UA104152C2 - Производные 3-фенил-3-метоксипирролидина, как модуляторы кортикальной катехоламинергической нейротрансмиссии - Google Patents

Производные 3-фенил-3-метоксипирролидина, как модуляторы кортикальной катехоламинергической нейротрансмиссии

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Publication number
UA104152C2
UA104152C2 UAA201105529A UAA201105529A UA104152C2 UA 104152 C2 UA104152 C2 UA 104152C2 UA A201105529 A UAA201105529 A UA A201105529A UA A201105529 A UAA201105529 A UA A201105529A UA 104152 C2 UA104152 C2 UA 104152C2
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UA
Ukraine
Prior art keywords
phenyl
modulators
derivatives
methoxypyrrolidine
methoxy
Prior art date
Application number
UAA201105529A
Other languages
English (en)
Ukrainian (uk)
Inventor
Клас СОНЕССОН
Ларс Свенсон
Фредрик ПЕТТЕРССОН
Original Assignee
Интергрейтив Рисерч Лебореториз Сведен АБ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Интергрейтив Рисерч Лебореториз Сведен АБ filed Critical Интергрейтив Рисерч Лебореториз Сведен АБ
Publication of UA104152C2 publication Critical patent/UA104152C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Заявленное изобретение касается новых производных 3-фенил-3-метоксипиролидина, полезных для модулирования внеклеточных уровней катехоламинов, допамина и норадреналина в областях коры головного мозга млекопитающего и, конкретнее, для лечения расстройств центральной нервной системы.В других аспектах изобретение касается фармацевтических композиций, которые содержат производные 3-фенил-3-метоксипиролидина, и применения этих соединений в терапии.
UAA201105529A 2008-11-24 2009-11-24 Производные 3-фенил-3-метоксипирролидина, как модуляторы кортикальной катехоламинергической нейротрансмиссии UA104152C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200801657 2008-11-24
PCT/EP2009/065676 WO2010058018A1 (en) 2008-11-24 2009-11-24 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission

Publications (1)

Publication Number Publication Date
UA104152C2 true UA104152C2 (ru) 2014-01-10

Family

ID=42197858

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201105529A UA104152C2 (ru) 2008-11-24 2009-11-24 Производные 3-фенил-3-метоксипирролидина, как модуляторы кортикальной катехоламинергической нейротрансмиссии

Country Status (19)

