SI0918791T1 - Postopek za pripravo drospirenona in intermediati zanj - Google Patents

Postopek za pripravo drospirenona in intermediati zanj

Info

Publication number
SI0918791T1
SI0918791T1 SI9730350T SI9730350T SI0918791T1 SI 0918791 T1 SI0918791 T1 SI 0918791T1 SI 9730350 T SI9730350 T SI 9730350T SI 9730350 T SI9730350 T SI 9730350T SI 0918791 T1 SI0918791 T1 SI 0918791T1
Authority
SI
Slovenia
Prior art keywords
15beta
16beta
6beta
7beta
17alpha
Prior art date
Application number
SI9730350T
Other languages
English (en)
Inventor
J�rg-Thorsten MOHR
Klaus Nickisch
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7803224&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI0918791(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of SI0918791T1 publication Critical patent/SI0918791T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/007—3 membered carbocyclic rings in position 6-7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fats And Perfumes (AREA)
  • Polyesters Or Polycarbonates (AREA)
SI9730350T 1996-08-12 1997-08-11 Postopek za pripravo drospirenona in intermediati zanj SI0918791T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19633685A DE19633685C1 (de) 1996-08-12 1996-08-12 Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
PCT/EP1997/004342 WO1998006738A1 (de) 1996-08-12 1997-08-11 Verfahren zur herstellung von drospirenon und zwischenprodukten davon
EP97937562A EP0918791B3 (de) 1996-08-12 1997-08-11 Verfahren zur herstellung von drospirenon und zwischenprodukte davon

Publications (1)

Publication Number Publication Date
SI0918791T1 true SI0918791T1 (sl) 2002-12-31

Family

ID=7803224

Family Applications (3)

Application Number Title Priority Date Filing Date
SI9730790T SI1149841T1 (sl) 1996-08-12 1997-08-11 Postopek za pripravo 6beta,7beta;15beta,16beta-dimetilen-5beta-hidroksi-3-okso-17alfa- androstan-21,17-karbolaktona
SI9730350T SI0918791T1 (sl) 1996-08-12 1997-08-11 Postopek za pripravo drospirenona in intermediati zanj
SI9730786T SI1149840T2 (sl) 1996-08-12 1997-08-11 Postopek priprave drospirenona

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI9730790T SI1149841T1 (sl) 1996-08-12 1997-08-11 Postopek za pripravo 6beta,7beta;15beta,16beta-dimetilen-5beta-hidroksi-3-okso-17alfa- androstan-21,17-karbolaktona

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI9730786T SI1149840T2 (sl) 1996-08-12 1997-08-11 Postopek priprave drospirenona

Country Status (27)

Country Link
US (2) US6121465A (sl)
EP (4) EP0918791B3 (sl)
JP (1) JP3333524B2 (sl)
KR (1) KR100473297B1 (sl)
CN (1) CN1158300C (sl)
AT (3) ATE215557T1 (sl)
AU (1) AU729149B2 (sl)
BG (1) BG62776B1 (sl)
BR (1) BR9711060A (sl)
CA (1) CA2261137C (sl)
CZ (1) CZ297255B6 (sl)
DE (4) DE19633685C1 (sl)
DK (4) DK2168974T3 (sl)
EA (1) EA001947B1 (sl)
ES (4) ES2335860T3 (sl)
HK (1) HK1021190A1 (sl)
HU (1) HU223106B1 (sl)
IL (1) IL127963A (sl)
IS (1) IS2100B (sl)
NZ (1) NZ333697A (sl)
PL (1) PL187474B1 (sl)
PT (4) PT1149840E (sl)
SI (3) SI1149841T1 (sl)
SK (1) SK283546B6 (sl)
TR (1) TR199900262T2 (sl)
UA (1) UA55423C2 (sl)
WO (1) WO1998006738A1 (sl)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9394334B2 (en) 2011-11-22 2016-07-19 Industriale Chimica S.R.L. Process for the preparation of drospirenone

