SG10201803874PA - Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor - Google Patents
Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitorInfo
- Publication number
- SG10201803874PA SG10201803874PA SG10201803874PA SG10201803874PA SG10201803874PA SG 10201803874P A SG10201803874P A SG 10201803874PA SG 10201803874P A SG10201803874P A SG 10201803874PA SG 10201803874P A SG10201803874P A SG 10201803874PA SG 10201803874P A SG10201803874P A SG 10201803874PA
- Authority
- SG
- Singapore
- Prior art keywords
- indoleamine
- synthesis
- dioxygenase
- inhibitor
- dioxygenase inhibitor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
- C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361901689P | 2013-11-08 | 2013-11-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201803874PA true SG10201803874PA (en) | 2018-07-30 |
Family
ID=52023608
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201803874PA SG10201803874PA (en) | 2013-11-08 | 2014-11-07 | Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor |
SG11201603433UA SG11201603433UA (en) | 2013-11-08 | 2014-11-07 | Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201603433UA SG11201603433UA (en) | 2013-11-08 | 2014-11-07 | Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor |
Country Status (31)
Country | Link |
---|---|
US (3) | US9321755B2 (fr) |
EP (2) | EP3066085B1 (fr) |
JP (4) | JP6461953B2 (fr) |
KR (2) | KR102370067B1 (fr) |
CN (2) | CN105899498B (fr) |
AR (1) | AR098343A1 (fr) |
AU (2) | AU2014346647B2 (fr) |
BR (2) | BR122020009912B1 (fr) |
CA (1) | CA2929552C (fr) |
CL (1) | CL2016001082A1 (fr) |
CR (2) | CR20160252A (fr) |
CY (1) | CY1123164T1 (fr) |
DK (1) | DK3066085T3 (fr) |
EA (2) | EA201991770A1 (fr) |
ES (1) | ES2799582T3 (fr) |
HR (1) | HRP20201089T1 (fr) |
HU (1) | HUE049337T2 (fr) |
IL (2) | IL245314B (fr) |
LT (1) | LT3066085T (fr) |
ME (1) | ME03792B (fr) |
MX (2) | MX366874B (fr) |
MY (1) | MY174254A (fr) |
PE (2) | PE20220430A1 (fr) |
PH (2) | PH12016500818A1 (fr) |
PL (1) | PL3066085T3 (fr) |
PT (1) | PT3066085T (fr) |
RS (1) | RS60598B1 (fr) |
SG (2) | SG10201803874PA (fr) |
SI (1) | SI3066085T1 (fr) |
TW (4) | TW202309014A (fr) |
WO (1) | WO2015070007A1 (fr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1879573T1 (sl) | 2005-05-10 | 2013-04-30 | Incyte Corporation Experimental Station | Modulatorji indolamin 2,3-dioksigenaze in postopki za uporabo le-te |
NO2824100T3 (fr) | 2008-07-08 | 2018-07-21 | ||
GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
ME03792B (fr) | 2013-11-08 | 2021-04-20 | Incyte Holdings Corp | Procédé pour la synthèse d'un inhibiteur de l'indoleamine 2,3-dioxygénase |
KR20220153677A (ko) * | 2014-02-04 | 2022-11-18 | 인사이트 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 ido1 억제제의 조합 |
CA2992238A1 (fr) * | 2015-07-14 | 2017-01-19 | Kyowa Hakko Kirin Co., Ltd. | Agent therapeutique pour tumeur comprenant un inhibiteur de l'ido administre en association avec un anticorps |
