SI1335728T1 - Medicament compositions based on tiotropium salts and on salmeterol salts - Google Patents

Medicament compositions based on tiotropium salts and on salmeterol salts

Info

Publication number
SI1335728T1
SI1335728T1 SI200130347T SI200130347T SI1335728T1 SI 1335728 T1 SI1335728 T1 SI 1335728T1 SI 200130347 T SI200130347 T SI 200130347T SI 200130347 T SI200130347 T SI 200130347T SI 1335728 T1 SI1335728 T1 SI 1335728T1
Authority
SI
Slovenia
Prior art keywords
salts
salmeterol
compositions based
tiotropium
medicament compositions
Prior art date
Application number
SI200130347T
Other languages
English (en)
Inventor
Christel Schmelzer
Juergen Nagel
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of SI1335728T1 publication Critical patent/SI1335728T1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI200130347T 2000-11-13 2001-11-09 Medicament compositions based on tiotropium salts and on salmeterol salts SI1335728T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10056104A DE10056104A1 (de) 2000-11-13 2000-11-13 Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols
PCT/EP2001/012962 WO2002038154A1 (de) 2000-11-13 2001-11-09 Neue arzneimittelkompositionen auf der basis von tiotropiumsalzen und salzen des salmeterols

Publications (1)

Publication Number Publication Date
SI1335728T1 true SI1335728T1 (en) 2005-08-31

Family

ID=7663071

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200130347T SI1335728T1 (en) 2000-11-13 2001-11-09 Medicament compositions based on tiotropium salts and on salmeterol salts
SI200130751T SI1514546T1 (sl) 2000-11-13 2001-11-09 Sestavki zdravil na osnovi tiotropijevih soli in salmeterolnih soli

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200130751T SI1514546T1 (sl) 2000-11-13 2001-11-09 Sestavki zdravil na osnovi tiotropijevih soli in salmeterolnih soli

Country Status (32)

Country Link
EP (3) EP1514546B1 (cs)
JP (2) JP4282322B2 (cs)
KR (2) KR100940752B1 (cs)
CN (1) CN1678318A (cs)
AT (2) ATE291428T1 (cs)
AU (3) AU2791002A (cs)
BG (1) BG107781A (cs)
BR (1) BR0115226A (cs)
CA (1) CA2429012A1 (cs)
CY (1) CY1106774T1 (cs)
CZ (1) CZ20031444A3 (cs)
DE (3) DE10056104A1 (cs)
DK (2) DK1335728T3 (cs)
EA (1) EA007904B1 (cs)
EC (1) ECSP034571A (cs)
EE (1) EE200300228A (cs)
ES (2) ES2240549T3 (cs)
HR (1) HRP20030378A2 (cs)
HU (1) HUP0301447A3 (cs)
IL (2) IL155718A0 (cs)
MX (1) MXPA03004164A (cs)
NO (1) NO20032111L (cs)
NZ (1) NZ526400A (cs)
PL (1) PL205330B1 (cs)
PT (2) PT1335728E (cs)
RS (2) RS50286B (cs)
SG (1) SG167657A1 (cs)
SI (2) SI1335728T1 (cs)
SK (2) SK286950B6 (cs)
UA (1) UA74853C2 (cs)
WO (1) WO2002038154A1 (cs)
ZA (1) ZA200302921B (cs)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7214687B2 (en) 1999-07-14 2007-05-08 Almirall Ag Quinuclidine derivatives and medicinal compositions containing the same
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
ATE286716T1 (de) * 1999-11-23 2005-01-15 Glaxo Group Ltd Pharmazeutische formulierungen enthaltend salmeterol
EP1429768B1 (de) * 2001-09-14 2016-11-16 Boehringer Ingelheim Pharma GmbH & Co.KG Neue arzneimittel zur inhalation
US7311894B2 (en) 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
DE10214263A1 (de) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
US7250426B2 (en) 2002-11-29 2007-07-31 Boehringer Ingelheim Pharma Gmbh & Co Kg Tiotropium-containing pharmaceutical combination for inhalation
DE10256080A1 (de) * 2002-11-29 2004-06-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropiumhaltige Arzneimittelkombination für die Inhalation
JP2006510680A (ja) * 2002-12-16 2006-03-30 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト チオトロピウムを含有するｈｆｃ溶液調合物
UA83813C2 (ru) * 2002-12-20 2008-08-26 Бёрингер Ингельхайм Фарма Гмбх & Ко. Кг Порошковое лекарственное средство, которое содержит соль тиотропия и ксинафоат салметерола
DE10345065A1 (de) * 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
CN100549010C (zh) * 2003-11-03 2009-10-14 贝林格尔.英格海姆国际有限公司 制备噻托铵盐类的方法,噻托铵盐类及含有该盐类的医药制剂
UA82414C2 (uk) * 2003-11-03 2008-04-10 Бёрингер Ингельхайм Интернациональ Гмбх Солі тіотропію, спосіб їх одержання, а також лікарські композиції, які їх містять
SI1765404T1 (sl) * 2004-05-31 2009-04-30 Almirall Lab Kombinacije, ki obsegajo antimuskarinska sredstva in beta-adrenergične agoniste
ES2257152B1 (es) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
EP1881980B1 (en) 2005-05-02 2012-08-22 Boehringer Ingelheim International GmbH Novel crystalline forms of tiotropium bromide
WO2007017437A1 (en) * 2005-08-06 2007-02-15 Boehringer Ingelheim International Gmbh Method for the treatment of dyspnea comprising combined administration of tiotropium salts and salts of salmeterol
ES2298049B1 (es) 2006-07-21 2009-10-20 Laboratorios Almirall S.A. Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
US20120220557A1 (en) * 2011-02-17 2012-08-30 Chiesi Farmaceutici S.P.A. Liquid propellant-free formulation comprising an antimuscarinic drug
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
JP6335798B2 (ja) * 2012-02-28 2018-05-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規噴射剤含有チオトロピウム製剤
WO2015065222A1 (ru) * 2013-10-28 2015-05-07 Шолекс Девелопмент Гмбх Фармацевтический ингаляционный препарат для лечения бронхиальной астмы и хронической обструктивной болезни легких, содержащий в качестве активного вещества микронизированный тиотропия бромид, и способ его получения
TW201835041A (zh) 2017-02-17 2018-10-01 印度商托仁特生技有限公司 具β-腎上腺素促效劑及抗蕈毒活性化合物
WO2019142214A1 (en) * 2018-01-19 2019-07-25 Cipla Limited Pharmaceutical composition comprising tiotropium for inhalation
CN111936124A (zh) * 2018-07-26 2020-11-13 四川海思科制药有限公司 一种含格隆铵盐及茚达特罗盐的气雾剂药物组合物及其制备方法与应用
CN116196298A (zh) * 2018-07-26 2023-06-02 四川海思科制药有限公司 一种含格隆铵盐的气雾剂药物组合物及其制备方法与应用
WO2022119661A1 (en) * 2020-12-04 2022-06-09 Tygrus, LLC THERAPEUTIC MATERIAL WITH LOW pH AND LOW TOXICITY ACTIVE AGAINST AT LEAST ONE PATHOGEN FOR ADDRESSING PATIENTS WITH RESPIRATORY ILLNESSES
US11826382B2 (en) 2020-05-01 2023-11-28 Tygrus, LLC Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses
US11642372B2 (en) 2020-05-01 2023-05-09 Tygrus, LLC Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses
US12042514B2 (en) 2020-05-01 2024-07-23 Tygrus, LLC Therapeutic material with low pH and low toxicity active against at least one pathogen for addressing patients with respiratory illnesses

