CU20120034A7 - Compuestos y composiciones como inhibidores de cinasa de proteína - Google Patents

Compuestos y composiciones como inhibidores de cinasa de proteína

Info

Publication number
CU20120034A7
CU20120034A7 CU20120034A CU20120034A CU20120034A7 CU 20120034 A7 CU20120034 A7 CU 20120034A7 CU 20120034 A CU20120034 A CU 20120034A CU 20120034 A CU20120034 A CU 20120034A CU 20120034 A7 CU20120034 A7 CU 20120034A7
Authority
CU
Cuba
Prior art keywords
compounds
compositions
protein kinase
kinase inhibitors
abnormal
Prior art date
Application number
CU20120034A
Other languages
English (en)
Other versions
CU24110B1 (es
Inventor
John E Tellew
Xianming Jin
Yongqin Wan
Yongping Xie
Xing Wang
Zuosheng Liu
Shenlin Huang
Daniel Poon
Original Assignee
Irm Llc
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42782253&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU20120034(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Irm Llc, Novartis Ag filed Critical Irm Llc
Publication of CU20120034A7 publication Critical patent/CU20120034A7/es
Publication of CU24110B1 publication Critical patent/CU24110B1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

La invención proporciona una clase novedosa de compuestos, composiciones farmacéuticas que comprenden estos compuestos, y métodos para utilizar tales compuestos con el objeto de tratar o prevenir las enfermedades o los trastornos asociados con una actividad de cinasa anormal o mal regulada, en particular las enfermedades o los trastornos que involucren una activación anormal de B-Raf.
CU2012000034A 2009-08-28 2010-08-27 Compuestos y composiciones como inhibidores de cinasa de proteína CU24110B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23807309P 2009-08-28 2009-08-28
US31303910P 2010-03-11 2010-03-11
PCT/US2010/046930 WO2011025927A1 (en) 2009-08-28 2010-08-27 Compounds and compositions as protein kinase inhibitors

Publications (2)

Publication Number Publication Date
CU20120034A7 true CU20120034A7 (es) 2012-06-21
CU24110B1 CU24110B1 (es) 2015-07-30

Family

ID=42782253

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2012000034A CU24110B1 (es) 2009-08-28 2010-08-27 Compuestos y composiciones como inhibidores de cinasa de proteína

Country Status (50)

