SI0918791T1 - Process for producing drospirenone and intermediates thereof - Google Patents

Process for producing drospirenone and intermediates thereof

Info

Publication number
SI0918791T1
SI0918791T1 SI9730350T SI9730350T SI0918791T1 SI 0918791 T1 SI0918791 T1 SI 0918791T1 SI 9730350 T SI9730350 T SI 9730350T SI 9730350 T SI9730350 T SI 9730350T SI 0918791 T1 SI0918791 T1 SI 0918791T1
Authority
SI
Slovenia
Prior art keywords
15beta
16beta
6beta
7beta
17alpha
Prior art date
Application number
SI9730350T
Other languages
English (en)
Slovenian (sl)
Inventor
J�rg-Thorsten MOHR
Klaus Nickisch
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7803224&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI0918791(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of SI0918791T1 publication Critical patent/SI0918791T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/007—3 membered carbocyclic rings in position 6-7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Fats And Perfumes (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
SI9730350T 1996-08-12 1997-08-11 Process for producing drospirenone and intermediates thereof SI0918791T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19633685A DE19633685C1 (de) 1996-08-12 1996-08-12 Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
PCT/EP1997/004342 WO1998006738A1 (de) 1996-08-12 1997-08-11 Verfahren zur herstellung von drospirenon und zwischenprodukten davon
EP97937562A EP0918791B3 (de) 1996-08-12 1997-08-11 Verfahren zur herstellung von drospirenon und zwischenprodukte davon

Publications (1)

Publication Number Publication Date
SI0918791T1 true SI0918791T1 (en) 2002-12-31

Family

ID=7803224

Family Applications (3)

Application Number Title Priority Date Filing Date
SI9730786T SI1149840T2 (sl) 1996-08-12 1997-08-11 Postopek priprave drospirenona
SI9730350T SI0918791T1 (en) 1996-08-12 1997-08-11 Process for producing drospirenone and intermediates thereof
SI9730790T SI1149841T1 (sl) 1996-08-12 1997-08-11 Postopek za pripravo 6beta,7beta;15beta,16beta-dimetilen-5beta-hidroksi-3-okso-17alfa- androstan-21,17-karbolaktona

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI9730786T SI1149840T2 (sl) 1996-08-12 1997-08-11 Postopek priprave drospirenona

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI9730790T SI1149841T1 (sl) 1996-08-12 1997-08-11 Postopek za pripravo 6beta,7beta;15beta,16beta-dimetilen-5beta-hidroksi-3-okso-17alfa- androstan-21,17-karbolaktona

Country Status (27)

Country Link
US (2) US6121465A (xx)
EP (4) EP2168974B1 (xx)
JP (1) JP3333524B2 (xx)
KR (1) KR100473297B1 (xx)
CN (1) CN1158300C (xx)
AT (3) ATE446966T1 (xx)
AU (1) AU729149B2 (xx)
BG (1) BG62776B1 (xx)
BR (1) BR9711060A (xx)
CA (1) CA2261137C (xx)
CZ (1) CZ297255B6 (xx)
DE (4) DE19633685C1 (xx)
DK (4) DK2168974T3 (xx)
EA (1) EA001947B1 (xx)
ES (4) ES2320626T5 (xx)
HK (1) HK1021190A1 (xx)
HU (1) HU223106B1 (xx)
IL (1) IL127963A (xx)
IS (1) IS2100B (xx)
NZ (1) NZ333697A (xx)
PL (1) PL187474B1 (xx)
PT (4) PT2168974E (xx)
SI (3) SI1149840T2 (xx)
SK (1) SK283546B6 (xx)
TR (1) TR199900262T2 (xx)
UA (1) UA55423C2 (xx)
WO (1) WO1998006738A1 (xx)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9394334B2 (en) 2011-11-22 2016-07-19 Industriale Chimica S.R.L. Process for the preparation of drospirenone

