HK1021190A1 - Process for producing drospirenone and 6b,7b;15b,16b-dimethylene-5b-hydroxy-3-oxo-17a-androstane-21,17-carbolactone used as intermediate in the process. - Google Patents

Process for producing drospirenone and 6b,7b;15b,16b-dimethylene-5b-hydroxy-3-oxo-17a-androstane-21,17-carbolactone used as intermediate in the process.

Info

Publication number
HK1021190A1
HK1021190A1 HK99105743A HK99105743A HK1021190A1 HK 1021190 A1 HK1021190 A1 HK 1021190A1 HK 99105743 A HK99105743 A HK 99105743A HK 99105743 A HK99105743 A HK 99105743A HK 1021190 A1 HK1021190 A1 HK 1021190A1
Authority
HK
Hong Kong
Prior art keywords
dimethylene
carbolactone
androstane
oxo
hydroxy
Prior art date
Application number
HK99105743A
Other languages
English (en)
Inventor
Jorg-Thorsten Mohr
Klaus Nickisch
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7803224&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1021190(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag filed Critical Schering Ag
Publication of HK1021190A1 publication Critical patent/HK1021190A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/007—3 membered carbocyclic rings in position 6-7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
HK99105743A 1996-08-12 1999-12-09 Process for producing drospirenone and 6b,7b;15b,16b-dimethylene-5b-hydroxy-3-oxo-17a-androstane-21,17-carbolactone used as intermediate in the process. HK1021190A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19633685A DE19633685C1 (de) 1996-08-12 1996-08-12 Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
PCT/EP1997/004342 WO1998006738A1 (de) 1996-08-12 1997-08-11 Verfahren zur herstellung von drospirenon und zwischenprodukten davon

Publications (1)

Publication Number Publication Date
HK1021190A1 true HK1021190A1 (en) 2000-06-02

Family

ID=7803224

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99105743A HK1021190A1 (en) 1996-08-12 1999-12-09 Process for producing drospirenone and 6b,7b;15b,16b-dimethylene-5b-hydroxy-3-oxo-17a-androstane-21,17-carbolactone used as intermediate in the process.

Country Status (27)