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19633685C1 (de) 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
EP2305267A3 (en) 1999-08-31 2011-08-17 Bayer Schering Pharma Aktiengesellschaft Pharmaceutical combination of ethinylestradiol and drospirenone for use as a contraceptive
US6787531B1 (en) * 1999-08-31 2004-09-07 Schering Ag Pharmaceutical composition for use as a contraceptive
NZ517845A (en) 1999-08-31 2004-12-24 Schering Ag Pharmaceutical combination of ethinylestradiol and drospirenone for use as a contraceptive
CN101934078A (zh) * 2000-01-18 2011-01-05 拜耳先灵医药股份有限公司 包含屈螺酮和雌激素的药物组合物及其应用
US20020132801A1 (en) * 2001-01-11 2002-09-19 Schering Aktiengesellschaft Drospirenone for hormone replacement therapy
WO2003006027A1 (en) 2001-07-13 2003-01-23 Schering Aktiengesellschaft Combination of drospirenone and an estrogen sulphamate for hrt
UA87437C2 (ru) * 2002-04-26 2009-07-27 Бристол-Майерс Сквибб Компани Айседжен Инк Лечение гипертензии у женщин, которые поддаются гормонзаместительной терапии
US7786101B2 (en) 2002-11-05 2010-08-31 Bayer Schering Pharma Ag Cardiovascular protection using anti-aldosteronic progestins
CL2004000574A1 (es) * 2003-03-21 2005-02-11 Pharmacia Corp Sa Organizada B Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion.
ITMI20040367A1 (it) * 2004-03-01 2004-06-01 Ind Chimica Srl Processo per la preparazione di drospirenone
HUP0402466A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
HUP0402465A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main intermediates of the process
DE102004058300B4 (de) * 2004-12-02 2016-09-15 Austriamicrosystems Ag Schaltungsanordnung zur Erzeugung eines komplexen Signals und Verwendung in einem Hochfrequenz-Sender oder -Empfänger
ITMI20042338A1 (it) * 2004-12-06 2005-03-06 Ind Chimica Srl Processo per la preparazione di drospirenone
US7319154B2 (en) 2005-07-21 2008-01-15 Bayer Schering Pharma Ag Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes
HUE027858T2 (en) * 2005-07-21 2016-11-28 Bayer Pharma AG Process for the preparation of 3-oxo-pregn-4-ene-21,17-carbolactones by the metal-free oxidation of 17- (3-hydroxypropyl) -3,17-dihydroxyandrostanes \ t
ATE403668T1 (de) * 2005-07-21 2008-08-15 Bayer Schering Pharma Ag Verfahren zur herstellung von 3-oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie oxidation von 17-(3-hydroxypropyl)-3,17- dihydroxyandrostanen
US20070255381A1 (en) 2006-04-27 2007-11-01 Peter Meyer Electrode pad packaging systems and methods
EP1902711A1 (en) * 2006-09-20 2008-03-26 KAIROSmed GmbH Oral modified release formulations containing Drospirenon and 8-Prenylnaringenin for use in Hormone Replacement Therapy (HRT)
EP2057182A2 (en) * 2007-05-01 2009-05-13 Sicor, Inc. A process for preparing drospirenone and intermediate thereof
DE102007030596B3 (de) * 2007-06-28 2009-03-12 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden
