali motnje, značilne po tem, da je bolezen ali motnja izbrana iz skupine, ki jo sestavljajo bolezni pljuč, vnetne bolezni in alergijske reakcije, značilne po tem, da protitelo ali njegov fragment vsebuje variabilno regijo težke verige (HCVR), ki vsebuje aminokislinsko zaporedje, prikazano v SEQ ID ŠT.: 162, in variabilno regijo lahke verige (LCVR), ki vsebuje aminokislinsko zaporedje, prikazano v SEQ ID ŠT.:164.
- 7. Protitelo ali njegov fragment z vezavo antigena, ki specifično veže humani receptor interlevkina-4 (hlL-4R) (SEQ ID ŠT.:274), za uporabo v metodi zdravljenja bolezni ali motnje, značilne po tem, da je bolezen ali motnja izbrana iz skupine, ki jo sestavljajo bolezni pljuč, vnetne bolezni in alergijske reakcije, značilne po tem, da protitelo ali njegov fragment vsebuje tri zaporedja težkoverižne regije za določanje komplementarnosti (HCDR), ki vsebujejo SEQ ID ŠT.:148, 150 in 152, in tri zaporedja lahkoverižne regije za določanje komplementarnosti (LCDR), ki vsebujejo SEQ ID ŠT.:156, 158 in 160.
- 8. Protitelo ali fragment z vezavo antigena za uporabo v metodi po zahtevku 7, značilen po tem, da protitelo ali njegov fragment z vezavo antigena vsebuje variabilno regijo težke verige (HCVR), ki vsebuje aminokislinsko zaporedje SEQ ID ŠT.:162.
- 9. Protitelo ali fragment z vezavo antigena za uporabo v metodi po zahtevku 7, značilen po tem, da protitelo ali njegov fragment z vezavo antigena vsebuje variabilno regijo lahke verige (LCVR), ki vsebuje aminokislinsko zaporedje SEQ ID ŠT.:164.
- 10. Protitelo ali fragment z vezavo antigena za uporabo v metodi po katerem koli od zahtevkov 7 do 9, značilen po tem, da se protitelo ali njegov fragment daje v kombinaciji z drugim terapevtskim sredstvom, izbranim iz montelukasta, pranlukasta, zafirlukasta in rilonacepta.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/260,307 US7608693B2 (en) | 2006-10-02 | 2008-10-29 | High affinity human antibodies to human IL-4 receptor |
EP16161244.5A EP3064511B1 (en) | 2008-10-29 | 2009-10-27 | Medical use of high affinity human antibodies to human il-4 receptor |
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Publication Number | Publication Date |
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SI3064511T1 true SI3064511T1 (sl) | 2018-08-31 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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SI200930614T SI2356151T1 (sl) | 2008-10-29 | 2009-10-27 | Visokoafinitetna humana protitelesa proti humanemu IL-4 receptorju |
SI200931856T SI3064511T1 (sl) | 2008-10-29 | 2009-10-27 | Medicinska uporaba humanih protiteles z visoko afiniteto za humani receptor il-4 |
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Application Number | Title | Priority Date | Filing Date |
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SI200930614T SI2356151T1 (sl) | 2008-10-29 | 2009-10-27 | Visokoafinitetna humana protitelesa proti humanemu IL-4 receptorju |
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Families Citing this family (126)
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JPWO2005105998A1 (ja) * | 2004-04-27 | 2008-07-31 | 財団法人化学及血清療法研究所 | ヒト抗アミロイドβペプチド抗体およびその抗体フラグメント |
US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
LT2769992T (lt) * | 2006-10-02 | 2021-04-12 | Regeneron Pharmaceuticals, Inc. | Didelio afiniškumo žmogaus antikūnai, atpažįstantys žmogaus il-4 receptorių |
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JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
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KR101964031B1 (ko) | 2011-09-16 | 2019-04-02 | 리제너론 파아마슈티컬스, 인크. | 전구단백질 전환효소 서브틸리신 켁신-9 (PCSK9)의 억제제를 투여함으로써 지질단백질(a)의 농도를 낮추는 방법 |
CN104011206B (zh) * | 2011-12-22 | 2017-03-08 | 安斯泰来制药株式会社 | 新型抗人ctgf抗体 |
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