NI201000168A - Aminas de tiazolopiridina-2-iloxi-fenil y tiazolopirazina-2-iloxi-fenil como moduladores del leucotrieno a4 hidrolasa. - Google Patents
Aminas de tiazolopiridina-2-iloxi-fenil y tiazolopirazina-2-iloxi-fenil como moduladores del leucotrieno a4 hidrolasa.Info
- Publication number
- NI201000168A NI201000168A NI201000168A NI201000168A NI201000168A NI 201000168 A NI201000168 A NI 201000168A NI 201000168 A NI201000168 A NI 201000168A NI 201000168 A NI201000168 A NI 201000168A NI 201000168 A NI201000168 A NI 201000168A
- Authority
- NI
- Nicaragua
- Prior art keywords
- phenyl
- iloxi
- thiazolopyrazine
- thiazolopyridine
- modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Se describen compuestos de aminas de tiazolopiridina-2-iloxi-fenil y tiazolopirazina-2-iloxi-fenil los cuales son útiles como moduladores (LTA4H) del LTA4 hidrolasa. Estos compuestos se pueden utilizar en composiciones farmacéuticas y métodos para la modulación del LTA4H y para el tratamiento de estados de enfermedad, trastornos y condiciones mediados por la actividad del LTA4 hidrolasa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4434908P | 2008-04-11 | 2008-04-11 | |
US14912909P | 2009-02-02 | 2009-02-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
NI201000168A true NI201000168A (es) | 2015-05-27 |
Family
ID=41130551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NI201000168A NI201000168A (es) | 2008-04-11 | 2010-10-11 | Aminas de tiazolopiridina-2-iloxi-fenil y tiazolopirazina-2-iloxi-fenil como moduladores del leucotrieno a4 hidrolasa. |
Country Status (36)
Country | Link |
---|---|
US (3) | US7939527B2 (es) |
EP (2) | EP2336125B1 (es) |
JP (2) | JP5530423B2 (es) |
KR (1) | KR101228378B1 (es) |
CN (1) | CN102056933B (es) |
AR (1) | AR072353A1 (es) |
AU (1) | AU2009234140B2 (es) |
BR (1) | BRPI0911336A2 (es) |
CA (1) | CA2721099C (es) |
CL (1) | CL2009000877A1 (es) |
CO (1) | CO6260069A2 (es) |
CY (1) | CY1114628T1 (es) |
DK (2) | DK2268646T3 (es) |
EA (1) | EA018802B1 (es) |
EC (1) | ECSP10010558A (es) |
ES (2) | ES2440746T3 (es) |
HK (2) | HK1152041A1 (es) |
HN (1) | HN2010002074A (es) |
HR (2) | HRP20130278T1 (es) |
IL (2) | IL208480A (es) |
JO (1) | JO2911B1 (es) |
MX (1) | MX2010011154A (es) |
MY (1) | MY157597A (es) |
NI (1) | NI201000168A (es) |
NZ (2) | NZ588341A (es) |
PE (1) | PE20091779A1 (es) |
PH (1) | PH12013500094A1 (es) |
PL (2) | PL2336125T3 (es) |
PT (2) | PT2268646E (es) |
RS (2) | RS52712B (es) |
SI (2) | SI2336125T1 (es) |
SV (1) | SV2010003694A (es) |
TW (2) | TWI461196B (es) |
UY (1) | UY31760A (es) |
WO (1) | WO2009126806A2 (es) |
ZA (1) | ZA201008054B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2440746T3 (es) * | 2008-04-11 | 2014-01-30 | Janssen Pharmaceutica, N.V. | Triazolopiridina-2-iloxi-fenil y triazolopiridina-iloxi-fenil amino como moduladores del leucotrieno A4 hidrolasa |
EP2822942B1 (en) * | 2012-03-06 | 2017-05-10 | Boehringer Ingelheim International GmbH | Benzodioxanes for inhibiting leukotriene production |
EA201400976A1 (ru) | 2012-03-06 | 2015-02-27 | Бёрингер Ингельхайм Интернациональ Гмбх | Бензодиоксаны в комбинации с другими активными средствами для ингибирования продуцирования лейкотриена |
US9403830B2 (en) | 2012-07-17 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
EP2746260A1 (en) | 2012-12-21 | 2014-06-25 | Basf Se | Substituted [1,2,4]triazole and imidazole compounds |
EP2746259A1 (en) | 2012-12-21 | 2014-06-25 | Basf Se | Substituted [1,2,4]triazole and imidazole compounds |