Country Link
US (2) US6121465A (xx)
EP (4) EP1149841B1 (xx)
JP (1) JP3333524B2 (xx)
KR (1) KR100473297B1 (xx)
CN (1) CN1158300C (xx)
AT (3) ATE446966T1 (xx)
AU (1) AU729149B2 (xx)
BG (1) BG62776B1 (xx)
BR (1) BR9711060A (xx)
CA (1) CA2261137C (xx)
CZ (1) CZ297255B6 (xx)
DE (4) DE19633685C1 (xx)
DK (4) DK2168974T3 (xx)
EA (1) EA001947B1 (xx)
ES (4) ES2175451T7 (xx)
HK (1) HK1021190A1 (xx)
HU (1) HU223106B1 (xx)
IL (1) IL127963A (xx)
IS (1) IS2100B (xx)
NZ (1) NZ333697A (xx)
PL (1) PL187474B1 (xx)
PT (4) PT1149841E (xx)
SI (3) SI1149840T2 (xx)
SK (1) SK283546B6 (xx)
TR (1) TR199900262T2 (xx)
UA (1) UA55423C2 (xx)
WO (1) WO1998006738A1 (xx)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19633685C1 (de) 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
US6787531B1 (en) * 1999-08-31 2004-09-07 Schering Ag Pharmaceutical composition for use as a contraceptive
JP4354667B2 (ja) 1999-08-31 2009-10-28 バイエル・シエーリング・ファーマ・アクチエンゲゼルシャフト 避妊薬としての使用へのエチニルエストラジオールとドロスピレノンの医薬用組合せ
EP2305267A3 (en) 1999-08-31 2011-08-17 Bayer Schering Pharma Aktiengesellschaft Pharmaceutical combination of ethinylestradiol and drospirenone for use as a contraceptive
WO2001052857A1 (en) * 2000-01-18 2001-07-26 Schering Aktiengesellschaft Drospirenone for hormone replacement therapy
US20020132801A1 (en) * 2001-01-11 2002-09-19 Schering Aktiengesellschaft Drospirenone for hormone replacement therapy
WO2003006027A1 (en) 2001-07-13 2003-01-23 Schering Aktiengesellschaft Combination of drospirenone and an estrogen sulphamate for hrt
BR0309780A (pt) 2002-04-26 2005-03-22 Schering Aktiengellschaft Tratamento da hipertensão em mulheres recebendo terapia de reposição hormonal
US7786101B2 (en) * 2002-11-05 2010-08-31 Bayer Schering Pharma Ag Cardiovascular protection using anti-aldosteronic progestins
CL2004000574A1 (es) * 2003-03-21 2005-02-11 Pharmacia Corp Sa Organizada B Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion.
ITMI20040367A1 (it) * 2004-03-01 2004-06-01 Ind Chimica Srl Processo per la preparazione di drospirenone
HUP0402466A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
HUP0402465A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main intermediates of the process
DE102004058300B4 (de) * 2004-12-02 2016-09-15 Austriamicrosystems Ag Schaltungsanordnung zur Erzeugung eines komplexen Signals und Verwendung in einem Hochfrequenz-Sender oder -Empfänger
ITMI20042338A1 (it) * 2004-12-06 2005-03-06 Ind Chimica Srl Processo per la preparazione di drospirenone
US7319154B2 (en) 2005-07-21 2008-01-15 Bayer Schering Pharma Ag Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes
ATE403668T1 (de) * 2005-07-21 2008-08-15 Bayer Schering Pharma Ag Verfahren zur herstellung von 3-oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie oxidation von 17-(3-hydroxypropyl)-3,17- dihydroxyandrostanen
RS56982B1 (sr) * 2005-07-21 2018-05-31 Bayer Ip Gmbh Proces za proizvodnju 3-okso-pregn-4-en-21,17-karbolaktona oksidacijom bez metala 17-(3-hidroksipropil)-3,17-dihidroksiandrostana
WO2007127266A2 (en) 2006-04-27 2007-11-08 Covidien Ag Electrode pad packaging systems and methods
EP1902711A1 (en) * 2006-09-20 2008-03-26 KAIROSmed GmbH Oral modified release formulations containing Drospirenon and 8-Prenylnaringenin for use in Hormone Replacement Therapy (HRT)
