IN2012DN02469A - - Google Patents
Download PDFInfo
- Publication number
- IN2012DN02469A IN2012DN02469A IN2469DEN2012A IN2012DN02469A IN 2012DN02469 A IN2012DN02469 A IN 2012DN02469A IN 2469DEN2012 A IN2469DEN2012 A IN 2469DEN2012A IN 2012DN02469 A IN2012DN02469 A IN 2012DN02469A
- Authority
- IN
- India
- Prior art keywords
- compounds
- disorders
- abnormal
- diseases
- raf
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000002159 abnormal effect Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- KKVYYGGCHJGEFJ-UHFFFAOYSA-N 1-n-(4-chlorophenyl)-6-methyl-5-n-[3-(7h-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine Chemical compound N=1C=CC2=C(NC=3C(=CC=CN=3)C=3C=4N=CNC=4N=CN=3)C(C)=CC=C2C=1NC1=CC=C(Cl)C=C1 KKVYYGGCHJGEFJ-UHFFFAOYSA-N 0.000 abstract 1
- 101100381978 Mus musculus Braf gene Proteins 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000002074 deregulated effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Chemical class 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Otolaryngology (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23807309P | 2009-08-28 | 2009-08-28 | |
| US31303910P | 2010-03-11 | 2010-03-11 | |
| PCT/US2010/046930 WO2011025927A1 (en) | 2009-08-28 | 2010-08-27 | Compounds and compositions as protein kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN02469A true IN2012DN02469A (en) | 2015-08-21 |
Family
ID=42782253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2469DEN2012 IN2012DN02469A (en) | 2009-08-28 | 2010-08-27 |
Country Status (49)
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR077975A1 (en) | 2009-08-28 | 2011-10-05 | Irm Llc | PIRAZOL PYRIMIDINE DERIVATIVES AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS |
| AU2011221227B2 (en) | 2010-02-25 | 2015-07-09 | Dana-Farber Cancer Institute, Inc. | BRAF mutations conferring resistance to BRAF inhibitors |
| US8907270B2 (en) | 2010-06-30 | 2014-12-09 | Schlumberger Technology Corporation | Method and apparatus for gain regulation in a gamma detector |
| CN108542906A (en) * | 2011-11-11 | 2018-09-18 | 诺华股份有限公司 | The method for treating proliferative disease |
| UA115039C2 (en) * | 2011-11-23 | 2017-09-11 | Еррей Біофарма Інк. | Pharmaceutical formulations |
| US9408885B2 (en) | 2011-12-01 | 2016-08-09 | Vib Vzw | Combinations of therapeutic agents for treating melanoma |
| CN103159736B (en) * | 2011-12-10 | 2015-05-13 | 通化济达医药有限公司 | Substitutional pyrazol kinase inhibitor |
| TW201332989A (en) * | 2011-12-23 | 2013-08-16 | Millennium Pharm Inc | Heteroaryls and uses thereof |
| MX351945B (en) | 2012-03-28 | 2017-11-03 | Dana Farber Cancer Inst Inc | C-RAF MUTANTS THAT CONFER RESISTANCE to RAF INHIBITORS. |
| CN104640857B (en) | 2012-07-18 | 2017-07-04 | 圣路易斯大学 | As the beta amino acids derivative of integrin antagonists |
| US8716226B2 (en) | 2012-07-18 | 2014-05-06 | Saint Louis University | 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists |
| AR091876A1 (en) * | 2012-07-26 | 2015-03-04 | Novartis Ag | PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF PROLIFERATIVE DISEASES |
| NZ703940A (en) * | 2012-08-07 | 2018-04-27 | Novartis Ag | Pharmaceutical combinations comprising a b-raf inhibitor, an egfr inhibitor and optionally a pi3k-alpha inhibitor |
| CN110251512A (en) | 2012-08-17 | 2019-09-20 | 霍夫曼-拉罗奇有限公司 | Combination therapy for melanoma including administration of COBIMETINIB and vemurafenib |
| US20150232452A1 (en) * | 2012-09-19 | 2015-08-20 | Ruga Corporation | Novel raf kinase inhibitors |