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1100465B1 (de) * 1998-07-24 2004-11-24 Jago Research Ag Medizinische aerosolformulierungen
DE19835346A1 (de) * 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren
DE19847971A1 (de) * 1998-10-17 1999-09-02 Schiering Verfahren und Einrichtung zur Verhinderung von Filterbränden (Staubfilter)
DE19847970A1 (de) * 1998-10-17 2000-04-20 Boehringer Ingelheim Pharma Lagerfähige Wirkstoff-Formulierung
DE19921693A1 (de) * 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
DE19961300A1 (de) * 1999-12-18 2001-06-21 Asta Medica Ag Vorratssystem für Arzneimittel in Pulverform und damit ausgestatteter Inhalator

Also Published As

Publication number Publication date
ATE291428T1 (de) 2005-04-15
CA2429012A1 (en) 2002-05-16
AU2007202303B2 (en) 2010-01-21
SK7412003A3 (en) 2003-10-07
AU2002227910B2 (en) 2007-03-01
AU2007202303A1 (en) 2007-06-14
DE50105729D1 (de) 2005-04-28
KR20080079701A (ko) 2008-09-01
BG107781A (bg) 2004-06-30
JP4282322B2 (ja) 2009-06-17
EP1514546A1 (de) 2005-03-16
KR100886094B1 (ko) 2009-02-27
KR100940752B1 (ko) 2010-02-11
EE200300228A (et) 2003-10-15
IL155718A0 (en) 2003-11-23
EA200300503A1 (ru) 2004-12-30
AU2791002A (en) 2002-05-21
IL155718A (en) 2010-06-30
JP4282594B2 (ja) 2009-06-24
SI1514546T1 (sl) 2007-10-31
EP1808174A1 (de) 2007-07-18
ES2240549T3 (es) 2005-10-16
EA007904B1 (ru) 2007-02-27
WO2002038154A1 (de) 2002-05-16
CY1106774T1 (el) 2012-05-23
DK1335728T3 (da) 2005-04-18
HUP0301447A3 (en) 2007-10-29
PL205330B1 (pl) 2010-04-30
SG167657A1 (en) 2011-01-28
NZ526400A (en) 2005-09-30
ZA200302921B (en) 2004-04-19
ECSP034571A (es) 2003-06-25
DK1514546T3 (da) 2007-09-24
PL365989A1 (en) 2005-01-24
NO20032111L (no) 2003-07-08
ATE362761T1 (de) 2007-06-15
EP1335728A1 (de) 2003-08-20
RS50286B (sr) 2009-09-08
HRP20030378A2 (en) 2005-04-30
CZ20031444A3 (cs) 2003-08-13
EP1514546B1 (de) 2007-05-23
BR0115226A (pt) 2003-10-07
SK286950B6 (sk) 2009-08-06
PT1335728E (pt) 2005-05-31
HUP0301447A2 (hu) 2003-10-28
EP1335728B1 (de) 2005-03-23
UA74853C2 (en) 2006-02-15
DE10056104A1 (de) 2002-05-23
SK286939B6 (sk) 2009-07-06
DE50112535D1 (de) 2007-07-05
CN1678318A (zh) 2005-10-05
MXPA03004164A (es) 2005-08-16
PT1514546E (pt) 2007-06-15
YU35503A (sh) 2006-05-25
JP2005068163A (ja) 2005-03-17
NO20032111D0 (no) 2003-05-12
KR20030065509A (ko) 2003-08-06
RS20090105A (sr) 2009-07-15
JP2004513146A (ja) 2004-04-30
ES2287629T3 (es) 2007-12-16

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