PT1149841E - Processo para a preparação de 6beta,7beta;15beta,16betadimetileno- 5beta-hidroxi-3-oxo-17alfa-androstano-21,17- carbolactona - Google Patents

Processo para a preparação de 6beta,7beta;15beta,16betadimetileno- 5beta-hidroxi-3-oxo-17alfa-androstano-21,17- carbolactona Download PDF

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Publication number
PT1149841E
PT1149841E PT01250278T PT01250278T PT1149841E PT 1149841 E PT1149841 E PT 1149841E PT 01250278 T PT01250278 T PT 01250278T PT 01250278 T PT01250278 T PT 01250278T PT 1149841 E PT1149841 E PT 1149841E
Authority
PT
Portugal
Prior art keywords
17alpha
dimethylene
carbolactone
androstane
oxo
Prior art date
Application number
PT01250278T
Other languages
English (en)
Inventor
Joerg-Thorsten Mohr
Klaus Nickisch
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7803224&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1149841(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of PT1149841E publication Critical patent/PT1149841E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/007—3 membered carbocyclic rings in position 6-7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fats And Perfumes (AREA)
  • Polyesters Or Polycarbonates (AREA)
PT01250278T 1996-08-12 1997-08-11 Processo para a preparação de 6beta,7beta;15beta,16betadimetileno- 5beta-hidroxi-3-oxo-17alfa-androstano-21,17- carbolactona PT1149841E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19633685A DE19633685C1 (de) 1996-08-12 1996-08-12 Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens

Publications (1)

Publication Number Publication Date
PT1149841E true PT1149841E (pt) 2010-01-29

Family

ID=7803224

Family Applications (4)

Application Number Title Priority Date Filing Date
PT91000117T PT2168974E (pt) 1996-08-12 1997-08-11 Processo para preparação de drospirenona (6ss,7ss;15ss,16ss-dimetileno-3-oxo-17alfa-pregna-4-eno- 21,17-carbolactona, drsp)
PT01250278T PT1149841E (pt) 1996-08-12 1997-08-11 Processo para a preparação de 6beta,7beta;15beta,16betadimetileno- 5beta-hidroxi-3-oxo-17alfa-androstano-21,17- carbolactona
PT01250277T PT1149840E (pt) 1996-08-12 1997-08-11 Drospirenona (6beta,7beta,15beta,16beta-dimetileno-3-oxo- 17alfa-pregna-4-eno-21,17-carbolactona, drsp) com menos do que 0,2% de impurezas
PT97937562T PT918791E (pt) 1996-08-12 1997-08-11 Processo para a preparacao de drospirenona e de produtos intermediarios para essa preparacao

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT91000117T PT2168974E (pt) 1996-08-12 1997-08-11 Processo para preparação de drospirenona (6ss,7ss;15ss,16ss-dimetileno-3-oxo-17alfa-pregna-4-eno- 21,17-carbolactona, drsp)

Family Applications After (2)

Application Number Title Priority Date Filing Date
PT01250277T PT1149840E (pt) 1996-08-12 1997-08-11 Drospirenona (6beta,7beta,15beta,16beta-dimetileno-3-oxo- 17alfa-pregna-4-eno-21,17-carbolactona, drsp) com menos do que 0,2% de impurezas
PT97937562T PT918791E (pt) 1996-08-12 1997-08-11 Processo para a preparacao de drospirenona e de produtos intermediarios para essa preparacao

Country Status (27)

