ES2073661T3 - Metodo para la isomerizacion fotoquimica de compuestos organicos bajo la influencia de un fotosensibilizador. - Google Patents

Metodo para la isomerizacion fotoquimica de compuestos organicos bajo la influencia de un fotosensibilizador.

Info

Publication number
ES2073661T3
ES2073661T3 ES91200828T ES91200828T ES2073661T3 ES 2073661 T3 ES2073661 T3 ES 2073661T3 ES 91200828 T ES91200828 T ES 91200828T ES 91200828 T ES91200828 T ES 91200828T ES 2073661 T3 ES2073661 T3 ES 2073661T3
Authority
ES
Spain
Prior art keywords
influence
cpds
photosensitizer
organic compounds
compounds under
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91200828T
Other languages
English (en)
Inventor
Louis F Pauli
Alphons Dufourny
Robert B Koolstra
Hans Wynberg
Hoeve Wolter Ten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duphar International Research BV
Original Assignee
Duphar International Research BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar International Research BV filed Critical Duphar International Research BV
Application granted granted Critical
Publication of ES2073661T3 publication Critical patent/ES2073661T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

LA INVENCION SE REFIERE A UN METODO PARA LA ISOMERIZACION FOTOQUIMICA DE COMPUESTOS ORGANICOS, EN ESPECIAL PARA LA CONVERSION FOTOQUIMICA DE COMPUESTOS DE TAQUISTEROL EN COMPUESTOS DE PREVITAMINA D Y DE COMPUESTOS DE TRANS-VITAMINA D EN COMPUESTOS DE CIS-VITAMINA D BAJO LA INFLUENCIA DE RADIACION, EXPONIENDO UNA DISOLUCION DEL COMPUESTO ORGANICO QUE VA A CONVERTIRSE EN PRESENCIA DE UN FOTOSENSIBILIZADOR NO-POLIMERICO A UNA LUZ CON UNA LONGITUD DE ONDA APROXIMADA ENTRE 300-1.000 NM, Y LUEGO AISLANDO EL PRODUCTO RESULTANTE, EN EL QUE SE UTILIZA COMO FOTOSENSIBILIZADOR UN DERIVADO DE TIOFENO SUSTITUIDO CON UNA ABSORCION SUSTANCIAL EN LA REGION DE LONGITUD DE ONDA. LA INVENCION TAMBIEN SE REFIERE A UN NUEVO FOTOSENSIBILIZADOR QUE SE UTILIZA EN LA REACCION DE ISOMERIZACION
ES91200828T 1990-04-27 1991-04-10 Metodo para la isomerizacion fotoquimica de compuestos organicos bajo la influencia de un fotosensibilizador. Expired - Lifetime ES2073661T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90201071 1990-04-27

Publications (1)

Publication Number Publication Date
ES2073661T3 true ES2073661T3 (es) 1995-08-16

Family

ID=8205006

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91200828T Expired - Lifetime ES2073661T3 (es) 1990-04-27 1991-04-10 Metodo para la isomerizacion fotoquimica de compuestos organicos bajo la influencia de un fotosensibilizador.

Country Status (12)

