MX9606100A - Sintesis asimetrica de metanaminas sustituidas con alfa-cicloalquilalquilo. - Google Patents

Sintesis asimetrica de metanaminas sustituidas con alfa-cicloalquilalquilo.

Info

Publication number
MX9606100A
MX9606100A MX9606100A MX9606100A MX9606100A MX 9606100 A MX9606100 A MX 9606100A MX 9606100 A MX9606100 A MX 9606100A MX 9606100 A MX9606100 A MX 9606100A MX 9606100 A MX9606100 A MX 9606100A
Authority
MX
Mexico
Prior art keywords
methanamines
cycloalkylalkyl substituted
asymmetric synthesis
pinene
relates
Prior art date
Application number
MX9606100A
Other languages
English (en)
Other versions
MXPA96006100A (es
Inventor
Gregory P Roth
John J Landi Jr
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MXPA96006100A publication Critical patent/MXPA96006100A/es
Publication of MX9606100A publication Critical patent/MX9606100A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/48—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by oxidation reactions with formation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/28—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of CHx-moieties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/487—Saturated compounds containing a keto group being part of a ring containing hydroxy groups
    • C07C49/507—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic
    • C07C49/513—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invencion se refiere a procedimientos para producir asimétricamente enantiomeros puros de metanaminas sustituidas con alfa-cicloalquilalquilo a partir del alfa-pineno. Una etapa clave del procedimiento de esta invencion utiliza el producto de oxidacion del alfa-pipeno, hidroxi-pinanona como un quiral auxiliar para dirigir la alquilacion esteroselectiva de la correspondiente cetimina. Esta invencion se refiere también a productos intermedios claves utiles en los procedimientos descritos en la presente memoria.
MX9606100A 1995-12-11 1996-12-04 Sintesis asimetrica de metanaminas sustituidas con alfa-cicloalquilalquilo. MX9606100A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US008468 1979-02-01
US846895P 1995-12-11 1995-12-11

Publications (2)

Publication Number Publication Date
MXPA96006100A MXPA96006100A (es) 1997-08-01
MX9606100A true MX9606100A (es) 1997-08-30

Family

ID=21731773

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9606100A MX9606100A (es) 1995-12-11 1996-12-04 Sintesis asimetrica de metanaminas sustituidas con alfa-cicloalquilalquilo.

Country Status (5)

Country Link
US (1) US5856497A (es)
EP (1) EP0781750A3 (es)
JP (1) JPH09221472A (es)
CA (1) CA2192417A1 (es)
MX (1) MX9606100A (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684159A (en) * 1995-05-30 1997-11-04 Rhone-Poulenc Rorer S.A. L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds
RU2509073C1 (ru) * 2012-12-14 2014-03-10 Федеральное Государственное Бюджетное Учреждение Науки Институт Химии Коми Научного Центра Уральского Отделения Российской Академии Наук СПОСОБ ПОЛУЧЕНИЯ 3α-ГИДРОКСИ-10β-ПИНАНОНА-4
CN103086852B (zh) * 2013-02-21 2015-10-21 南京林业大学 一种制备2,3-蒎二酮的新方法
CN105859519B (zh) * 2016-04-19 2018-08-24 上海格物致知医药科技有限公司 一种手性邻二醇的合成方法及其产品
US20220388931A1 (en) * 2019-11-04 2022-12-08 International Flavors & Fragrances Inc. Dihydroxylation of olefins using osmate (vi) salts

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2265370C2 (de) * 1972-05-03 1982-12-02 Kali-Chemie Ag, 3000 Hannover 6-Phenyl-1,2,3,4-tetrahydro-1,5-benzodiazocinderivate
US4546107A (en) * 1982-09-07 1985-10-08 Yoshitomi Pharmaceutical Industries, Ltd. 1,4-Methano-2-benzazepine derivatives useful as cerebal dysfunction-improving drugs, anti-convulsant, anti-epileptic or anti-anxiety drugs
CN1014885B (zh) * 1988-07-26 1991-11-27 中国科学院成都有机化学研究所 光学活性α-取代苄胺的不对称合成
US5169971A (en) * 1989-04-04 1992-12-08 Mitsui Toatsu Chemicals, Inc. Process for producing norcamphane dicarbonitriles
US5296486A (en) * 1991-09-24 1994-03-22 Boehringer Ingelheim Pharmaceuticals, Inc. Leukotriene biosynthesis inhibitors

Also Published As

Publication number Publication date
EP0781750A2 (en) 1997-07-02
JPH09221472A (ja) 1997-08-26
EP0781750A3 (en) 1998-03-18
CA2192417A1 (en) 1997-06-12
US5856497A (en) 1999-01-05

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