DK2617420T3 - Heterocykliske phenoxymethylforbindelser - Google Patents
Heterocykliske phenoxymethylforbindelser Download PDFInfo
- Publication number
- DK2617420T3 DK2617420T3 DK13150322.9T DK13150322T DK2617420T3 DK 2617420 T3 DK2617420 T3 DK 2617420T3 DK 13150322 T DK13150322 T DK 13150322T DK 2617420 T3 DK2617420 T3 DK 2617420T3
- Authority
- DK
- Denmark
- Prior art keywords
- phenoxymethyl
- heterocyclic
- compounds
- phenoxymethyl compounds
- heterocyclic phenoxymethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Addiction (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17641309P | 2009-05-07 | 2009-05-07 | |
| EP09796217A EP2427454B1 (en) | 2009-05-07 | 2009-12-18 | Phenoxymethyl heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2617420T3 true DK2617420T3 (da) | 2015-12-07 |
Family
ID=41549054
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09796217.9T DK2427454T3 (da) | 2009-05-07 | 2009-12-18 | Heterocykliske phenoxymethylforbindelser |
| DK13150322.9T DK2617420T3 (da) | 2009-05-07 | 2009-12-18 | Heterocykliske phenoxymethylforbindelser |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09796217.9T DK2427454T3 (da) | 2009-05-07 | 2009-12-18 | Heterocykliske phenoxymethylforbindelser |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US8343973B2 (da) |
| EP (3) | EP2617420B1 (da) |
| JP (2) | JP5628902B2 (da) |
| KR (1) | KR101662699B1 (da) |
| CN (2) | CN102459242B (da) |
| AU (1) | AU2009345802B2 (da) |
| BR (1) | BRPI0924617A8 (da) |
| CA (1) | CA2761032A1 (da) |
| CL (1) | CL2011002792A1 (da) |
| CO (1) | CO6460744A2 (da) |
| CR (1) | CR20110648A (da) |
| DK (2) | DK2427454T3 (da) |
| EC (1) | ECSP11011479A (da) |
| ES (2) | ES2554788T3 (da) |
| HK (2) | HK1167402A1 (da) |
| HR (2) | HRP20130482T1 (da) |
| HU (1) | HUE026238T2 (da) |
| IL (2) | IL216149A (da) |
| ME (1) | ME02375B (da) |
| MX (1) | MX2011011755A (da) |
| MY (1) | MY183910A (da) |
| NZ (1) | NZ596753A (da) |
| PE (1) | PE20120900A1 (da) |
| PH (1) | PH12013501321A1 (da) |
| PL (2) | PL2427454T3 (da) |
| PT (2) | PT2427454E (da) |
| RS (2) | RS52838B (da) |
| RU (1) | RU2531274C2 (da) |
| SG (1) | SG175900A1 (da) |
| SI (2) | SI2617420T1 (da) |
| SM (2) | SMT201300070B (da) |
| WO (1) | WO2010128995A1 (da) |
| ZA (1) | ZA201108920B (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110031355A (ko) | 2008-06-25 | 2011-03-25 | 엔비보 파마슈티칼즈, 인코퍼레이티드 | １,２―이치환된 헤테로사이클릭 화합물 |
| WO2010128995A1 (en) | 2009-05-07 | 2010-11-11 | Envivo Pharmaceuticals, Inc. | Phenoxymethyl heterocyclic compounds |
| BR112013021180A2 (pt) | 2011-02-18 | 2019-09-24 | Allergan Inc | derivados de 6,7-dialcóxi-3-isoquinolinol substituído como inibidores de fosfodiesterase 10 (pde10a) |
| CA2874953A1 (en) | 2012-06-12 | 2013-12-19 | Abbvie Inc. | Pyridinone and pyridazinone derivatives |
| WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| ES2480341B1 (es) | 2013-01-24 | 2015-01-22 | Palobiofarma S.L | Nuevos derivados de pirimidina como inhibidores de la fosfodiesterasa 10 (PDE-10) |
| TW201512201A (zh) * | 2013-03-14 | 2015-04-01 | Forum Pharmaceuticals Inc | 化合物的多晶型及鹽類 |
| TWI634114B (zh) * | 2013-05-08 | 2018-09-01 | 永恒生物科技公司 | 作為激酶抑制劑之呋喃酮化合物 |
| US10039764B2 (en) | 2013-07-12 | 2018-08-07 | University Of South Alabama | Treatment and diagnosis of cancer and precancerous conditions using PDE10A inhibitors and methods to measure PDE10A expression |
| US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
| WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL200167B1 (pl) * | 1999-11-05 | 2008-12-31 | Sod Conseils Rech Applic | Związki heterocykliczne o aktywności hamowania kalpain i/lub pułapkowania ROS, ich zastosowanie i kompozycje farmaceutyczne je zawierające oraz związki pośrednie |
| US20030032579A1 (en) | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
| CA2493854A1 (en) | 2002-06-26 | 2004-01-08 | Kyowa Hakko Kogyo Co., Ltd. | Phosphodiesterase inhibitor |
| PL1841757T3 (pl) * | 2005-01-07 | 2010-10-29 | Pfizer Prod Inc | Heteroaromatyczne związki chinoliny i ich zastosowanie jako inhibitorów PDE10 |
| NL2000397C2 (nl) * | 2006-01-05 | 2007-10-30 | Pfizer Prod Inc | Bicyclische heteroarylverbindingen als PDE10 inhibitoren. |
| EP1845098A1 (en) * | 2006-03-29 | 2007-10-17 | Ferrer Internacional, S.A. | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands |
| JP2009535394A (ja) | 2006-05-02 | 2009-10-01 | ファイザー・プロダクツ・インク | Ｐｄｅ１０阻害剤としての二環式ヘテロアリール化合物 |
| WO2008033455A2 (en) | 2006-09-13 | 2008-03-20 | The Institutes For Pharmaceutical Discovery, Llc | Biphenyl and heteroaryl phenyl derivatives as protein tyrosine phosphatases inhibitors |
| FR2928924B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique |
| KR20110031355A (ko) | 2008-06-25 | 2011-03-25 | 엔비보 파마슈티칼즈, 인코퍼레이티드 | １,２―이치환된 헤테로사이클릭 화합물 |
| WO2010128995A1 (en) | 2009-05-07 | 2010-11-11 | Envivo Pharmaceuticals, Inc. | Phenoxymethyl heterocyclic compounds |
| RU2012112151A (ru) * | 2009-09-03 | 2013-10-10 | Аллерган, Инк. | Соединения как модуляторы тирозинкиназы |
| BR112013003631B1 (pt) * | 2010-08-18 | 2021-10-13 | Samumed, Llc | Beta- e gama-dicetonas e gama-hidroxicetonas e composições farmacêuticas que as compreendem |
-
2009
- 2009-12-18 WO PCT/US2009/068644 patent/WO2010128995A1/en active Application Filing
- 2009-12-18 DK DK09796217.9T patent/DK2427454T3/da active
- 2009-12-18 ES ES13150322.9T patent/ES2554788T3/es active Active
- 2009-12-18 PT PT97962179T patent/PT2427454E/pt unknown
- 2009-12-18 PE PE2011001918A patent/PE20120900A1/es not_active Application Discontinuation
- 2009-12-18 RS RS20130218A patent/RS52838B/en unknown
- 2009-12-18 SI SI200931314T patent/SI2617420T1/sl unknown
- 2009-12-18 DK DK13150322.9T patent/DK2617420T3/da active
- 2009-12-18 ES ES09796217T patent/ES2409404T3/es active Active
- 2009-12-18 CN CN200980159735.6A patent/CN102459242B/zh not_active Expired - Fee Related
- 2009-12-18 MX MX2011011755A patent/MX2011011755A/es active IP Right Grant
- 2009-12-18 MY MYPI2011005358A patent/MY183910A/en unknown
- 2009-12-18 HU HUE13150322A patent/HUE026238T2/en unknown
- 2009-12-18 NZ NZ596753A patent/NZ596753A/xx not_active IP Right Cessation
- 2009-12-18 PL PL09796217T patent/PL2427454T3/pl unknown
- 2009-12-18 EP EP13150322.9A patent/EP2617420B1/en active Active
- 2009-12-18 KR KR1020117028223A patent/KR101662699B1/ko active IP Right Grant
- 2009-12-18 SI SI200930609T patent/SI2427454T1/sl unknown
- 2009-12-18 US US12/642,026 patent/US8343973B2/en not_active Expired - Fee Related
- 2009-12-18 PL PL13150322T patent/PL2617420T3/pl unknown
- 2009-12-18 BR BRPI0924617A patent/BRPI0924617A8/pt not_active IP Right Cessation
- 2009-12-18 CN CN201510438849.1A patent/CN105125547A/zh active Pending
- 2009-12-18 AU AU2009345802A patent/AU2009345802B2/en not_active Ceased
- 2009-12-18 EP EP15184753.0A patent/EP3020716A1/en not_active Withdrawn
- 2009-12-18 EP EP09796217A patent/EP2427454B1/en active Active
- 2009-12-18 RS RS20150803A patent/RS54529B1/en unknown
- 2009-12-18 ME MEP-2015-210A patent/ME02375B/me unknown
- 2009-12-18 SG SG2011081437A patent/SG175900A1/en unknown
- 2009-12-18 JP JP2012509778A patent/JP5628902B2/ja not_active Expired - Fee Related
- 2009-12-18 CA CA2761032A patent/CA2761032A1/en not_active Abandoned
- 2009-12-18 RU RU2011149637/04A patent/RU2531274C2/ru not_active IP Right Cessation
- 2009-12-18 PT PT131503229T patent/PT2617420E/pt unknown
-
2011
- 2011-11-03 IL IL216149A patent/IL216149A/en not_active IP Right Cessation
- 2011-11-07 CL CL2011002792A patent/CL2011002792A1/es unknown
- 2011-11-11 CO CO11153626A patent/CO6460744A2/es active IP Right Grant
- 2011-11-24 EC EC2011011479A patent/ECSP11011479A/es unknown
- 2011-12-05 CR CR20110648A patent/CR20110648A/es unknown
- 2011-12-05 ZA ZA2011/08920A patent/ZA201108920B/en unknown
-
2012
- 2012-08-21 HK HK12108181.8A patent/HK1167402A1/xx not_active IP Right Cessation
- 2012-12-20 US US13/722,595 patent/US8946222B2/en not_active Expired - Fee Related
-
2013
- 2013-05-31 HR HRP20130482AT patent/HRP20130482T1/hr unknown
- 2013-06-20 SM SM201300070T patent/SMT201300070B/xx unknown
- 2013-06-20 PH PH12013501321A patent/PH12013501321A1/en unknown
-
2014
- 2014-01-06 HK HK14100085.0A patent/HK1186981A1/xx not_active IP Right Cessation
- 2014-10-02 JP JP2014204220A patent/JP5943053B2/ja not_active Expired - Fee Related
- 2014-12-09 US US14/564,507 patent/US20150322069A1/en not_active Abandoned
-
2015
- 2015-11-25 HR HRP20151273TT patent/HRP20151273T1/hr unknown
-
2016
- 2016-02-04 SM SM201600031T patent/SMT201600031B/it unknown
- 2016-02-10 IL IL244059A patent/IL244059A0/en unknown
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