| CA2890663A1 (en) | 2012-11-08 | 2014-05-15 | Novartis Ag | Pharmaceutical combination comprising a b-raf inhibitor and a histone deacetylase inhibitor and their use in the treatment of proliferative diseases |
| SG10201906270VA (en) * | 2013-03-21 | 2019-08-27 | Novartis Ag | Combination therapy comprising a b-raf inhibitor and a second inhibitor |
| TWI634114B (en) | 2013-05-08 | 2018-09-01 | 永恒生物科技公司 | Furanone compound as a kinase inhibitor |
| CN105228983A (en) * | 2013-05-30 | 2016-01-06 | 普莱希科公司 | The compound regulated for kinases and indication thereof |
| EP3757130A1 (en) | 2013-09-26 | 2020-12-30 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
| TW201605450A (en) | 2013-12-03 | 2016-02-16 | 諾華公司 | Combination of Mdm2 inhibitor and BRAF inhibitor and their use |
| AU2014368906B2 (en) * | 2013-12-20 | 2020-04-30 | Biomed Valley Discoveries, Inc. | Cancer treatment using combinations of ERK and RAF inhibitors |
| KR20160100975A (en) * | 2013-12-23 | 2016-08-24 | 노파르티스 아게 | Pharmaceutical combinations |
| JOP20200094A1 (en) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | Antibody Molecules of PD-1 and Their Uses |
| JOP20200096A1 (en) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | Antibody molecules to tim-3 and uses thereof |
| DE102015103158A1 (en) | 2014-03-04 | 2015-09-10 | Bergische Universität Wuppertal | Compounds for the treatment of melanoma |
| TWI852057B (en) | 2014-03-14 | 2024-08-11 | 瑞士商諾華公司 | Antibody molecules to lag-3 and uses thereof |
| WO2015145388A2 (en) | 2014-03-27 | 2015-10-01 | Novartis Ag | Methods of treating colorectal cancers harboring upstream wnt pathway mutations |
| US10428387B2 (en) | 2014-05-16 | 2019-10-01 | University Of Massachusetts | Treating chronic myelogenous leukemia (CML) |
| WO2015196072A2 (en) | 2014-06-19 | 2015-12-23 | Whitehead Institute For Biomedical Research | Uses of kinase inhibitors for inducing and maintaining pluripotency |
| WO2016038582A1 (en) * | 2014-09-12 | 2016-03-17 | Novartis Ag | Compounds and compositions as raf kinase inhibitors |
| EP3659621A1 (en) | 2014-09-13 | 2020-06-03 | Novartis AG | Combination therapies for cancer |
| BR112017006664A2 (en) | 2014-10-03 | 2017-12-26 | Novartis Ag | combination therapies |
| MA41044A (en) | 2014-10-08 | 2017-08-15 | Novartis Ag | COMPOSITIONS AND METHODS OF USE FOR INCREASED IMMUNE RESPONSE AND CANCER TREATMENT |
| ES2952717T3 (en) | 2014-10-14 | 2023-11-03 | Novartis Ag | Antibody molecules against PD-L1 and uses thereof |
| BR112017018908A2 (en) | 2015-03-10 | 2018-04-17 | Aduro Biotech, Inc. | compositions and methods for activating interferon gene stimulator-dependent signaling |
| HRP20211058T8 (en) | 2015-07-29 | 2021-11-26 | Novartis Ag | Combination therapies comprising antibody molecules to lag-3 |
| EP3316902A1 (en) | 2015-07-29 | 2018-05-09 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
| US20180222982A1 (en) | 2015-07-29 | 2018-08-09 | Novartis Ag | Combination therapies comprising antibody molecules to pd-1 |
| LT3370768T (en) | 2015-11-03 | 2022-05-25 | Janssen Biotech, Inc. | ANTIBODIES SPECIFICLY BINDING PD-1 AND THEIR USE |
| WO2017106656A1 (en) | 2015-12-17 | 2017-06-22 | Novartis Ag | Antibody molecules to pd-1 and uses thereof |
| WO2017117538A1 (en) | 2015-12-30 | 2017-07-06 | Saint Louis University | Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists |
| RU2615986C1 (en) * | 2016-02-25 | 2017-04-12 | Закрытое акционерное общество "Р-Фарм" (ЗАО "Р-Фарм") | Substituted methyl(2-{4-[3-(3-methanesulfonylamino-2-fluoro-5-chloro-phenyl)-1h-pyrazol-4-yl]pyrimidin-2-ylamino}ethyl) carbamates, process for their preparation and application |
| PT3463345T (en) * | 2016-06-03 | 2023-01-06 | Array Biopharma Inc | Pharmaceutical combinations |
| US11098077B2 (en) | 2016-07-05 | 2021-08-24 | Chinook Therapeutics, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
| CA3048376A1 (en) * | 2016-12-27 | 2018-07-05 | Riken | Bmp-signal-inhibiting compound |
| JP7341060B2 (en) | 2017-02-10 | 2023-09-08 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Methods and pharmaceutical compositions for the treatment of cancer associated with MAPK pathway activation |
| UY37695A (en) | 2017-04-28 | 2018-11-30 | Novartis Ag | BIS 2’-5’-RR- (3’F-A) (3’F-A) CYCLE DINUCLEOTIDE COMPOUND AND USES OF THE SAME |
| CN107540699A (en) * | 2017-10-16 | 2018-01-05 | 康化（上海）新药研发有限公司 | A kind of synthetic method of the boric acid hydrochloride of 2 amino, 3 fluorine pyridine 4 |
| JP7416716B2 (en) | 2017-12-28 | 2024-01-17 | トラクト ファーマシューティカルズ インコーポレイテッド | Stem cell culture system for columnar epithelial stem cells and related uses |
| US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
| WO2020011141A1 (en) * | 2018-07-12 | 2020-01-16 | 深圳市塔吉瑞生物医药有限公司 | Diarylpyrazole compound, composition comprising same, and use thereof |
| WO2020124397A1 (en) * | 2018-12-19 | 2020-06-25 | Inventisbio Shanghai Ltd. | C-terminal src kinase inhibitors |
| KR20210107069A (en) | 2018-12-21 | 2021-08-31 | 다이이찌 산쿄 가부시키가이샤 | Combination of antibody-drug conjugates and kinase inhibitors |
| US20220168250A1 (en) | 2019-05-16 | 2022-06-02 | Eli Lilly And Company | TRIPLE COMBINATION OF AN ERK1/2 INHIBITOR WITH A BRAF INHIBITOR AND AN EGFR INHIBITOR FOR USE IN THE TREATMENT OF BRAFv6ooE COLORECTAL CANCER |
| US20230036867A1 (en) | 2019-12-05 | 2023-02-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | N-(3-(5-(pyrimidin-4-yl)thiazol-4-yl)phenyl)sulfonamide compounds and their uses as braf inhibitors |
| WO2021250521A1 (en) | 2020-06-09 | 2021-12-16 | Array Biopharma Inc. | 4-oxo-3,4-dihydroquinazolinon compounds for the treatment of braf-associated diseases and disorders |
| EP4196228A1 (en) | 2020-08-13 | 2023-06-21 | Albert Einstein College of Medicine | N-cyclyl-sulfonamides useful for inhibiting raf |
| WO2022074011A1 (en) | 2020-10-05 | 2022-04-14 | Pierre Fabre Medicament | Combination of encorafenib and binimetinib as adjuvant treatment for resected stage ii melanoma |
| JP2024511373A (en) | 2021-03-18 | 2024-03-13 | ノバルティス アーゲー | Biomarkers and their use for cancer |
| US12371667B2 (en) | 2021-05-13 | 2025-07-29 | Washington University | Enhanced methods for inducing and maintaining naive human pluripotent stem cells |
| TW202313046A (en) | 2021-06-09 | 2023-04-01 | 瑞士商赫孚孟拉羅股份公司 | Combination therapy for cancer treatment |
| CN114557977A (en) * | 2022-02-16 | 2022-05-31 | 北京康立生医药技术开发有限公司 | Preparation method, preparation and purity analysis method of medicine for treating intestinal cancer |
| WO2023230554A1 (en) | 2022-05-25 | 2023-11-30 | Pfizer Inc. | Combination of a braf inhibitor, an egfr inhibitor, and a pd-1 antagonist for the treatment of braf v600e-mutant, msi-h/dmmr colorectal cancer |
| WO2024163166A1 (en) * | 2023-01-30 | 2024-08-08 | 5Metis, Inc. | Boron containing compounds and their uses |
| CN116396222A (en) * | 2023-04-10 | 2023-07-07 | 上海睿腾医药科技有限公司 | Synthesis method of Kangafinil intermediate 1- (3-amino-1-isopropyl-1H-pyrazol-4-yl) ethyl-1-ketone |