Country Link
US (12) US8501758B2 (es)
EP (2) EP2727918B1 (es)
JP (2) JP5475888B2 (es)
KR (1) KR101413392B1 (es)
CN (2) CN103896921B (es)
AR (1) AR077975A1 (es)
AU (1) AU2010286569C1 (es)
BR (1) BR112012004453B1 (es)
CA (1) CA2771775C (es)
CL (1) CL2012000340A1 (es)
CO (1) CO6612222A2 (es)
CR (1) CR20120102A (es)
CU (1) CU24110B1 (es)
CY (3) CY1118452T1 (es)
DK (2) DK2470526T3 (es)
DO (1) DOP2012000051A (es)
EA (2) EA025222B1 (es)
EC (2) ECSP12011700A (es)
ES (2) ES2492499T3 (es)
GE (1) GEP20146102B (es)
GT (1) GT201200053A (es)
HK (1) HK1167390A1 (es)
HN (1) HN2012000441A (es)
HR (2) HRP20140799T1 (es)
HU (3) HUE032847T2 (es)
IL (1) IL218084A (es)
IN (1) IN2012DN02469A (es)
JO (1) JO3002B1 (es)
LT (3) LT2727918T (es)
LU (1) LUC00101I2 (es)
MA (1) MA33604B1 (es)
ME (2) ME01860B (es)
MX (1) MX2012002546A (es)
MY (1) MY156259A (es)
NI (1) NI201200029A (es)
NL (1) NL300973I2 (es)
NO (1) NO2019011I1 (es)
NZ (1) NZ598924A (es)
PE (1) PE20120861A1 (es)
PL (2) PL2727918T3 (es)
PT (2) PT2470526E (es)
RS (2) RS55568B1 (es)
SG (2) SG10201405311TA (es)
SI (2) SI2470526T1 (es)
SM (2) SMT201400133B (es)
TN (1) TN2012000081A1 (es)
UA (1) UA112285C2 (es)
UY (1) UY32860A (es)
WO (1) WO2011025927A1 (es)
ZA (1) ZA201202020B (es)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3002B1 (ar) 2009-08-28 2016-09-05 Irm Llc مركبات و تركيبات كمثبطات كيناز بروتين
AU2011221227B2 (en) 2010-02-25 2015-07-09 Dana-Farber Cancer Institute, Inc. BRAF mutations conferring resistance to BRAF inhibitors
US8907270B2 (en) 2010-06-30 2014-12-09 Schlumberger Technology Corporation Method and apparatus for gain regulation in a gamma detector
CA2855243C (en) * 2011-11-11 2020-04-14 Novartis Ag Method of treating a proliferative disease
CN105708819B (zh) 2011-11-23 2020-12-29 诺华股份有限公司 医药制剂
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
CN103159736B (zh) * 2011-12-10 2015-05-13 通化济达医药有限公司 取代的吡唑激酶抑制剂
EP2793880A4 (en) * 2011-12-23 2015-06-24 Millennium Pharm Inc HETEROARYLE AND USES THEREOF
EA028135B1 (ru) 2012-03-28 2017-10-31 Дана-Фарбер Кэнсер Инститьют, Инк. Мутанты c-raf, придающие резистентность к ингибиторам raf
US8716226B2 (en) 2012-07-18 2014-05-06 Saint Louis University 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
CA2878469A1 (en) 2012-07-18 2014-01-23 Saint Louis University Beta amino acid derivatives as integrin antagonists
AR091876A1 (es) * 2012-07-26 2015-03-04 Novartis Ag Combinaciones farmaceuticas para el tratamiento de enfermedades proliferativas
PT2882440T (pt) 2012-08-07 2019-04-23 Array Biopharma Inc Combinações farmacêuticas compreendendo um inibidor de braf, um inibidor de egfr e opcionalmente um inibidor de pi3k-alfa
KR20150038068A (ko) 2012-08-17 2015-04-08 에프. 호프만-라 로슈 아게 코비메티닙 및 베무라피닙을 투여함을 포함하는 흑색종의 조합 치료법
WO2014047330A1 (en) * 2012-09-19 2014-03-27 Jean-Michel Vernier Novel raf kinase inhibitors
CN104994850A (zh) * 2012-11-08 2015-10-21 诺华股份有限公司 包含b-raf抑制剂和组蛋白脱乙酰基酶抑制剂的药物组合以及其在治疗增生性疾病中的用途
SG10201906270VA (en) * 2013-03-21 2019-08-27 Novartis Ag Combination therapy comprising a b-raf inhibitor and a second inhibitor
TWI634114B (zh) * 2013-05-08 2018-09-01 永恒生物科技公司 作為激酶抑制劑之呋喃酮化合物
CA2912568A1 (en) 2013-05-30 2014-12-04 Plexxikon Inc. Compounds for kinase modulation, and indications therefor
EP3049442A4 (en) 2013-09-26 2017-06-28 Costim Pharmaceuticals Inc. Methods for treating hematologic cancers
TW201605450A (zh) 2013-12-03 2016-02-16 諾華公司 Ｍｄｍ２抑制劑與ＢＲＡＦ抑制劑之組合及其用途
BR112016014481B1 (pt) * 2013-12-20 2022-11-08 Biomed Valley Discoveries, Inc Uso de uma composição farmacêutica, método in vitro para efetuar a morte de células cancerosas, e kit
CN105848682A (zh) * 2013-12-23 2016-08-10 诺华股份有限公司 药物组合
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
DE102015103158A1 (de) 2014-03-04 2015-09-10 Bergische Universität Wuppertal Verbindungen für die Behandlung des Melanoms
