PT2268646E - Aminas de tiazolopiridina-2-iloxi-fenil e de tiazolopirazina-2-iloxi-fenilo como moduladores da hidrolase de leucotrieno a4 - Google Patents

Aminas de tiazolopiridina-2-iloxi-fenil e de tiazolopirazina-2-iloxi-fenilo como moduladores da hidrolase de leucotrieno a4 Download PDF

Info

Publication number
PT2268646E
PT2268646E PT97295968T PT09729596T PT2268646E PT 2268646 E PT2268646 E PT 2268646E PT 97295968 T PT97295968 T PT 97295968T PT 09729596 T PT09729596 T PT 09729596T PT 2268646 E PT2268646 E PT 2268646E
Authority
PT
Portugal
Prior art keywords
yloxy
phenyl
thiazolopyrazin
thiazolopyridin
modulators
Prior art date
Application number
PT97295968T
Other languages
English (en)
Inventor
Cheryl A Grice
Xiaohu Deng
Jimmy T Liang
Neelakandha S Mani
Genesis M Bacani
Diego Broggini
Eugene Y Cheung
Christa C Chrovian
Anne M Fourine
Laurent Gomez
Aaron M Kearney
Adrienne M Landry-Bayle
Alice Lee-Dutra
Susanne Lochner
Virginia M Tanis
Alvah T Wickboldt
Hartmut Zinser
Alejandro Santillan
Kathleen C Sappey
Kia Sepassi
John J M Wiener
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PT2268646E publication Critical patent/PT2268646E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
PT97295968T 2008-04-11 2009-04-09 Aminas de tiazolopiridina-2-iloxi-fenil e de tiazolopirazina-2-iloxi-fenilo como moduladores da hidrolase de leucotrieno a4 PT2268646E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4434908P 2008-04-11 2008-04-11
US14912909P 2009-02-02 2009-02-02

Publications (1)

Publication Number Publication Date
PT2268646E true PT2268646E (pt) 2013-12-10

Family

ID=41130551

Family Applications (2)

Application Number Title Priority Date Filing Date
PT97295968T PT2268646E (pt) 2008-04-11 2009-04-09 Aminas de tiazolopiridina-2-iloxi-fenil e de tiazolopirazina-2-iloxi-fenilo como moduladores da hidrolase de leucotrieno a4
PT111592366T PT2336125E (pt) 2008-04-11 2009-04-09 Tiazolopiridina-2-iloxi-fenil e tiazolopirazin-2-iloxifenil aminas como moduladores de leucotrieno a4 hidrolase

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT111592366T PT2336125E (pt) 2008-04-11 2009-04-09 Tiazolopiridina-2-iloxi-fenil e tiazolopirazin-2-iloxifenil aminas como moduladores de leucotrieno a4 hidrolase

Country Status (36)

