SI0888327T1 - Benzopyran derivatives having leukotriene-antagonistic action - Google Patents
Benzopyran derivatives having leukotriene-antagonistic actionInfo
- Publication number
- SI0888327T1 SI0888327T1 SI9730340T SI9730340T SI0888327T1 SI 0888327 T1 SI0888327 T1 SI 0888327T1 SI 9730340 T SI9730340 T SI 9730340T SI 9730340 T SI9730340 T SI 9730340T SI 0888327 T1 SI0888327 T1 SI 0888327T1
- Authority
- SI
- Slovenia
- Prior art keywords
- pct
- leukotriene
- compounds
- antagonistic action
- sec
- Prior art date
Links
- 150000001562 benzopyrans Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000006201 3-phenylpropyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- -1 benzyloxymethyl Chemical group 0.000 abstract 1
- OTAFHZMPRISVEM-UHFFFAOYSA-N chromone Chemical class C1=CC=C2C(=O)C=COC2=C1 OTAFHZMPRISVEM-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009600682A ES2127106B1 (es) | 1996-03-21 | 1996-03-21 | Derivados benzopiranicos con accion antagonista de los leucotrienos, procedimiento para su preparacion y utilizacion de los mismos. |
| EP97914280A EP0888327B1 (en) | 1996-03-21 | 1997-03-20 | Benzopyran derivatives having leukotriene-antagonistic action |
| PCT/EP1997/001418 WO1997034885A1 (en) | 1996-03-21 | 1997-03-20 | Benzopyran derivatives having leukotriene-antagonistic action |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI0888327T1 true SI0888327T1 (en) | 2002-10-31 |
Family
ID=8294261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9730340T SI0888327T1 (en) | 1996-03-21 | 1997-03-20 | Benzopyran derivatives having leukotriene-antagonistic action |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US5990142A (cs) |
| EP (1) | EP0888327B1 (cs) |
| JP (1) | JP3914575B2 (cs) |
| KR (1) | KR100378892B1 (cs) |
| CN (1) | CN1182129C (cs) |
| AT (1) | ATE219073T1 (cs) |
| AU (1) | AU707282B2 (cs) |
| BG (1) | BG63433B1 (cs) |
| BR (1) | BR9708215A (cs) |
| CA (1) | CA2249402C (cs) |
| CU (1) | CU22777A3 (cs) |
| CZ (1) | CZ296260B6 (cs) |
| DE (1) | DE69713300T2 (cs) |
| DK (1) | DK0888327T3 (cs) |
| EA (1) | EA001680B1 (cs) |
| EE (1) | EE03526B1 (cs) |
| ES (2) | ES2127106B1 (cs) |
| GE (1) | GEP20012416B (cs) |
| HU (1) | HUP9901326A3 (cs) |
| IL (1) | IL126296A (cs) |
| NO (1) | NO319612B1 (cs) |
| NZ (1) | NZ331953A (cs) |
| PL (1) | PL189562B1 (cs) |
| PT (1) | PT888327E (cs) |
| RS (1) | RS49588B (cs) |
| SI (1) | SI0888327T1 (cs) |
| SK (1) | SK282979B6 (cs) |
| TR (1) | TR199801857T2 (cs) |
| UA (1) | UA65535C2 (cs) |
| WO (1) | WO1997034885A1 (cs) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001038582A1 (en) | 1999-11-24 | 2001-05-31 | The Research Foundation Of State University Of New York | CATALYTIC RNAs WITH AMINOACYLATION ACTIVITY |
| AU2003213136A1 (en) * | 2002-02-15 | 2003-09-09 | The Research Foundation Of State University Of New York At Buffalo | RIBOZYMES WITH BROAD tRNA AMINOACYLATION ACTIVITY |
| US7851486B2 (en) | 2002-10-17 | 2010-12-14 | Decode Genetics Ehf. | Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment |
| AU2003301305A1 (en) * | 2002-10-17 | 2004-05-04 | Decode Genetics Ehf. | Susceptibility gene for myocardial infarction; methods of treatment |
| ITTO20030140U1 (it) * | 2003-09-16 | 2005-03-17 | Interfila Srl | Matita cosmetica |
| WO2005032544A1 (en) | 2003-09-19 | 2005-04-14 | Galileo Pharmaceuticals, Inc. | Treatment of mitochondrial diseases |
| CN100475781C (zh) * | 2004-02-13 | 2009-04-08 | 沃尼尔·朗伯有限责任公司 | 雄激素受体调节剂 |
| EA009902B1 (ru) * | 2004-02-13 | 2008-04-28 | УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си | Модуляторы рецепторов андрогенов |