Country Link
US (2) US6121465A (pt)
EP (4) EP1149840B2 (pt)
JP (1) JP3333524B2 (pt)
KR (1) KR100473297B1 (pt)
CN (1) CN1158300C (pt)
AT (3) ATE420098T1 (pt)
AU (1) AU729149B2 (pt)
BG (1) BG62776B1 (pt)
BR (1) BR9711060A (pt)
CA (1) CA2261137C (pt)
CZ (1) CZ297255B6 (pt)
DE (4) DE19633685C1 (pt)
DK (4) DK1149840T5 (pt)
EA (1) EA001947B1 (pt)
ES (4) ES2335860T3 (pt)
HK (1) HK1021190A1 (pt)
HU (1) HU223106B1 (pt)
IL (1) IL127963A (pt)
IS (1) IS2100B (pt)
NZ (1) NZ333697A (pt)
PL (1) PL187474B1 (pt)
PT (4) PT2168974E (pt)
SI (3) SI0918791T1 (pt)
SK (1) SK283546B6 (pt)
TR (1) TR199900262T2 (pt)
UA (1) UA55423C2 (pt)
WO (1) WO1998006738A1 (pt)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19633685C1 (de) 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
EP2305267A3 (en) 1999-08-31 2011-08-17 Bayer Schering Pharma Aktiengesellschaft Pharmaceutical combination of ethinylestradiol and drospirenone for use as a contraceptive
US6787531B1 (en) * 1999-08-31 2004-09-07 Schering Ag Pharmaceutical composition for use as a contraceptive
KR101019361B1 (ko) 1999-08-31 2011-03-07 바이엘 쉐링 파마 악티엔게젤샤프트 피임약으로서의 사용을 위한 에티닐에스트라디올과드로스피렌온의 약학적 조합
US20020132801A1 (en) * 2001-01-11 2002-09-19 Schering Aktiengesellschaft Drospirenone for hormone replacement therapy
ES2332226T3 (es) * 2000-01-18 2010-01-29 Bayer Schering Pharma Aktiengesellschaft Composiciones farmaceuticas que comprenden drospirenona.
JP2004521951A (ja) 2001-07-13 2004-07-22 シエーリング アクチエンゲゼルシャフト Ｈｒｔのためのドロスピレノン及びエストロゲンスルファメートの組み合わせ
AU2003239162A1 (en) 2002-04-26 2003-11-10 Schering Ag Treatment of hypertension in women receiving hormone replacement therapy
US7786101B2 (en) * 2002-11-05 2010-08-31 Bayer Schering Pharma Ag Cardiovascular protection using anti-aldosteronic progestins
CL2004000574A1 (es) * 2003-03-21 2005-02-11 Pharmacia Corp Sa Organizada B Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion.
ITMI20040367A1 (it) * 2004-03-01 2004-06-01 Ind Chimica Srl Processo per la preparazione di drospirenone
HUP0402465A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main intermediates of the process
HUP0402466A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
DE102004058300B4 (de) * 2004-12-02 2016-09-15 Austriamicrosystems Ag Schaltungsanordnung zur Erzeugung eines komplexen Signals und Verwendung in einem Hochfrequenz-Sender oder -Empfänger
ITMI20042338A1 (it) * 2004-12-06 2005-03-06 Ind Chimica Srl Processo per la preparazione di drospirenone
DE502005004948D1 (de) * 2005-07-21 2008-09-18 Bayer Schering Pharma Ag Verfahren zur Herstellung von 3-Oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie Oxidation von 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanen
PL2527356T3 (pl) * 2005-07-21 2018-06-29 Bayer Intellectual Property Gmbh Sposób wytwarzania 3-okso-pregn-4-eno-21,17-karbolaktonów za pomocą wolnego od metali utleniania 17-(3-hydroksypropylo)-3,17- dihydroksyandrostanów
US7319154B2 (en) 2005-07-21 2008-01-15 Bayer Schering Pharma Ag Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes
WO2007127266A2 (en) 2006-04-27 2007-11-08 Covidien Ag Electrode pad packaging systems and methods
EP1902711A1 (en) * 2006-09-20 2008-03-26 KAIROSmed GmbH Oral modified release formulations containing Drospirenon and 8-Prenylnaringenin for use in Hormone Replacement Therapy (HRT)