RU2686101C2 (ru) | 2013-03-12 | 2019-04-24 | Селтакссис, Инк. | Способы ингибирования лейкотриен- а4-гидролазы |
CA2906086A1 (en) * | 2013-03-14 | 2014-09-25 | Celtaxsys, Inc. | Inhibitors of leukotriene a4 hydrolase |
BR112015022226A2 (pt) | 2013-03-14 | 2017-07-18 | Celtaxsys Inc | inibidores de leucotrieno a4 hidrolase |
US10898484B2 (en) | 2018-05-31 | 2021-01-26 | Celltaxis, Llc | Method of reducing pulmonary exacerbations in respiratory disease patients |
BR112021013637A2 (pt) * | 2019-01-11 | 2021-09-14 | Naegis Pharmaceuticals Inc. | Inibidores da síntese de leucotrieno |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5008A (en) * | 1847-03-13 | Machinery for cleaning | ||
IL59004A0 (en) | 1978-12-30 | 1980-03-31 | Beecham Group Ltd | Substituted benzamides their preparation and pharmaceutical compositions containing them |
US4329466A (en) | 1979-01-16 | 1982-05-11 | Delalande S.A. | Certain nor-tropan-8-amine-3-aryl or heteroaryl derivatives |
US4321378A (en) * | 1979-01-16 | 1982-03-23 | Delalande S.A. | 8-(5-Pyrimidinecarboxamide)nor-tropane derivatives |
FR2476088A2 (fr) | 1979-01-16 | 1981-08-21 | Delalande Sa | Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique |
FR2446823A1 (fr) | 1979-01-16 | 1980-08-14 | Delalande Sa | Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique |
US4424358A (en) | 1979-01-16 | 1984-01-03 | Delalande S.A. | β-3-Amino nor-tropane compounds |
US4352802A (en) | 1980-06-10 | 1982-10-05 | Beecham Group Limited | Bicyclo[3.3.1]nonyl-benzamide |
NZ199080A (en) | 1980-12-12 | 1984-07-31 | Beecham Group Ltd | 2-alkoxy-4-amino-5-alkylsulphonyl-n-(3beta-(8-hydrocarbyl-8-azabicyclo (3,2,1)octyl))benzamides |
US4432983A (en) | 1981-04-30 | 1984-02-21 | Research Corporation | Conformationally restricted histamine H2 -receptor antagonists containing a tropane ring |
DE3137996A1 (de) * | 1981-09-24 | 1983-04-28 | Hoechst Ag, 6230 Frankfurt | Heterocyclische phenylaether, verfahren zu deren herstellung und diese enthaltende herbizide mittel |
US4571396A (en) * | 1984-04-16 | 1986-02-18 | Warner-Lambert Company | Antibacterial agents |
US4873346A (en) * | 1985-09-20 | 1989-10-10 | The Upjohn Company | Substituted benzothiazoles, benzimidazoles, and benzoxazoles |
NZ222047A (en) | 1986-10-08 | 1991-01-29 | Bristol Myers Co | Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents |
DK171349B1 (da) * | 1986-11-14 | 1996-09-16 | Hoffmann La Roche | Tetrahydronaphthalenderivater, fremgangsmåde til fremstilling deraf, lægemidler indeholdende forbindelserne samt anvendelse af forbindelserne til fremstilling af lægemidler |
JPS63170356A (ja) | 1986-12-30 | 1988-07-14 | Yamanouchi Pharmaceut Co Ltd | アニリン誘導体及びその製造法 |
FI91859C (fi) * | 1987-06-17 | 1994-08-25 | Eisai Co Ltd | Analogiamenetelmä antiallergisena aineena aktiivisen bentsotiatsolijohdannaisen valmistamiseksi |
US5070094A (en) | 1989-09-05 | 1991-12-03 | G. D. Searle & Co. | N-benzyltropaneamides |
US5220063A (en) * | 1991-05-10 | 1993-06-15 | Hoechst Celanese Corporation | Method for the preparation of arylalkanolacylamides |
US5296486A (en) * | 1991-09-24 | 1994-03-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Leukotriene biosynthesis inhibitors |
US5472964A (en) * | 1992-12-22 | 1995-12-05 | Merck Frosst Canada, Inc. | Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists |
TW251287B (es) | 1993-04-30 | 1995-07-11 | Nissei Co Ltd | |
