CO6220948A2 - Derivados de ciclohexano espirociclico - Google Patents
Derivados de ciclohexano espirociclicoInfo
- Publication number
- CO6220948A2 CO6220948A2 CO09086728A CO09086728A CO6220948A2 CO 6220948 A2 CO6220948 A2 CO 6220948A2 CO 09086728 A CO09086728 A CO 09086728A CO 09086728 A CO09086728 A CO 09086728A CO 6220948 A2 CO6220948 A2 CO 6220948A2
- Authority
- CO
- Colombia
- Prior art keywords
- spirociclic
- cyclhexan
- derivatives
- spirocyclic cyclohexane
- cyclohexane compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Abstract
en donde, R1 y R2 en forma conjunta forman un anillo y representan -CH2CH2CH2- o -CH2CH2CH2CH2- o R1 y R2 significan H;R3 es alquilo C1-5, ya sea saturado o no saturado, ramificado o no ramificado, sustituido en forma simple o múltiple o no sustituido; cicloalquilo C3-8, ya sea saturado o no saturado, sustituido en forma simple o múltiple o no sustituido; arilo o heteroarilo, ya sea no sustituido o sustituido en forma simple o múltiple; arilo o cicloalquilo C3-8, unido mediante grupo alquilo C1-3, ya sea no sustituido o sustituido en forma simple o múltiple; R5 es =O; H; alquilo C1-5, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; COOR13, CONR13, OR13; cicloalquilo C3-8, saturado o no saturado, no sustituido o sustituido en forma simple o múltiple; arilo o heteroarilo, no sustituido o sustituido en forma simple o múltiple; arilo, cicloalquilo C3-8 o heteroarilo unido mediante alquilo C1-3, no sustituido o sustituido en forma simple o múltiple; R6 es H; F, CI, NO2, CF3, OR13, SR13, SO2R13, SO2R13, CN, COOR13, NR14R15 alquilo C1-5, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; cicloalquilo C3-8, saturado o no saturado, no sustituido o sustituido en forma simple o múltiple, arilo o heteroarilo, no sustituido o sustituido en forma simple o múltiple; o arilo, cicloalquilo C3-8 o heteroarilo, unido mediante alquilo C1-3, no sustituido o sustituido en forma simple o múltiple; o R5 y R6 en forma conjunta significan (CH2)n con n= 2, 3, 4, 5 ó 6, en donde cada átomo de hidrógeno también puede ser sustituido por F, CI, Br, I, NO2, CF3, OR13, CN ó alquilo C1-5; R7, R8, R9 y R10 en forma independiente significan H, F, CI, Br, I, NO2, CF3, OR13, SR13, SO2R13, SO2OR13, NHC(=O)NR14R15, SO2NR14R15, CN, COOR13, NR14R15; alquilo C1-5, cicloalquilo C3-8, no sustituido o sustituido en forma simple o múltiple; arilo o heteroarilo, no sustituido o sustituido en forma simple o múltiple; o arilo, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007009319A DE102007009319A1 (de) | 2007-02-22 | 2007-02-22 | Spirocyclische Cyclohexan-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6220948A2 true CO6220948A2 (es) | 2010-11-19 |
Family
ID=39531427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09086728A CO6220948A2 (es) | 2007-02-22 | 2009-08-19 | Derivados de ciclohexano espirociclico |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7960404B2 (es) |
| EP (1) | EP2121691B1 (es) |
| JP (1) | JP5514556B2 (es) |
| KR (1) | KR101517748B1 (es) |
| CN (1) | CN101622256B (es) |
| AT (1) | ATE554089T1 (es) |
| AU (1) | AU2008217277B2 (es) |
| BR (1) | BRPI0806794A2 (es) |
| CA (1) | CA2679173C (es) |
| CO (1) | CO6220948A2 (es) |
| CY (1) | CY1112725T1 (es) |
| DE (1) | DE102007009319A1 (es) |
| DK (1) | DK2121691T3 (es) |
| EC (1) | ECSP099621A (es) |
| ES (1) | ES2386387T3 (es) |
| HK (1) | HK1136827A1 (es) |
| HR (1) | HRP20120511T1 (es) |
| IL (1) | IL200496A (es) |
| MX (1) | MX2009007387A (es) |
| NZ (1) | NZ578589A (es) |
| PL (1) | PL2121691T3 (es) |
| PT (1) | PT2121691E (es) |
| RU (1) | RU2470933C2 (es) |
| SI (1) | SI2121691T1 (es) |
| WO (1) | WO2008101660A1 (es) |
| ZA (1) | ZA200906584B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006033114A1 (de) * | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
| EP2476680B1 (en) | 2008-01-11 | 2014-08-27 | Albany Molecular Research, Inc. | (1-Azinone)-Substituted Pyridoindoles |
| US8357705B2 (en) | 2008-03-27 | 2013-01-22 | Gruenenthal Gmbh | Substituted cyclohexyldiamines |
| WO2009118169A1 (de) | 2008-03-27 | 2009-10-01 | Grünenthal GmbH | Spiro(5.5)undecan derivate |