US20090023914A1 (en) * 2007-05-01 2009-01-22 Alessandro Pontiroli Process for preparing drospirenone and intermediate thereof
DE102007030596B3 (de) * 2007-06-28 2009-03-12 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden
WO2009111574A2 (en) * 2008-03-05 2009-09-11 Evestra, Inc. BISMETHYLENE-17α CARBOLACTONES AND RELATED USES
WO2010068500A2 (en) * 2008-11-25 2010-06-17 Evestra, Inc. PROGESTATIONAL 3-(6,6-ETHYLENE-17b-HYDROXY-3-OXO-17a-PREGNA-4-ENE-17a -YL) PROPIONIC ACID g-LACTONES
US20120114757A1 (en) 2009-02-18 2012-05-10 Bayer Pharma Aktiengesellschaft Particles comprising drospirenone encapsulated in a polymer
EP2398461A1 (en) 2009-02-18 2011-12-28 Bayer Pharma Aktiengesellschaft Formulation comprising drospirenone for subcutaneous or intramuscular administration
US8334375B2 (en) * 2009-04-10 2012-12-18 Evestra, Inc. Methods for the preparation of drospirenone
EP2266998B1 (en) 2009-06-16 2013-07-24 Crystal Pharma, S.A.U. Process for obtaining 17-spirolactones in steroids
DE102009031909B4 (de) 2009-07-01 2017-02-09 Heyl Chemisch-Pharmazeutische Fabrik Gmbh & Co. Kg Verfahren zur Herstellung von Drospirenon aus Prasteron
US8921346B2 (en) 2010-03-16 2014-12-30 Taizhou Taifa Pharmaceuticals Co., Ltd. Preparation method of drospirenone
CN101830959B (zh) * 2010-05-27 2012-07-18 杭州龙山化工有限公司 一种曲螺酮的合成方法
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US11351122B1 (en) 2010-07-28 2022-06-07 Laboratorios Leon Farma Sa Synthetic progestogens and pharmaceutical compositions comprising the same
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
EP2415778B1 (en) 2010-08-03 2013-05-15 Newchem S.p.A. Methods for the preparation of Drospirenone and intermediates thereof
WO2012107513A1 (en) 2011-02-10 2012-08-16 Crystal Pharma, S.A.U. Process for obtaining drospirenone
ITMI20111383A1 (it) 2011-07-25 2013-01-26 Ind Chimica Srl Processo per la preparazione di drospirenone
WO2013064620A1 (de) * 2011-11-04 2013-05-10 Bayer Pharma Aktiengesellschaft 18-METHYL-6,7-METHYLEN-3-OXO-17-PREGN-4-EN-21,17β-CARBOLACTONE, PHARMAZEUTISCHE PRÄPARATE ENTHALTEND DIE GENANNTEN VERBINDUNGEN UND DEREN ANWENDUNG BEI DER THERAPIE DER ENDOMETRIOSE
EP2597101A1 (en) 2011-11-22 2013-05-29 Industriale Chimica S.R.L. Process for the preparation of drospirenone
WO2013076118A1 (en) 2011-11-22 2013-05-30 Industriale Chimica S.R.L. Process for the preparation of drospirenone
EP2958929B1 (en) 2013-02-20 2017-09-13 Industriale Chimica S.R.L. Process for the preparation of drospirenone
CA2909087C (en) 2013-04-12 2020-01-07 Industriale Chimica S.R.L. Process for the preparation of drospirenone
DK3313408T3 (da) 2015-06-23 2024-01-29 Laboratorios Leon Farma Sa Drospirenon-baseret svangerskabsforebyggende middel til en kvindelig patient, som lider af overvægt
EP3108889A1 (en) 2015-06-23 2016-12-28 Philippe Perrin Drospirenone-based contraceptive for a female patient affected with excess weight
CN113387993A (zh) * 2021-07-06 2021-09-14 江西百思康瑞药业有限公司 一种屈螺酮的合成方法
EP4134082A1 (en) 2021-08-12 2023-02-15 Chemo Research, S.L. Method for treating endometriosis and providing effective contraception
WO2023152658A1 (en) 2022-02-10 2023-08-17 Lupin Limited Slow release drospirenone tablet composition
WO2023165988A1 (en) 2022-03-01 2023-09-07 Chemo Research, S.L. Chewable oral contraceptive

