SG97885G - Spiro-quaternary ammonium halides and n-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process - Google Patents

Spiro-quaternary ammonium halides and n-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process

Info

Publication number
SG97885G
SG97885G SG978/85A SG97885A SG97885G SG 97885 G SG97885 G SG 97885G SG 978/85 A SG978/85 A SG 978/85A SG 97885 A SG97885 A SG 97885A SG 97885 G SG97885 G SG 97885G
Authority
SG
Singapore
Prior art keywords
piperazinylalkylazaspiroalkanedione
spiro
pyrimidinyl
quaternary ammonium
ammonium halides
Prior art date
Application number
SG978/85A
Other languages
English (en)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22729338&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG97885(G) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SG97885G publication Critical patent/SG97885G/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG978/85A 1980-10-16 1985-12-23 Spiro-quaternary ammonium halides and n-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process SG97885G (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/197,416 US4351939A (en) 1980-10-16 1980-10-16 Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process

Publications (1)

Publication Number Publication Date
SG97885G true SG97885G (en) 1986-07-25

Family

ID=22729338

Family Applications (1)

Application Number Title Priority Date Filing Date
SG978/85A SG97885G (en) 1980-10-16 1985-12-23 Spiro-quaternary ammonium halides and n-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process

Country Status (33)

Country Link
US (1) US4351939A (https=)
JP (2) JPS5724384A (https=)
KR (2) KR870000321B1 (https=)
AT (1) AT382153B (https=)
AU (1) AU524822B2 (https=)
BE (1) BE890509A (https=)
CA (1) CA1175832A (https=)
CH (1) CH647778A5 (https=)
CY (1) CY1325A (https=)
DE (1) DE3141256C2 (https=)
DK (1) DK148481C (https=)
ES (2) ES501994A0 (https=)
FI (1) FI75159C (https=)
FR (1) FR2492383A1 (https=)
GB (1) GB2085436B (https=)
GR (1) GR74687B (https=)
HK (1) HK35386A (https=)
HU (2) HU185967B (https=)
IE (1) IE51646B1 (https=)
IL (1) IL64047A (https=)
IT (1) IT1143244B (https=)
KE (1) KE3596A (https=)
LU (1) LU83657A1 (https=)
MY (1) MY8600475A (https=)
NL (2) NL179055C (https=)
NZ (1) NZ196974A (https=)
OA (1) OA06920A (https=)
PT (1) PT73824B (https=)
SE (2) SE439167B (https=)
SG (1) SG97885G (https=)
SU (1) SU1342420A3 (https=)
YU (2) YU42565B (https=)
ZA (1) ZA812759B (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT387221B (de) * 1980-09-08 1988-12-27 Bristol Myers Co Verfahren zur herstellung des neuen
US4507303A (en) * 1981-12-22 1985-03-26 Sumitomo Chemical Company, Limited Succinimide derivatives, compositions and method of use
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
JPS5945380U (ja) * 1982-09-20 1984-03-26 いすゞ自動車株式会社 車両用帯状体の固定装置
US5066783A (en) * 1986-05-20 1991-11-19 Cohen Eric A Antiviral peptides and means for treating herpes infections
US5015646A (en) * 1987-08-28 1991-05-14 Bristol-Myers Squibb Co. Pharmaceutically useful polymorphic modification of buspirone
US4810789A (en) * 1987-08-28 1989-03-07 Bristol-Myers Company Process for buspirone hydrochloride polymorphic crystalline form conversion
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
FR2705098B1 (fr) * 1993-05-10 1995-08-04 Esteve Labor Dr Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) .
US5521313A (en) * 1994-05-05 1996-05-28 Bristol-Myers Squibb Company Process for preparing certain azapirones
CA2146593A1 (en) * 1994-05-05 1995-11-06 Jack Melton Large-scale process for azapirone synthesis
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
TW200302728A (en) * 2002-02-01 2003-08-16 Novartis Ag Substituted amines as IgE inhibitors
DE06790055T1 (de) * 2005-08-30 2008-09-25 Honeywell International Inc. Verfahren zur synthese von quaternären ammoniumspirosystemen
CN101089000B (zh) 2006-06-16 2011-01-05 北京大学 螺环哌嗪季铵盐类化合物及其制备方法和应用
CN101362751B (zh) * 2007-08-10 2011-05-11 成都科瑞德医药投资有限责任公司 枸橼酸坦度螺酮及其制备方法、制剂和质量控制方法
WO2011136384A1 (en) * 2010-04-26 2011-11-03 Dainippon Sumitomo Pharma Co., Ltd. A process of a quaternary ammonium salt using phosphate
DK2563790T3 (en) * 2010-04-26 2016-10-24 Sumitomo Dainippon Pharma Co Ltd PROCESS FOR quaternary ammonium salt
CN120463721A (zh) 2018-11-21 2025-08-12 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
IT201900000657A1 (it) 2019-01-16 2020-07-16 Procos Spa Processo per la sintesi di gepirone
CN117024414A (zh) * 2023-08-11 2023-11-10 浙江九洲药业股份有限公司 一种枸橼酸坦度螺酮的合成方法
CN119409681B (zh) * 2024-03-28 2025-12-16 北京华素制药股份有限公司 一种盐酸丁螺环酮的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB948730A (en) * 1959-04-08 1964-02-05 Wellcome Found Substituted cyclopropanes and related compounds
US3968216A (en) * 1969-10-29 1976-07-06 Smith Kline & French Laboratories Limited Method of inhibiting histamine activity with guanidine compounds
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation

Also Published As

Publication number Publication date
JPS61178983A (ja) 1986-08-11
ES8304967A1 (es) 1983-03-16
FR2492383B1 (https=) 1985-01-25
CH647778A5 (de) 1985-02-15
YU42565B (en) 1988-10-31
KE3596A (en) 1986-02-07
NL8104660A (nl) 1982-05-17
CY1325A (en) 1986-06-27
ZA812759B (en) 1982-05-26
YU43316B (en) 1989-06-30
GR74687B (https=) 1984-07-03
GB2085436B (en) 1984-01-18
IL64047A0 (en) 1982-01-31
BE890509A (fr) 1982-03-25
NL179055C (nl) 1986-07-01
DK148481C (da) 1985-12-16
LU83657A1 (fr) 1982-04-14
US4351939A (en) 1982-09-28
ES8206516A1 (es) 1982-08-16
HK35386A (en) 1986-05-30
JPS634828B2 (https=) 1988-02-01
SE8600174L (sv) 1986-01-15
IT1143244B (it) 1986-10-22
YU136083A (en) 1986-02-28
KR890000465B1 (ko) 1989-03-18
ES501994A0 (es) 1982-08-16
GB2085436A (en) 1982-04-28
JPS6153353B2 (https=) 1986-11-17
ATA444681A (de) 1986-06-15
SU1342420A3 (ru) 1987-09-30
DK433781A (da) 1982-04-17
DE3141256A1 (de) 1982-08-19
SE8106060L (sv) 1982-04-17
MY8600475A (en) 1986-12-31
FI75159C (fi) 1988-05-09
ES511079A0 (es) 1983-03-16
AU524822B2 (en) 1982-10-07
KR830007659A (ko) 1983-11-04
OA06920A (fr) 1983-05-31
HU185967B (en) 1985-04-28
YU110381A (en) 1983-12-31
IL64047A (en) 1984-12-31
KR870000321B1 (en) 1987-02-27
NZ196974A (en) 1983-05-31
SE8600174D0 (sv) 1986-01-15
AU7029281A (en) 1982-04-22
NL8501430A (nl) 1985-09-02
HU187999B (en) 1986-03-28
IT8149476A0 (it) 1981-10-13
CA1175832A (en) 1984-10-09
FI813178L (fi) 1982-04-17
DE3141256C2 (de) 1986-06-05
AT382153B (de) 1987-01-26
PT73824A (en) 1981-11-01
SE439167B (sv) 1985-06-03
IE812420L (en) 1982-04-16
NL179055B (nl) 1986-02-03
JPS5724384A (en) 1982-02-08
SE447257B (sv) 1986-11-03
FI75159B (fi) 1988-01-29
DK148481B (da) 1985-07-15
IE51646B1 (en) 1987-01-21
PT73824B (en) 1983-10-31
FR2492383A1 (fr) 1982-04-23

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