| AR073841A1 (es) | 2008-03-27 | 2010-12-09 | Gruenenthal Chemie | Hidroximetilciclohexilaminas, medicamentos y uso de los mismos para la fabricacion de medicamentos. |
| BRPI0910607A2 (pt) | 2008-03-27 | 2015-09-22 | Gruenenthal Gmbh | derivados do ciclohexano espirocíclicos substituídos |
| ES2694103T3 (es) | 2008-03-27 | 2018-12-18 | Grünenthal GmbH | Derivados de 4-aminociclohexano sustituidos |
| WO2011003012A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof |
| WO2011003021A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
| WO2011003005A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof |
| US8629158B2 (en) | 2009-07-01 | 2014-01-14 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
| CA2820413C (en) | 2010-12-08 | 2019-05-07 | Grunenthal Gmbh | Method for synthesising substituted aminocyclohexanone derivatives |
| US8697700B2 (en) | 2010-12-21 | 2014-04-15 | Albany Molecular Research, Inc. | Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof |
| US8993765B2 (en) | 2010-12-21 | 2015-03-31 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof |
| CN104159902B (zh) * | 2011-12-12 | 2016-05-04 | 格吕伦塔尔有限公司 | 制备(1r,4r)-6’-氟-(N,N-二甲基-和N-甲基)-4-苯基-4’,9’-二氢-3’H-螺[环己烷-1,1’-吡喃并[3,4,b]吲哚]-4-胺的方法 |
| CN105246892B (zh) | 2013-03-15 | 2019-05-03 | 格吕伦塔尔有限公司 | 结晶化合物 |
| PT3169666T (pt) | 2014-07-15 | 2018-10-19 | Gruenenthal Gmbh | Derivados sbstituidos de azaspiro(4,5)decano |
| TW201607923A (zh) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環（４．５）癸烷衍生物 |
| TW201642853A (zh) * | 2015-01-23 | 2016-12-16 | 歌林達有限公司 | 用於治療肝功能之損傷及／或腎功能之損傷個體疼痛之西博帕多（Ｃｅｂｒａｎｏｐａｄｏｌ） |
| CN107383027A (zh) * | 2017-07-24 | 2017-11-24 | 扬州大学 | 一种四氢螺类化合物的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2426730C2 (ru) * | 2001-04-18 | 2011-08-20 | Эро-Селтик, С.А. | Аналоги ноцицептина |
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10360792A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102005016460A1 (de) * | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit |
| DE102006046745A1 (de) * | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
-
2007
- 2007-02-22 DE DE102007009319A patent/DE102007009319A1/de not_active Withdrawn
-
2008
- 2008-02-19 EP EP08715856A patent/EP2121691B1/de not_active Not-in-force
- 2008-02-19 DK DK08715856.4T patent/DK2121691T3/da active
- 2008-02-19 AU AU2008217277A patent/AU2008217277B2/en not_active Ceased
- 2008-02-19 NZ NZ578589A patent/NZ578589A/en not_active IP Right Cessation
- 2008-02-19 ES ES08715856T patent/ES2386387T3/es active Active
- 2008-02-19 MX MX2009007387A patent/MX2009007387A/es active IP Right Grant
- 2008-02-19 PT PT08715856T patent/PT2121691E/pt unknown
- 2008-02-19 SI SI200830635T patent/SI2121691T1/sl unknown
- 2008-02-19 JP JP2009550672A patent/JP5514556B2/ja not_active Expired - Fee Related
- 2008-02-19 CN CN200880006055.6A patent/CN101622256B/zh not_active Expired - Fee Related
- 2008-02-19 KR KR1020097019738A patent/KR101517748B1/ko not_active IP Right Cessation
- 2008-02-19 BR BRPI0806794-5A patent/BRPI0806794A2/pt not_active IP Right Cessation
- 2008-02-19 AT AT08715856T patent/ATE554089T1/de active
- 2008-02-19 WO PCT/EP2008/001271 patent/WO2008101660A1/de active Application Filing
- 2008-02-19 PL PL08715856T patent/PL2121691T3/pl unknown
- 2008-02-19 CA CA2679173A patent/CA2679173C/en not_active Expired - Fee Related
- 2008-02-19 RU RU2009135070/04A patent/RU2470933C2/ru not_active IP Right Cessation
-
2009
- 2009-08-19 CO CO09086728A patent/CO6220948A2/es active IP Right Grant
- 2009-08-20 IL IL200496A patent/IL200496A/en active IP Right Grant
- 2009-08-21 US US12/545,261 patent/US7960404B2/en not_active Expired - Fee Related
- 2009-09-09 EC EC2009009621A patent/ECSP099621A/es unknown
- 2009-09-21 ZA ZA200906584A patent/ZA200906584B/xx unknown
-
2010
- 2010-04-13 HK HK10103563.9A patent/HK1136827A1/xx not_active IP Right Cessation
-
2012
- 2012-05-11 CY CY20121100445T patent/CY1112725T1/el unknown
- 2012-06-19 HR HRP20120511AT patent/HRP20120511T1/hr unknown
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