SG11201601424PA - Site-specific antibody conjugation methods and compositions - Google Patents
Site-specific antibody conjugation methods and compositionsInfo
- Publication number
- SG11201601424PA SG11201601424PA SG11201601424PA SG11201601424PA SG11201601424PA SG 11201601424P A SG11201601424P A SG 11201601424PA SG 11201601424P A SG11201601424P A SG 11201601424PA SG 11201601424P A SG11201601424P A SG 11201601424PA SG 11201601424P A SG11201601424P A SG 11201601424PA
- Authority
- SG
- Singapore
- Prior art keywords
- compositions
- site
- specific antibody
- antibody conjugation
- conjugation methods
- Prior art date
Links
- 230000021615 conjugation Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6843—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361871173P | 2013-08-28 | 2013-08-28 | |
US201361871289P | 2013-08-28 | 2013-08-28 | |
PCT/US2014/053014 WO2015031541A1 (en) | 2013-08-28 | 2014-08-27 | Novel sez6 modulators and methods of use |
PCT/US2014/053310 WO2015031698A1 (en) | 2013-08-28 | 2014-08-28 | Site-specific antibody conjugation methods and compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201601424PA true SG11201601424PA (en) | 2016-03-30 |
Family
ID=52587354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201601424PA SG11201601424PA (en) | 2013-08-28 | 2014-08-28 | Site-specific antibody conjugation methods and compositions |
Country Status (17)
Country | Link |
---|---|
US (2) | US10035853B2 (me) |
EP (2) | EP3892294A1 (me) |
JP (3) | JP2016531915A (me) |
KR (1) | KR20160044042A (me) |
CN (1) | CN105848671B (me) |
AU (1) | AU2014312215B2 (me) |
BR (1) | BR112016004242A8 (me) |
CA (1) | CA2922547C (me) |
CL (2) | CL2016000465A1 (me) |
ES (1) | ES2871418T3 (me) |
IL (1) | IL244277A0 (me) |
MX (1) | MX2016002547A (me) |
PE (1) | PE20160674A1 (me) |
PH (1) | PH12016500391A1 (me) |
RU (1) | RU2016111131A (me) |
SG (1) | SG11201601424PA (me) |
WO (1) | WO2015031698A1 (me) |
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US9778264B2 (en) | 2010-09-03 | 2017-10-03 | Abbvie Stemcentrx Llc | Identification and enrichment of cell subpopulations |
SG189212A1 (en) | 2010-09-03 | 2013-05-31 | Stem Centrx Inc | Identification and enrichment of cell subpopulations |
EP2648749A2 (en) | 2010-12-08 | 2013-10-16 | Stem Centrx, Inc. | Novel modulators and methods of use |
SA112330278B1 (ar) | 2011-02-18 | 2015-10-09 | ستيم سينتركس، انك. | مواد ضابطة جديدة وطرق للاستخدام |
US9534058B2 (en) | 2012-02-08 | 2017-01-03 | Abbvie Stemcentrx Llc | Anti-CD324 monoclonal antibodies and uses thereof |
EP3539985A1 (en) | 2012-02-24 | 2019-09-18 | AbbVie Stemcentrx LLC | Anti sez6 antibodies and methods of use |
PL2817338T3 (pl) | 2012-02-24 | 2017-12-29 | Abbvie Stemcentrx Llc | Modulatory DLL3 i sposoby zastosowania |
EP2954056A4 (en) | 2013-02-08 | 2016-09-21 | Stemcentrx Inc | NEW MULTISPECIFIC CONSTRUCTIONS |
RU2684468C2 (ru) | 2013-02-22 | 2019-04-09 | ЭББВИ СТЕМСЕНТРКС ЭлЭлСи | Новые конъюгаты антител и их применения |
MX2016002547A (es) | 2013-08-28 | 2016-06-17 | Stemcentrx Inc | Metodos de conjugacion de anticuerpos especificos de sitio y composiciones. |
KR20160046914A (ko) | 2013-08-28 | 2016-04-29 | 스템센트알엑스 인코포레이티드 | 신규한 sez6 조절물질 및 사용방법 |
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ES2967613T3 (es) | 2015-06-19 | 2024-05-03 | Eisai R&D Man Co Ltd | Inmunoglobulinas conjugadas en Cys80 |
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EP3374379A4 (en) | 2015-11-09 | 2019-05-15 | The University Of British Columbia | N-TERMINAL EPITOPES IN BETA-AMYLOID AND CONFORMATIONALLY SELECTIVE ANTIBODIES THEREOF |
