SI1256585T1 - Process for preparing 9-(2-(diethylphosphonomethoxy)ethyl)-adenine - Google Patents

Process for preparing 9-(2-(diethylphosphonomethoxy)ethyl)-adenine

Info

Publication number
SI1256585T1
SI1256585T1 SI9830716T SI9830716T SI1256585T1 SI 1256585 T1 SI1256585 T1 SI 1256585T1 SI 9830716 T SI9830716 T SI 9830716T SI 9830716 T SI9830716 T SI 9830716T SI 1256585 T1 SI1256585 T1 SI 1256585T1
Authority
SI
Slovenia
Prior art keywords
diethylphosphonomethoxy
adenine
ethyl
preparing
Prior art date
Application number
SI9830716T
Other languages
English (en)
Slovenian (sl)
Inventor
Murty N Arimilli
Thomas T.K Lee
Lawrence V Manes
John D. Munger Jr
Ernest J Prisbe
Lisa M Schultze
Daphne E Kelly
Original Assignee
Gilead Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26732226&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1256585(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Priority claimed from EP02016429A external-priority patent/EP1256585B1/en
Publication of SI1256585T1 publication Critical patent/SI1256585T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Transplanting Machines (AREA)
SI9830716T 1997-07-25 1998-07-23 Process for preparing 9-(2-(diethylphosphonomethoxy)ethyl)-adenine SI1256585T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90074597A 1997-07-25 1997-07-25
US5377197P 1997-07-25 1997-07-25
EP02016429A EP1256585B1 (en) 1997-07-25 1998-07-23 Process for preparing 9-(2-(diethylphosphonomethoxy)ethyl)-adenine

Publications (1)

Publication Number Publication Date
SI1256585T1 true SI1256585T1 (en) 2005-02-28

Family

ID=26732226

Family Applications (2)

Application Number Title Priority Date Filing Date
SI9830716T SI1256585T1 (en) 1997-07-25 1998-07-23 Process for preparing 9-(2-(diethylphosphonomethoxy)ethyl)-adenine
SI9830712T SI1256584T1 (en) 1997-07-25 1998-07-23 Process for preparing Adefovir Dipivoxil

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI9830712T SI1256584T1 (en) 1997-07-25 1998-07-23 Process for preparing Adefovir Dipivoxil

Country Status (24)