CN106103484B (zh) 2014-03-14 2021-08-20 诺华股份有限公司 针对lag-3的抗体分子及其用途
WO2015145388A2 (en) 2014-03-27 2015-10-01 Novartis Ag Methods of treating colorectal cancers harboring upstream wnt pathway mutations
EP3143166A4 (en) 2014-05-16 2018-04-18 University of Massachusetts Treating chronic myelogenous leukemia (cml)
JP6636014B2 (ja) * 2014-09-12 2020-01-29 ノバルティス アーゲー Ｒａｆキナーゼ阻害剤としての化合物および組成物
US9993551B2 (en) 2014-09-13 2018-06-12 Novartis Ag Combination therapies of EGFR inhibitors
KR20170066546A (ko) 2014-10-03 2017-06-14 노파르티스 아게 조합 요법
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
CU20170052A7 (es) 2014-10-14 2017-11-07 Dana Farber Cancer Inst Inc Moléculas de anticuerpo que se unen a pd-l1
MY190404A (en) 2015-03-10 2022-04-21 Aduro Biotech Inc Compositions and methods for activating "stimulator of interferon gene"-dependent signalling
SI3317301T1 (sl) 2015-07-29 2021-10-29 Novartis Ag Kombinirane terapije, ki obsegajo molekule protitelesa na LAG-3
EP3316902A1 (en) 2015-07-29 2018-05-09 Novartis AG Combination therapies comprising antibody molecules to tim-3
BR112018008904A2 (pt) 2015-11-03 2018-11-27 Janssen Biotech Inc anticorpos que se ligam especificamente a tim-3 e seus usos
CA3007671A1 (en) 2015-12-17 2017-06-22 Novartis Ag Antibody molecules to pd-1 and uses thereof
EP3294716B1 (en) 2015-12-30 2020-04-15 Saint Louis University Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists
RU2615986C1 (ru) * 2016-02-25 2017-04-12 Закрытое акционерное общество "Р-Фарм" (ЗАО "Р-Фарм") Замещенные метил (2-{ 4-[3-(3-метансульфониламино-2-фтор-5-хлор-фенил)-1Н-пиразол-4-ил]пиримидин-2-иламино} -этил)карбаматы, способ их получения и применения
SG11201810793XA (en) 2016-06-03 2018-12-28 Giordano Caponigro Pharmaceutical combinations
EP3507367A4 (en) 2016-07-05 2020-03-25 Aduro BioTech, Inc. CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
CA3048376A1 (en) 2016-12-27 2018-07-05 Riken Bmp-signal-inhibiting compound
US11471538B2 (en) 2017-02-10 2022-10-18 INSERM (Institut National de la Santéet de la Recherche Medicale) Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the MAPK pathway
UY37695A (es) 2017-04-28 2018-11-30 Novartis Ag Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
CN107540699A (zh) * 2017-10-16 2018-01-05 康化（上海）新药研发有限公司 一种2‑氨基‑3‑氟吡啶‑4‑硼酸盐酸盐的合成方法
EP3732285A1 (en) 2017-12-28 2020-11-04 Tract Pharmaceuticals, Inc. Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
US20210283132A1 (en) * 2018-07-12 2021-09-16 Shenzhen Targetrx, Inc. Diarylpyrazole compound, composition comprising same, and use thereof
WO2020124397A1 (en) * 2018-12-19 2020-06-25 Inventisbio Shanghai Ltd. C-terminal src kinase inhibitors
BR112021011894A2 (pt) 2018-12-21 2021-09-08 Daiichi Sankyo Company, Limited Composição farmacêutica
US20220168250A1 (en) 2019-05-16 2022-06-02 Eli Lilly And Company TRIPLE COMBINATION OF AN ERK1/2 INHIBITOR WITH A BRAF INHIBITOR AND AN EGFR INHIBITOR FOR USE IN THE TREATMENT OF BRAFv6ooE COLORECTAL CANCER
WO2021110997A1 (en) 2019-12-05 2021-06-10 INSERM (Institut National de la Santé et de la Recherche Médicale) N-(3-(5-(pyrimidin-4-yl)thiazol-4-yl)phenyl)sulfonamide compounds and their uses as braf inhibitors
EP4196228A1 (en) 2020-08-13 2023-06-21 Albert Einstein College of Medicine N-cyclyl-sulfonamides useful for inhibiting raf
EP4225307A1 (en) 2020-10-05 2023-08-16 Pierre Fabre Medicament Combination of encorafenib and binimetinib as adjuvant treatment for resected stage ii melanoma
CN117321418A (zh) 2021-03-18 2023-12-29 诺华股份有限公司 癌症生物标志物及其使用方法
CN117642166A (zh) 2021-06-09 2024-03-01 中外制药株式会社 用于癌症治疗的组合疗法
CN114557977A (zh) * 2022-02-16 2022-05-31 北京康立生医药技术开发有限公司 一种治疗肠癌的药物的制备方法、制剂及纯度分析方法
WO2023230554A1 (en) 2022-05-25 2023-11-30 Pfizer Inc. Combination of a braf inhibitor, an egfr inhibitor, and a pd-1 antagonist for the treatment of braf v600e-mutant, msi-h/dmmr colorectal cancer