Country Link
US (3) US8673962B2 (ru)
EP (2) EP2367787B1 (ru)
JP (1) JP5716202B2 (ru)
KR (1) KR101660936B1 (ru)
CN (1) CN102224136B (ru)
AU (1) AU2009317156B2 (ru)
BR (1) BRPI0921561B1 (ru)
CA (1) CA2744308C (ru)
DK (1) DK2367787T3 (ru)
ES (1) ES2402713T3 (ru)
HK (1) HK1162173A1 (ru)
IL (1) IL212601A (ru)
MX (1) MX2011005036A (ru)
NZ (1) NZ592566A (ru)
PL (1) PL2367787T3 (ru)
RU (1) RU2524214C2 (ru)
UA (1) UA104152C2 (ru)
WO (2) WO2010058019A1 (ru)
ZA (1) ZA201103169B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102224136B (zh) * 2008-11-24 2014-01-22 Nsab神经研究瑞典公司分公司 用作皮质儿茶酚胺能神经传递调节剂的3-苯基-3-甲氧基-吡咯烷衍生物
US8586572B2 (en) 2008-11-24 2013-11-19 Integrative Research Laboratories Sweden Ab 3-phenyl-azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
CN102766079B (zh) * 2011-05-06 2015-04-08 上海医药工业研究院 一类吡咯烷衍生物、其制备方法及应用
CN107646031B (zh) * 2015-05-20 2020-11-17 综合研究实验室瑞典股份公司 用作皮质儿茶酚胺能神经传递调节剂的氮杂环丁烷衍生物
US10875829B1 (en) 2016-11-18 2020-12-29 Integrative Research Laboratories Sweden Ab Azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
JP7126522B2 (ja) * 2017-05-19 2022-08-26 インテグレイティブ・リサーチ・ラボラトリーズ・スウェーデン・アーベー （＋）－３－（２，３－ジフルオロフェニル）－３－メトキシピロリジンまたはその薬学的に許容される塩、それを調製するための方法およびその使用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1144279B (de) * 1957-09-26 1963-02-28 Robins Co Inc A H Verfahren zur Herstellung von 3-Aryl-3-hydroxypyrrolidinen und deren Salzen
US3119907A (en) 1960-12-30 1964-01-28 Texas Instruments Inc Electromechanical commutator with rolling contact-type structure
US3118907A (en) 1961-08-14 1964-01-21 Mead Johnson & Co 3-substituted-3-pyrrolidinols
US3635982A (en) 1969-04-08 1972-01-18 American Home Prod Amino-substituted-quinoxalinyloxazolidines and -oxazines
ATE201669T1 (de) 1991-04-17 2001-06-15 Upjohn Co Substituierte (s)-3-phenylpiperidin derivate, deren herstellung und deren verwendung als dopamin autorezeptor antagonisten
EP0586229A1 (en) 1992-09-01 1994-03-09 Zeneca Limited 3-Hydroxy-3-(subst-akyl)-pyrrolidines as 5-lipoxygenase inhibitors
AU4444393A (en) 1992-09-01 1994-03-10 Zeneca Limited Pyrrolidine derivatives
EP2146961B1 (en) * 2007-04-12 2014-01-29 IVAX International GmbH N-oxide and/or di-n-oxide derivatives of dopamine receptor stabilizers/modulators displaying improved cardiovascular side-effects profiles
CA2690091A1 (en) 2007-06-05 2008-12-11 Nsab, Filial Af Neurosearch Sweden Ab, Sverige New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
CA2689692A1 (en) 2007-06-05 2008-12-11 Clas Sonesson New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
CN102224136B (zh) * 2008-11-24 2014-01-22 Nsab神经研究瑞典公司分公司 用作皮质儿茶酚胺能神经传递调节剂的3-苯基-3-甲氧基-吡咯烷衍生物
US8586572B2 (en) 2008-11-24 2013-11-19 Integrative Research Laboratories Sweden Ab 3-phenyl-azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
US20110257148A1 (en) 2008-11-24 2011-10-20 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Novel 1-alkyl-3-hydroxy-3-phenylazetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission

Also Published As

Publication number Publication date
EP2367787A1 (en) 2011-09-28
US20140135505A1 (en) 2014-05-15
AU2009317156B2 (en) 2015-12-03
CN102224136A (zh) 2011-10-19
HK1162173A1 (en) 2012-08-24
ES2402713T3 (es) 2013-05-08
IL212601A (en) 2014-12-31
NZ592566A (en) 2013-03-28
ZA201103169B (en) 2012-09-26
PL2367787T3 (pl) 2013-06-28
US20110257242A1 (en) 2011-10-20
BRPI0921561B1 (pt) 2022-02-15
CA2744308C (en) 2017-05-30
US9035073B2 (en) 2015-05-19
JP2012509861A (ja) 2012-04-26
WO2010058019A1 (en) 2010-05-27
IL212601A0 (en) 2011-07-31
DK2367787T3 (da) 2013-03-25
EP2367788A1 (en) 2011-09-28
MX2011005036A (es) 2011-06-16
CN102224136B (zh) 2014-01-22
WO2010058018A1 (en) 2010-05-27
BRPI0921561A2 (pt) 2018-10-09
JP5716202B2 (ja) 2015-05-13
EP2367787B1 (en) 2013-01-09
US20110257241A1 (en) 2011-10-20
US8673962B2 (en) 2014-03-18
CA2744308A1 (en) 2010-05-27
RU2011120817A (ru) 2012-12-27
RU2524214C2 (ru) 2014-07-27
AU2009317156A1 (en) 2010-05-27
KR20110087339A (ko) 2011-08-02
KR101660936B1 (ko) 2016-10-05

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