Country Link
EP (1) EP0996430B1 (da)
JP (4) JP3573713B2 (da)
KR (3) KR100700087B1 (da)
CN (2) CN1216062C (da)
AR (1) AR016548A1 (da)
AT (3) ATE277936T1 (da)
AU (1) AU747163B2 (da)
BR (1) BR9811552A (da)
CA (3) CA2298057C (da)
CO (1) CO4980869A1 (da)
DE (3) DE69826735T2 (da)
DK (1) DK0996430T3 (da)
ES (3) ES2187991T3 (da)
HK (5) HK1046357B (da)
ID (1) ID28006A (da)
IL (1) IL133461A (da)
IN (1) IN190037B (da)
MY (1) MY129451A (da)
NZ (1) NZ501659A (da)
PT (3) PT1256585E (da)
SI (2) SI1256585T1 (da)
TR (3) TR200200117T2 (da)
TW (1) TW584635B (da)
WO (1) WO1999004774A2 (da)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100700087B1 (ko) * 1997-07-25 2007-03-28 길리애드 사이언시즈, 인코포레이티드 뉴클레오티드 동족체의 제조 방법
TWI230618B (en) * 1998-12-15 2005-04-11 Gilead Sciences Inc Pharmaceutical compositions of 9-[2-[[bis[(pivaloyloxy)methyl]phosphono]methoxy]ethyl]adenine and tablets or capsules containing the same
US6635278B1 (en) * 1998-12-15 2003-10-21 Gilead Sciences, Inc. Pharmaceutical formulations
JP4651264B2 (ja) 2000-07-21 2011-03-16 ギリアード サイエンシーズ， インコーポレイテッド ホスホネートヌクレオチドアナログのプロドラッグならびにこれを選択および作製するための方法。
EP1504014B1 (en) 2002-05-13 2015-12-02 Metabasis Therapeutics, Inc. Process for preparation of cyclic prodrugs of pmea and pmpa
JP4476811B2 (ja) 2002-05-13 2010-06-09 メタバシス・セラピューティクス・インコーポレイテッド Ｐｍｅａおよびそのアナログの新規ホスホン酸系プロドラッグ
CN100383149C (zh) * 2002-11-12 2008-04-23 天津帝士力投资控股集团有限公司 一种新的晶状埃地双酯及其组合物
AU2003284800A1 (en) * 2002-11-12 2004-06-03 Tianjin Kinsly Pharmaceutical Co., Ltd. A new crystal form of adefovir dipivoxil and its composition
CN1303089C (zh) * 2002-11-19 2007-03-07 天津药物研究院 阿德福韦酯结晶形态及其制备方法
CN100415756C (zh) * 2003-10-14 2008-09-03 沈阳药科大学 草酸阿地福韦酯及其晶型和制备方法及用途
CN100358907C (zh) * 2004-03-31 2008-01-02 河北医科大学生物医学工程中心 一种非晶状阿德福韦酯的制备方法
CN100374118C (zh) * 2004-05-20 2008-03-12 江苏吴中中药研发有限公司 含有阿德福韦酯的滴丸剂及其制备方法
KR20070029196A (ko) 2004-06-08 2007-03-13 메타베이시스 테라퓨틱스, 인크. 고리 에스테르의 루이스 산 매개 합성
CN102240295B (zh) * 2005-06-13 2013-04-03 博瑞生物医药技术(苏州)有限公司 泰诺福韦衍生物及用途
CN100395248C (zh) * 2006-05-26 2008-06-18 华东理工大学 一种9-(二乙氧基磷酰基甲氧基乙基)-腺嘌啉的制备方法
ITMI20071594A1 (it) * 2007-08-02 2009-02-03 Solmag Spa Forma cristallina monoidrata di adefovir dipivoxil
CN101343290B (zh) * 2008-05-24 2011-02-02 广东肇庆星湖生物科技股份有限公司 一种阿德福韦酯无水结晶物的制备方法、所得的阿德福韦酯无水结晶物及其应用
WO2010005195A2 (ko) * 2008-07-07 2010-01-14 (주)아모레퍼시픽 아데포버 디피복실의 결정형 ｌ의 제조방법
KR20100031045A (ko) 2008-09-11 2010-03-19 씨제이제일제당 (주) 아데포비어 디피복실의 정제방법
EP2332941A4 (en) * 2008-09-17 2012-08-08 Cj Cheiljedang Corp STABILIZED SOLIDS DISPERSION FROM ADEFOVIR-DIPIVOXIL AND PROCESS FOR THE PRODUCTION THEREOF
KR20100032803A (ko) 2008-09-18 2010-03-26 씨제이제일제당 (주) 아데포비어디피복실의 개선된 제조방법