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4104250A (en) * 1976-08-11 1978-08-01 Borg-Warner Corporation Flame-retardant polymers with 1,3,5-triazines having halo- and halo-aryl substitutents
JPS5475888A (en) 1977-11-29 1979-06-18 Jiyasuko Kk Surgical laser
EP0184384B1 (en) 1984-12-06 1989-08-02 Pfizer Inc. Substituted dihydroquinolone carboxylic acids, anti-bacterial compositions containing them
US6391636B1 (en) 1994-05-31 2002-05-21 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of raf gene expression
US6358932B1 (en) 1994-05-31 2002-03-19 Isis Pharmaceticals, Inc. Antisense oligonucleotide inhibition of raf gene expression
US6037136A (en) 1994-10-24 2000-03-14 Cold Spring Harbor Laboratory Interactions between RaF proto-oncogenes and CDC25 phosphatases, and uses related thereto
WO1997008950A1 (en) 1995-09-07 1997-03-13 Fuisz Technologies, Ltd. System for rendering substantially non-dissoluble bio-affecting agents bio-available
US5717100A (en) 1995-10-06 1998-02-10 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
CA2256109A1 (en) 1996-05-23 1997-11-27 Applied Research Systems Ars Holding N.V. Compounds that inhibit the binding of raf-1 or 14-3-3 proteins to the beta chain of il-2 receptor, and pharmaceutical compositions containing same
AR012634A1 (es) 1997-05-02 2000-11-08 Sugen Inc Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion
US6514977B1 (en) 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
CN1264377A (zh) 1997-05-22 2000-08-23 G·D·西尔公司 用作p38激酶抑制剂的取代的吡唑化合物
US6187799B1 (en) 1997-05-23 2001-02-13 Onyx Pharmaceuticals Inhibition of raf kinase activity using aryl ureas
GB9716557D0 (en) 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
US6204467B1 (en) 1998-03-24 2001-03-20 Ford Global Technologies, Inc. Method and apparatus for resistive welding
US7351834B1 (en) 1999-01-13 2008-04-01 Bayer Pharmaceuticals Corporation ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US6316435B2 (en) 1999-02-24 2001-11-13 Supergen, Inc. Combination therapy for lymphoproliferative diseases
EP2415462A1 (en) 1999-12-23 2012-02-08 Mayne Pharma International Pty Ltd. Improved pharmaceutical compositions for poorly soluble drugs
AU2001285349A1 (en) 2000-08-30 2002-03-13 The Board Of Trustees Of The University Of Arkansas Induction of ldl receptor expression by extracellular-signal regulated kinase, erk-1/2
PE20020354A1 (es) 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
CN100506224C (zh) 2001-10-25 2009-07-01 诺瓦提斯公司 包含选择性环加氧酶-2抑制剂的组合
DE60222804T2 (de) 2001-12-21 2008-07-03 Vernalis (Cambridge) Ltd., Abington 3-(2,4)dihydroxyphenyl-4-phenylpyrazole und deren medizinische verwendung
