SE9503380D0 - Protein derivatives - Google Patents
Protein derivativesInfo
- Publication number
- SE9503380D0 SE9503380D0 SE9503380A SE9503380A SE9503380D0 SE 9503380 D0 SE9503380 D0 SE 9503380D0 SE 9503380 A SE9503380 A SE 9503380A SE 9503380 A SE9503380 A SE 9503380A SE 9503380 D0 SE9503380 D0 SE 9503380D0
- Authority
- SE
- Sweden
- Prior art keywords
- factor
- biocompatible polymer
- relates
- protein derivatives
- adsorbent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/813—Carrier is a saccharide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polyesters Or Polycarbonates (AREA)
- Polyamides (AREA)
Priority Applications (31)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9503380A SE9503380D0 (sv) | 1995-09-29 | 1995-09-29 | Protein derivatives |
PT02013613T PT1258497E (pt) | 1995-09-29 | 1996-09-27 | Conjugados de factor viii e um polimero biocompativel |
AU71517/96A AU706246B2 (en) | 1995-09-29 | 1996-09-27 | Conjugates of a polypeptide and a biocompatible polymer |
EP02013613A EP1258497B1 (en) | 1995-09-29 | 1996-09-27 | Method to prepare conjugates of factor VIII and a biocompatible polymer |
HU9901203A HU221208B1 (en) | 1995-09-29 | 1996-09-27 | Conjugates of a polypeptide and a biocompatible polymer |
DE69625085T DE69625085T2 (de) | 1995-09-29 | 1996-09-27 | Konjugate eines polypeptids und eines biologisch verträglichem polymer |
US09/029,672 US6048720A (en) | 1995-09-29 | 1996-09-27 | Conjugates of a polypeptide and a biocompatible polymer |
PT96932915T PT871649E (pt) | 1995-09-29 | 1996-09-27 | Conjugados de um polipeptideo e de um polimero biocompativel |
DK96932915T DK0871649T3 (da) | 1995-09-29 | 1996-09-27 | Konjugater af et polypeptid og en biokompatibel polymer |
ES96932915T ES2187676T3 (es) | 1995-09-29 | 1996-09-27 | Conjugados de un polipeptido y un polimero biocompatible. |
EP02013607A EP1260582B1 (en) | 1995-09-29 | 1996-09-27 | Conjugates of factor IX and a biocompatible polymer |
DK02013607T DK1260582T3 (da) | 1995-09-29 | 1996-09-27 | Konjugater af faktor IX og en bioforligelig polymer |
PCT/SE1996/001215 WO1997011957A1 (en) | 1995-09-29 | 1996-09-27 | Conjugates of a polypeptide and a biocompatible polymer |
NZ319322A NZ319322A (en) | 1995-09-29 | 1996-09-27 | Conjugates of factor viii and a biopolymer |
EP96932915A EP0871649B1 (en) | 1995-09-29 | 1996-09-27 | Conjugates of a polypeptide and a biocompatible polymer |
AT96932915T ATE228531T1 (de) | 1995-09-29 | 1996-09-27 | Konjugate eines polypeptids und eines biologisch verträglichem polymer |
ES02013613T ES2238522T3 (es) | 1995-09-29 | 1996-09-27 | Metodo para preparar conjugados del factor viii y un polimero biocompatible. |
ZA968139A ZA968139B (en) | 1995-09-29 | 1996-09-27 | Protein derivatives |
PL96325958A PL185821B1 (pl) | 1995-09-29 | 1996-09-27 | Sposób udoskonalania funkcji in-vivo zrekombinowanSposób udoskonalania funkcji in-vivo zrekombinowanego czynnika VIII SQego czynnika VIII SQ |
AT02013613T ATE289321T1 (de) | 1995-09-29 | 1996-09-27 | Verfahren zur herstellung von konjugaten vom faktor viii mit einem biologisch verträglichen polymer |
ES02013607T ES2236396T3 (es) | 1995-09-29 | 1996-09-27 | Conjugados de factor ixy un polimero biocompatible. |
DK02013613T DK1258497T3 (da) | 1995-09-29 | 1996-09-27 | Fremgangsmåde til fremstilling af konjugater af faktor VIII og en biokompatibel polymer |
DE69634373T DE69634373T2 (de) | 1995-09-29 | 1996-09-27 | Verfahren zur Herstellung von Konjugaten vom Faktor VIII mit einem biologisch verträglichen Polymer |