| WO2025003956A1 (en) | 2023-06-30 | 2025-01-02 | Pfizer Inc. | High drug loading formulations of encorafenib |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4104250A (en) * | 1976-08-11 | 1978-08-01 | Borg-Warner Corporation | Flame-retardant polymers with 1,3,5-triazines having halo- and halo-aryl substitutents |
| JPS5475888A (en) | 1977-11-29 | 1979-06-18 | Jiyasuko Kk | Surgical laser |
| DE3571974D1 (en) | 1984-12-06 | 1989-09-07 | Pfizer | Substituted dihydroquinolone carboxylic acids, anti-bacterial compositions containing them |
| US6391636B1 (en) | 1994-05-31 | 2002-05-21 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of raf gene expression |
| US6358932B1 (en) | 1994-05-31 | 2002-03-19 | Isis Pharmaceticals, Inc. | Antisense oligonucleotide inhibition of raf gene expression |
| US6037136A (en) | 1994-10-24 | 2000-03-14 | Cold Spring Harbor Laboratory | Interactions between RaF proto-oncogenes and CDC25 phosphatases, and uses related thereto |
| WO1997008950A1 (en) | 1995-09-07 | 1997-03-13 | Fuisz Technologies, Ltd. | System for rendering substantially non-dissoluble bio-affecting agents bio-available |
| US5717100A (en) | 1995-10-06 | 1998-02-10 | Merck & Co., Inc. | Substituted imidazoles having anti-cancer and cytokine inhibitory activity |
| WO1997044058A1 (en) | 1996-05-23 | 1997-11-27 | Applied Research Systems Ars Holding N.V. | Compounds that inhibit the binding of raf-1 or 14-3-3 proteins to the beta chain of il-2 receptor, and pharmaceutical compositions containing same |
| AR012634A1 (en) | 1997-05-02 | 2000-11-08 | Sugen Inc | QUINAZOLINE BASED COMPOUND, FAMACEUTICAL COMPOSITION THAT UNDERSTANDS IT, METHOD TO SYNTHESIZE IT, ITS USE, METHODS OF MODULATION OF THE DESERINE / TREONIN PROTEIN-KINASE FUNCTION AND IN VITRO METHOD TO IDENTIFY COMPOUNDS THAT MODULATE |
| US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
| BR9809147A (en) | 1997-05-22 | 2000-08-01 | Searle & Co | Substituted pyrazole compound, pharmaceutical composition, processes for treating a tnf mediated disorder, a p38 kinase mediated disorder, inflammation and arthritis, and for preparing pyrazoles |
| US6187799B1 (en) | 1997-05-23 | 2001-02-13 | Onyx Pharmaceuticals | Inhibition of raf kinase activity using aryl ureas |
| GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| US6022884A (en) | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
| US6204467B1 (en) | 1998-03-24 | 2001-03-20 | Ford Global Technologies, Inc. | Method and apparatus for resistive welding |
| RU2319693C9 (en) | 1999-01-13 | 2008-08-20 | Байер Копэрейшн | Derivatives of urea (variants), pharmaceutical composition (variants) and method for treatment of diseases associated with cancer cells growth (variants) |
| US6316435B2 (en) | 1999-02-24 | 2001-11-13 | Supergen, Inc. | Combination therapy for lymphoproliferative diseases |
| AU2331801A (en) | 1999-12-23 | 2001-07-09 | F.H. Faulding & Co. Limited | Improved pharmaceutical compositions for poorly soluble drugs |
| US6756410B2 (en) | 2000-08-30 | 2004-06-29 | Kamal D. Mehta | Induction of LDL receptor expression by extracellular-signal regulated kinase, ERK-1/2 |
| PE20020354A1 (en) | 2000-09-01 | 2002-06-12 | Novartis Ag | HYDROXAMATE COMPOUNDS AS HISTONE-DESACETILASE (HDA) INHIBITORS |
| PT1441714E (en) | 2001-10-25 | 2008-03-10 | Novartis Ag | Combinations comprising a selective cyclooxygenase-2 inhibitor |
