SG11201601495VA - New salvianolic acid compound t, preparation method therefor, and use thereof - Google Patents

New salvianolic acid compound t, preparation method therefor, and use thereof

Info

Publication number
SG11201601495VA
SG11201601495VA SG11201601495VA SG11201601495VA SG11201601495VA SG 11201601495V A SG11201601495V A SG 11201601495VA SG 11201601495V A SG11201601495V A SG 11201601495VA SG 11201601495V A SG11201601495V A SG 11201601495VA SG 11201601495V A SG11201601495V A SG 11201601495VA
Authority
SG
Singapore
Prior art keywords
preparation
acid compound
method therefor
salvianolic acid
new
Prior art date
Application number
SG11201601495VA
Other languages
English (en)
Inventor
Shuiping Zhou
Wei Li
Yuanpeng Jin
Xinxin Li
Xiaohui Ma
Wei Zhou
Min Han
Shuming Li
Original Assignee
Tasly Pharmaceutical Group Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tasly Pharmaceutical Group Co filed Critical Tasly Pharmaceutical Group Co
Publication of SG11201601495VA publication Critical patent/SG11201601495VA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG11201601495VA 2013-08-29 2014-08-26 New salvianolic acid compound t, preparation method therefor, and use thereof SG11201601495VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201310384234 2013-08-29
PCT/CN2014/085154 WO2015027891A1 (zh) 2013-08-29 2014-08-26 一种新的丹酚酸化合物t、其制备方法和用途

Publications (1)

Publication Number Publication Date
SG11201601495VA true SG11201601495VA (en) 2016-04-28

Family

ID=52585584

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201601495VA SG11201601495VA (en) 2013-08-29 2014-08-26 New salvianolic acid compound t, preparation method therefor, and use thereof

Country Status (11)

Country Link
US (1) US10626077B2 (ja)
EP (1) EP3040328B1 (ja)
JP (1) JP6517206B2 (ja)
KR (1) KR102193363B1 (ja)
CN (1) CN104418744B (ja)
AU (1) AU2014314827B2 (ja)
CA (2) CA2932187C (ja)
RU (1) RU2668955C2 (ja)
SG (1) SG11201601495VA (ja)
WO (1) WO2015027891A1 (ja)
ZA (1) ZA201601937B (ja)

Families Citing this family (12)

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ES2869918T3 (es) 2013-07-11 2021-10-26 Tasly Pharmaceutical Group Co Método de preparación de una píldora de microgota de medicina tradicional china y píldora de microgota de medicina tradicional china preparada usando el método
GEP20186877B (en) 2013-07-11 2018-07-10 Tasly Pharmaceutical Group Co Traditional chinese medicine composition, and preparation and application thereof
EP3020407A4 (en) 2013-07-11 2017-05-03 Tasly Pharmaceutical Group Co., Ltd. Traditional chinese medicine composition, and preparation and application thereof
WO2017128163A1 (zh) * 2016-01-28 2017-08-03 天津国际生物医药联合研究院 含笑内酯二甲基胺的应用
CN106938972A (zh) * 2016-12-31 2017-07-11 京津冀联创药物研究（北京）有限公司 一种丹参丹酚酸a的制备方法
CN111850033B (zh) * 2017-06-14 2023-08-18 上海长征医院 提高丹参毛状根中丹酚酸b含量的方法及漆酶基因
CN108949677B (zh) * 2018-07-05 2021-11-30 浙江大学 地黄苷c和丹酚酸a在促进体外培养骨髓间充质干细胞增殖和抑制复制性衰老中的应用
CN109748793B (zh) * 2018-12-29 2021-07-09 正大青春宝药业有限公司 一种去除丹酚酸a钠中异丹酚酸a1和异丹酚酸a2的方法
CN109939659A (zh) * 2019-04-22 2019-06-28 西北大学 一种高效疏水相互作用色谱介质、制备方法及其在提取丹酚酸b中的应用
CN110420237A (zh) * 2019-08-20 2019-11-08 南京中医药大学 黄芪花及其提取物在制备防治肺纤维化的药物或保健品中的应用
US20220395476A1 (en) * 2019-09-30 2022-12-15 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Drug for treating artery-related diseases, and use thereof
CN113662979B (zh) * 2021-09-13 2022-09-16 南昌大学 一种具有缓解结肠炎作用的富含酰基的羽衣甘蓝黄酮纯化方法及其应用

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ES2869918T3 (es) 2013-07-11 2021-10-26 Tasly Pharmaceutical Group Co Método de preparación de una píldora de microgota de medicina tradicional china y píldora de microgota de medicina tradicional china preparada usando el método
GEP20186877B (en) * 2013-07-11 2018-07-10 Tasly Pharmaceutical Group Co Traditional chinese medicine composition, and preparation and application thereof
EP3020407A4 (en) * 2013-07-11 2017-05-03 Tasly Pharmaceutical Group Co., Ltd. Traditional chinese medicine composition, and preparation and application thereof
JP6372897B2 (ja) * 2013-08-29 2018-08-15 タスリー・ファーマシューティカル・グループ・カンパニー・リミテッドＴａｓｌｙ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｇｒｏｕｐ Ｃｏ．， Ｌｔｄ． 漢方薬組成物

Also Published As

Publication number Publication date
RU2668955C2 (ru) 2018-10-05
CN104418744B (zh) 2017-03-01
CA2932187C (en) 2021-06-22
KR20160048093A (ko) 2016-05-03
EP3040328A4 (en) 2016-09-07
RU2016106144A (ru) 2017-08-29
AU2014314827B2 (en) 2018-01-04
EP3040328A1 (en) 2016-07-06
CA2921757A1 (en) 2015-03-05
US20160200661A1 (en) 2016-07-14
EP3040328B1 (en) 2017-10-18
JP2016534119A (ja) 2016-11-04
AU2014314827A1 (en) 2016-04-14
RU2016106144A3 (ja) 2018-04-02
CN104418744A (zh) 2015-03-18
WO2015027891A1 (zh) 2015-03-05
KR102193363B1 (ko) 2020-12-22
JP6517206B2 (ja) 2019-05-22
ZA201601937B (en) 2017-05-31
US10626077B2 (en) 2020-04-21
CA2932187A1 (en) 2015-03-05

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