Country Link
US (1) US5252191A (es)
EP (1) EP0454204B1 (es)
JP (1) JP2945505B2 (es)
AT (1) ATE124394T1 (es)
CA (1) CA2041135C (es)
CZ (1) CZ287447B6 (es)
DE (1) DE69110739T2 (es)
DK (1) DK0454204T3 (es)
ES (1) ES2073661T3 (es)
GR (1) GR3017441T3 (es)
IL (1) IL97934A (es)
SK (1) SK281371B6 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543016A (en) * 1991-07-12 1996-08-06 Inrad Photoconversion of steroids in microreactors
US5578636A (en) * 1994-04-08 1996-11-26 Purdue Research Foundation Polythiophene anti-tumor agents
ITFI940095A1 (it) * 1994-05-23 1995-11-23 Molteni & C Coniugati fotodinamici aventi proprieta' biocide
US20040043971A1 (en) * 1995-04-03 2004-03-04 Bone Care International, Inc. Method of treating and preventing hyperparathyroidism with active vitamin D analogs
US6242434B1 (en) 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
US20020183288A1 (en) * 1995-04-03 2002-12-05 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
EP1007035A4 (en) * 1996-11-26 2000-11-22 Purdue Research Foundation POLYTHIOPHENES AS ANTITUARY AGENTS
JP2002516306A (ja) 1998-05-29 2002-06-04 ボーン ケア インターナショナル インコーポレイテッド ヒドロキシ−２５−エン−ビタミンｄ化合物の製造方法
US5972917A (en) * 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
US20040186082A1 (en) * 2003-03-20 2004-09-23 Hartman Raymond A. Enhanced phototherapy for the treatment of cancer and autoimmune disease
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
EP1928822B1 (en) 2005-09-26 2013-02-27 Life Technologies Corporation Violet laser excitable dyes and their method of use
CA2807419C (en) * 2010-08-18 2019-09-24 Sunil Kumar Kc Diketones and hydroxyketones as catenin signaling pathway activators
AU2014218720B2 (en) 2013-02-22 2018-09-27 Samumed, Llc Gamma-diketones as Wnt/beta -catenin signaling pathway activators
WO2016029021A1 (en) 2014-08-20 2016-02-25 Samumed, Llc Gamma-diketones for treatment and prevention of aging skin and wrinkles
CA3137162A1 (en) * 2019-05-10 2020-11-19 Fermenta Biotech Limited Irradiation process of pro vitamin d
US20220298106A1 (en) * 2019-05-15 2022-09-22 Fermenta Biotech Limited Improved photochemical synthesis of vitamin d3 using sensitizers
CA3136920A1 (en) * 2019-06-06 2020-12-10 Fermenta Biotech Limited An improved process to synthesize 5-(3-pyridyl)-2,2'-bithiophene(sensitizer)
CA3136913A1 (en) * 2019-07-09 2021-01-14 Fermenta Biotech Limited Improved, cost effective process for synthesis of vitamin d3 and its analogue calcifediol from ergosterol
WO2021005618A1 (en) * 2019-07-09 2021-01-14 Fermenta Biotech Limited Synthesis of cholesterol and vitamin d3 from phytosterols
WO2021019558A1 (en) * 2019-07-30 2021-02-04 Fermenta Biotech Limited An efficient method for synthesis of 5-(3-pyridyl)-2,2'-bithiophene(sensitizer)
WO2021019559A1 (en) * 2019-07-30 2021-02-04 Fermenta Biotech Limited Synthesis of 5-(3-pyridyl)-2,2'-bithiophene(sensitizer)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4551214A (en) * 1983-07-01 1985-11-05 Hoffmann-La Roche Inc. Photochemical preparation of previtamin D
DE3346175A1 (de) * 1983-12-21 1985-07-11 Merck Patent Gmbh, 6100 Darmstadt Pyridylthiophene
US4686023A (en) * 1985-11-26 1987-08-11 Solarchem Research, Division Of Brolor Investments, Ltd. Sensitized photochemical preparation of vitamin D
NO872850L (no) * 1986-07-09 1988-01-11 Solarchem Res Fotokjemisk sensitiverende materialer.
US5089365A (en) * 1987-10-07 1992-02-18 Fuji Electric Co., Ltd. Photosensitive member for electrophotography with thiophene containing moiety on charge transport compound
US4886625A (en) * 1987-10-29 1989-12-12 Miles Inc. Functionalized conducting polymers and their use in diagnostic devices
ATE90075T1 (de) * 1988-12-12 1993-06-15 Duphar Int Res Verfahren zur photochemischen umwandlung von tachysterol-derivaten in praevitamin d-derivate und von transvitamin d-derivaten in cisvitamin d- derivate.

Also Published As

Publication number Publication date
JPH04225951A (ja) 1992-08-14
DE69110739T2 (de) 1995-11-23
CA2041135A1 (en) 1991-10-28
IL97934A0 (en) 1992-06-21
CA2041135C (en) 2003-02-11
DK0454204T3 (da) 1995-08-28
JP2945505B2 (ja) 1999-09-06
CZ287447B6 (cs) 2000-11-15
SK281371B6 (sk) 2001-03-12
CS114991A3 (en) 1992-01-15
EP0454204B1 (en) 1995-06-28
IL97934A (en) 1996-09-12
EP0454204A3 (en) 1992-10-07
DE69110739D1 (de) 1995-08-03
ATE124394T1 (de) 1995-07-15
US5252191A (en) 1993-10-12
GR3017441T3 (en) 1995-12-31
EP0454204A2 (en) 1991-10-30

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