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AU2016354688B2 (en) | 2015-11-09 | 2021-12-16 | The University Of British Columbia | Epitopes in Amyloid beta mid-region and conformationally-selective antibodies thereto |
BR112018067379A2 (pt) | 2016-03-02 | 2019-01-15 | Eisai R&D Man Co Ltd | conjugado anticorpo-droga, composição, método para tratamento de um paciente que tem ou corre o risco de ter um câncer, para produzir o conjugado anticorpo-droga ou a composição, para determinar se um paciente será responsivo a um tratamento com o conjugado anticorpo-droga ou a composição, e, uso de um conjugado anticorpo-droga ou de uma composição. |
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-
2014
- 2014-08-28 MX MX2016002547A patent/MX2016002547A/es active IP Right Grant
- 2014-08-28 RU RU2016111131A patent/RU2016111131A/ru not_active Application Discontinuation
- 2014-08-28 BR BR112016004242A patent/BR112016004242A8/pt active Search and Examination
- 2014-08-28 WO PCT/US2014/053310 patent/WO2015031698A1/en active Application Filing
- 2014-08-28 JP JP2016537871A patent/JP2016531915A/ja active Pending
- 2014-08-28 CN CN201480056095.7A patent/CN105848671B/zh not_active Expired - Fee Related
- 2014-08-28 EP EP21161264.3A patent/EP3892294A1/en not_active Withdrawn
- 2014-08-28 SG SG11201601424PA patent/SG11201601424PA/en unknown
- 2014-08-28 CA CA2922547A patent/CA2922547C/en active Active
- 2014-08-28 KR KR1020167008242A patent/KR20160044042A/ko not_active Application Discontinuation
- 2014-08-28 AU AU2014312215A patent/AU2014312215B2/en not_active Ceased
- 2014-08-28 EP EP14839285.5A patent/EP3038644B1/en active Active
- 2014-08-28 PE PE2016000316A patent/PE20160674A1/es unknown
- 2014-08-28 ES ES14839285T patent/ES2871418T3/es active Active
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2016
- 2016-02-24 IL IL244277A patent/IL244277A0/en unknown
- 2016-02-29 PH PH12016500391A patent/PH12016500391A1/en unknown
- 2016-02-29 US US15/056,490 patent/US10035853B2/en active Active
- 2016-02-29 CL CL2016000465A patent/CL2016000465A1/es unknown
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2017
- 2017-05-19 CL CL2017001295A patent/CL2017001295A1/es unknown
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2018
- 2018-07-30 US US16/049,349 patent/US20180346565A1/en not_active Abandoned
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2019
- 2019-12-05 JP JP2019220107A patent/JP2020063271A/ja active Pending
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2021
- 2021-04-23 JP JP2021073091A patent/JP2021120382A/ja active Pending
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CL2017001295A1 (es) | 2018-02-09 |
US10035853B2 (en) | 2018-07-31 |
US20180346565A1 (en) | 2018-12-06 |
BR112016004242A8 (pt) | 2018-06-12 |
RU2016111131A3 (me) | 2018-11-12 |
MX2016002547A (es) | 2016-06-17 |
PH12016500391A1 (en) | 2016-05-16 |
EP3892294A1 (en) | 2021-10-13 |
AU2014312215B2 (en) | 2020-02-27 |
CL2016000465A1 (es) | 2016-12-16 |
RU2016111131A (ru) | 2017-10-03 |
PE20160674A1 (es) | 2016-07-21 |
JP2020063271A (ja) | 2020-04-23 |
JP2021120382A (ja) | 2021-08-19 |
WO2015031698A8 (en) | 2015-12-03 |
IL244277A0 (en) | 2016-04-21 |
KR20160044042A (ko) | 2016-04-22 |
EP3038644B1 (en) | 2021-04-07 |
ES2871418T3 (es) | 2021-10-28 |
EP3038644A4 (en) | 2017-08-30 |
WO2015031698A1 (en) | 2015-03-05 |
CA2922547A1 (en) | 2015-03-05 |
CN105848671B (zh) | 2019-12-13 |
US20160176964A1 (en) | 2016-06-23 |
BR112016004242A2 (pt) | 2017-10-17 |
CA2922547C (en) | 2020-03-10 |
JP2016531915A (ja) | 2016-10-13 |
CN105848671A (zh) | 2016-08-10 |
EP3038644A1 (en) | 2016-07-06 |
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