SG11201601495VA - New salvianolic acid compound t, preparation method therefor, and use thereof - Google Patents

New salvianolic acid compound t, preparation method therefor, and use thereof

Info

Publication number
SG11201601495VA
SG11201601495VA SG11201601495VA SG11201601495VA SG11201601495VA SG 11201601495V A SG11201601495V A SG 11201601495VA SG 11201601495V A SG11201601495V A SG 11201601495VA SG 11201601495V A SG11201601495V A SG 11201601495VA SG 11201601495V A SG11201601495V A SG 11201601495VA
Authority
SG
Singapore
Prior art keywords
preparation
acid compound
method therefor
salvianolic acid
new
Prior art date
Application number
SG11201601495VA
Inventor
Shuiping Zhou
Wei Li
Yuanpeng Jin
Xinxin Li
Xiaohui Ma
Wei Zhou
Min Han
Shuming Li
Original Assignee
Tasly Pharmaceutical Group Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tasly Pharmaceutical Group Co filed Critical Tasly Pharmaceutical Group Co
Publication of SG11201601495VA publication Critical patent/SG11201601495VA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG11201601495VA 2013-08-29 2014-08-26 New salvianolic acid compound t, preparation method therefor, and use thereof SG11201601495VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201310384234 2013-08-29
PCT/CN2014/085154 WO2015027891A1 (en) 2013-08-29 2014-08-26 New salvianolic acid compound t, preparation method therefor, and use thereof

Publications (1)

Publication Number Publication Date
SG11201601495VA true SG11201601495VA (en) 2016-04-28

Family

ID=52585584

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201601495VA SG11201601495VA (en) 2013-08-29 2014-08-26 New salvianolic acid compound t, preparation method therefor, and use thereof

Country Status (11)

Country Link
US (1) US10626077B2 (en)
EP (1) EP3040328B1 (en)
JP (1) JP6517206B2 (en)
KR (1) KR102193363B1 (en)
CN (1) CN104418744B (en)
AU (1) AU2014314827B2 (en)
CA (2) CA2932187C (en)
RU (1) RU2668955C2 (en)
SG (1) SG11201601495VA (en)
WO (1) WO2015027891A1 (en)
ZA (1) ZA201601937B (en)

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HUE054609T2 (en) 2013-07-11 2021-09-28 Tasly Pharmaceutical Group Co Preparation method for traditional chinese medicine micro drop pill and traditional chinese medicine micro drop pill prepared by using the method
EP3020408B1 (en) 2013-07-11 2022-01-12 Tasly Pharmaceutical Group Co., Ltd. Traditional chinese medicine composition, and preparation and application thereof
USRE49050E1 (en) 2013-07-11 2022-04-26 Tasly Pharmaceutical Group Co., Ltd. Traditional Chinese medicine composition, and preparation and application thereof
PT3320901T (en) * 2016-01-28 2020-04-24 Tianjin Int Joint Academy Of Biotechnology & Medicine Application of dimethylamino micheliolide
CN106938972A (en) * 2016-12-31 2017-07-11 京津冀联创药物研究（北京）有限公司 A kind of preparation method of danshen root salvianolic acid A
CN111850033B (en) * 2017-06-14 2023-08-18 上海长征医院 Method for improving salvianolic acid B content in hairy roots of red sage root and laccase gene
CN108949677B (en) * 2018-07-05 2021-11-30 浙江大学 Application of rehmannia root glycoside C and salvianolic acid A in promoting proliferation of mesenchymal stem cells cultured in vitro and inhibiting replicative senescence
CN109748793B (en) * 2018-12-29 2021-07-09 正大青春宝药业有限公司 Method for removing isosalvianolic acid A1 and isosalvianolic acid A2 from sodium salvianolic acid A
CN109939659A (en) * 2019-04-22 2019-06-28 西北大学 A kind of efficient hydrophobic interaction chromatograph medium, preparation method and its extracting the application in tanshin polyphenolic acid B
CN110420237A (en) * 2019-08-20 2019-11-08 南京中医药大学 The application of Astragalis flower and its extract in the drug or health care product of preparation prevention and treatment pulmonary fibrosis
CN113662979B (en) * 2021-09-13 2022-09-16 南昌大学 Purification method and application of acyl-rich collard flavone with colitis relieving effect

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EP1371368A1 (en) * 2002-06-11 2003-12-17 N.V. Nutricia Salvianolic acid components as lipase inhibitors
CN1267111C (en) 2002-12-23 2006-08-02 北京采瑞医药有限公司 Compound red sage drip pill for treating cardiac and cerebral vascular diseases and its prepn process
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USRE49050E1 (en) 2013-07-11 2022-04-26 Tasly Pharmaceutical Group Co., Ltd. Traditional Chinese medicine composition, and preparation and application thereof
EP3020408B1 (en) 2013-07-11 2022-01-12 Tasly Pharmaceutical Group Co., Ltd. Traditional chinese medicine composition, and preparation and application thereof
US10300030B2 (en) 2013-08-29 2019-05-28 Tasly Pharmaceutical Group Co., Ltd. Traditional Chinese medicine composition

Also Published As

Publication number Publication date
EP3040328A1 (en) 2016-07-06
EP3040328B1 (en) 2017-10-18
KR20160048093A (en) 2016-05-03
CN104418744B (en) 2017-03-01
JP2016534119A (en) 2016-11-04
RU2016106144A (en) 2017-08-29
CN104418744A (en) 2015-03-18
CA2932187A1 (en) 2015-03-05
CA2921757A1 (en) 2015-03-05
AU2014314827A1 (en) 2016-04-14
ZA201601937B (en) 2017-05-31
WO2015027891A1 (en) 2015-03-05
AU2014314827B2 (en) 2018-01-04
EP3040328A4 (en) 2016-09-07
US20160200661A1 (en) 2016-07-14
RU2668955C2 (en) 2018-10-05
JP6517206B2 (en) 2019-05-22
US10626077B2 (en) 2020-04-21
CA2932187C (en) 2021-06-22
KR102193363B1 (en) 2020-12-22
RU2016106144A3 (en) 2018-04-02

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