EP2057182A2 (en) * 2007-05-01 2009-05-13 Sicor, Inc. A process for preparing drospirenone and intermediate thereof
DE102007030596B3 (de) * 2007-06-28 2009-03-12 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden
US7960368B2 (en) * 2008-03-05 2011-06-14 Everstra, Inc. Bismethylene-17A carbolactones and related uses
EP2367808A4 (en) * 2008-11-25 2012-05-09 Evestra Inc g-LACTONES OF 3- (6,6-ETHYLENE-17β-HYDROXY-3-OXO-17α-PREGEN-4-EENE-17α-YL) PROGESTATIVE PROPIONIC ACID
US20120114757A1 (en) 2009-02-18 2012-05-10 Bayer Pharma Aktiengesellschaft Particles comprising drospirenone encapsulated in a polymer
EP2398461A1 (en) 2009-02-18 2011-12-28 Bayer Pharma Aktiengesellschaft Formulation comprising drospirenone for subcutaneous or intramuscular administration
US8334375B2 (en) * 2009-04-10 2012-12-18 Evestra, Inc. Methods for the preparation of drospirenone
EP2266998B1 (en) * 2009-06-16 2013-07-24 Crystal Pharma, S.A.U. Process for obtaining 17-spirolactones in steroids
DE102009031909B4 (de) 2009-07-01 2017-02-09 Heyl Chemisch-Pharmazeutische Fabrik Gmbh & Co. Kg Verfahren zur Herstellung von Drospirenon aus Prasteron
US8921346B2 (en) 2010-03-16 2014-12-30 Taizhou Taifa Pharmaceuticals Co., Ltd. Preparation method of drospirenone
CN101830959B (zh) * 2010-05-27 2012-07-18 杭州龙山化工有限公司 一种曲螺酮的合成方法
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US11351122B1 (en) 2010-07-28 2022-06-07 Laboratorios Leon Farma Sa Synthetic progestogens and pharmaceutical compositions comprising the same
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
EP2415778B1 (en) 2010-08-03 2013-05-15 Newchem S.p.A. Methods for the preparation of Drospirenone and intermediates thereof
WO2012107513A1 (en) 2011-02-10 2012-08-16 Crystal Pharma, S.A.U. Process for obtaining drospirenone
ITMI20111383A1 (it) 2011-07-25 2013-01-26 Ind Chimica Srl Processo per la preparazione di drospirenone
CN103957921A (zh) * 2011-11-04 2014-07-30 拜耳医药股份有限公司 18-甲基-6，7-亚甲基-3-氧代-17-孕甾-4-烯-21，17β-碳内酯、包含所述化合物的药物制剂及其在治疗子宫内膜异位症中的用途
EP2597101A1 (en) 2011-11-22 2013-05-29 Industriale Chimica S.R.L. Process for the preparation of drospirenone
PL2782924T3 (pl) 2011-11-22 2017-07-31 Industriale Chimica S.R.L. Proces otrzymywania drospirenonu
WO2014128525A1 (en) 2013-02-20 2014-08-28 Industriale Chimica S.R.L. Process for the preparation of drospirenone
US9556220B2 (en) 2013-04-12 2017-01-31 Industriale Chimica S.R.L. Process for the preparation of drospirenone
EP3108889A1 (en) 2015-06-23 2016-12-28 Philippe Perrin Drospirenone-based contraceptive for a female patient affected with excess weight
HRP20240121T8 (hr) 2015-06-23 2024-05-10 Laboratorios Leon Farma Sa Kontracepcija na bazi drospirenona za pacijenticu s viškom tjelesne težine
CN113387993A (zh) * 2021-07-06 2021-09-14 江西百思康瑞药业有限公司 一种屈螺酮的合成方法
EP4134082A1 (en) 2021-08-12 2023-02-15 Chemo Research, S.L. Method for treating endometriosis and providing effective contraception
WO2023152658A1 (en) 2022-02-10 2023-08-17 Lupin Limited Slow release drospirenone tablet composition
WO2023165988A1 (en) 2022-03-01 2023-09-07 Chemo Research, S.L. Chewable oral contraceptive