| WO2003055860A1 (en) | 2001-12-21 | 2003-07-10 | Vernalis (Cambridge) Limited | 3,4-diarylpyrazoles and their use in the therapy of cancer |
| HUE025767T2 (en) | 2002-03-13 | 2016-05-30 | Array Biopharma Inc | N3-alkylated benzimidazole derivatives as MEK inhibitors |
| KR20060097000A (en) | 2003-09-23 | 2006-09-13 | 노파르티스 아게 | Combinations of Chemotherapy Agents and VEUF Inhibitors |
| CA2545942C (en) | 2003-11-14 | 2012-07-10 | Lorus Therapeutics Inc. | Aryl imidazoles and their use as anti-cancer agents |
| KR20060127032A (en) | 2004-01-09 | 2006-12-11 | 노파르티스 아게 | Phenyl- [4- (3-phenyl-1H-pyrazol-4-yl) -pyrimidin-2-yl] -amine derivative as an IFF-IR inhibitor |
| ES2396135T3 (en) | 2004-06-10 | 2013-02-19 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| US20060058311A1 (en) | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| BRPI0606281A2 (en) | 2005-03-17 | 2009-06-09 | Novartis Ag | organic compounds |
| US20070099856A1 (en) | 2005-05-13 | 2007-05-03 | Gumerlock Paul H | Combined treatment with docetaxel and an epidermal growth factor receptor kinase inhibitor using an intermittent dosing regimen |
| CA2618377A1 (en) | 2005-08-12 | 2007-02-22 | Synta Pharmaceuticals Corp. | Pyrazole compounds that modulate hsp90 activity |
| US20090214645A1 (en) | 2005-08-22 | 2009-08-27 | Andrea Kramer | Pharmaceutical compositions comprising a ph-dependent drug, a ph modifier and a retarding agent |
| EP1917258A2 (en) | 2005-08-26 | 2008-05-07 | SmithKline Beecham Corporation | Pyrimidinyl-pyrazole inhibitors of aurora kinases |
| PE20070335A1 (en) | 2005-08-30 | 2007-04-21 | Novartis Ag | SUBSTITUTE BENZIMIDAZOLES AND METHODS FOR THEIR PREPARATION |
| CA2643066A1 (en) * | 2006-03-16 | 2007-09-20 | Pfizer Products Inc. | Pyrazole compounds |
| CN101415411A (en) | 2006-04-05 | 2009-04-22 | 诺瓦提斯公司 | Combinations of therapeutic agents for treating cancer |
| US7501430B2 (en) * | 2006-04-17 | 2009-03-10 | Arqule, Inc. | RAF inhibitors and their uses |
| EP2061772A4 (en) | 2006-09-11 | 2011-06-29 | Curis Inc | Multi-functional small molecules as anti-proliferative agents |
| BRPI0717586A2 (en) | 2006-09-18 | 2013-10-29 | Boehringer Ingelheim Int | METHOD FOR TREATING CANCER PRESENTING EGFR CHANGES |
| EA015751B1 (en) | 2006-10-02 | 2011-12-30 | АйАрЭм ЭлЭлСи | Compounds and compositions as protein kinase inhibitors |
| BRPI0717805A2 (en) * | 2006-10-06 | 2013-10-29 | Irm Llc | PROTEIN KINASE INHIBITORS AND METHODS OF USE |
| CA2677651A1 (en) | 2007-02-15 | 2008-08-21 | Novartis Ag | Combinations of therapeutic agents for treating cancer |
| US20090022789A1 (en) | 2007-07-18 | 2009-01-22 | Supernus Pharmaceuticals, Inc. | Enhanced formulations of lamotrigine |
| EA201000113A1 (en) * | 2007-08-01 | 2010-08-30 | Пфайзер Инк. | PYRAZOL COMPOUNDS |
| CA2699301A1 (en) | 2007-10-19 | 2009-04-23 | Abbott Gmbh & Co. Kg | Solid dispersion product of n-aryl urea-based drugs |
| MX2010005110A (en) * | 2007-11-14 | 2010-09-09 | Ortho Mcneil Janssen Pharm | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors. |
| AU2009227013B2 (en) | 2008-03-21 | 2013-01-10 | Novartis Ag | Novel heterocyclic compounds and uses therof |
| UA103319C2 (en) * | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| CN102105459B (en) * | 2008-07-24 | 2014-09-10 | 内尔维阿诺医学科学有限公司 | 3,4-diarylpyrazoles as protein kinase inhibitors |
| WO2010014611A1 (en) | 2008-07-28 | 2010-02-04 | Gilead Colorado, Inc. | Cycloalkylidene and heterocycloalkylidene histone deacetylase inhibitor compounds |