KR20100061401A (ko) * 2008-11-28 2010-06-07 (주)아모레퍼시픽 아데포버 디피복실의 결정형, 그 제조방법 및 그를 포함하는 약제학적 조성물
EP2411392B1 (en) 2009-03-26 2014-02-26 Daewoong Pharmaceutical Co., Ltd. Novel crystal forms of adefovir dipivoxil and processes for preparing the same
KR20100113302A (ko) * 2009-04-13 2010-10-21 한미홀딩스 주식회사 결정형 아데포비어 디피복실의 제조방법 및 이에 사용되는 아데포비어 디피복실 부탄올레이트
KR101528754B1 (ko) * 2009-04-14 2015-06-17 중앙대학교 산학협력단 신규한 복합결정형의 화합물, 그 제조방법 및 이를 포함하는 약제학적 조성물
KR100971486B1 (ko) * 2009-06-11 2010-07-21 주식회사 셀트리온화학연구소 아데포비어 다이피복실 말론산염 및 이를 포함하는 약제학적 조성물
KR101089620B1 (ko) * 2009-07-20 2011-12-06 경희대학교 산학협력단 무수결정형 아데포비어 디피복실 및 이온성 액체를 사용한 이의 제조 방법
WO2011016611A2 (ko) * 2009-08-03 2011-02-10 제일약품주식회사 새로운 결정형을 갖는 아데포비어 디피복실, 이의 제조방법 및 이를 유효성분으로 함유하는 만성 ｂ형 간염의 예방 또는 치료용 조성물
KR101129575B1 (ko) * 2009-09-02 2012-03-28 경희대학교 산학협력단 반수화물 아데포비어 디피복실 및 이온성 액체를 사용한 이의 제조 방법
KR101048024B1 (ko) * 2009-10-09 2011-07-13 주식회사 삼오제약 9-(2-포스포닐메톡시에틸)아데닌, 아데포비아 디피복실 및 무정형 아데포비아 디피복실의 제조방법
EP2343056A1 (en) 2009-12-30 2011-07-13 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Producing stable adefovir dipivoxil solid dispersions
WO2012032541A1 (en) * 2010-09-06 2012-03-15 Matrix Laboratories Ltd "adefovir dipivoxil pseudopolymorph"
WO2012062835A1 (en) 2010-11-12 2012-05-18 Glaxo Wellcome Manufacturing Pte Ltd Novel pharmaceutical compositions
CN102250146A (zh) * 2011-05-27 2011-11-23 扬州三友合成化工有限公司 抗乙肝药物阿德福韦的一种合成方法
KR101357687B1 (ko) * 2011-11-25 2014-02-05 숭실대학교산학협력단 고분자 첨가제를 이용한 아데포비어 디피복실 복합체의 결정입자 제어방법 및 이의 응용
KR101258678B1 (ko) 2012-02-29 2013-04-26 제일약품주식회사 새로운 결정형을 갖는 아데포비어 디피복실, 이의 제조방법 및 이를 유효성분으로 함유하는 만성 β형 간염의 예방 또는 치료용 조성물
CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
CN102816184B (zh) * 2012-09-07 2015-11-18 山东大学 (2-(2-氧基-4-硫代嘧啶)乙氧基)甲基膦酸酯类衍生物及其制备与应用
CN103709198A (zh) * 2012-09-28 2014-04-09 江苏天士力帝益药业有限公司 一种阿德福韦酯的结晶方法
CN103333208B (zh) * 2013-06-04 2016-05-11 广州晶莱医药科技有限公司 阿德福韦酯马来酸盐及其制备方法和组合物
US10449210B2 (en) 2014-02-13 2019-10-22 Ligand Pharmaceuticals Inc. Prodrug compounds and their uses
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
EP3372227A1 (en) 2017-03-06 2018-09-12 MH10 Spolka z ograniczona odpowiedzialnoscia Tablet formulation of adefovir dipivoxil
US11970482B2 (en) 2018-01-09 2024-04-30 Ligand Pharmaceuticals Inc. Acetal compounds and therapeutic uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0481214T3 (da) * 1990-09-14 1999-02-22 Acad Of Science Czech Republic Prolægemidler af phosphonater
ATE199906T1 (de) * 1993-06-29 2001-04-15 Mitsubishi Chem Corp Phosphonat-nukleotid ester-derivate
JP4033494B2 (ja) * 1996-07-26 2008-01-16 ギリヤド サイエンシーズ， インコーポレイテッド ヌクレオチドアナログ
KR100700087B1 (ko) * 1997-07-25 2007-03-28 길리애드 사이언시즈, 인코포레이티드 뉴클레오티드 동족체의 제조 방법

