HK1162173A1 - 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission 3--3-- - Google Patents

3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission 3--3--

Info

Publication number
HK1162173A1
HK1162173A1 HK12102575.5A HK12102575A HK1162173A1 HK 1162173 A1 HK1162173 A1 HK 1162173A1 HK 12102575 A HK12102575 A HK 12102575A HK 1162173 A1 HK1162173 A1 HK 1162173A1
Authority
HK
Hong Kong
Prior art keywords
modulators
phenyl
methoxypyrrolidine
derivatives
cortical
Prior art date
Application number
HK12102575.5A
Other languages
English (en)
Chinese (zh)
Inventor
.索內松
.斯萬松
.彼得松
Original Assignee
綜合研究實驗室瑞典股份公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 綜合研究實驗室瑞典股份公司 filed Critical 綜合研究實驗室瑞典股份公司
Publication of HK1162173A1 publication Critical patent/HK1162173A1/xx

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12Oxygen or sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
HK12102575.5A 2008-11-24 2012-03-14 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission 3--3-- HK1162173A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200801657 2008-11-24
US11782208P 2008-11-25 2008-11-25
PCT/EP2009/065676 WO2010058018A1 (en) 2008-11-24 2009-11-24 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission

Publications (1)

Publication Number Publication Date
HK1162173A1 true HK1162173A1 (en) 2012-08-24

Family

ID=42197858

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12102575.5A HK1162173A1 (en) 2008-11-24 2012-03-14 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission 3--3--

Country Status (19)

Country Link
US (3) US8673962B2 (ru)
EP (2) EP2367787B1 (ru)
JP (1) JP5716202B2 (ru)
KR (1) KR101660936B1 (ru)
CN (1) CN102224136B (ru)
AU (1) AU2009317156B2 (ru)
BR (1) BRPI0921561B1 (ru)
CA (1) CA2744308C (ru)
DK (1) DK2367787T3 (ru)
ES (1) ES2402713T3 (ru)
HK (1) HK1162173A1 (ru)
IL (1) IL212601A (ru)
MX (1) MX2011005036A (ru)
NZ (1) NZ592566A (ru)
PL (1) PL2367787T3 (ru)
RU (1) RU2524214C2 (ru)
UA (1) UA104152C2 (ru)
WO (2) WO2010058019A1 (ru)
ZA (1) ZA201103169B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2367785B1 (en) 2008-11-24 2014-10-15 Integrative Research Laboratories Sweden AB Novel 3-phenyl-azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
AU2009317156B2 (en) 2008-11-24 2015-12-03 Integrative Research Laboratories Sweden Ab 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission
CN102766079B (zh) * 2011-05-06 2015-04-08 上海医药工业研究院 一类吡咯烷衍生物、其制备方法及应用
PT3297987T (pt) 2015-05-20 2019-06-19 Integrative Res Laboratories Sweden Ab Novos derivados de azetidina úteis como moduladores da neurotransmissão catecolaminérgica cortical
JP6990702B2 (ja) 2016-11-18 2022-01-13 インテグレーティブ リサーチ ラボラトリーズ スウェーデン アーベー 皮質カテコールアミン作動性神経伝達のモジュレーターとして有用な新規アゼチジン誘導体
JP7126522B2 (ja) * 2017-05-19 2022-08-26 インテグレイティブ・リサーチ・ラボラトリーズ・スウェーデン・アーベー (+)-3-(2,3-ジフルオロフェニル)-3-メトキシピロリジンまたはその薬学的に許容される塩、それを調製するための方法およびその使用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH372667A (de) * 1957-09-26 1963-10-31 Robins Co Inc A H Verfahren zur Herstellung von 3-Aryl-3-pyrrolidinolen
US3119907A (en) 1960-12-30 1964-01-28 Texas Instruments Inc Electromechanical commutator with rolling contact-type structure
US3118907A (en) 1961-08-14 1964-01-21 Mead Johnson & Co 3-substituted-3-pyrrolidinols
US3647790A (en) 1969-04-08 1972-03-07 American Home Prod Ouinoxalinyl-oxazolidines and -oxazines
ES2157204T3 (es) 1991-04-17 2001-08-16 Upjohn Co Derivados de (s)-3-fenilpiperidina sustituidos, su preparacion y uso como antagonistas de autorreceptores de dopamina.
AU4444393A (en) * 1992-09-01 1994-03-10 Zeneca Limited Pyrrolidine derivatives
EP0586229A1 (en) * 1992-09-01 1994-03-09 Zeneca Limited 3-Hydroxy-3-(subst-akyl)-pyrrolidines as 5-lipoxygenase inhibitors
PL2146961T3 (pl) * 2007-04-12 2014-09-30 Teva Pharmaceuticals Int Gmbh Pochodne N-tlenkowe i/lub Di-N-tlenkowe stabilizatorów/modulatorów receptora dopaminowego, wykazujące udoskonalone profile efektów ubocznych
EP2155669B1 (en) 2007-06-05 2011-05-04 NSAB, Filial af NeuroSearch Sweden AB, Sverige New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
NZ581364A (en) 2007-06-05 2011-10-28 Nsab Af Neurosearch Sweden Ab Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
AU2009317156B2 (en) * 2008-11-24 2015-12-03 Integrative Research Laboratories Sweden Ab 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission
EP2367785B1 (en) 2008-11-24 2014-10-15 Integrative Research Laboratories Sweden AB Novel 3-phenyl-azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
EP2367786B1 (en) 2008-11-24 2013-01-09 NSAB, Filial af NeuroSearch Sweden AB, Sverige Novel 1 -alkyl- 3 -hydroxy- 3 -phenylazetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission

Also Published As

Publication number Publication date
ZA201103169B (en) 2012-09-26
IL212601A0 (en) 2011-07-31
US9035073B2 (en) 2015-05-19
AU2009317156B2 (en) 2015-12-03
US20110257242A1 (en) 2011-10-20
EP2367787A1 (en) 2011-09-28
RU2011120817A (ru) 2012-12-27
ES2402713T3 (es) 2013-05-08
WO2010058018A1 (en) 2010-05-27
WO2010058019A1 (en) 2010-05-27
PL2367787T3 (pl) 2013-06-28
NZ592566A (en) 2013-03-28
CN102224136B (zh) 2014-01-22
EP2367787B1 (en) 2013-01-09
KR20110087339A (ko) 2011-08-02
IL212601A (en) 2014-12-31
JP5716202B2 (ja) 2015-05-13
UA104152C2 (ru) 2014-01-10
US20110257241A1 (en) 2011-10-20
KR101660936B1 (ko) 2016-10-05
BRPI0921561B1 (pt) 2022-02-15
AU2009317156A1 (en) 2010-05-27
CA2744308A1 (en) 2010-05-27
CN102224136A (zh) 2011-10-19
DK2367787T3 (da) 2013-03-25
MX2011005036A (es) 2011-06-16
US20140135505A1 (en) 2014-05-15
EP2367788A1 (en) 2011-09-28
JP2012509861A (ja) 2012-04-26
RU2524214C2 (ru) 2014-07-27
BRPI0921561A2 (pt) 2018-10-09
US8673962B2 (en) 2014-03-18
CA2744308C (en) 2017-05-30

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