ES2879314T3 - Dicetonas e hidroxicetonas como activadores de la vía de señalización de catenina - Google Patents

Dicetonas e hidroxicetonas como activadores de la vía de señalización de catenina Download PDF

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Publication number
ES2879314T3
ES2879314T3 ES17193280T ES17193280T ES2879314T3 ES 2879314 T3 ES2879314 T3 ES 2879314T3 ES 17193280 T ES17193280 T ES 17193280T ES 17193280 T ES17193280 T ES 17193280T ES 2879314 T3 ES2879314 T3 ES 2879314T3
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compound
disease
cells
bone
pharmaceutically acceptable
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Sunil Kumar Kc
David Mark Wallace
John Hood
Charlene F Barroga
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Biosplice Therapeutics Inc
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Biosplice Therapeutics Inc
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/784—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic with all keto groups bound to a non-condensed ring
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
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    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
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    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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ES17193280T 2010-08-18 2011-08-17 Dicetonas e hidroxicetonas como activadores de la vía de señalización de catenina Active ES2879314T3 (es)

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US37468710P 2010-08-18 2010-08-18
US201061427974P 2010-12-29 2010-12-29

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ES2879314T3 true ES2879314T3 (es) 2021-11-22

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ES17193280T Active ES2879314T3 (es) 2010-08-18 2011-08-17 Dicetonas e hidroxicetonas como activadores de la vía de señalización de catenina
ES11818727.7T Active ES2652363T3 (es) 2010-08-18 2011-08-17 Dicetonas e hidroxicetonas como activadores de la vía de señalización de catenina

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US (9) US8609717B2 (enExample)
EP (3) EP2605652B1 (enExample)
JP (3) JP6086864B2 (enExample)
CN (2) CN104672202B (enExample)
AU (1) AU2011291989B2 (enExample)
BR (1) BR112013003631B1 (enExample)
CA (1) CA2807419C (enExample)
CY (2) CY1120061T1 (enExample)
DK (2) DK3311666T3 (enExample)
ES (2) ES2879314T3 (enExample)
HR (2) HRP20180196T1 (enExample)
HU (2) HUE036240T2 (enExample)
LT (2) LT3311666T (enExample)
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PL (2) PL3311666T3 (enExample)
PT (2) PT2605652T (enExample)
RS (2) RS56855B1 (enExample)
RU (2) RU2016124136A (enExample)
SI (2) SI2605652T1 (enExample)
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WO2009158393A1 (en) 2008-06-25 2009-12-30 Envivo Pharmaceuticals, Inc. 1, 2 disubstituted heterocyclic compounds
EP2617420B1 (en) 2009-05-07 2015-09-23 Forum Pharmaceuticals Inc. Phenoxymethyl heterocyclic compounds
DK2987487T3 (da) 2009-08-10 2020-12-07 Samumed Llc Indazolinhibitorer af wnt-signalvejen og terapeutiske anvendelser deraf
SMT201800065T1 (it) * 2010-08-18 2018-03-08 Samumed Llc Dichetoni e idrossichetoni come attivatori della via di segnalazione della catechina
US20140037599A1 (en) * 2012-08-03 2014-02-06 The Trustees Of The University Of Pennsylvania Compositions and Methods of Treating T Cell Deficiency
EP2968249B1 (en) * 2013-02-22 2018-11-14 Samumed, LLC Gamma-diketones as wnt/beta -catenin signaling pathway activators
ES2762559T3 (es) * 2014-08-20 2020-05-25 Samumed Llc Gamma-dicetonas para tratamiento y prevención de envejecimiento de la piel y arrugas
IL319729A (en) * 2016-07-19 2025-05-01 Accellta Ltd Medium for growing pluripotent stem cells in suspension
BR112019013388A2 (pt) 2016-12-30 2020-03-03 Frequency Therapeutics, Inc. Compostos de 1h-pirrol-2,5-diona e métodos de uso dos mesmos para induzir a autorrenovação de células de suporte tronco/progenitoras
WO2020037323A1 (en) 2018-08-17 2020-02-20 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by upregulating jag-1
EP3837351A1 (en) 2018-08-17 2021-06-23 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by downregulating foxo
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