Country Link
US (3) US7939527B2 (pt)
EP (2) EP2268646B9 (pt)
JP (2) JP5530423B2 (pt)
KR (1) KR101228378B1 (pt)
CN (1) CN102056933B (pt)
AR (1) AR072353A1 (pt)
AU (1) AU2009234140B2 (pt)
BR (1) BRPI0911336A2 (pt)
CA (1) CA2721099C (pt)
CL (1) CL2009000877A1 (pt)
CO (1) CO6260069A2 (pt)
CY (1) CY1114628T1 (pt)
DK (2) DK2336125T3 (pt)
EA (1) EA018802B1 (pt)
EC (1) ECSP10010558A (pt)
ES (2) ES2440746T3 (pt)
HK (2) HK1152041A1 (pt)
HN (1) HN2010002074A (pt)
HR (2) HRP20130278T1 (pt)
IL (2) IL208480A (pt)
JO (1) JO2911B1 (pt)
MX (1) MX2010011154A (pt)
MY (1) MY157597A (pt)
NI (1) NI201000168A (pt)
NZ (2) NZ588341A (pt)
PE (1) PE20091779A1 (pt)
PH (1) PH12013500094A1 (pt)
PL (2) PL2336125T3 (pt)
PT (2) PT2268646E (pt)
RS (2) RS52712B (pt)
SI (2) SI2336125T1 (pt)
SV (1) SV2010003694A (pt)
TW (2) TWI461196B (pt)
UY (1) UY31760A (pt)
WO (1) WO2009126806A2 (pt)
ZA (1) ZA201008054B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2009000877A1 (es) * 2008-04-11 2009-11-27 Janssen Pharmaceutica Nv Compuestos derivados de [tiazolopiridin o tiazolopirazin-2-iloxi fenilamina; proceso de preparacion; composicion farmaceutica; y uso para el tratamiento de un trastorno o afeccion mediado por leucotrieno a4 hidrolasa, tales como alergia, asma, inflamacion, psoriasis, lupus, miastenia gravis, entre otros.
TW201350474A (zh) * 2012-03-06 2013-12-16 Boehringer Ingelheim Int 白三烯素生成之苯并二噁烷抑制劑
EA201400976A1 (ru) 2012-03-06 2015-02-27 Бёрингер Ингельхайм Интернациональ Гмбх Бензодиоксаны в комбинации с другими активными средствами для ингибирования продуцирования лейкотриена
EP2885285B1 (en) 2012-07-17 2016-10-19 Boehringer Ingelheim International GmbH Pyrazole drivatives which inhibit leukotriene production
EP2746260A1 (en) 2012-12-21 2014-06-25 Basf Se Substituted [1,2,4]triazole and imidazole compounds
EP2746259A1 (en) 2012-12-21 2014-06-25 Basf Se Substituted [1,2,4]triazole and imidazole compounds
CA2905340C (en) 2013-03-12 2022-05-31 Celtaxsys, Inc. Low dose oral formulations of acebilustat
EP2968264A4 (en) 2013-03-14 2016-11-02 Celtaxsys Inc INHIBITORS OF LEUCOTRIENE A4 HYDROLASE
KR20150131211A (ko) * 2013-03-14 2015-11-24 켈탁시스, 인코퍼레이티드 류코트라이엔 a4 가수분해효소의 저해제
CA3102077A1 (en) 2018-05-31 2019-12-05 Sanjeev AHUJA Method of reducing pulmonary exacerbations in respiratory disease patients
SG11202107080VA (en) * 2019-01-11 2021-07-29 Naegis Pharmaceuticals Inc Leukotriene synthesis inhibitors