PT02013607T PT1260582E (pt) | 1995-09-29 | 1996-09-27 | Conjugados de factor ix e um polimero biocompativel |
AT02013607T ATE283351T1 (de) | 1995-09-29 | 1996-09-27 | Konjugate von faktor ix und einem biologisch verträglichen polymer |
JP51336397A JP3911023B2 (ja) | 1995-09-29 | 1996-09-27 | ポリペプチドと生体適合性ポリマーとのコンジュゲート |
BR9610695A BR9610695A (pt) | 1995-09-29 | 1996-09-27 | Polipeptideo conjugado em um polipeptídeo e um polímero biocompatível e do fator viii do fator de von willebrand ou um combinação destes e utilização dos mesmos |
DE69633952T DE69633952T2 (de) | 1995-09-29 | 1996-09-27 | Konjugate von Faktor IX und einem biologisch verträglichen Polymer |
CA2231801A CA2231801C (en) | 1995-09-29 | 1996-09-27 | Conjugates of a polypeptide and a biocompatible polymer |
NO19981408A NO321096B1 (no) | 1995-09-29 | 1998-03-27 | Fremgangsmate for forbedring av in vivo-funksjonen av rekombinant faktor VIII SQ ved a skjerme utsatte mal pa polypeptidet |
NO20051950A NO20051950L (no) | 1995-09-29 | 2005-04-21 | Konjugater av et polypeptid og en biokompatibel polymer |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9503380A SE9503380D0 (sv) | 1995-09-29 | 1995-09-29 | Protein derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
SE9503380D0 true SE9503380D0 (sv) | 1995-09-29 |
Family
ID=20399642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9503380A SE9503380D0 (sv) | 1995-09-29 | 1995-09-29 | Protein derivatives |
Country Status (18)
Country | Link |
---|---|
US (1) | US6048720A (xx) |
EP (3) | EP1258497B1 (xx) |
JP (1) | JP3911023B2 (xx) |
AT (3) | ATE289321T1 (xx) |
AU (1) | AU706246B2 (xx) |
BR (1) | BR9610695A (xx) |
CA (1) | CA2231801C (xx) |
DE (3) | DE69634373T2 (xx) |
DK (3) | DK0871649T3 (xx) |
ES (3) | ES2238522T3 (xx) |
HU (1) | HU221208B1 (xx) |
NO (2) | NO321096B1 (xx) |
NZ (1) | NZ319322A (xx) |
PL (1) | PL185821B1 (xx) |
PT (3) | PT1258497E (xx) |
SE (1) | SE9503380D0 (xx) |
WO (1) | WO1997011957A1 (xx) |
ZA (1) | ZA968139B (xx) |
Families Citing this family (170)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT405740B (de) * | 1996-12-13 | 1999-11-25 | Immuno Ag | Von willebrand-faktor-derivat sowie ein verfahren zur isolierung von proteinen |
JP4574007B2 (ja) | 1998-04-28 | 2010-11-04 | メルク・セローノ・ソシエテ・アノニム | ポリオール−ifn−ベータ複体 |
US7425541B2 (en) * | 1998-12-11 | 2008-09-16 | Medarex, Inc. | Enzyme-cleavable prodrug compounds |
CN100553678C (zh) | 1999-02-22 | 2009-10-28 | 巴克斯特国际有限公司 | 新的无白蛋白的因子ⅷ制剂 |
US6635676B2 (en) * | 1999-04-28 | 2003-10-21 | Regents Of The University Of Michigan | Non-toxic antimicrobial compositions and methods of use |
US7655252B2 (en) | 1999-04-28 | 2010-02-02 | The Regents Of The University Of Michigan | Antimicrobial nanoemulsion compositions and methods |
IT1318484B1 (it) * | 2000-04-21 | 2003-08-25 | Univ Roma | Derivati di colina per il trattamento della malattia di alzheimer. |
US7160540B2 (en) | 2000-06-30 | 2007-01-09 | Regents Of The University Of Minnesota | Methods for detecting activity of clottings factors |
US6423826B1 (en) | 2000-06-30 | 2002-07-23 | Regents Of The University Of Minnesota | High molecular weight derivatives of vitamin K-dependent polypeptides |
US20030211094A1 (en) | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
WO2002004483A1 (en) * | 2000-07-07 | 2002-01-17 | Samokhin Gennady P | Biologically active protein conjugates formed by first protecting active site |
AU2002225681A1 (en) * | 2000-11-15 | 2002-05-27 | Globe Immune, Inc. | Yeast-dentritic cell vaccines and uses thereof |
JP2010209109A (ja) * | 2001-06-25 | 2010-09-24 | Regents Of The Univ Of Michigan | 抗微生物ナノエマルジョンの組成物および方法 |