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19633685C1 (de) 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
PT1214076E (pt) 1999-08-31 2004-04-30 Schering Ag Combinacao farmaceutica de etinilestradiol e drospirenona para utilizacao como um contraceptivo
EP2305267A3 (en) 1999-08-31 2011-08-17 Bayer Schering Pharma Aktiengesellschaft Pharmaceutical combination of ethinylestradiol and drospirenone for use as a contraceptive
US6787531B1 (en) * 1999-08-31 2004-09-07 Schering Ag Pharmaceutical composition for use as a contraceptive
US20020132801A1 (en) * 2001-01-11 2002-09-19 Schering Aktiengesellschaft Drospirenone for hormone replacement therapy
SK287719B6 (en) * 2000-01-18 2011-07-06 Bayer Schering Pharma Ag Drospirenone for hormone replacement therapy
EP1406634A1 (en) 2001-07-13 2004-04-14 Schering Aktiengesellschaft Combination of drospirenone and an estrogen sulphamate for hrt
AU2003239162A1 (en) 2002-04-26 2003-11-10 Schering Ag Treatment of hypertension in women receiving hormone replacement therapy
US7786101B2 (en) * 2002-11-05 2010-08-31 Bayer Schering Pharma Ag Cardiovascular protection using anti-aldosteronic progestins
CL2004000574A1 (es) * 2003-03-21 2005-02-11 Pharmacia Corp Sa Organizada B Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion.
ITMI20040367A1 (it) * 2004-03-01 2004-06-01 Ind Chimica Srl Processo per la preparazione di drospirenone
HUP0402465A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main intermediates of the process
HUP0402466A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
DE102004058300B4 (de) * 2004-12-02 2016-09-15 Austriamicrosystems Ag Schaltungsanordnung zur Erzeugung eines komplexen Signals und Verwendung in einem Hochfrequenz-Sender oder -Empfänger
ITMI20042338A1 (it) * 2004-12-06 2005-03-06 Ind Chimica Srl Processo per la preparazione di drospirenone
DE502005004948D1 (de) * 2005-07-21 2008-09-18 Bayer Schering Pharma Ag Verfahren zur Herstellung von 3-Oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie Oxidation von 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanen
US7319154B2 (en) 2005-07-21 2008-01-15 Bayer Schering Pharma Ag Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes
KR101410583B1 (ko) * 2005-07-21 2014-06-23 바이엘 파마 악티엔게젤샤프트 17-(3-히드록시프로필)-3,17-디히드록시안드로스탄의금속-무함유 산화에 의한3-옥소-프레근-4-엔-21,17-카르보락톤의 제조 방법
US20070255381A1 (en) 2006-04-27 2007-11-01 Peter Meyer Electrode pad packaging systems and methods
EP1902711A1 (en) * 2006-09-20 2008-03-26 KAIROSmed GmbH Oral modified release formulations containing Drospirenon and 8-Prenylnaringenin for use in Hormone Replacement Therapy (HRT)
WO2008137050A2 (en) 2007-05-01 2008-11-13 Sicor Inc. A process for preparing drospirenone and intermediate thereof
DE102007030596B3 (de) * 2007-06-28 2009-03-12 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden
US7960368B2 (en) * 2008-03-05 2011-06-14 Everstra, Inc. Bismethylene-17A carbolactones and related uses
US8222237B2 (en) * 2008-11-25 2012-07-17 Evestra, Inc. Progestational 3-(6,6-ethylene-17B-hydroxy-3-oxo-17A-pregna-4-ene-17A-yl)propionic acid G-lactones
WO2010094623A1 (en) 2009-02-18 2010-08-26 Bayer Schering Pharma Aktiengesellschaft Formulation comprising drospirenone for subcutaneous or intramuscular administration
US20120114757A1 (en) 2009-02-18 2012-05-10 Bayer Pharma Aktiengesellschaft Particles comprising drospirenone encapsulated in a polymer
US8334375B2 (en) * 2009-04-10 2012-12-18 Evestra, Inc. Methods for the preparation of drospirenone
ES2432063T3 (es) * 2009-06-16 2013-11-29 Crystal Pharma, S.A.U. Procedimiento para la obtención de 17-espirolactonas en esteroides
DE102009031909B4 (de) 2009-07-01 2017-02-09 Heyl Chemisch-Pharmazeutische Fabrik Gmbh & Co. Kg Verfahren zur Herstellung von Drospirenon aus Prasteron
US8921346B2 (en) 2010-03-16 2014-12-30 Taizhou Taifa Pharmaceuticals Co., Ltd. Preparation method of drospirenone
CN101830959B (zh) * 2010-05-27 2012-07-18 杭州龙山化工有限公司 一种曲螺酮的合成方法
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
US11351122B1 (en) 2010-07-28 2022-06-07 Laboratorios Leon Farma Sa Synthetic progestogens and pharmaceutical compositions comprising the same
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
ES2419663T3 (es) 2010-08-03 2013-08-21 Newchem S.P.A. Métodos para la preparación de Drospirenona y productos intermedios de la misma
WO2012107513A1 (en) 2011-02-10 2012-08-16 Crystal Pharma, S.A.U. Process for obtaining drospirenone
ITMI20111383A1 (it) 2011-07-25 2013-01-26 Ind Chimica Srl Processo per la preparazione di drospirenone
CA2854215A1 (en) * 2011-11-04 2013-05-10 Bayer Pharma Aktiengesellschaft 18-methyl-6,7-methylene-3-oxo-17-pregn-4-ene-21,17.beta.-carbolactones, pharmaceutical preparations comprising said compounds and use thereof in the treatment of endometriosis
EP2597101A1 (en) 2011-11-22 2013-05-29 Industriale Chimica S.R.L. Process for the preparation of drospirenone
ES2651145T3 (es) 2013-02-20 2018-01-24 Industriale Chimica S.R.L. Proceso para la preparación de drospirenona
HUE032858T2 (en) 2013-04-12 2017-11-28 Ind Chimica Srl Method for producing drospirenone
MY187233A (en) 2015-06-23 2021-09-13 Laboratorios Leon Farma Sa Drospirenone-based contraceptive for a female patient affected with excess weight
EP3108889A1 (en) 2015-06-23 2016-12-28 Philippe Perrin Drospirenone-based contraceptive for a female patient affected with excess weight
CN113387993A (zh) * 2021-07-06 2021-09-14 江西百思康瑞药业有限公司 一种屈螺酮的合成方法
EP4134082A1 (en) 2021-08-12 2023-02-15 Chemo Research, S.L. Method for treating endometriosis and providing effective contraception
WO2023152658A1 (en) 2022-02-10 2023-08-17 Lupin Limited Slow release drospirenone tablet composition
WO2023165988A1 (en) 2022-03-01 2023-09-07 Chemo Research, S.L. Chewable oral contraceptive