SG148857A1 (en) 2002-03-13 2009-01-29 Array Biopharma Inc N3 alkylated benzimidazole derivatives as mek inhibitors
JP2007505938A (ja) 2003-09-23 2007-03-15 ノバルティス アクチエンゲゼルシャフト Ｖｅｇｆ受容体阻害剤と化学療法剤の組み合わせ
AU2004289539C1 (en) 2003-11-14 2012-06-07 Lorus Therapeutics Inc. Aryl imidazoles and their use as anti-cancer agents
AU2005205118B2 (en) 2004-01-09 2009-02-26 Novartis Ag Phenyl-[4-(3-phenyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amine derivatives as IGF-IR inhibitors
TW200610762A (en) 2004-06-10 2006-04-01 Irm Llc Compounds and compositions as protein kinase inhibitors
US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
EP1871773A1 (en) 2005-03-17 2008-01-02 Novartis AG N-[3-(1-amino-5,6,7,8-tetrahydro-2,4,4b-triazafluoren-9-yl)-phenyl]benzamides as tyrosine/threonine kinase inhibitors, in particular b-raf kinase
US20070099856A1 (en) 2005-05-13 2007-05-03 Gumerlock Paul H Combined treatment with docetaxel and an epidermal growth factor receptor kinase inhibitor using an intermittent dosing regimen
AU2006279794B2 (en) 2005-08-12 2011-04-07 Synta Pharmaceuticals Corp. Pyrazole compounds that modulate HSP90 activity
EP1919460A2 (en) 2005-08-22 2008-05-14 Novartis AG Pharmaceutical compositions comprising a ph-dependent drug, a ph modifier and a retarding agent
WO2007024843A2 (en) 2005-08-26 2007-03-01 Smithkline Beecham Corporation Pyrimidinyl-pyrazole inhibitors of aurora kinases
TW200804345A (en) 2005-08-30 2008-01-16 Novartis Ag Substituted benzimidazoles and methods of preparation
WO2007105058A2 (en) * 2006-03-16 2007-09-20 Pfizer Products Inc. Pyrazole compounds
JP2009532497A (ja) 2006-04-05 2009-09-10 ノバルティス アクチエンゲゼルシャフト 癌を処置するための治療剤の組合せ
WO2007123892A2 (en) * 2006-04-17 2007-11-01 Arqule Inc. Raf inhibitors and their uses
KR20090077914A (ko) 2006-09-11 2009-07-16 쿠리스 인코퍼레이션 항증식제로서의 다작용성 소분자
MX2009002710A (es) 2006-09-18 2009-03-25 Boehringer Ingelheim Int Metodos para tratar canceres que portan mutaciones de egfr.
CA2663366C (en) 2006-10-02 2012-02-07 Irm Llc Compounds and compositions as protein kinase inhibitors
EP2076128A4 (en) * 2006-10-06 2011-01-05 PROTEIN CHINESE INHIBITOR AND ITS USE METHOD
CN101626758A (zh) 2007-02-15 2010-01-13 诺瓦提斯公司 用于治疗癌症的lbh589和其他治疗剂的组合
US20090022789A1 (en) 2007-07-18 2009-01-22 Supernus Pharmaceuticals, Inc. Enhanced formulations of lamotrigine
AP2010005167A0 (en) * 2007-08-01 2010-02-28 Pfizer Pyrazole compounds and their use as RAF inhibitors
CA2699301A1 (en) 2007-10-19 2009-04-23 Abbott Gmbh & Co. Kg Solid dispersion product of n-aryl urea-based drugs
ES2637794T3 (es) * 2007-11-14 2017-10-17 Janssen Pharmaceuticals, Inc. Derivados de imidazo[1,2-A]piridina y su uso como moduladores alostéricos positivos de receptores MGLUR2
JP5384611B2 (ja) * 2008-03-21 2014-01-08 ノバルティス アーゲー 新規ヘテロ環式化合物およびそれらの使用