| UY32146A (en) | 2008-09-29 | 2010-04-30 | Boehringer Ingelheim Int | DERIVATIVES OF THE 5- [4- (1,5-DIMETIL-1H-PIRAZOL-4-IL) -1,2,3-TRIAZOL-1-IL] -6-METHYL-NICOTINAMIDS N- (REPLACED) AND THE N- {5- [4- (1,5-DIMETHYL-1H-PIRAZOL-4-IL) -1,2,3-TRIAZOL-1-IL] -6-METHYL-PIRIDIN-3-IL} -BENZAMIDES REPLACED AND COMPOSITIONS CONTAINING THEM |
| MY160340A (en) | 2008-10-07 | 2017-02-28 | Astrazeneca Uk Ltd | Pharmaceutical formulation 514 |
| US20110293750A1 (en) * | 2008-11-11 | 2011-12-01 | Yale University | Activated wnt-beta-catenin signaling in melanoma |
| ES2422263T3 (en) | 2008-12-19 | 2013-09-10 | Nerviano Medical Sciences Srl | Bicyclic pyrazoles as protein kinase inhibitors |
| AR075180A1 (en) | 2009-01-29 | 2011-03-16 | Novartis Ag | SOLID ORAL FORMULATIONS OF A PYRIDOID-PYRIMIDINONE |
| RU2402602C1 (en) | 2009-02-12 | 2010-10-27 | Государственное учреждение Российский онкологический научный центр им. Н.Н. Блохина РАМН | CELL LINE OF HUMAN MELANOMA mel Rac, APPLIED FOR OBTAINING ANTITUMOUR VACCINE |
| WO2010100127A1 (en) * | 2009-03-04 | 2010-09-10 | Novartis Ag | Disubstituted imidazole derivatives as modulators of raf kinase |
| TWI532484B (en) | 2009-06-08 | 2016-05-11 | 艾伯維有限公司 | Solid dispersions containing an apoptosis-promoting agent |
| EP3045457B1 (en) * | 2009-06-15 | 2018-05-09 | Nerviano Medical Sciences S.r.l. | Substituted pyrimidinylpyrrolopyridinone derivatives, process for their preparation and their use as kinase inhibitors |
| KR101256018B1 (en) * | 2009-08-20 | 2013-04-18 | 한국과학기술연구원 | 1,3,6-Substituted indole derivatives having inhibitory activity for protein kinase |
| AR077975A1 (en) | 2009-08-28 | 2011-10-05 | Irm Llc | PIRAZOL PYRIMIDINE DERIVATIVES AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS |
| US8242260B2 (en) | 2009-08-28 | 2012-08-14 | Novartis Ag | Compounds and compositions as protein kinase inhibitors |
| EA023942B1 (en) | 2010-01-27 | 2016-07-29 | НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. | Sulfonamido derivatives of 3,4-diarylpyrazoles as protein kinase inhibitors |
| SG10201502484SA (en) | 2010-03-30 | 2015-05-28 | Verseon Corp | Multisubstituted aromatic compounds as inhibitors of thrombin |
| CN103153980B (en) | 2010-08-03 | 2015-12-16 | 内尔维安诺医学科学有限公司 | The derivative of pyrazolo phenyl benzenesulfonamides compound and the purposes as antitumour drug thereof |
| US20140093565A1 (en) | 2011-03-21 | 2014-04-03 | Valcuria Ab | A pharmaceutical composition comprising a hdac inhibitor and a steroid and the use thereof |
| KR20140056212A (en) | 2011-06-14 | 2014-05-09 | 노파르티스 아게 | Combination of panobinostat and ruxolitinib in the treatment of cancer such as a myeloproliferative neoplasm |
| CN108542906A (en) | 2011-11-11 | 2018-09-18 | 诺华股份有限公司 | The method for treating proliferative disease |
| UA115039C2 (en) | 2011-11-23 | 2017-09-11 | Еррей Біофарма Інк. | Pharmaceutical formulations |
| CA2890663A1 (en) | 2012-11-08 | 2014-05-15 | Novartis Ag | Pharmaceutical combination comprising a b-raf inhibitor and a histone deacetylase inhibitor and their use in the treatment of proliferative diseases |
| US10576680B2 (en) | 2015-11-19 | 2020-03-03 | The Boeing Company | Modular thermoforming system |
-
2010
- 2010-08-26 AR ARP100103123A patent/AR077975A1/en active IP Right Grant
- 2010-08-26 JO JOP/2010/0297A patent/JO3002B1/en active
- 2010-08-27 SI SI201030711T patent/SI2470526T1/en unknown
- 2010-08-27 JP JP2012527014A patent/JP5475888B2/en active Active
- 2010-08-27 IN IN2469DEN2012 patent/IN2012DN02469A/en unknown
