MX2009012787A - Nuevas fenilpirrolidinas disustituidas como moduladores de neurotransmision catecolaminergica cortical. - Google Patents

Nuevas fenilpirrolidinas disustituidas como moduladores de neurotransmision catecolaminergica cortical.

Info

Publication number
MX2009012787A
MX2009012787A MX2009012787A MX2009012787A MX2009012787A MX 2009012787 A MX2009012787 A MX 2009012787A MX 2009012787 A MX2009012787 A MX 2009012787A MX 2009012787 A MX2009012787 A MX 2009012787A MX 2009012787 A MX2009012787 A MX 2009012787A
Authority
MX
Mexico
Prior art keywords
modulators
disubstituted
phenylpyrrolidines
cortical
catecholaminergic neurotransmission
Prior art date
Application number
MX2009012787A
Other languages
English (en)
Inventor
Lars Swanson
Nicholas Waters
Clas Sonesson
Fredrik Pettersson
Susanna Waters
Original Assignee
Nsab Af Neurosearch Sweden Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nsab Af Neurosearch Sweden Ab filed Critical Nsab Af Neurosearch Sweden Ab
Publication of MX2009012787A publication Critical patent/MX2009012787A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La presente invención se refiere al uso de compuestos que incrementan los niveles extracelulares de las catecolaminas, dopamina y norepinefrina, en áreas cortical y cerebral del cerebro mamífero, y de manera más especifica al uso de fenil-1-pirrolidinoles 3-disubstituidos para el tratamiento de trastornos del sistema nervioso central.
MX2009012787A 2007-06-05 2008-06-04 Nuevas fenilpirrolidinas disustituidas como moduladores de neurotransmision catecolaminergica cortical. MX2009012787A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94199407P 2007-06-05 2007-06-05
SE0701387 2007-06-05
PCT/EP2008/056915 WO2008148801A2 (en) 2007-06-05 2008-06-04 Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission

Publications (1)

Publication Number Publication Date
MX2009012787A true MX2009012787A (es) 2009-12-15

Family

ID=39743744

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012787A MX2009012787A (es) 2007-06-05 2008-06-04 Nuevas fenilpirrolidinas disustituidas como moduladores de neurotransmision catecolaminergica cortical.

Country Status (16)

Country Link
US (1) US8188301B2 (es)
EP (1) EP2155671B8 (es)
JP (1) JP5444535B2 (es)
KR (1) KR20100038295A (es)
CN (1) CN101808987A (es)
AU (1) AU2008258599B2 (es)
BR (1) BRPI0812740A2 (es)
CA (1) CA2690091A1 (es)
CO (1) CO6251288A2 (es)
IL (1) IL202045A0 (es)
MX (1) MX2009012787A (es)
NZ (1) NZ581364A (es)
RU (1) RU2471781C2 (es)
UA (1) UA98783C2 (es)
WO (1) WO2008148801A2 (es)
ZA (1) ZA200908592B (es)

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EP2155671B8 (en) 2007-06-05 2018-02-21 Integrative Research Laboratories Sweden AB Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
ES2402713T3 (es) 2008-11-24 2013-05-08 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Derivados de 3-fenilo-3-metoxipirrolidina como moduladores de la transmisión catecolaminérgica cortical
WO2010058020A1 (en) * 2008-11-24 2010-05-27 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Novel 1 -alkyl- 3 -hydroxy- 3 -phenylazetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
JP5621087B2 (ja) 2008-11-24 2014-11-05 インテグレイティブ・リサーチ・ラボラトリーズ・スウェーデン・アーベー 皮質のカテコールアミン作動性神経伝達のモジュレーターとして有用な新規な３−フェニル−アゼチジン誘導体
KR101881596B1 (ko) 2008-12-02 2018-07-24 웨이브 라이프 사이언시스 재팬 인코포레이티드 인 원자 변형된 핵산의 합성 방법
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EP4219516A3 (en) 2012-07-13 2024-01-10 Wave Life Sciences Ltd. Chiral control
BR112015000723A2 (pt) 2012-07-13 2017-06-27 Shin Nippon Biomedical Laboratories Ltd adjuvante de ácido nucléico quiral
US9598458B2 (en) 2012-07-13 2017-03-21 Wave Life Sciences Japan, Inc. Asymmetric auxiliary group
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
EP3095461A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
WO2015108046A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
BR112016016400A2 (pt) 2014-01-16 2017-10-03 Wave Life Sciences Ltd Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos
MX365283B (es) * 2015-05-20 2019-05-29 Integrative Res Laboratories Sweden Ab Derivados de azetidina novedosos útiles como moduladores de neurotransmisión catecolaminérgica cortical.
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Also Published As

Publication number Publication date
AU2008258599A1 (en) 2008-12-11
UA98783C2 (en) 2012-06-25
BRPI0812740A2 (pt) 2016-07-19
AU2008258599B2 (en) 2013-06-13
CO6251288A2 (es) 2011-02-21
RU2471781C2 (ru) 2013-01-10
NZ581364A (en) 2011-10-28
US8188301B2 (en) 2012-05-29
US20100179211A1 (en) 2010-07-15
WO2008148801A2 (en) 2008-12-11
IL202045A0 (en) 2010-06-16
JP5444535B2 (ja) 2014-03-19
EP2155671B8 (en) 2018-02-21
CN101808987A (zh) 2010-08-18
EP2155671B1 (en) 2017-12-20
EP2155671A2 (en) 2010-02-24
JP2010529081A (ja) 2010-08-26
KR20100038295A (ko) 2010-04-14
WO2008148801A3 (en) 2009-01-29
RU2009143104A (ru) 2011-07-20
ZA200908592B (en) 2011-02-23
CA2690091A1 (en) 2008-12-11
WO2008148801A8 (en) 2009-12-10

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