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2652761C2 (de) * 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE3022337A1 (de) * 1980-06-11 1982-01-07 Schering Ag Berlin Und Bergkamen, 1000 Berlin Praeparate zur kontrazeption und zur behandlung gynaekologischer stoerungen
DE3042136A1 (de) 1980-11-03 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden
DE3265852D1 (en) * 1981-09-21 1985-10-03 Schering Ag 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation
DE3414508A1 (de) * 1984-04-13 1985-10-24 Schering AG, 1000 Berlin und 4709 Bergkamen Mehrfach tritiierte steroid-20.17-spirolactone und ihre verwendung als tracersubstanzen
DE3626838A1 (de) * 1986-08-08 1988-02-11 Schering Ag Verfahren zur herstellung von 17(alpha)-pregnan-21,17-carbolactonen
US5106995A (en) * 1989-05-05 1992-04-21 Isp Investments Inc. Production of lactones from diols
DE19633685C1 (de) 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens

Also Published As

Publication number Publication date
PT918791E (pt) 2002-09-30
EP1149841A3 (de) 2004-12-01
ES2320626T3 (es) 2009-05-27
EP1149840A2 (de) 2001-10-31
SI1149840T1 (sl) 2009-06-30
EP1149840B2 (de) 2013-05-15
ATE420098T1 (de) 2009-01-15
SI1149841T1 (sl) 2010-02-26
SK283546B6 (sk) 2003-09-11
EP0918791B8 (de) 2003-01-08
DE19633685C1 (de) 1997-10-09
DK1149840T5 (da) 2013-09-30
CA2261137C (en) 2005-03-15
BG102976A (en) 1999-08-31
US6121465A (en) 2000-09-19
ES2175451T3 (es) 2002-11-16
ES2438941T1 (es) 2014-01-20
IS2100B (is) 2006-04-12
EA001947B1 (ru) 2001-10-22
IS4965A (is) 1999-01-29
BR9711060A (pt) 1999-08-17
CA2261137A1 (en) 1998-02-19
PT1149840E (pt) 2009-03-31
KR100473297B1 (ko) 2005-03-07
AU4014497A (en) 1998-03-06
DK1149840T3 (da) 2009-04-27
EP2168974A2 (de) 2010-03-31
CZ297255B6 (cs) 2006-10-11
PL187474B1 (pl) 2004-07-30
IL127963A (en) 2004-06-20
EP1149841B1 (de) 2009-10-28
DK1149841T3 (da) 2010-03-08
EP1149840A3 (de) 2004-12-01
WO1998006738A1 (de) 1998-02-19
EP1149840B1 (de) 2009-01-07
EP1149841A2 (de) 2001-10-31
US6933395B1 (en) 2005-08-23
EA199900153A1 (ru) 1999-06-24
PT2168974E (pt) 2014-08-26
DE59712991D1 (de) 2009-02-26
CN1158300C (zh) 2004-07-21
SK19499A3 (en) 1999-10-08
ES2320626T5 (es) 2013-09-05
PT1149841E (pt) 2010-01-29
NZ333697A (en) 2000-08-25
ATE446966T1 (de) 2009-11-15
JP2000516226A (ja) 2000-12-05
UA55423C2 (uk) 2003-04-15
EP0918791A1 (de) 1999-06-02
AU729149B2 (en) 2001-01-25
KR20000029939A (ko) 2000-05-25
EP0918791B3 (de) 2012-01-18
DK1149840T4 (da) 2013-07-01
TR199900262T2 (xx) 1999-03-22
SI1149840T2 (sl) 2013-08-30
DK2168974T3 (da) 2014-08-11
EP2168974B1 (de) 2014-07-02
JP3333524B2 (ja) 2002-10-15
HU223106B1 (hu) 2004-03-29
HUP9903089A3 (en) 2001-07-30
ES2335860T3 (es) 2010-04-06
EP0918791B1 (de) 2002-04-03
ES2175451T7 (es) 2012-11-19
EP2168974A3 (de) 2013-03-06
CN1223662A (zh) 1999-07-21
DE59713018D1 (de) 2009-12-10
PL331530A1 (en) 1999-07-19
IL127963A0 (en) 1999-11-30
SI0918791T1 (en) 2002-12-31
ES2438941T3 (es) 2014-07-21
CZ47099A3 (cs) 1999-05-12
DK0918791T3 (da) 2002-07-15
DE59706887D1 (de) 2002-05-08
ATE215557T1 (de) 2002-04-15
BG62776B1 (bg) 2000-07-31

Similar Documents

Publication Publication Date Title
HK1021190A1 (en) Process for producing drospirenone and 6b,7b;15b,16b-dimethylene-5b-hydroxy-3-oxo-17a-androstane-21,17-carbolactone used as intermediate in the process.
AU9744298A (en) Substituted tetrahydronaphthaline and analogous compounds
CA2384433A1 (en) Novel betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis
HUT74942A (en) New conversion of bisnoralcohol to bisnoraldehyde
MY127864A (en) Improved process for the hydrogenation of maleic acid to 1,4-butanediol
MY120550A (en) Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols, processes for preparing them and their use as pharmaceutical compositions.
MX9706744A (es) Proceso novedosos para preparar derivados de 2,3-dihidro-benzofuranol.
RU93057747A (ru) Новый метод получения серосодержащих производных имидазола и новые полученные промежуточные продукты
BG105326A (en) Novel benzoylguanadine derivatives with advantageous properties, method for producing them and their use in the production of medicaments
AU4502097A (en) Process for the production of cyanocinnamamides
MX9606100A (es) Sintesis asimetrica de metanaminas sustituidas con alfa-cicloalquilalquilo.
DE50006244D1 (en) Neue substituierte 3-phenoxy- und 3-phenylalkyloxy-2-phenyl-propylamine
MXPA02012053A (es) Procedimiento para la obtencion de 3,3,5-trimetilciclohexanol.
IL138501A0 (en) A CONVERGENT SYNTHESIS OF α-ARYL-β-KETONITRILES
AU2002227970A1 (en) Method for producing cis-2-tert-butylcyclohexanol
ZA957059B (en) Improved process for the conversion of substituted steroidal 3-halogen-3,5-diene derivatives to substituted steroidal 3,5-diene-3-carboxylic acid derivatives
ZA994944B (en) Catalyst for the hydrogenation of maleic acid to 1,4 butanediol.
AU2003240686A1 (en) Method for producing cyclohexadecanone
EP0684256A3 (en) Improved process for the production of 3-beta, 14-beta-dihydroxyethialnaldehydes.
NO20000869D0 (no) Fremgangsmåte for fremstilling av 1-(cyklopentenyloksy-4- alkoksyfenyl)-4-oksocykloheksankarbonitril

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20170810