- 2010-08-27 HR HRP20140799AT patent/HRP20140799T1/en unknown
- 2010-08-27 RS RS20140430A patent/RS53489B1/en unknown
- 2010-08-27 EA EA201200373A patent/EA025222B1/en not_active IP Right Cessation
- 2010-08-27 SG SG2012009304A patent/SG178351A1/en unknown
- 2010-08-27 DK DK10748211.9T patent/DK2470526T3/en active
- 2010-08-27 DK DK14152945.3T patent/DK2727918T3/en active
- 2010-08-27 SI SI201031371A patent/SI2727918T1/en unknown
- 2010-08-27 UY UY0001032860A patent/UY32860A/en active IP Right Grant
- 2010-08-27 BR BR112012004453-2A patent/BR112012004453B1/en active IP Right Grant
- 2010-08-27 GE GEAP201012645A patent/GEP20146102B/en unknown
- 2010-08-27 ES ES10748211.9T patent/ES2492499T3/en active Active
- 2010-08-27 AU AU2010286569A patent/AU2010286569C1/en active Active
- 2010-08-27 PE PE2012000268A patent/PE20120861A1/en active IP Right Grant
- 2010-08-27 ME MEP-2014-94A patent/ME01860B/en unknown
- 2010-08-27 KR KR1020127007860A patent/KR101413392B1/en active Active
- 2010-08-27 CA CA2771775A patent/CA2771775C/en active Active
- 2010-08-27 CN CN201080038197.8A patent/CN102725283B/en active Active
- 2010-08-27 NZ NZ598924A patent/NZ598924A/en unknown
- 2010-08-27 PL PL14152945T patent/PL2727918T3/en unknown
- 2010-08-27 SG SG10201405311TA patent/SG10201405311TA/en unknown
- 2010-08-27 SM SM20170036T patent/SMT201700036T1/en unknown
- 2010-08-27 EP EP10748211.9A patent/EP2470526B1/en active Active
- 2010-08-27 ES ES14152945.3T patent/ES2610825T3/en active Active
- 2010-08-27 PT PT107482119T patent/PT2470526E/en unknown
- 2010-08-27 US US12/870,130 patent/US8501758B2/en not_active Ceased
- 2010-08-27 CN CN201410040923.XA patent/CN103896921B/en active Active
- 2010-08-27 LT LTEP14152945.3T patent/LT2727918T/en unknown
- 2010-08-27 PT PT141529453T patent/PT2727918T/en unknown
- 2010-08-27 WO PCT/US2010/046930 patent/WO2011025927A1/en active Application Filing
- 2010-08-27 ME MEP-2017-6A patent/ME02684B/en unknown
- 2010-08-27 MY MYPI2012000611A patent/MY156259A/en unknown
- 2010-08-27 HU HUE14152945A patent/HUE032847T2/en unknown
- 2010-08-27 UA UAA201203042A patent/UA112285C2/en unknown
- 2010-08-27 EP EP14152945.3A patent/EP2727918B1/en active Active
- 2010-08-27 EA EA201500175A patent/EA201500175A1/en unknown
- 2010-08-27 MX MX2012002546A patent/MX2012002546A/en active IP Right Grant
- 2010-08-27 CU CU2012000034A patent/CU24110B1/en active IP Right Grant
- 2010-08-27 RS RS20170017A patent/RS55568B1/en unknown
- 2010-08-27 PL PL10748211T patent/PL2470526T3/en unknown
-
2012
- 2012-02-09 CL CL2012000340A patent/CL2012000340A1/en unknown
- 2012-02-13 IL IL218084A patent/IL218084A/en active IP Right Grant
- 2012-02-17 TN TNP2012000081A patent/TN2012000081A1/en unknown
- 2012-02-24 NI NI201200029A patent/NI201200029A/en unknown
- 2012-02-24 CO CO12032570A patent/CO6612222A2/en active IP Right Grant
- 2012-02-24 DO DO2012000051A patent/DOP2012000051A/en unknown
- 2012-02-27 HN HN2012000441A patent/HN2012000441A/en unknown
- 2012-02-27 GT GT201200053A patent/GT201200053A/en unknown
- 2012-02-28 EC ECSP12011700 patent/ECSP12011700A/en unknown
- 2012-02-28 CR CR20120102A patent/CR20120102A/en unknown
- 2012-03-19 ZA ZA2012/02020A patent/ZA201202020B/en unknown
- 2012-03-23 MA MA34716A patent/MA33604B1/en unknown
-
2013
- 2013-06-28 US US13/931,111 patent/US9314464B2/en active Active
-
2014
- 2014-02-06 JP JP2014021339A patent/JP6045519B2/en active Active
- 2014-09-12 SM SM201400133T patent/SMT201400133B/en unknown
-
2016