EP2265629B1 (en) * 2008-03-05 2015-06-24 Evestra, Inc. Bismethylene-17 carbolactones and related uses
EP2367808A4 (en) * 2008-11-25 2012-05-09 Evestra Inc g-LACTONES OF 3- (6,6-ETHYLENE-17β-HYDROXY-3-OXO-17α-PREGEN-4-EENE-17α-YL) PROGESTATIVE PROPIONIC ACID
EP2398467A1 (en) 2009-02-18 2011-12-28 Bayer Pharma Aktiengesellschaft Particles comprising drospirenone encapsulated in a polymer
CA2752805A1 (en) 2009-02-18 2010-08-26 Bayer Pharma Aktiengesellschaft Formulation comprising drospirenone for subcutaneous or intramuscular administration
US8334375B2 (en) * 2009-04-10 2012-12-18 Evestra, Inc. Methods for the preparation of drospirenone
ES2432063T3 (es) * 2009-06-16 2013-11-29 Crystal Pharma, S.A.U. Procedimiento para la obtención de 17-espirolactonas en esteroides
DE102009031909B4 (de) 2009-07-01 2017-02-09 Heyl Chemisch-Pharmazeutische Fabrik Gmbh & Co. Kg Verfahren zur Herstellung von Drospirenon aus Prasteron
CN102395596B (zh) * 2010-03-16 2013-02-13 台州太法药业有限公司 屈螺酮制备方法
CN101830959B (zh) * 2010-05-27 2012-07-18 杭州龙山化工有限公司 一种曲螺酮的合成方法
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
US11351122B1 (en) 2010-07-28 2022-06-07 Laboratorios Leon Farma Sa Synthetic progestogens and pharmaceutical compositions comprising the same
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
EP2415778B1 (en) 2010-08-03 2013-05-15 Newchem S.p.A. Methods for the preparation of Drospirenone and intermediates thereof
WO2012107513A1 (en) 2011-02-10 2012-08-16 Crystal Pharma, S.A.U. Process for obtaining drospirenone
ITMI20111383A1 (it) 2011-07-25 2013-01-26 Ind Chimica Srl Processo per la preparazione di drospirenone
EA201400537A1 (ru) * 2011-11-04 2014-10-30 Байер Фарма Акциенгезельшафт 18-МЕТИЛ-6,7-МЕТИЛЕН-3-ОКСО-17-ПРЕГН-4-ЕН-21,17β-КАРБОЛАКТОНЫ, ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ СОЕДИНЕНИЯ, И ИХ ПРИМЕНЕНИЕ В ЛЕЧЕНИИ ЭНДОМЕТРИОЗА
EP2597101A1 (en) 2011-11-22 2013-05-29 Industriale Chimica S.R.L. Process for the preparation of drospirenone
WO2014128525A1 (en) 2013-02-20 2014-08-28 Industriale Chimica S.R.L. Process for the preparation of drospirenone
US9556220B2 (en) 2013-04-12 2017-01-31 Industriale Chimica S.R.L. Process for the preparation of drospirenone
EP3108889A1 (en) 2015-06-23 2016-12-28 Philippe Perrin Drospirenone-based contraceptive for a female patient affected with excess weight
ES2970532T3 (es) 2015-06-23 2024-05-29 Laboratorios Leon Farma Sa Anticonceptivo basado en drospirenona para una paciente que presenta exceso de peso
CN113387993A (zh) * 2021-07-06 2021-09-14 江西百思康瑞药业有限公司 一种屈螺酮的合成方法
EP4134082A1 (en) 2021-08-12 2023-02-15 Chemo Research, S.L. Method for treating endometriosis and providing effective contraception
WO2023152658A1 (en) 2022-02-10 2023-08-17 Lupin Limited Slow release drospirenone tablet composition
WO2023165988A1 (en) 2022-03-01 2023-09-07 Chemo Research, S.L. Chewable oral contraceptive