Also Published As

Publication number Publication date
KR100700089B1 (ko) 2007-03-28
EP0996430B1 (en) 2002-11-27
KR20060038363A (ko) 2006-05-03
JP2003342283A (ja) 2003-12-03
CN1274700C (zh) 2006-09-13
TR200200117T2 (tr) 2002-06-21
ES2229030T3 (es) 2005-04-16
CA2596320C (en) 2008-12-23
ATE277937T1 (de) 2004-10-15
HK1051694A1 (en) 2003-08-15
ES2187991T3 (es) 2003-06-16
IL133461A (en) 2005-05-17
TR200200137T2 (tr) 2002-09-23
JP2001512712A (ja) 2001-08-28
CN1216062C (zh) 2005-08-24
ATE228357T1 (de) 2002-12-15
CA2596320A1 (en) 1999-02-04
HK1051693A1 (en) 2003-08-15
KR20010014284A (ko) 2001-02-26
AU747163B2 (en) 2002-05-09
IL133461A0 (en) 2001-04-30
MY129451A (en) 2007-04-30
CN1251592A (zh) 2000-04-26
WO1999004774A2 (en) 1999-02-04
DE69826735D1 (de) 2004-11-04
JP3573713B2 (ja) 2004-10-06
JP2005306879A (ja) 2005-11-04
AU8660998A (en) 1999-02-16
DE69809749T2 (de) 2003-09-11
ID28006A (id) 2001-05-03
HK1046357A1 (en) 2003-01-10
CA2596497C (en) 2008-12-23
KR20060038364A (ko) 2006-05-03
KR100618663B1 (ko) 2006-09-08
DE69826734D1 (de) 2004-11-04
NZ501659A (en) 2004-12-24
DE69826734T2 (de) 2005-10-06
CA2298057C (en) 2008-11-18
KR100700087B1 (ko) 2007-03-28
HK1046357B (zh) 2007-08-24
AR016548A1 (es) 2001-07-25
JP4452034B2 (ja) 2010-04-21
DK0996430T3 (da) 2003-03-10
CA2596497A1 (en) 1999-02-04
CN1347695A (zh) 2002-05-08
HK1091211A1 (en) 2007-01-12
CA2298057A1 (en) 1999-02-04
JP2009263389A (ja) 2009-11-12
ATE277936T1 (de) 2004-10-15
EP0996430A2 (en) 2000-05-03
DE69809749D1 (de) 2003-01-09
ES2229029T3 (es) 2005-04-16
PT996430E (pt) 2003-03-31
DE69826735T2 (de) 2005-10-06
CO4980869A1 (es) 2000-11-27
SI1256584T1 (en) 2005-02-28
TR200000224T2 (tr) 2000-07-21
IN190037B (da) 2003-05-31
PT1256585E (pt) 2005-01-31
WO1999004774A3 (en) 1999-04-15
HK1091212A1 (en) 2007-01-12
BR9811552A (pt) 2000-08-29
TW584635B (en) 2004-04-21
PT1256584E (pt) 2004-12-31

Similar Documents

Publication Publication Date Title
SI1256585T1 (en) Process for preparing 9-(2-(diethylphosphonomethoxy)ethyl)-adenine
CZ252597A3 (cs) Způsob výroby azacyklohexapeptidů
HUP0004239A3 (en) Process for synthesizing phosphodiesters
AU1542697A (en) Process for preparing purine derivatives
HUP9900318A3 (en) Process for preparing 4-aryl-piperidine derivatives
AU7984198A (en) Process for preparing hydrofluorocarbons
HUP0004251A3 (en) Method for preparing bromomethyl-biphenyl derivatives
AU7582698A (en) Apparatus for holding an article
EP1023250A4 (en) METHOD FOR PRODUCING 2,6-DIALKYLNAPHTHALINE
EP1026255A4 (en) PROCESS FOR THE PREPARATION OF XYLITOL
SG70092A1 (en) Process for preparing dialkylnaphthalene
AU1592997A (en) Process for preparing purine derivatives
IL134059A0 (en) Process for preparing aminoarylacetylenes
EG23935A (en) Process for preparing eprosartin
IL118992A (en) Process for preparing norbenzomorphan derivatives
IL136602A0 (en) Process for preparing toluene derivatives
EG22077A (en) Process for preparing 4-substituted-ih-indole-3 glyoxamides
EP1026254A4 (en) METHOD FOR PRODUCING XYLITOL
AU1592897A (en) Process for preparing purine derivatives
AU8647398A (en) Process for preparing pentafluoroethane
IL126184A0 (en) Process for preparing pentafluoropentanol
GR3035341T3 (en) Process for preparing dioxoazabicyclohexanes
IL133288A (en) Process for preparing 3-isochromanone
AU8799298A (en) Process for preparing nifedipine
IL125646A0 (en) Process for preparing n-pyruvyl-l-proline