BR112013003631A8 - beta- e gama-dicetonas e gama-hidroxicetonas como ativadores de trajetórias de sinalização de wnt/beta-catenina - Google Patents

beta- e gama-dicetonas e gama-hidroxicetonas como ativadores de trajetórias de sinalização de wnt/beta-catenina

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Publication number
BR112013003631A8
BR112013003631A8 BR112013003631A BR112013003631A BR112013003631A8 BR 112013003631 A8 BR112013003631 A8 BR 112013003631A8 BR 112013003631 A BR112013003631 A BR 112013003631A BR 112013003631 A BR112013003631 A BR 112013003631A BR 112013003631 A8 BR112013003631 A8 BR 112013003631A8
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BR
Brazil
Prior art keywords
beta
gamma
disease
diketones
diseases
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BR112013003631A
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English (en)
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BR112013003631B1 (pt
BR112013003631A2 (pt
Inventor
F Barroga Charlene
Mark Wallace David
Hood John
Kumar Kc Sunil
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Samumed Llc
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Publication of BR112013003631A2 publication Critical patent/BR112013003631A2/pt
Publication of BR112013003631A8 publication Critical patent/BR112013003631A8/pt
Publication of BR112013003631B1 publication Critical patent/BR112013003631B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract

beta- e gama-dicetonas e gama-hidroxicetonas como ativadores de trajetórias de sinalização de wnt/beta-catetina. a presente invenção refere-se a <225>-dicetonas, <sym>-dicetonas ou <sym>-hidroxicetonas ou seus análogos, que ativam sinalização de beta catenina/wnt e assim tratam ou previnem doenças relacionadas com transdução de sinal, tais como osteoporose e osteoartropatia; osteogênese imperfeita, defeitos ósseos, fraturas de osso, doença periondotal, otoesclerose, cura de ferimento, defeitos crânio-facial, doença óssea oncolítica, lesões cerebrais traumáticas relacionadas com a diferenciação e desenvolvimento do sistema nervoso central, compreendendo doença de parkinsom, acidentes vasculares cerebrais, doença cerebral isquêmica, epilepsia, doença de alzheimer, depressão, distúrbio bipolar, esquizofrenia; doenças oculares tais como degeneração macular relacionada com a idade, edema macular diabética ou retinite pigmentosa e doenças relacionadas com diferenciação e crescimento de célula-tronco, compreendendo perda de cabelo, doenças relacionadas como hematopoiese e doenças relacionadas com regeneração de tecido.
BR112013003631-1A 2010-08-18 2011-08-17 Beta- e gama-dicetonas e gama-hidroxicetonas e composições farmacêuticas que as compreendem BR112013003631B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US37468710P 2010-08-18 2010-08-18
US61/374,687 2010-08-18
US201061427974P 2010-12-29 2010-12-29
US61/427,974 2010-12-29
PCT/US2011/048086 WO2012024404A1 (en) 2010-08-18 2011-08-17 Diketones and hydroxyketones as catenin signaling pathway activators

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BR112013003631A2 BR112013003631A2 (pt) 2016-08-30
BR112013003631A8 true BR112013003631A8 (pt) 2017-12-26
BR112013003631B1 BR112013003631B1 (pt) 2021-10-13

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CN (2) CN103153053B (pt)
AU (1) AU2011291989B2 (pt)
BR (1) BR112013003631B1 (pt)
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DK (2) DK3311666T3 (pt)
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