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DE2652761C2 (de) * 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE3022337A1 (de) * 1980-06-11 1982-01-07 Schering Ag Berlin Und Bergkamen, 1000 Berlin Praeparate zur kontrazeption und zur behandlung gynaekologischer stoerungen
DE3042136A1 (de) † 1980-11-03 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden
EP0075189B1 (en) * 1981-09-21 1985-08-28 Schering Aktiengesellschaft 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation
DE3414508A1 (de) * 1984-04-13 1985-10-24 Schering AG, 1000 Berlin und 4709 Bergkamen Mehrfach tritiierte steroid-20.17-spirolactone und ihre verwendung als tracersubstanzen
DE3626838A1 (de) * 1986-08-08 1988-02-11 Schering Ag Verfahren zur herstellung von 17(alpha)-pregnan-21,17-carbolactonen
US5106995A (en) * 1989-05-05 1992-04-21 Isp Investments Inc. Production of lactones from diols
DE19633685C1 (de) 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9394334B2 (en) 2011-11-22 2016-07-19 Industriale Chimica S.R.L. Process for the preparation of drospirenone

Also Published As

Publication number Publication date
PT918791E (pt) 2002-09-30
ES2438941T3 (es) 2014-07-21
ATE446966T1 (de) 2009-11-15
PL187474B1 (pl) 2004-07-30
EP2168974B1 (de) 2014-07-02
TR199900262T2 (xx) 1999-03-22
EP1149841B1 (de) 2009-10-28
HK1021190A1 (en) 2000-06-02
CZ297255B6 (cs) 2006-10-11
EP2168974A3 (de) 2013-03-06
KR20000029939A (ko) 2000-05-25
CN1158300C (zh) 2004-07-21
EP1149840A3 (de) 2004-12-01
IS4965A (is) 1999-01-29
EP1149841A3 (de) 2004-12-01
ES2320626T3 (es) 2009-05-27
AU729149B2 (en) 2001-01-25
US6933395B1 (en) 2005-08-23
US6121465A (en) 2000-09-19
BG102976A (en) 1999-08-31
EA001947B1 (ru) 2001-10-22
ATE420098T1 (de) 2009-01-15
DK0918791T3 (da) 2002-07-15
IS2100B (is) 2006-04-12
SK19499A3 (en) 1999-10-08
HU223106B1 (hu) 2004-03-29
HUP9903089A3 (en) 2001-07-30
DK1149840T3 (da) 2009-04-27
PT1149840E (pt) 2009-03-31
JP2000516226A (ja) 2000-12-05
CA2261137C (en) 2005-03-15
EP0918791B8 (de) 2003-01-08
ES2175451T3 (es) 2002-11-16
ES2438941T1 (es) 2014-01-20
EP1149841A2 (de) 2001-10-31
EP0918791B3 (de) 2012-01-18
EP1149840B1 (de) 2009-01-07
UA55423C2 (uk) 2003-04-15
SI1149840T1 (sl) 2009-06-30
BG62776B1 (bg) 2000-07-31
KR100473297B1 (ko) 2005-03-07
AU4014497A (en) 1998-03-06
DK1149840T4 (da) 2013-07-01
EP1149840B2 (de) 2013-05-15
ATE215557T1 (de) 2002-04-15
PT2168974E (pt) 2014-08-26
DE59713018D1 (de) 2009-12-10
SK283546B6 (sk) 2003-09-11
JP3333524B2 (ja) 2002-10-15
DK1149841T3 (da) 2010-03-08
ES2175451T7 (es) 2012-11-19
EP0918791B1 (de) 2002-04-03
NZ333697A (en) 2000-08-25
WO1998006738A1 (de) 1998-02-19
DE59706887D1 (de) 2002-05-08
CN1223662A (zh) 1999-07-21
ES2320626T5 (es) 2013-09-05
CA2261137A1 (en) 1998-02-19
SI1149841T1 (sl) 2010-02-26
DE19633685C1 (de) 1997-10-09
DE59712991D1 (de) 2009-02-26
EP0918791A1 (de) 1999-06-02
ES2335860T3 (es) 2010-04-06
DK1149840T5 (da) 2013-09-30
DK2168974T3 (da) 2014-08-11
IL127963A0 (en) 1999-11-30
IL127963A (en) 2004-06-20
EP2168974A2 (de) 2010-03-31
PL331530A1 (en) 1999-07-19
BR9711060A (pt) 1999-08-17
SI1149840T2 (sl) 2013-08-30
EA199900153A1 (ru) 1999-06-24
CZ47099A3 (cs) 1999-05-12
EP1149840A2 (de) 2001-10-31
PT1149841E (pt) 2010-01-29

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