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DE2652761C2 (de) * 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE3022337A1 (de) * 1980-06-11 1982-01-07 Schering Ag Berlin Und Bergkamen, 1000 Berlin Praeparate zur kontrazeption und zur behandlung gynaekologischer stoerungen
DE3042136A1 (de) * 1980-11-03 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden
EP0075189B1 (en) * 1981-09-21 1985-08-28 Schering Aktiengesellschaft 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation
DE3414508A1 (de) * 1984-04-13 1985-10-24 Schering AG, 1000 Berlin und 4709 Bergkamen Mehrfach tritiierte steroid-20.17-spirolactone und ihre verwendung als tracersubstanzen
DE3626838A1 (de) * 1986-08-08 1988-02-11 Schering Ag Verfahren zur herstellung von 17(alpha)-pregnan-21,17-carbolactonen
US5106995A (en) * 1989-05-05 1992-04-21 Isp Investments Inc. Production of lactones from diols
DE19633685C1 (de) 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9394334B2 (en) 2011-11-22 2016-07-19 Industriale Chimica S.R.L. Process for the preparation of drospirenone

Also Published As

Publication number Publication date
DE59712991D1 (de) 2009-02-26
EP0918791A1 (de) 1999-06-02
ES2438941T3 (es) 2014-07-21
KR100473297B1 (ko) 2005-03-07
ATE215557T1 (de) 2002-04-15
CA2261137A1 (en) 1998-02-19
US6933395B1 (en) 2005-08-23
SI1149841T1 (sl) 2010-02-26
KR20000029939A (ko) 2000-05-25
JP2000516226A (ja) 2000-12-05
CN1158300C (zh) 2004-07-21
EP2168974A2 (de) 2010-03-31
PL331530A1 (en) 1999-07-19
EP1149840B2 (de) 2013-05-15
BG62776B1 (bg) 2000-07-31
EP1149840A3 (de) 2004-12-01
EP0918791B8 (de) 2003-01-08
HU223106B1 (hu) 2004-03-29
HUP9903089A3 (en) 2001-07-30
ATE420098T1 (de) 2009-01-15
UA55423C2 (uk) 2003-04-15
PT918791E (pt) 2002-09-30
BG102976A (en) 1999-08-31
AU729149B2 (en) 2001-01-25
US6121465A (en) 2000-09-19
EP1149841A2 (de) 2001-10-31
IS4965A (is) 1999-01-29
ES2320626T5 (es) 2013-09-05
JP3333524B2 (ja) 2002-10-15
NZ333697A (en) 2000-08-25
CZ297255B6 (cs) 2006-10-11
DK1149840T5 (da) 2013-09-30
WO1998006738A1 (de) 1998-02-19
DK2168974T3 (da) 2014-08-11
EA199900153A1 (ru) 1999-06-24
EP1149841A3 (de) 2004-12-01
ES2320626T3 (es) 2009-05-27
TR199900262T2 (xx) 1999-03-22
DE19633685C1 (de) 1997-10-09
SI1149840T1 (sl) 2009-06-30
IL127963A (en) 2004-06-20
IL127963A0 (en) 1999-11-30
EP2168974A3 (de) 2013-03-06
DK1149841T3 (da) 2010-03-08
SK19499A3 (en) 1999-10-08
CZ47099A3 (cs) 1999-05-12
IS2100B (is) 2006-04-12
DE59713018D1 (de) 2009-12-10
CN1223662A (zh) 1999-07-21
AU4014497A (en) 1998-03-06
ES2335860T3 (es) 2010-04-06
PL187474B1 (pl) 2004-07-30
DK1149840T3 (da) 2009-04-27
EA001947B1 (ru) 2001-10-22
EP1149840A2 (de) 2001-10-31
SK283546B6 (sk) 2003-09-11
ES2175451T3 (es) 2002-11-16
ES2438941T1 (es) 2014-01-20
DK0918791T3 (da) 2002-07-15
EP0918791B1 (de) 2002-04-03
EP1149840B1 (de) 2009-01-07
PT2168974E (pt) 2014-08-26
EP2168974B1 (de) 2014-07-02
CA2261137C (en) 2005-03-15
PT1149841E (pt) 2010-01-29
EP1149841B1 (de) 2009-10-28
ATE446966T1 (de) 2009-11-15
DE59706887D1 (de) 2002-05-08
EP0918791B3 (de) 2012-01-18
SI1149840T2 (sl) 2013-08-30
PT1149840E (pt) 2009-03-31
HK1021190A1 (en) 2000-06-02
DK1149840T4 (da) 2013-07-01
ES2175451T7 (es) 2012-11-19
BR9711060A (pt) 1999-08-17

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