US5585492A (en) * | 1994-10-11 | 1996-12-17 | G. D. Searle & Co. | LTA4 Hydrolase inhibitors |
US6506876B1 (en) | 1994-10-11 | 2003-01-14 | G.D. Searle & Co. | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use |
US5700816A (en) | 1995-06-12 | 1997-12-23 | Isakson; Peter C. | Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor |
US6632976B1 (en) * | 1995-08-29 | 2003-10-14 | Kirin Beer Kabushiki Kaisha | Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene |
US5794887A (en) | 1995-11-17 | 1998-08-18 | Komerath; Narayanan M. | Stagnation point vortex controller |
ES2183140T3 (es) | 1996-02-13 | 2003-03-16 | Searle & Co | Combinaciones, que tienen efectos inmunosupresores, que contienen un inhibidor de ciclooxigenasa-2 y un inhibidor de leucotrieno a4 hidrolasa. |
US6110994A (en) * | 1996-06-14 | 2000-08-29 | Cabot Corporation | Polymeric products containing modified carbon products and methods of making and using the same |
US6110944A (en) | 1997-03-12 | 2000-08-29 | G. D. Searle & Co. | LTA4, hydrolase inhibitors |
US6632823B1 (en) | 1997-12-22 | 2003-10-14 | Merck & Co., Inc. | Substituted pyridine compounds useful as modulators of acetylcholine receptors |
US6432976B1 (en) | 1999-10-29 | 2002-08-13 | Merck & Co., Inc. | 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists |
US6559140B2 (en) * | 2000-03-09 | 2003-05-06 | Abbott Laboratories | Cyclic and bicyclic diamino histamine-3 receptor antagonists |
MY145722A (en) | 2000-04-27 | 2012-03-30 | Abbott Lab | Diazabicyclic central nervous system active agents |
FR2831884B1 (fr) * | 2001-11-02 | 2003-12-26 | Pf Medicament | Nouveaux derives amides heteroaromatiques de 3 beta-amino azabicyclooctane, leur procede de preparation et leurs applications en therapeutique |
US7152144B2 (en) * | 2002-05-29 | 2006-12-19 | Hitachi, Ltd. | Centralized storage management method |
US7329682B2 (en) * | 2003-04-03 | 2008-02-12 | Ewha University-Industry Collaboration Foundation | Method for inhibiting 5-lipoxygenase using a benzoxazole derivative |
SE0301373D0 (sv) * | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Novel compounds |
EP1636183A1 (en) | 2003-05-16 | 2006-03-22 | Ambit Biosciences Corporation | Pyrrole compounds and uses thereof |
BRPI0413072A (pt) | 2003-07-28 | 2006-10-03 | Janssen Pharmaceutica Nv | moduladores de lta4h |
CN101407471A (zh) * | 2003-08-29 | 2009-04-15 | 小野药品工业株式会社 | 能够结合s1p受体的化合物及其药物用途 |
US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
TW200610761A (en) | 2004-04-23 | 2006-04-01 | Astrazeneca Ab | Chemical compounds |
ATE444066T1 (de) | 2004-06-22 | 2009-10-15 | Schering Corp | Liganden für den cannabinoidrezeptoren |
GB2415818B (en) | 2004-06-30 | 2008-12-31 | Autoliv Dev | Arrangement for triggering a vehicle safety device |
CN101775013A (zh) | 2004-09-13 | 2010-07-14 | 小野药品工业株式会社 | 含氮杂环衍生物及含有其作为活性成分的药物 |
KR20080003385A (ko) * | 2005-03-31 | 2008-01-07 | 얀센 파마슈티카 엔.브이. | 페닐 및 피리딜 lta4h 조절제 |
ES2277745B1 (es) | 2005-06-14 | 2008-06-01 | Laboratorios Almirall S.A. | Derivados n-amida de 8-azabiciclo /3.2.1/oct-3-ilo como antagonistas de ccr1. |
GB0514018D0 (en) | 2005-07-07 | 2005-08-17 | Ionix Pharmaceuticals Ltd | Chemical compounds |
WO2007079078A1 (en) | 2005-12-29 | 2007-07-12 | Bayer Schering Pharma Aktiengesellschaft | Diamine derivatives as inhibitors of leukotriene a4 hydrolase |
US20090156465A1 (en) | 2005-12-30 | 2009-06-18 | Sattigeri Jitendra A | Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors |
EP2044038B1 (en) | 2006-06-06 | 2014-07-02 | Cornerstone Therapeutics Inc. | Novel piperazines, pharmaceutical compositions and methods of use thereof |
WO2008016811A2 (en) | 2006-07-31 | 2008-02-07 | Neurogen Corporation | Aminopiperidines and realted compounds |
WO2008077103A1 (en) * | 2006-12-19 | 2008-06-26 | Auspex Pharmaceuticals, Inc. | Preperation and utility of ccr5 inhibitors |
TW200906396A (en) * | 2007-02-14 | 2009-02-16 | Janssen Pharmaceutica Nv | LTA4H modulators and uses thereof |
US7935725B2 (en) * | 2007-10-31 | 2011-05-03 | Janssen Pharmaceutica Nv | Aryl-substituted bridged or fused diamines as modulators of leukotriene A4 hydrolase |
ES2440746T3 (es) * | 2008-04-11 | 2014-01-30 | Janssen Pharmaceutica, N.V. | Triazolopiridina-2-iloxi-fenil y triazolopiridina-iloxi-fenil amino como moduladores del leucotrieno A4 hidrolasa |
-
2009
- 2009-04-09 ES ES09729596.8T patent/ES2440746T3/es active Active
- 2009-04-09 CL CL2009000877A patent/CL2009000877A1/es unknown
- 2009-04-09 MY MYPI2010004692A patent/MY157597A/en unknown
- 2009-04-09 EP EP11159236A patent/EP2336125B1/en active Active
- 2009-04-09 MX MX2010011154A patent/MX2010011154A/es active IP Right Grant
- 2009-04-09 NZ NZ588341A patent/NZ588341A/en not_active IP Right Cessation
- 2009-04-09 RS RS20130120A patent/RS52712B/en unknown
- 2009-04-09 NZ NZ599853A patent/NZ599853A/xx not_active IP Right Cessation
- 2009-04-09 DK DK09729596.8T patent/DK2268646T3/da active
- 2009-04-09 BR BRPI0911336-3A patent/BRPI0911336A2/pt not_active Application Discontinuation
- 2009-04-09 KR KR1020107025118A patent/KR101228378B1/ko active IP Right Grant
- 2009-04-09 US US12/421,406 patent/US7939527B2/en active Active
- 2009-04-09 AU AU2009234140A patent/AU2009234140B2/en not_active Ceased
- 2009-04-09 EA EA201071186A patent/EA018802B1/ru unknown
- 2009-04-09 JO JO2009128A patent/JO2911B1/en active
- 2009-04-09 CA CA2721099A patent/CA2721099C/en not_active Expired - Fee Related
- 2009-04-09 SI SI200930535T patent/SI2336125T1/sl unknown
- 2009-04-09 PT PT97295968T patent/PT2268646E/pt unknown
- 2009-04-09 JP JP2011504176A patent/JP5530423B2/ja not_active Expired - Fee Related
- 2009-04-09 DK DK11159236.6T patent/DK2336125T3/da active
- 2009-04-09 SI SI200930743T patent/SI2268646T1/sl unknown
- 2009-04-09 EP EP09729596.8A patent/EP2268646B9/en active Active
- 2009-04-09 PL PL11159236T patent/PL2336125T3/pl unknown
- 2009-04-09 ES ES11159236T patent/ES2400875T3/es active Active
- 2009-04-09 PT PT111592366T patent/PT2336125E/pt unknown
- 2009-04-09 WO PCT/US2009/040070 patent/WO2009126806A2/en active Application Filing
- 2009-04-09 CN CN200980122416.8A patent/CN102056933B/zh not_active Expired - Fee Related
- 2009-04-09 PL PL09729596T patent/PL2268646T3/pl unknown
- 2009-04-09 RS RS20130527A patent/RS53081B/en unknown
- 2009-04-10 TW TW098111909A patent/TWI461196B/zh not_active IP Right Cessation
- 2009-04-10 TW TW103104197A patent/TW201420100A/zh unknown
- 2009-04-13 AR ARP090101295A patent/AR072353A1/es unknown
- 2009-04-13 UY UY0001031760A patent/UY31760A/es unknown
- 2009-04-13 PE PE2009000508A patent/PE20091779A1/es active IP Right Grant
-
2010
- 2010-10-05 IL IL208480A patent/IL208480A/en active IP Right Grant
- 2010-10-11 NI NI201000168A patent/NI201000168A/es unknown
- 2010-10-11 SV SV2010003694A patent/SV2010003694A/es unknown
- 2010-10-11 HN HN2010002074A patent/HN2010002074A/es unknown
- 2010-10-20 EC EC2010010558A patent/ECSP10010558A/es unknown
- 2010-10-22 CO CO10131314A patent/CO6260069A2/es active IP Right Grant