AU2002325819B2 (en) * | 2001-07-11 | 2008-06-19 | Maxygen, Inc. | G-CSF Conjugates |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
DK1578771T3 (da) * | 2001-10-10 | 2013-06-10 | Novo Nordisk As | Remodellering og glycokonjugering af peptider |
US8008252B2 (en) * | 2001-10-10 | 2011-08-30 | Novo Nordisk A/S | Factor VII: remodeling and glycoconjugation of Factor VII |
US7214660B2 (en) * | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
SE0104186D0 (sv) * | 2001-12-12 | 2001-12-12 | Darcy Birse | Method and device |
PT3025726T (pt) * | 2002-01-18 | 2020-01-09 | Biogen Ma Inc | Compostos do polímero polialquileno e utilizações dos mesmos |
US20030149246A1 (en) * | 2002-02-01 | 2003-08-07 | Russell John C. | Macromolecular conjugates and processes for preparing the same |
CA2475370A1 (en) * | 2002-03-02 | 2003-09-12 | F. Hoffmann-La Roche Ag | Conjugates of the c domain of human gelatinase a and polyethylene glycol, methods of purification and uses thereof |
DE60336555D1 (de) * | 2002-06-21 | 2011-05-12 | Novo Nordisk Healthcare Ag | Pegylierte glykoformen von faktor vii |
DK2357006T3 (en) * | 2002-07-31 | 2015-12-21 | Seattle Genetics Inc | Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease |
ES2911435T3 (es) | 2003-02-26 | 2022-05-19 | Nektar Therapeutics | Conjugados de polímero-resto de Factor VIII |
WO2004103270A2 (en) * | 2003-04-02 | 2004-12-02 | Suntory Pharmaceutical Research Laboratories Llc | Compounds and methods for treatment of thrombosis |
CA2522345A1 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
CA2525464A1 (en) * | 2003-05-12 | 2004-11-25 | Qun Yin | Novel poly(ethylene glycol) modified compounds and uses thereof |
PL2644206T3 (pl) * | 2003-05-23 | 2019-09-30 | Nektar Therapeutics | Pochodne PEG zawierające dwa łańcuchy PEG |
US7947261B2 (en) | 2003-05-23 | 2011-05-24 | Nektar Therapeutics | Conjugates formed from polymer derivatives having particular atom arrangements |
WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
CN1938046B (zh) | 2003-11-06 | 2014-03-19 | 西雅图基因公司 | 能够与配体偶联的单甲基缬氨酸化合物 |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
MXPA06006023A (es) * | 2003-12-03 | 2006-08-23 | Neose Technologies Inc | Factor ix glicopegilado. |
US20050171002A1 (en) * | 2004-02-03 | 2005-08-04 | Mohanty Dillip K. | Polyoxyalkylene compound and method for making |
JP5037331B2 (ja) | 2004-03-19 | 2012-09-26 | バクスター・インターナショナル・インコーポレイテッド | 出血性障害の処置のための第ixa因子 |
CN1997401A (zh) * | 2004-06-08 | 2007-07-11 | 阿尔扎公司 | 通过四组分的缩合反应来制备大分子共轭物 |
AU2014280936B2 (en) * | 2004-06-30 | 2016-12-15 | Nektar Therapeutics | Polymer-factor ix moiety conjugates |
WO2006005058A2 (en) * | 2004-06-30 | 2006-01-12 | Nektar Therapeutics Al, Corporation | Polymer-factor ix moiety conjugates |
WO2006010143A2 (en) | 2004-07-13 | 2006-01-26 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1] |
AU2005292135B2 (en) * | 2004-09-29 | 2011-09-29 | The Administrators Of The Tulane Educational Fund | Inhibitors of hepatitits C virus |
EP3061461A1 (en) | 2004-10-29 | 2016-08-31 | ratiopharm GmbH | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
AU2016203693B2 (en) * | 2004-11-12 | 2018-08-23 | Bayer Healthcare Llc | Site-directed modification of FVIII |
AU2013203348B2 (en) * | 2004-11-12 | 2016-03-03 | Bayer Healthcare Llc | Site-directed modification of FVIII |
AU2012203813B2 (en) * | 2004-11-12 | 2013-10-24 | Bayer Healthcare Llc | Site-directed modification of FVIII |
CN105753968A (zh) | 2004-11-12 | 2016-07-13 | 拜尔健康护理有限责任公司 | Fviii的位点定向修饰 |
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