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008A (en) * 1847-03-13 Machinery for cleaning
IL59004A0 (en) 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
US4329466A (en) 1979-01-16 1982-05-11 Delalande S.A. Certain nor-tropan-8-amine-3-aryl or heteroaryl derivatives
US4424358A (en) 1979-01-16 1984-01-03 Delalande S.A. β-3-Amino nor-tropane compounds
US4321378A (en) 1979-01-16 1982-03-23 Delalande S.A. 8-(5-Pyrimidinecarboxamide)nor-tropane derivatives
FR2476088A2 (fr) 1979-01-16 1981-08-21 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
FR2446823A1 (fr) 1979-01-16 1980-08-14 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
US4352802A (en) 1980-06-10 1982-10-05 Beecham Group Limited Bicyclo[3.3.1]nonyl-benzamide
NZ199080A (en) 1980-12-12 1984-07-31 Beecham Group Ltd 2-alkoxy-4-amino-5-alkylsulphonyl-n-(3beta-(8-hydrocarbyl-8-azabicyclo (3,2,1)octyl))benzamides
US4432983A (en) 1981-04-30 1984-02-21 Research Corporation Conformationally restricted histamine H2 -receptor antagonists containing a tropane ring
DE3137996A1 (de) * 1981-09-24 1983-04-28 Hoechst Ag, 6230 Frankfurt Heterocyclische phenylaether, verfahren zu deren herstellung und diese enthaltende herbizide mittel
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
US4873346A (en) * 1985-09-20 1989-10-10 The Upjohn Company Substituted benzothiazoles, benzimidazoles, and benzoxazoles
NZ222047A (en) 1986-10-08 1991-01-29 Bristol Myers Co Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
CA1319144C (en) * 1986-11-14 1993-06-15 Quirico Branca Tetrahydronaphthalene derivatives
JPS63170356A (ja) 1986-12-30 1988-07-14 Yamanouchi Pharmaceut Co Ltd アニリン誘導体及びその製造法
FI91859C (fi) * 1987-06-17 1994-08-25 Eisai Co Ltd Analogiamenetelmä antiallergisena aineena aktiivisen bentsotiatsolijohdannaisen valmistamiseksi
US5070094A (en) 1989-09-05 1991-12-03 G. D. Searle & Co. N-benzyltropaneamides
US5220063A (en) * 1991-05-10 1993-06-15 Hoechst Celanese Corporation Method for the preparation of arylalkanolacylamides
US5296486A (en) * 1991-09-24 1994-03-22 Boehringer Ingelheim Pharmaceuticals, Inc. Leukotriene biosynthesis inhibitors
US5472964A (en) * 1992-12-22 1995-12-05 Merck Frosst Canada, Inc. Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists
TW251287B (pt) 1993-04-30 1995-07-11 Nissei Co Ltd
US6506876B1 (en) 1994-10-11 2003-01-14 G.D. Searle & Co. LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
US5585492A (en) 1994-10-11 1996-12-17 G. D. Searle & Co. LTA4 Hydrolase inhibitors
US5700816A (en) 1995-06-12 1997-12-23 Isakson; Peter C. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
US6632976B1 (en) * 1995-08-29 2003-10-14 Kirin Beer Kabushiki Kaisha Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene
US5794887A (en) 1995-11-17 1998-08-18 Komerath; Narayanan M. Stagnation point vortex controller
CA2246336A1 (en) 1996-02-13 1997-08-21 G.D. Searle & Co. Combinations, having immunosuppressive effects, containing a cyclooxygenase-2 inhibitor and a leukotriene a4 hydrolase inhibitor
US6110994A (en) * 1996-06-14 2000-08-29 Cabot Corporation Polymeric products containing modified carbon products and methods of making and using the same
US6110944A (en) 1997-03-12 2000-08-29 G. D. Searle & Co. LTA4, hydrolase inhibitors
US6632823B1 (en) 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
US6432976B1 (en) 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6559140B2 (en) 2000-03-09 2003-05-06 Abbott Laboratories Cyclic and bicyclic diamino histamine-3 receptor antagonists
MY137020A (en) 2000-04-27 2008-12-31 Abbott Lab Diazabicyclic central nervous system active agents
FR2831884B1 (fr) 2001-11-02 2003-12-26 Pf Medicament Nouveaux derives amides heteroaromatiques de 3 beta-amino azabicyclooctane, leur procede de preparation et leurs applications en therapeutique
US7152144B2 (en) 2002-05-29 2006-12-19 Hitachi, Ltd. Centralized storage management method
US7329682B2 (en) * 2003-04-03 2008-02-12 Ewha University-Industry Collaboration Foundation Method for inhibiting 5-lipoxygenase using a benzoxazole derivative
SE0301373D0 (sv) * 2003-05-09 2003-05-09 Astrazeneca Ab Novel compounds
EP1626713A2 (en) 2003-05-16 2006-02-22 Ambit Biosciences Corporation Heterocyclic compounds and uses thereof
US20050043379A1 (en) * 2003-07-28 2005-02-24 Axe Frank U. LTA4H Modulators
CN101407471A (zh) 2003-08-29 2009-04-15 小野药品工业株式会社 能够结合s1p受体的化合物及其药物用途
US7435831B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
TW200610761A (en) 2004-04-23 2006-04-01 Astrazeneca Ab Chemical compounds
DE602005016929D1 (de) 2004-06-22 2009-11-12 Schering Corp Liganden für den cannabinoidrezeptoren
GB2415818B (en) 2004-06-30 2008-12-31 Autoliv Dev Arrangement for triggering a vehicle safety device
CN101775013A (zh) 2004-09-13 2010-07-14 小野药品工业株式会社 含氮杂环衍生物及含有其作为活性成分的药物
EP1868605A2 (en) 2005-03-31 2007-12-26 Janssen Pharmaceutica, N.V. Phenyl and pyridyl lta4h modulators
ES2277745B1 (es) 2005-06-14 2008-06-01 Laboratorios Almirall S.A. Derivados n-amida de 8-azabiciclo /3.2.1/oct-3-ilo como antagonistas de ccr1.
GB0514018D0 (en) 2005-07-07 2005-08-17 Ionix Pharmaceuticals Ltd Chemical compounds
DK1976828T3 (en) * 2005-12-29 2017-03-06 Celtaxsys Inc DIAMINE DERIVATIVES AS INhibitors of Leukotriene A4 HYDROLASE
US20090156465A1 (en) 2005-12-30 2009-06-18 Sattigeri Jitendra A Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors
ES2498043T3 (es) 2006-06-06 2014-09-24 Cornerstone Therapeutics Inc. Piperazinas novedosas, composiciones farmacéuticas y métodos de uso de las mismas
WO2008016811A2 (en) 2006-07-31 2008-02-07 Neurogen Corporation Aminopiperidines and realted compounds
WO2008077103A1 (en) * 2006-12-19 2008-06-26 Auspex Pharmaceuticals, Inc. Preperation and utility of ccr5 inhibitors
CL2008000468A1 (es) 2007-02-14 2008-08-22 Janssen Pharmaceutica Nv Uso de compuestos derivados de heterociclos, inhibidores de leucotrina a4 hidrolasa (lta4h), utiles para tratar o prevenir la dermatitis, acne, infarto al miocardio, dolor, picazon, gingivitis, cancer, artritis, entre otras.
PA8802501A1 (es) * 2007-10-31 2009-06-23 Janssen Pharmaceutica Nv Diaminas en puente o fusionadas sustituidas con arilo como moduladores de leucotrieno, hidrolasa
CL2009000877A1 (es) * 2008-04-11 2009-11-27 Janssen Pharmaceutica Nv Compuestos derivados de [tiazolopiridin o tiazolopirazin-2-iloxi fenilamina; proceso de preparacion; composicion farmaceutica; y uso para el tratamiento de un trastorno o afeccion mediado por leucotrieno a4 hidrolasa, tales como alergia, asma, inflamacion, psoriasis, lupus, miastenia gravis, entre otros.