| US7507860B2 (en) | 2004-04-13 | 2009-03-24 | Pfizer Inc. | Androgen modulators |
| EP1781598A1 (en) * | 2004-07-08 | 2007-05-09 | Warner-Lambert Company LLC | Androgen modulators |
| BRPI0514469A (pt) * | 2004-08-18 | 2008-06-10 | Warner Lambert Co | moduladores de androgênio |
| TW200724139A (en) | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
| US20090170886A1 (en) * | 2005-08-08 | 2009-07-02 | Pfizer Inc | Androgen modulators |
| US8188260B2 (en) * | 2005-12-06 | 2012-05-29 | The University Of Tokyo | Versatile acylation catalytic RNAs and uses thereof |
| ITMI20061606A1 (it) * | 2006-08-09 | 2008-02-10 | Dipharma Spa | Procedimento per la preparazione di composti nitrilici |
| CN102304052A (zh) * | 2011-07-28 | 2012-01-04 | 浙江大学 | 一种制备5-溴-2-羟基-3-硝基苯乙酮的方法 |
| CN103980257B (zh) * | 2014-05-28 | 2016-04-27 | 苏州开元民生科技股份有限公司 | 8-硝基-2-四氮唑基-4-羰基苯并吡喃的合成方法 |
| CN104402711A (zh) * | 2014-11-12 | 2015-03-11 | 平湖优康药物研发有限公司 | 一种抗哮喘药物普伦斯特中间体的合成工艺 |
| CN113651788B (zh) * | 2021-09-16 | 2023-11-21 | 东华理工大学 | 一种3-胺烷基色酮化合物及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4977162A (en) * | 1989-07-13 | 1990-12-11 | Rorer Pharmaceutical Corporation | Quinolinyl-chromone derivatives and use for treatment of hypersensitive ailments |
| JPH0395144A (ja) * | 1989-08-04 | 1991-04-19 | Ono Pharmaceut Co Ltd | アミノフェノール誘導体の製造方法 |
-
1996
- 1996-03-21 ES ES009600682A patent/ES2127106B1/es not_active Expired - Lifetime
-
1997
- 1997-03-20 US US09/142,922 patent/US5990142A/en not_active Expired - Fee Related
- 1997-03-20 PT PT97914280T patent/PT888327E/pt unknown
- 1997-03-20 ES ES97914280T patent/ES2176719T3/es not_active Expired - Lifetime
- 1997-03-20 DE DE69713300T patent/DE69713300T2/de not_active Expired - Fee Related
- 1997-03-20 AT AT97914280T patent/ATE219073T1/de not_active IP Right Cessation
- 1997-03-20 SI SI9730340T patent/SI0888327T1/xx unknown
- 1997-03-20 EA EA199800738A patent/EA001680B1/ru unknown
- 1997-03-20 HU HU9901326A patent/HUP9901326A3/hu unknown
- 1997-03-20 DK DK97914280T patent/DK0888327T3/da active
- 1997-03-20 GE GEAP19974493A patent/GEP20012416B/en unknown
- 1997-03-20 PL PL97329027A patent/PL189562B1/pl not_active IP Right Cessation
- 1997-03-20 SK SK1272-98A patent/SK282979B6/sk not_active IP Right Cessation
- 1997-03-20 NZ NZ331953A patent/NZ331953A/xx not_active IP Right Cessation
- 1997-03-20 UA UA98094930A patent/UA65535C2/uk unknown
- 1997-03-20 KR KR10-1998-0707399A patent/KR100378892B1/ko not_active Expired - Fee Related
- 1997-03-20 JP JP53315997A patent/JP3914575B2/ja not_active Expired - Fee Related
- 1997-03-20 IL IL12629697A patent/IL126296A/en not_active IP Right Cessation
- 1997-03-20 WO PCT/EP1997/001418 patent/WO1997034885A1/en active IP Right Grant
- 1997-03-20 EE EE9800318A patent/EE03526B1/xx not_active IP Right Cessation
- 1997-03-20 CZ CZ0299598A patent/CZ296260B6/cs not_active IP Right Cessation
- 1997-03-20 CA CA002249402A patent/CA2249402C/en not_active Expired - Fee Related
- 1997-03-20 EP EP97914280A patent/EP0888327B1/en not_active Expired - Lifetime
- 1997-03-20 AU AU21587/97A patent/AU707282B2/en not_active Ceased
- 1997-03-20 TR TR1998/01857T patent/TR199801857T2/xx unknown
- 1997-03-20 BR BR9708215-5A patent/BR9708215A/pt not_active Application Discontinuation
- 1997-03-20 CN CNB971931933A patent/CN1182129C/zh not_active Expired - Fee Related
-
1998
- 1998-09-17 BG BG102775A patent/BG63433B1/bg unknown
- 1998-09-17 NO NO19984330A patent/NO319612B1/no not_active IP Right Cessation
- 1998-09-18 RS YUP-407/98A patent/RS49588B/sr unknown
- 1998-09-18 CU CU1998130A patent/CU22777A3/es not_active IP Right Cessation
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