SE9903544D0 - Novel compounds - Google Patents

Novel compounds

Info

Publication number
SE9903544D0
SE9903544D0 SE9903544A SE9903544A SE9903544D0 SE 9903544 D0 SE9903544 D0 SE 9903544D0 SE 9903544 A SE9903544 A SE 9903544A SE 9903544 A SE9903544 A SE 9903544A SE 9903544 D0 SE9903544 D0 SE 9903544D0
Authority
SE
Sweden
Prior art keywords
novel compounds
solvate
chem
therapy
processes
Prior art date
Application number
SE9903544A
Other languages
English (en)
Swedish (sv)
Inventor
Roger Bonnert
Fraser Hunt
Paul Willis
Original Assignee
Astra Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod
Priority to SE9903544A priority Critical patent/SE9903544D0/xx
Publication of SE9903544D0 publication Critical patent/SE9903544D0/xx
Priority to DK00960891T priority patent/DK1222195T3/da
Priority to JP2001528186A priority patent/JP4824889B2/ja
Priority to DE60037836T priority patent/DE60037836T2/de
Priority to KR1020027004180A priority patent/KR100765051B1/ko
Priority to PT00960891T priority patent/PT1222195E/pt
Priority to EEP200200174A priority patent/EE05037B1/xx
Priority to EP03015019A priority patent/EP1348709B1/en
Priority to AT03015019T priority patent/ATE384068T1/de
Priority to ES00960891T priority patent/ES2213043T3/es
Priority to MXPA02003263A priority patent/MXPA02003263A/es
Priority to PL365778A priority patent/PL203572B1/pl
Priority to AU73049/00A priority patent/AU777872B2/en
Priority to HU0204246A priority patent/HUP0204246A3/hu
Priority to NZ517880A priority patent/NZ517880A/en
Priority to BR0014334-0A priority patent/BR0014334A/pt
Priority to AT00960891T priority patent/ATE257838T1/de
Priority to US10/089,571 priority patent/US6790850B1/en
Priority to SI200030314T priority patent/SI1222195T1/xx
Priority to CZ20021113A priority patent/CZ20021113A3/cs
Priority to EP00960891A priority patent/EP1222195B1/en
Priority to CNB008163189A priority patent/CN1210279C/zh
Priority to UA2002032035A priority patent/UA73521C2/uk
Priority to CA2385269A priority patent/CA2385269C/en
Priority to DE60007768T priority patent/DE60007768T2/de
Priority to IL14891000A priority patent/IL148910A0/xx
Priority to PCT/GB2000/003692 priority patent/WO2001025242A1/en
Priority to ES03015019T priority patent/ES2298451T3/es
Priority to TW089121952A priority patent/TWI260324B/zh
Priority to IS6306A priority patent/IS2229B/is
Priority to NO20021448A priority patent/NO327706B1/no
Priority to ZA200202380A priority patent/ZA200202380B/en
Priority to IL148910A priority patent/IL148910A/en
Priority to HK03104330A priority patent/HK1052009A1/xx
Priority to US10/863,995 priority patent/US20040224961A1/en
Priority to US12/432,224 priority patent/US8143261B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SE9903544A 1999-10-01 1999-10-01 Novel compounds SE9903544D0 (sv)

Priority Applications (36)