Also Published As

Publication number Publication date
HRP20130278T1 (en) 2013-06-30
EA201071186A1 (ru) 2011-06-30
CO6260069A2 (es) 2011-03-22
CL2009000877A1 (es) 2009-11-27
HRP20131192T1 (hr) 2014-01-17
CA2721099A1 (en) 2009-10-15
EA018802B1 (ru) 2013-10-30
KR101228378B1 (ko) 2013-01-31
US20110190503A1 (en) 2011-08-04
CN102056933B (zh) 2014-09-17
PL2336125T3 (pl) 2013-06-28
ES2400875T3 (es) 2013-04-15
NZ599853A (en) 2012-08-31
ES2440746T3 (es) 2014-01-30
JP2011516571A (ja) 2011-05-26
US20090258854A1 (en) 2009-10-15
SI2336125T1 (sl) 2013-04-30
ZA201008054B (en) 2012-04-25
NI201000168A (es) 2015-05-27
WO2009126806A3 (en) 2010-03-18
JP2014144949A (ja) 2014-08-14
EP2336125A1 (en) 2011-06-22
JP5675943B2 (ja) 2015-02-25
IL208480A (en) 2014-11-30
JO2911B1 (en) 2015-09-15
ECSP10010558A (es) 2010-11-30
PH12013500094B1 (en) 2015-02-23
CN102056933A (zh) 2011-05-11
AU2009234140A1 (en) 2009-10-15
US20110159563A1 (en) 2011-06-30
MY157597A (en) 2016-06-30
SV2010003694A (es) 2011-03-17
WO2009126806A2 (en) 2009-10-15
RS52712B (en) 2013-08-30
BRPI0911336A2 (pt) 2021-06-29
PT2336125E (pt) 2013-03-18
TW201002320A (en) 2010-01-16
HK1152041A1 (en) 2012-02-17
EP2336125B1 (en) 2013-01-09
IL208480A0 (en) 2010-12-30
MX2010011154A (es) 2010-12-21
JP5530423B2 (ja) 2014-06-25
KR20110013386A (ko) 2011-02-09
EP2268646A2 (en) 2011-01-05
EP2268646B1 (en) 2013-10-02
PH12013500094A1 (en) 2015-02-23
IL226244A (en) 2014-12-31
HK1158208A1 (en) 2012-07-13
DK2336125T3 (da) 2013-04-08
AU2009234140B2 (en) 2013-04-11
TWI461196B (zh) 2014-11-21
WO2009126806A8 (en) 2010-11-18
DK2268646T3 (da) 2013-11-18
SI2268646T1 (sl) 2013-12-31
PL2268646T3 (pl) 2014-02-28
PE20091779A1 (es) 2009-11-14
RS53081B (en) 2014-06-30
CA2721099C (en) 2017-04-25
US8357684B2 (en) 2013-01-22
EP2268646B9 (en) 2014-11-19
TW201420100A (zh) 2014-06-01
NZ588341A (en) 2012-06-29
IL226244A0 (en) 2013-06-27
CY1114628T1 (el) 2016-10-05
UY31760A (es) 2009-11-10
HN2010002074A (es) 2012-12-03
US7939527B2 (en) 2011-05-10
AR072353A1 (es) 2010-08-25