MX2018005600A (es) | 2015-11-04 | 2018-11-09 | Incyte Corp | Composiciones farmaceuticas y metodos para la inhibicion de indolamina 2,3-dioxigenasa e indicaciones para ello. |
EP3389783A4 (fr) * | 2015-12-15 | 2019-05-15 | Merck Sharp & Dohme Corp. | Nouveaux composés utilisés comme inhibiteurs de l'indoléamine 2,3-dioxygénase |
US9624185B1 (en) * | 2016-01-20 | 2017-04-18 | Yong Xu | Method for preparing IDO inhibitor epacadostat |
CN105646389B (zh) * | 2016-01-28 | 2019-06-28 | 中国科学院上海有机化学研究所 | 一种作为吲哚胺-2,3-双加氧酶抑制剂的氨基磺酸脂及其制备方法和用途 |
CN107304191B (zh) * | 2016-04-20 | 2023-09-29 | 上海翰森生物医药科技有限公司 | 吲哚胺2,3-双加氧酶抑制剂及其制备方法与应用 |
WO2017181849A1 (fr) * | 2016-04-20 | 2017-10-26 | 江苏豪森药业集团有限公司 | Inhibiteur de l'indoléamine 2,3-dioxygénase, procédé pour sa préparation et application |
EP3505517A4 (fr) | 2016-08-23 | 2020-01-15 | Beijing InnoCare Pharma Tech Co., Ltd. | Dérivé hétérocyclique fusionné, son procédé de préparation et son utilisation médicale |
CN109952300B (zh) | 2016-09-24 | 2022-01-18 | 百济神州有限公司 | 5或8-取代的咪唑并[1,5-a]吡啶 |
US11168078B2 (en) * | 2016-11-28 | 2021-11-09 | Shanghai Fochon Pharmaceutical Co., Ltd. | Sulfoximine, sulfonimidamide, sulfondiimine and diimidosulfonamide compounds as inhibitors of indoleamine 2,3-dioxygenase |
CN110382508B (zh) | 2016-12-22 | 2022-08-02 | 卡里塞拉生物科学股份公司 | 用于抑制精氨酸酶活性的组合物和方法 |
CN109206380A (zh) * | 2017-07-03 | 2019-01-15 | 上海时莱生物技术有限公司 | 吲哚胺2,3-双加氧酶抑制剂化合物及其制备方法和用途 |
CN110066253B (zh) * | 2018-01-24 | 2023-06-23 | 江苏柯菲平医药股份有限公司 | 1,2,5-噁二唑类衍生物,其制备方法及其在医药中的应用 |
CN108101899B (zh) * | 2018-02-11 | 2021-01-26 | 中国药科大学 | IDO1抑制剂Epacadostat中间体的制备方法 |
CN109180603A (zh) * | 2018-10-10 | 2019-01-11 | 中国药科大学 | Epacadostat关键中间体的制备方法 |
AU2020319875A1 (en) | 2019-08-01 | 2022-02-17 | Incyte Corporation | A dosing regimen for an IDO inhibitor |
JP2023501496A (ja) * | 2019-11-14 | 2023-01-18 | ノバ サウスイースタン ユニバーシティー | F16イソインドール小分子を使用する固形腫瘍の治療のための方法及び組成物 |
CN112341403B (zh) * | 2020-11-10 | 2022-06-28 | 南京工业大学 | 一种利用微流场反应技术制备3-氨基-4-偕胺肟基呋咱的方法 |
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BR112023017582A2 (pt) | 2021-03-05 | 2023-12-05 | Univ Basel | Composições para o tratamento de doenças ou condições associadas ao ebv |
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CL2008000066A1 (es) | 2007-01-12 | 2008-08-01 | Smithkline Beecham Corp | Compuestos derivados de (5-hidroxi-3-oxo-2,3-dihidropiridazina-4-carbonil)glicina, inhibidores de hif prolil hidroxilasas; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anem |
CA2709784A1 (fr) | 2007-12-21 | 2009-07-09 | University Of Rochester | Procede permettant de modifier la duree de vie d'organismes eucaryotes |
WO2009128521A1 (fr) * | 2008-04-15 | 2009-10-22 | 帝人ファーマ株式会社 | Inhibiteur de cystéine protéase |
NO2824100T3 (fr) | 2008-07-08 | 2018-07-21 | ||
ME03792B (fr) | 2013-11-08 | 2021-04-20 | Incyte Holdings Corp | Procédé pour la synthèse d'un inhibiteur de l'indoleamine 2,3-dioxygénase |
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