Application Number Priority Date Filing Date Title
SE9903544A SE9903544D0 (sv) 1999-10-01 1999-10-01 Novel compounds
US10/089,571 US6790850B1 (en) 1999-10-01 2000-09-26 Thiazolo(4,5-d)pyrimidine compounds
AT00960891T ATE257838T1 (de) 1999-10-01 2000-09-26 Neue thiazolo(4,5-d)pyrimidinverbindungen
SI200030314T SI1222195T1 (en) 1999-10-01 2000-09-26 Novel thiazolo(4,5-d)pyrimidine compounds
DE60037836T DE60037836T2 (de) 1999-10-01 2000-09-26 ThiazoloÄ4,5-dÜpyrimidinverbindungen zur Behandlung von rheumathoider Arthritis
JP2001528186A JP4824889B2 (ja) 1999-10-01 2000-09-26 新規チアゾロ（４，５−ｄ）ピリミジン化合物
PT00960891T PT1222195E (pt) 1999-10-01 2000-09-26 Novos compostos de tiazolo(4,5-d)pirimidina
CZ20021113A CZ20021113A3 (cs) 1999-10-01 2000-09-26 Deriváty thiazolo [4,5-d]pyrimidinu, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje
EP03015019A EP1348709B1 (en) 1999-10-01 2000-09-26 Thiazolo[4,5-d]pyrimidine compounds for the treatment of rheumatoid arthritis
AT03015019T ATE384068T1 (de) 1999-10-01 2000-09-26 Thiazolo(4,5-d)pyrimidinverbindungen zur behandlung von rheumathoider arthritis
ES00960891T ES2213043T3 (es) 1999-10-01 2000-09-26 Nuevos compuestos de tiazolo(4,5-d)pirimidina.
MXPA02003263A MXPA02003263A (es) 1999-10-01 2000-09-26 Compuestos novedosos de tiazol(4,5-d)pirimidina.
PL365778A PL203572B1 (pl) 1999-10-01 2000-09-26 Zwi azek tiazolo[4,5-d]pirymidynowy, sposób jego wytwarzania, zwi azki po srednie, srodek farmaceutyczny oraz zastosowanie tego zwi azku
AU73049/00A AU777872B2 (en) 1999-10-01 2000-09-26 Novel thiazolo(4,5-D)pyrimidine compounds
HU0204246A HUP0204246A3 (en) 1999-10-01 2000-09-26 Novel thiazolo[4,5-d]pyrimidine compounds, process for their preparation, pharmaceutical compositions containing them and their use
NZ517880A NZ517880A (en) 1999-10-01 2000-09-26 Novel thiazolo(4,5-D)pyrimidine compounds
BR0014334-0A BR0014334A (pt) 1999-10-01 2000-09-26 Novos compostos de tiazolo (4,5-d) pirimidina
DK00960891T DK1222195T3 (da) 1999-10-01 2000-09-26 Hidtil ukendte thiazolo[4,5-d]pyrimidinforbindelser
ES03015019T ES2298451T3 (es) 1999-10-01 2000-09-26 Compuestos de tiazolo (4,5-d)pirimidina para el tratamiento de la artritis reumatoide.
KR1020027004180A KR100765051B1 (ko) 1999-10-01 2000-09-26 신규 티아졸로(4,5-ｄ)피리미딘 화합물
EEP200200174A EE05037B1 (et) 1999-10-01 2000-09-26 Tiasolo( 4,5-d) primidiinihendid, meetod nende valmistamiseks ning neid sisaldav ravimkoostis
EP00960891A EP1222195B1 (en) 1999-10-01 2000-09-26 Novel thiazolo(4,5-d)pyrimidine compounds
CNB008163189A CN1210279C (zh) 1999-10-01 2000-09-26 新的噻唑并(4,5－d)嘧啶化合物
UA2002032035A UA73521C2 (en) 1999-10-01 2000-09-26 Thiazolo[4,5-d]pyrimidine derivatives, a method for the preparation thereof (variants), intermediary compounds, pharmaceutical composition based thereon and a method for the preparation of such composition
CA2385269A CA2385269C (en) 1999-10-01 2000-09-26 Novel thiazolo(4,5-d)pyrimidine compounds
DE60007768T DE60007768T2 (de) 1999-10-01 2000-09-26 Neue thiazolo(4,5-d)pyrimidinverbindungen
IL14891000A IL148910A0 (en) 1999-10-01 2000-09-26 Novel thiazolo (4,5-d) pyrimidine compounds
PCT/GB2000/003692 WO2001025242A1 (en) 1999-10-01 2000-09-26 Novel thiazolo(4,5-d)pyrimidine compounds
TW089121952A TWI260324B (en) 1999-10-01 2000-10-19 Thiazolopyrimidinone compounds, process for preparing the same, and pharmaceutical composition comprising the same
IS6306A IS2229B (is) 1999-10-01 2002-03-18 Ný þíasóló(4,5-d)pýrimídínefnasambönd
NO20021448A NO327706B1 (no) 1999-10-01 2002-03-22 Nye tiazolo-(4,5-D)pyrimidinforbindelser, fremgangsmate for fremstilling derav, farmasoytisk preparat og mellomprodukter
ZA200202380A ZA200202380B (en) 1999-10-01 2002-03-25 Novel thiazolo(4,5-D)pyrimidine compounds.
IL148910A IL148910A (en) 1999-10-01 2002-03-26 7 - Amino - Thiazole (D – 5,4) Pyrimidine - 2 - (N3) - Converted lobes in position 5, their preparation, pharmaceutical preparations containing them and a number of their intermediates
HK03104330A HK1052009A1 (en) 1999-10-01 2003-06-17 Novel thiazolo (4,5-D) pyrimidine compounds
US10/863,995 US20040224961A1 (en) 1999-10-01 2004-06-09 Novel thiazolo (4,5-D) pyrimidine compounds
US12/432,224 US8143261B2 (en) 1999-10-01 2009-04-29 Thiazolo (4,5-D) pyrimidine compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9903544A SE9903544D0 (sv) 1999-10-01 1999-10-01 Novel compounds

Publications (1)

Publication Number Publication Date
SE9903544D0 true SE9903544D0 (sv) 1999-10-01

Family

ID=20417218

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9903544A SE9903544D0 (sv) 1999-10-01 1999-10-01 Novel compounds

Country Status (27)