Similar Documents

Publication Publication Date Title
PT2268646E (pt) Aminas de tiazolopiridina-2-iloxi-fenil e de tiazolopirazina-2-iloxi-fenilo como moduladores da hidrolase de leucotrieno a4
WO2010021693A3 (en) Mif modulators
WO2011022489A3 (en) (bis) urea and (bis) thiourea compounds as epigenic modulators of lysine-specific demethylase 1 and methods of treating disorders
WO2012034116A3 (en) Small molecules as epigenetic modulators of lysine-specific demethylase 1 and methods of treating disorders
MX2012004551A (es) Nuevas composiciones para prevenir y/o tratar trastornos de almacenamiento lisosomal.
WO2011140202A3 (en) Mif modulators
GEP20146082B (en) Compositions and methods of wnt signaling modulators
EA201001329A1 (ru) Соединения и композиции в качестве модуляторов активности gpr119
EA201001332A1 (ru) Соединения и композиции в качестве модуляторов активности gpr119
EA201001330A1 (ru) Соединения и композиции в качестве модуляторов активности gpr119
HRP20170236T1 (hr) Novi pripravci za sprječavanje i/ili liječenje degenerativnih poremećaja središnjeg živčanog sustava
MX2010002926A (es) Moduladores de tieno y furo-pirimidina del receptor h4 de histamina.
GB2465814B (en) Method,composition and device for the treatment of enzymes and saccharides disorders
MX2011012190A (es) Compuestos con dos porciones de heteroarilo biciclico fusionado como moduladores de la leucotrieno a4 hidrolasa.
WO2009037542A3 (en) Spirocyclic compounds as stearoyl coa desaturase inhibitors
WO2010065861A3 (en) Inhibitors of bace 1 and methods for treating alzheimer&#39;s disease
UA102544C2 (en) Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene a4 hydrolase
AU2013205607A1 (en) Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase
WO2010147969A3 (en) Gamma secretase modulators
GB2479294B (en) Method, composition and device for the treatment of enzymes and saccharides disorders
GEP20135801B (en) New compounds of azabicyclo[3.2.0]hept-3-yl, method for preparing same and pharmaceutical compositions containing them
UA97289C2 (ru) Соединения и их композиция как модуляторы gpr119 активности
TH152256A (th) ไธแอโซโลพิริดิน-2-อิลออกซิ-เฟนิล และไธแอโซโลพิแรซิน-2-อิลออกซิ-เฟนิล แอมีนเป็นมอดูเลเตอร์ของลิวโคไทรอีน a4 ไฮโดรเลส