- 2010-11-10 ZA ZA2010/08054A patent/ZA201008054B/en unknown
-
2011
- 2011-03-02 US US13/039,105 patent/US20110190503A1/en not_active Abandoned
- 2011-03-02 US US13/039,017 patent/US8357684B2/en active Active
- 2011-06-16 HK HK11106213.5A patent/HK1152041A1/xx not_active IP Right Cessation
- 2011-11-24 HK HK11112776.2A patent/HK1158208A1/xx not_active IP Right Cessation
-
2013
- 2013-01-14 PH PH12013500094A patent/PH12013500094A1/en unknown
- 2013-03-27 HR HRP20130278AT patent/HRP20130278T1/hr unknown
- 2013-05-09 IL IL226244A patent/IL226244A/en active IP Right Grant
- 2013-11-20 CY CY20131101029T patent/CY1114628T1/el unknown
- 2013-12-16 HR HRP20131192AT patent/HRP20131192T1/hr unknown
- 2013-12-25 JP JP2013266767A patent/JP5675943B2/ja not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NI201000168A (es) | Aminas de tiazolopiridina-2-iloxi-fenil y tiazolopirazina-2-iloxi-fenil como moduladores del leucotrieno a4 hidrolasa. | |
BR112017003111A2 (pt) | composições e métodos para o tratamento de distúrbios neurológicos | |
BRPI0808775A2 (pt) | compostos e composições como moduladores de atividade de gpr119 | |
CU20120034A7 (es) | Compuestos y composiciones como inhibidores de cinasa de proteína | |
UY30479A1 (es) | Moduladores de benzofuro- y benzotienopirimidina del receptor de histamina h4 | |
CR20110103A (es) | Heteroarilos sustituidos | |
EA201001329A1 (ru) | Соединения и композиции в качестве модуляторов активности gpr119 | |
CR11284A (es) | Sulfonamidas como moduladores de trpm8 | |
CL2012003421A1 (es) | Compuestos derivados de 3-amino-n-(4-carbamoilpiridin-3-il)(aril/heteroaril)-2-carboxamida; procedimiento de preparacion; composicion farmaceutica que los comprende; y su uso en el tratamiento de una enfermedad del snc, oncologica, entre otras. pct fase nacional | |
UY35029A (es) | Derivados tricíclicos de quinolinas y de quinoxalinas | |
EA201001332A1 (ru) | Соединения и композиции в качестве модуляторов активности gpr119 | |
MX2018000352A (es) | 4-azaindoles sustituidos y su uso como moduladores del receptor glun2b. | |
CR20110029A (es) | Moduladores de diamino-piridina, pirimidina, y piridazina del receptor h4 de histamina | |
CL2015002434A1 (es) | Moduladores benzoimidazol-2-il pirimidinas del receptor h4 de histamina. | |
EA201001330A1 (ru) | Соединения и композиции в качестве модуляторов активности gpr119 | |
BR112012008004A2 (pt) | compostos e composições como moduladores da atividade de gpr119 | |
UY31340A1 (es) | Moduladores tieno- y furo-pirimidina del receptor de histamina h4 | |
PA8808201A1 (es) | Moduladores imidazolo-,oxazolo-, y tiazolopirimidina del trpvi | |
CL2012001031A1 (es) | Compuestos derivados de 2-oxo-1-pirrolidinil-imidazotiadiazol; composición farmacéutica que los comprende; útiles para el tratamiento de la epilepsia, transtornos neurológicos, entre otros. | |
UY34070A (es) | Método y composición para tratamiento de semillas. | |
TR201909158T4 (tr) | siRNA ve göz rahatsızlıklarının tedavisi ve/veya önlenmesine yönelik yöntemler ve bileşimlerde kullanımları. | |
PE20150707A1 (es) | Inhibidores de la beta-secretasa | |
GB201302343D0 (en) | Pharmaceutical compositions comprising 15-OHEPA and methods for using the same | |
UY32641A (es) | Compuestos con dos porciones heteroarilo bicíclicas fusionadas como moduladores de la hidrolasa de leucotrieno a4 | |
UA102544C2 (en) | Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene a4 hydrolase |