Country Link
US (3) US6790850B1 (es)
EP (2) EP1348709B1 (es)
JP (1) JP4824889B2 (es)
KR (1) KR100765051B1 (es)
CN (1) CN1210279C (es)
AT (2) ATE257838T1 (es)
AU (1) AU777872B2 (es)
BR (1) BR0014334A (es)
CA (1) CA2385269C (es)
CZ (1) CZ20021113A3 (es)
DE (2) DE60007768T2 (es)
DK (1) DK1222195T3 (es)
EE (1) EE05037B1 (es)
ES (2) ES2298451T3 (es)
HK (1) HK1052009A1 (es)
HU (1) HUP0204246A3 (es)
IL (2) IL148910A0 (es)
IS (1) IS2229B (es)
MX (1) MXPA02003263A (es)
NO (1) NO327706B1 (es)
NZ (1) NZ517880A (es)
PT (1) PT1222195E (es)
SE (1) SE9903544D0 (es)
TW (1) TWI260324B (es)
UA (1) UA73521C2 (es)
WO (1) WO2001025242A1 (es)
ZA (1) ZA200202380B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9903544D0 (sv) * 1999-10-01 1999-10-01 Astra Pharma Prod Novel compounds
GB2359081A (en) * 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active thiazolopyrimidines
EP1257555B1 (en) * 2000-02-11 2003-12-03 AstraZeneca AB Pyrimidine compounds and their use as modulators of chemokine receptor activity
GB2359078A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
SE0003828D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
SE0101322D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
SE0102716D0 (sv) * 2001-08-14 2001-08-14 Astrazeneca Ab Novel compounds
EP1458726B1 (en) 2001-12-06 2009-07-15 Merck & Co., Inc. Mitotic kinesin inhibitors
CA2468156A1 (en) 2001-12-06 2003-06-19 Merck & Co., Inc. Azolopyrimidinone compounds and their use
GB0217431D0 (en) 2002-07-27 2002-09-04 Astrazeneca Ab Novel compounds
DE60304718T2 (de) 2002-08-06 2007-04-26 Astrazeneca Ab Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivität
ES2295685T3 (es) 2002-08-24 2008-04-16 Astrazeneca Ab Derivados de pirimidina como moduladores de la actividad del receptor de quimioquinas.
GB0221829D0 (en) * 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
GB0221828D0 (en) * 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
KR20060120014A (ko) * 2003-10-07 2006-11-24 아스트라제네카 아베 케모킨, 특히 ｃｘ3ｃｒ1 수용체 길항제로서 유용한 신규한2-치환된 4-아미노-티아졸로[4,5-ｄ]피리미딘
GB0328243D0 (en) * 2003-12-05 2004-01-07 Astrazeneca Ab Methods
KR101280095B1 (ko) 2004-08-28 2013-09-09 아스트라제네카 아베 케모킨 수용체 조절제로서의 피리미딘 술폰아미드 유도체
EP1844054A2 (en) * 2004-12-17 2007-10-17 AstraZeneca AB Thiazolopyrimidine compounds for the modulation of chemokine receptor activity
US20090305321A1 (en) * 2005-03-23 2009-12-10 Astrazeneca Ab Assays for Allosteric Modulators of G-Protein Coupled Receptors (GPCRs)
UA90707C2 (en) * 2005-04-06 2010-05-25 Астразенека Аб Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives
AR053347A1 (es) * 2005-04-06 2007-05-02 Astrazeneca Ab Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos
TW200820973A (en) 2006-09-29 2008-05-16 Astrazeneca Ab Novel compounds 480
AR071036A1 (es) * 2008-03-26 2010-05-19 Astrazeneca Ab Derivados 5, 7-disustituidos de [1, 3]tiazolo[4, 5-d]pirimidin-2 (3h)-ona, una composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por el receptor cx3cr1.
CN101671336B (zh) 2009-09-23 2013-11-13 辽宁利锋科技开发有限公司 芳杂环并嘧啶衍生物和类似物及其制备方法和用途
CN101899058B (zh) * 2010-05-24 2012-05-23 中国人民解放军第四军医大学 一种噻唑并嘧啶化合物及其制备方法和应用
US10301378B2 (en) 2013-06-18 2019-05-28 New York University Cellular factors involved in the cytotoxicity of Staphylococcus aureus leukocidins: novel therapeutic targets
US10561676B2 (en) 2013-08-02 2020-02-18 Syntrix Biosystems Inc. Method for treating cancer using dual antagonists of CXCR1 and CXCR2
US8969365B2 (en) 2013-08-02 2015-03-03 Syntrix Biosystems, Inc. Thiopyrimidinecarboxamides as CXCR1/2 modulators
US10046002B2 (en) 2013-08-02 2018-08-14 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
KR102107372B1 (ko) * 2013-08-02 2020-05-07 신트릭스 바이오시스템즈, 인코포레이티드 2-[5-[n-(4-플루오로페닐)카바모일]피리미딘-2-일설파닐메틸]-4-(트리플루오로-메톡시)페닐]보론산
WO2018073248A1 (en) 2016-10-17 2018-04-26 Icm (Institut Du Cerveau Et De La Moelle Épinière) Prognosis of demyelinating diseases patients and treatment thereof
CN110172067B (zh) * 2019-04-11 2021-06-15 河南科技大学第一附属医院 一种具有杀菌活性的噻唑类药物分子及其制备方法

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DE60007768T2 (de) 2004-12-02
HUP0204246A3 (en) 2006-01-30
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EE05037B1 (et) 2008-06-16
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BR0014334A (pt) 2002-06-11
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