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DE2652761C2 (de) 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE3022337A1 (de) * 1980-06-11 1982-01-07 Schering Ag Berlin Und Bergkamen, 1000 Berlin Praeparate zur kontrazeption und zur behandlung gynaekologischer stoerungen
DE3042136A1 (de) * 1980-11-03 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden
DE3265852D1 (en) * 1981-09-21 1985-10-03 Schering Ag 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation
DE3414508A1 (de) * 1984-04-13 1985-10-24 Schering AG, 1000 Berlin und 4709 Bergkamen Mehrfach tritiierte steroid-20.17-spirolactone und ihre verwendung als tracersubstanzen
DE3626838A1 (de) * 1986-08-08 1988-02-11 Schering Ag Verfahren zur herstellung von 17(alpha)-pregnan-21,17-carbolactonen
US5106995A (en) * 1989-05-05 1992-04-21 Isp Investments Inc. Production of lactones from diols
DE19633685C1 (de) 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens

Also Published As

Publication number Publication date
DE19633685C1 (de) 1997-10-09
EP0918791A1 (de) 1999-06-02
PL331530A1 (en) 1999-07-19
JP2000516226A (ja) 2000-12-05
DK2168974T3 (da) 2014-08-11
EP1149840B1 (de) 2009-01-07
SI1149840T2 (sl) 2013-08-30
HK1021190A1 (en) 2000-06-02
EP1149841A3 (de) 2004-12-01
ES2320626T3 (es) 2009-05-27
US6121465A (en) 2000-09-19
CN1223662A (zh) 1999-07-21
EP1149840A2 (de) 2001-10-31
CZ297255B6 (cs) 2006-10-11
DK0918791T3 (da) 2002-07-15
EP2168974A2 (de) 2010-03-31
DK1149840T5 (da) 2013-09-30
PL187474B1 (pl) 2004-07-30
HU223106B1 (hu) 2004-03-29
HUP9903089A3 (en) 2001-07-30
EP0918791B3 (de) 2012-01-18
SI1149840T1 (sl) 2009-06-30
EP0918791B1 (de) 2002-04-03
IL127963A (en) 2004-06-20
IL127963A0 (en) 1999-11-30
IS4965A (is) 1999-01-29
CA2261137A1 (en) 1998-02-19
CA2261137C (en) 2005-03-15
SK19499A3 (en) 1999-10-08
ES2175451T7 (es) 2012-11-19
EP1149840A3 (de) 2004-12-01
EP1149840B2 (de) 2013-05-15
TR199900262T2 (xx) 1999-03-22
PT918791E (pt) 2002-09-30
DK1149840T4 (da) 2013-07-01
ES2335860T3 (es) 2010-04-06
EP0918791B8 (de) 2003-01-08
JP3333524B2 (ja) 2002-10-15
DE59712991D1 (de) 2009-02-26
PT2168974E (pt) 2014-08-26
ATE420098T1 (de) 2009-01-15
AU4014497A (en) 1998-03-06
ES2175451T3 (es) 2002-11-16
ES2438941T1 (es) 2014-01-20
CN1158300C (zh) 2004-07-21
ATE446966T1 (de) 2009-11-15
PT1149840E (pt) 2009-03-31
IS2100B (is) 2006-04-12
DK1149840T3 (da) 2009-04-27
BG62776B1 (bg) 2000-07-31
BG102976A (en) 1999-08-31
DE59713018D1 (de) 2009-12-10
CZ47099A3 (cs) 1999-05-12
EP1149841B1 (de) 2009-10-28
DE59706887D1 (de) 2002-05-08
KR20000029939A (ko) 2000-05-25
KR100473297B1 (ko) 2005-03-07
SI1149841T1 (sl) 2010-02-26
UA55423C2 (uk) 2003-04-15
SI0918791T1 (en) 2002-12-31
ES2438941T3 (es) 2014-07-21
EP2168974B1 (de) 2014-07-02
EP2168974A3 (de) 2013-03-06
EA001947B1 (ru) 2001-10-22
US6933395B1 (en) 2005-08-23
EP1149841A2 (de) 2001-10-31
BR9711060A (pt) 1999-08-17
ATE215557T1 (de) 2002-04-15
AU729149B2 (en) 2001-01-25
NZ333697A (en) 2000-08-25
ES2320626T5 (es) 2013-09-05
WO1998006738A1 (de) 1998-02-19
EA199900153A1 (ru) 1999-06-24
DK1149841T3 (da) 2010-03-08
SK283546B6 (sk) 2003-09-11

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