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
MX2011000738A (es) * 2008-07-24 2011-02-23 Nerviano Medical Sciences Srl 3,4-diarilpirazoles como inhibidoers de proteina cinasa.
NZ590747A (en) 2008-07-28 2012-11-30 Gilead Sciences Inc Cycloalkylidene and heterocycloalkylidene hdac inhibitor compounds
BRPI0920608A2 (pt) 2008-09-29 2019-09-24 Boehringer Ingelheim Int compostos quimicos
CN102238945B (zh) 2008-10-07 2014-10-29 阿斯利康(英国)有限公司 药物制剂514
WO2010056662A1 (en) * 2008-11-11 2010-05-20 University Of Washington Activated wnt-beta-catenin signaling in melanoma
EP2373664B1 (en) 2008-12-19 2013-06-12 Nerviano Medical Sciences S.r.l. Bicyclic pyrazoles as protein kinase inhibitors
AR075180A1 (es) 2009-01-29 2011-03-16 Novartis Ag Formulaciones orales solidas de una pirido-pirimidinona
RU2402602C1 (ru) 2009-02-12 2010-10-27 Государственное учреждение Российский онкологический научный центр им. Н.Н. Блохина РАМН КЛЕТОЧНАЯ ЛИНИЯ МЕЛАНОМЫ ЧЕЛОВЕКА mel Rac, ИСПОЛЬЗУЕМАЯ ДЛЯ ПОЛУЧЕНИЯ ПРОТИВООПУХОЛЕВЫХ ВАКЦИН
WO2010100127A1 (en) 2009-03-04 2010-09-10 Novartis Ag Disubstituted imidazole derivatives as modulators of raf kinase
TWI532484B (zh) 2009-06-08 2016-05-11 艾伯維有限公司 包含凋亡促進劑之固態分散劑
EP3045457B1 (en) * 2009-06-15 2018-05-09 Nerviano Medical Sciences S.r.l. Substituted pyrimidinylpyrrolopyridinone derivatives, process for their preparation and their use as kinase inhibitors
KR101256018B1 (ko) * 2009-08-20 2013-04-18 한국과학기술연구원 단백질 키나아제 저해활성을 갖는 1,3,6-치환된 인돌 화합물
US8242260B2 (en) 2009-08-28 2012-08-14 Novartis Ag Compounds and compositions as protein kinase inhibitors
JO3002B1 (ar) 2009-08-28 2016-09-05 Irm Llc مركبات و تركيبات كمثبطات كيناز بروتين
CN104958294A (zh) 2010-01-27 2015-10-07 内尔维安诺医学科学有限公司 作为蛋白激酶抑制剂的3,4-二芳基吡唑的亚磺酰氨基衍生物
SG10201502484SA (en) 2010-03-30 2015-05-28 Verseon Corp Multisubstituted aromatic compounds as inhibitors of thrombin
US9114137B2 (en) 2010-08-03 2015-08-25 Nerviano Medical Sciences S.R.L. Derivatives of pyrazolophenyl-benzenesulfonamide compounds and use thereof as antitumor agents
WO2012128709A1 (en) 2011-03-21 2012-09-27 Valcuria Ab A pharmaceutical composition comprising a hdac inhibitor and a steroid and the use thereof.
MX344580B (es) 2011-06-14 2016-12-20 Novartis Ag Combinacion de panobinostat y ruxolitinib en el tratamiento del cancer tal como una neoplasia mieloproliferativa.
CA2855243C (en) 2011-11-11 2020-04-14 Novartis Ag Method of treating a proliferative disease
CN105708819B (zh) 2011-11-23 2020-12-29 诺华股份有限公司 医药制剂
CN104994850A (zh) 2012-11-08 2015-10-21 诺华股份有限公司 包含b-raf抑制剂和组蛋白脱乙酰基酶抑制剂的药物组合以及其在治疗增生性疾病中的用途
US10576680B2 (en) 2015-11-19 2020-03-03 The Boeing Company Modular thermoforming system

