MX354133B - Dicetonas e hidroxicetonas como activadores de la trayectoria de señalizacion de catenina. - Google Patents

Dicetonas e hidroxicetonas como activadores de la trayectoria de señalizacion de catenina.

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Publication number
MX354133B
MX354133B MX2016010036A MX2016010036A MX354133B MX 354133 B MX354133 B MX 354133B MX 2016010036 A MX2016010036 A MX 2016010036A MX 2016010036 A MX2016010036 A MX 2016010036A MX 354133 B MX354133 B MX 354133B
Authority
MX
Mexico
Prior art keywords
disease
diseases
diketones
hydroxyketones
bone
Prior art date
Application number
MX2016010036A
Other languages
English (en)
Inventor
Kumar Kc Sunil
Hood John
Mark Wallace David
F Barroga Charlene
Original Assignee
Samumed Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samumed Llc filed Critical Samumed Llc
Publication of MX354133B publication Critical patent/MX354133B/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract

La presente invención describe ß-dicetonas, ?-dicetonas o ?-hidroxicetonas o análogos de las mismas, que activan la señalización de Wnt/ß-catenina y de esta manera tratan o evitan enfermedades relacionadas con la transducción de señal, tales como osteoporosis y osteoartropatía; osteogénesis imperfecta, defectos óseos, fracturas de hueso, enfermedad periodontal, otosclerosis, sanación de heridas, defectos cráneo-facial, enfermedad ósea oncolítica, daños cerebrales traumáticos relacionados con la diferenciación y desarrollo del sistema nervioso central, que comprende enfermedad de Parkinson, apoplejías, enfermedad cerebral isquémica, epilepsia, enfermedad de Alzheimer, depresión, trastorno bipolar, esquizofrenia; enfermedades del ojo tales como degeneración macular relacionada con la edad, edema macular diabético o retinitis pigmentos y enfermedades relacionadas con diferenciación y crecimiento de célula madre, que comprende pérdida del cabello, enfermedades relacionadas con hematopoyesis y enfermedades relacionadas con regeneración de tejido.
MX2016010036A 2010-08-18 2011-08-17 Dicetonas e hidroxicetonas como activadores de la trayectoria de señalizacion de catenina. MX354133B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37468710P 2010-08-18 2010-08-18
US201061427974P 2010-12-29 2010-12-29
PCT/US2011/048086 WO2012024404A1 (en) 2010-08-18 2011-08-17 Diketones and hydroxyketones as catenin signaling pathway activators

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MX354133B true MX354133B (es) 2018-02-14

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MX2016010036A MX354133B (es) 2010-08-18 2011-08-17 Dicetonas e hidroxicetonas como activadores de la trayectoria de señalizacion de catenina.
MX2013001940A MX340997B (es) 2010-08-18 2011-08-17 Dicetonas e hidroxicetonas como activadores de la trayectoria de señalizacion de catenina.

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Families Citing this family (13)

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Publication number Priority date Publication date Assignee Title
AU2009262241B2 (en) 2008-06-25 2014-05-22 Forum Pharmaceuticals Inc. 1, 2 disubstituted heterocyclic compounds
DK2617420T3 (da) 2009-05-07 2015-12-07 Forum Pharmaceuticals Inc Heterocykliske phenoxymethylforbindelser
JP5763072B2 (ja) 2009-08-10 2015-08-12 サミュメッド リミテッド ライアビリティ カンパニー Ｗｎｔシグナル経路のインダゾール阻害剤およびその治療的使用
MX354133B (es) 2010-08-18 2018-02-14 Samumed Llc Dicetonas e hidroxicetonas como activadores de la trayectoria de señalizacion de catenina.
US20140037599A1 (en) * 2012-08-03 2014-02-06 The Trustees Of The University Of Pennsylvania Compositions and Methods of Treating T Cell Deficiency
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