SI2605652T1 - Diketones and hydroxyketones as catenin signaling pathways - Google Patents
Diketones and hydroxyketones as catenin signaling pathways Download PDFInfo
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- SI2605652T1 SI2605652T1 SI201131411T SI201131411T SI2605652T1 SI 2605652 T1 SI2605652 T1 SI 2605652T1 SI 201131411 T SI201131411 T SI 201131411T SI 201131411 T SI201131411 T SI 201131411T SI 2605652 T1 SI2605652 T1 SI 2605652T1
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- 230000019491 signal transduction Effects 0.000 title claims abstract 3
- 102000016362 Catenins Human genes 0.000 title claims 2
- 108010067316 Catenins Proteins 0.000 title claims 2
- 239000012190 activator Substances 0.000 title claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 title claims 2
- 125000005594 diketone group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 230000007547 defect Effects 0.000 abstract 2
- 230000004069 differentiation Effects 0.000 abstract 2
- 201000004384 Alopecia Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000015735 Beta-catenin Human genes 0.000 abstract 1
- 108060000903 Beta-catenin Proteins 0.000 abstract 1
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 208000010392 Bone Fractures Diseases 0.000 abstract 1
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 208000018152 Cerebral disease Diseases 0.000 abstract 1
- 206010012688 Diabetic retinal oedema Diseases 0.000 abstract 1
- 206010057178 Osteoarthropathies Diseases 0.000 abstract 1
- 206010031243 Osteogenesis imperfecta Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000007014 Retinitis pigmentosa Diseases 0.000 abstract 1
- 208000030886 Traumatic Brain injury Diseases 0.000 abstract 1
- 206010064930 age-related macular degeneration Diseases 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000018109 developmental process Effects 0.000 abstract 1
- 201000011190 diabetic macular edema Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 208000030533 eye disease Diseases 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 208000024963 hair loss Diseases 0.000 abstract 1
- 230000003676 hair loss Effects 0.000 abstract 1
- 230000011132 hemopoiesis Effects 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 208000002780 macular degeneration Diseases 0.000 abstract 1
- 230000000174 oncolytic effect Effects 0.000 abstract 1
- 206010033103 otosclerosis Diseases 0.000 abstract 1
- 208000028169 periodontal disease Diseases 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
- 230000017423 tissue regeneration Effects 0.000 abstract 1
- 230000009529 traumatic brain injury Effects 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
- C07C49/784—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic with all keto groups bound to a non-condensed ring
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
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- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37468710P | 2010-08-18 | 2010-08-18 | |
| US201061427974P | 2010-12-29 | 2010-12-29 | |
| EP11818727.7A EP2605652B1 (en) | 2010-08-18 | 2011-08-17 | Diketones and hydroxyketones as catenin signaling pathway activators |
| PCT/US2011/048086 WO2012024404A1 (en) | 2010-08-18 | 2011-08-17 | Diketones and hydroxyketones as catenin signaling pathway activators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2605652T1 true SI2605652T1 (en) | 2018-04-30 |
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ID=45594555
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201131411T SI2605652T1 (en) | 2010-08-18 | 2011-08-17 | Diketones and hydroxyketones as catenin signaling pathways |
| SI201131978T SI3311666T1 (sl) | 2010-08-18 | 2011-08-17 | Diketoni in hidroksiketoni, kot aktivatorji signalne poti katenina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201131978T SI3311666T1 (sl) | 2010-08-18 | 2011-08-17 | Diketoni in hidroksiketoni, kot aktivatorji signalne poti katenina |
Country Status (22)
| Country | Link |
|---|---|
| US (9) | US8609717B2 (enExample) |
| EP (3) | EP2605652B1 (enExample) |
| JP (3) | JP6086864B2 (enExample) |
| CN (2) | CN104672202B (enExample) |
| AU (1) | AU2011291989B2 (enExample) |
| BR (1) | BR112013003631B1 (enExample) |
| CA (1) | CA2807419C (enExample) |
| CY (2) | CY1120061T1 (enExample) |
| DK (2) | DK3311666T3 (enExample) |
| ES (2) | ES2879314T3 (enExample) |
| HR (2) | HRP20180196T1 (enExample) |
| HU (2) | HUE036240T2 (enExample) |
| LT (2) | LT3311666T (enExample) |
| MX (2) | MX340997B (enExample) |
| NO (1) | NO2605652T3 (enExample) |
| PL (2) | PL3311666T3 (enExample) |
| PT (2) | PT2605652T (enExample) |
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| SI (2) | SI2605652T1 (enExample) |
| SM (2) | SMT201800065T1 (enExample) |
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2020
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