Also Published As

Publication number Publication date
AU2010286569C1 (en) 2019-11-28
US8501758B2 (en) 2013-08-06
HUS1900013I1 (hu) 2019-04-29
JP2013503186A (ja) 2013-01-31
NO2019011I1 (no) 2019-03-05
AU2010286569B2 (en) 2013-10-10
CY2019013I1 (el) 2019-11-27
LTC2470526I2 (lt) 2020-04-27
PL2470526T3 (pl) 2014-10-31
NL300973I2 (nl) 2022-05-05
IN2012DN02469A (es) 2015-08-21
CY2019014I2 (el) 2019-11-27
CY1118452T1 (el) 2017-07-12
LUC00101I2 (es) 2020-01-23
UY32860A (es) 2011-03-31
HUE032847T2 (hu) 2017-11-28
CU24110B1 (es) 2015-07-30
WO2011025927A1 (en) 2011-03-03
IL218084A0 (en) 2012-04-30
SI2470526T1 (sl) 2014-09-30
HRP20140799T1 (hr) 2014-11-07
ME02684B (me) 2017-06-20
HRP20170005T1 (hr) 2017-03-10
USRE49556E1 (en) 2023-06-20
US20200323852A1 (en) 2020-10-15
SG178351A1 (en) 2012-03-29
UA112285C2 (uk) 2016-08-25
SMT201700036B (it) 2017-03-08
LTPA2019006I1 (lt) 2019-03-25
JP2014098022A (ja) 2014-05-29
LT2727918T (lt) 2017-01-25
US9593100B2 (en) 2017-03-14
ZA201202020B (en) 2012-12-27
EA201200373A1 (ru) 2012-09-28
CN103896921B (zh) 2016-02-24
ECSP12011700A (es) 2012-03-30
US10005761B2 (en) 2018-06-26
BR112012004453A8 (pt) 2021-06-08
US20130296318A1 (en) 2013-11-07
NZ598924A (en) 2013-07-26
US20180297986A1 (en) 2018-10-18
CN102725283B (zh) 2014-02-26
CO6612222A2 (es) 2013-02-01
PT2727918T (pt) 2017-01-20
JP6045519B2 (ja) 2016-12-14
IL218084A (en) 2016-11-30
SI2727918T1 (sl) 2017-02-28
RS53489B1 (en) 2015-02-27
CY2019013I2 (el) 2019-11-27
US20160280687A1 (en) 2016-09-29
US9850229B2 (en) 2017-12-26
HN2012000441A (es) 2015-01-05
EP2470526B1 (en) 2014-05-28
PE20120861A1 (es) 2012-07-14
US20110306625A1 (en) 2011-12-15
NL300973I1 (es) 2019-03-27
RS55568B1 (sr) 2017-05-31
MX2012002546A (es) 2012-04-11
EP2727918B1 (en) 2016-10-12
ES2610825T3 (es) 2017-05-03
US9314464B2 (en) 2016-04-19
ES2492499T3 (es) 2014-09-09
BR112012004453A2 (pt) 2021-03-09
EP2727918A1 (en) 2014-05-07
US10568884B2 (en) 2020-02-25
CA2771775A1 (en) 2011-03-03
US20160263113A1 (en) 2016-09-15
JP5475888B2 (ja) 2014-04-16
MA33604B1 (fr) 2012-09-01
TN2012000081A1 (en) 2013-09-19
KR20120062839A (ko) 2012-06-14
NI201200029A (es) 2012-05-29
US9593099B2 (en) 2017-03-14
EA025222B1 (ru) 2016-12-30
DK2727918T3 (da) 2017-01-23
EA201500175A1 (ru) 2015-05-29
MY156259A (en) 2016-01-29
CA2771775C (en) 2015-01-20
CY2019014I1 (el) 2019-11-27
SMT201400133B (it) 2014-11-10
PL2727918T3 (pl) 2017-06-30
US9850230B2 (en) 2017-12-26
LUC00101I1 (es) 2019-02-13
GT201200053A (es) 2014-03-27
ECSP23004573A (es) 2023-04-28
LTPA2019005I1 (lt) 2019-03-25
HUS1900012I1 (hu) 2019-04-29
US20160280686A1 (en) 2016-09-29
PT2470526E (pt) 2014-09-01
GEP20146102B (en) 2014-05-27
US20160120866A1 (en) 2016-05-05
US10576080B2 (en) 2020-03-03
DOP2012000051A (es) 2012-05-31
HK1167390A1 (en) 2012-11-30
US20230116233A1 (en) 2023-04-13
US20180297985A1 (en) 2018-10-18
AR077975A1 (es) 2011-10-05
DK2470526T3 (da) 2014-08-25
CL2012000340A1 (es) 2012-08-17
BR112012004453B1 (pt) 2022-04-26
CN102725283A (zh) 2012-10-10
KR101413392B1 (ko) 2014-06-27
AU2010286569A1 (en) 2012-04-12
CN103896921A (zh) 2014-07-02
ME01860B (me) 2014-12-20
SG10201405311TA (en) 2014-09-26
US20160122324A1 (en) 2016-05-05
JO3002B1 (ar) 2016-09-05
CR20120102A (es) 2012-05-02
EP2470526A1 (en) 2012-07-04