- 2016-01-13 US US14/994,710 patent/US9593099B2/en active Active
- 2016-01-13 US US14/994,827 patent/US9593100B2/en active Active
- 2016-03-15 US US15/070,905 patent/US10005761B2/en active Active
- 2016-06-10 US US15/179,644 patent/US9850230B2/en active Active
- 2016-06-10 US US15/179,385 patent/US9850229B2/en active Active
-
2017
- 2017-01-03 HR HRP20170005TT patent/HRP20170005T1/en unknown
- 2017-01-10 CY CY20171100028T patent/CY1118452T1/en unknown
- 2017-01-19 SM SM201700036T patent/SMT201700036B/en unknown
- 2017-11-20 US US15/818,082 patent/US10576080B2/en active Active
- 2017-11-20 US US15/818,264 patent/US10568884B2/en active Active
-
2019
- 2019-02-12 LU LU00101C patent/LUC00101I2/fr unknown
- 2019-02-12 LU LU00102C patent/LUC00102I2/fr unknown
- 2019-03-01 HU HUS1900013C patent/HUS1900013I1/en unknown
- 2019-03-01 HU HUS1900012C patent/HUS1900012I1/en unknown
- 2019-03-05 NO NO2019012C patent/NO2019012I1/en unknown
- 2019-03-05 NO NO2019011C patent/NO2019011I1/en unknown
- 2019-03-07 LT LTPA2019006C patent/LTPA2019006I1/en unknown
- 2019-03-07 LT LTPA2019005C patent/LTC2470526I2/en unknown
- 2019-03-15 NL NL300973C patent/NL300973I2/en unknown
- 2019-03-18 CY CY2019013C patent/CY2019013I2/en unknown
- 2019-03-18 CY CY2019014C patent/CY2019014I1/en unknown
-
2020
- 2020-01-14 US US16/741,937 patent/US20200323852A1/en not_active Abandoned
-
2021
- 2021-07-15 US US17/376,199 patent/USRE49556E1/en active Active
-
2022
- 2022-04-20 US US17/724,589 patent/US20230116233A1/en not_active Abandoned
-
2023
- 2023-01-27 EC ECSENADI20234573A patent/ECSP23004573A/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2012DN02469A (en) | ||
| PH12020550450A1 (en) | Certain chemical entities, compositions and methods | |
| MX2009011951A (en) | Compounds and compositions as c-kit and pdgfr kinase inhibitors. | |
| MX2009007944A (en) | Compounds and compositions as kinase inhibitors. | |
| TN2013000348A1 (en) | Compounds and compositions as trk inhibitors | |
| TN2010000122A1 (en) | Compounds and compositions as modulators of gpr119 activity | |
| MX2009009491A (en) | Compounds and compositions as modulators of gpr119 activity. | |
| IN2012DN02471A (en) | ||
| WO2011014795A3 (en) | Compounds and compositions as syk kinase inhibitors | |
| MX2009011952A (en) | Compounds and compositions as c-kit and pdgfr kinase inhibitors. | |
| MX2009011950A (en) | Pyrimidine derivatives and compositions as c-kit and pdgfr kinase inhibitors. | |
| IN2012DN01961A (en) | ||
| MX2014002486A (en) | Compounds and compositions as pdgfr kinase inhibitors. | |
| MX2010009207A (en) | Heterocyclic compounds and compositions as c-kit and pdgfr kinase inhibitors. | |
| UY33597A (en) | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF THE TRK | |
| MX339937B (en) | Compounds and compositions as c-kit kinase inhibitors. | |
| MY165728A (en) | Selective glycosidase inhibitors and uses thereof | |
| PH12014500351B1 (en) | COMPOUNDS AND COMPOSITIONS AS c-KIT KINASE INHIBITORS | |
| TW200637547A (en) | Compounds and compositions as protein kinase inhibitors | |
| MX2009004716A (en) | Compounds and compositions as protein kinase inhibitors. | |
| EA200901032A1 (en) | COMPOUNDS AND COMPOSITIONS AS GPR119 ACTIVITY MODULATORS | |
| MY172151A (en) | Certain chemical entities, compositions and methods | |
| DE602006016449D1 (en) | ||
| MX2009006170A (en) | Compounds and compositions as kinase inhibitors. | |
| WO2011014520A3 (en) | Compounds and compositions as modulators of gpr119 activity |