Similar Documents

Publication Publication Date Title
ECSP23004573A (es) Compuestos y composiciones como inhibidores de cinasa de proteina
UY32809A (es) Compuestos y composiciones como inhibidores de cinasa s y k
NI201600071A (es) Compuestos de inhibidor de autotaxina
GT201300209A (es) Compuestos y composiciones como inhibidores de la trk
GT201400036A (es) Compuestos y composiciones como inhibidores de la quinasa c - kit
UY32937A (es) Compuestos y composiciones como moduladores de la actividad de gpr119
ECSP099378A (es) Compuestos y composiciones como inhibidores de la proteina quinasa
GT201400034A (es) Compuestos y composiciones como inhibidores de la quinasa c-kit
CO6551721A2 (es) Moduladores de cinasa novedosos
UY33597A (es) Compuestos y composiciones como inhibidores de la trk
SV2015005066A (es) Compuestos de biaril-amida como inhibidores de cinasa
UY31624A1 (es) Compuestos y composiciones como inhibidores de cinasa
UY34545A (es) Novedosas dihidropirimidinoisoquinolinonas y composiciones farmacéuticas de las mismas para el tratamiento de trastornos inflamatorios.
DOP2012000257A (es) Derivados del acido 1-amino-2-ciclopropiletilboronico
ECSP12011720A (es) Compuestos heterocíclicos y usos de los mismos
SV2009003307A (es) Quinazolinas para la inhibicion de pdk1
CR20110103A (es) Heteroarilos sustituidos
UY32926A (es) Compuestos como antagonistas de los receptores de ácido lisofosfatídico
BRPI0808775A2 (pt) compostos e composições como moduladores de atividade de gpr119
CL2008002793A1 (es) Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras
NI201100166A (es) Derivados de benzofuranilo utilizados como inhibidores de glucoquinasa
CU20100049A7 (es) Derivados de bencimidazol e indol sustituidos por oxadiazol y oxasol como inhibidores de dgat1
CR11264A (es) Compuestos de 5-(4-halo-alcoxi)-fenil)-pirimidin-2-amina y composiciones como inhibidores de cinasa
ECSP16078782A (es) Compuestos de isoindolinona como moduladores de gpr119 para el tratamiento de diabetes, obesidad, dislipidemia y trastornos relacionados
HN2012000023A (es) Compuestos y composiciones para el tratamiento de enfermedades parasitarias

Legal Events

Date Code Title Description
FG Grant of patent