WO1993020852A3 - Macrocyclic chelating agents, chelates and conjugates thereof - Google Patents

Macrocyclic chelating agents, chelates and conjugates thereof Download PDF

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Publication number
WO1993020852A3
WO1993020852A3 PCT/US1993/003483 US9303483W WO9320852A3 WO 1993020852 A3 WO1993020852 A3 WO 1993020852A3 US 9303483 W US9303483 W US 9303483W WO 9320852 A3 WO9320852 A3 WO 9320852A3
Authority
WO
WIPO (PCT)
Prior art keywords
chelating agents
chelates
conjugates
macrocyclic chelating
macrocyclic
Prior art date
Application number
PCT/US1993/003483
Other languages
French (fr)
Other versions
WO1993020852A2 (en
Inventor
Roberta C Cheng
William A Fordyce
William J Kruper Jr
George R Litwinski
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Priority to EP93912231A priority Critical patent/EP0662842A1/en
Priority to JP5518572A priority patent/JPH07505886A/en
Priority to AU42850/93A priority patent/AU677006C/en
Publication of WO1993020852A2 publication Critical patent/WO1993020852A2/en
Publication of WO1993020852A3 publication Critical patent/WO1993020852A3/en
Priority to NO943847A priority patent/NO943847L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Abstract

The present invention is directed to an improved process for preparing macrocyclic chelating agents and for conjugating the macrocyclic chelating agents to biological molecules.
PCT/US1993/003483 1992-04-13 1993-04-13 Macrocyclic chelating agents, chelates and conjugates thereof WO1993020852A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP93912231A EP0662842A1 (en) 1992-04-13 1993-04-13 Process for preparing macrocyclic chelating agents and formation of chelates and conjugates thereof
JP5518572A JPH07505886A (en) 1992-04-13 1993-04-13 Method for producing macrocyclic chelating agent, formation of chelate, and conjugate thereof
AU42850/93A AU677006C (en) 1992-04-13 1993-04-13 Process for preparing macrocyclic chelating agents and formation of chelates and conjugates thereof
NO943847A NO943847L (en) 1992-04-13 1994-10-12 Process for preparing macrocyclic chelating agents and forming chelates and conjugates thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86807892A 1992-04-13 1992-04-13
US07/868,078 1992-04-13

Publications (2)

Publication Number Publication Date
WO1993020852A2 WO1993020852A2 (en) 1993-10-28
WO1993020852A3 true WO1993020852A3 (en) 1993-11-25

Family

ID=25351031

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/003483 WO1993020852A2 (en) 1992-04-13 1993-04-13 Macrocyclic chelating agents, chelates and conjugates thereof

Country Status (7)

Country Link
EP (1) EP0662842A1 (en)
JP (1) JPH07505886A (en)
AU (1) AU694074B2 (en)
CA (1) CA2117775A1 (en)
NO (1) NO943847L (en)
SG (1) SG52470A1 (en)
WO (1) WO1993020852A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69433534T2 (en) * 1994-09-07 2004-07-08 The Dow Chemical Co., Midland METHOD FOR PRODUCING MACROCYCLIC AGENTS AND THEIR CHELATES AND CONJUGATES
CA2522148C (en) * 2003-04-15 2010-07-13 Algeta As Thorium-227 for use in radiotherapy of soft tissue disease
US20090208421A1 (en) * 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
JP5376130B2 (en) * 2009-03-24 2013-12-25 独立行政法人日本原子力研究開発機構 Separation and purification of carrier-free 177Lu capable of antibody labeling
GB201002508D0 (en) 2010-02-12 2010-03-31 Algeta As Product

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0292689A2 (en) * 1987-04-24 1988-11-30 Bracco International B.V. Substituted 1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclo-dodecane and analogs
EP0296522A2 (en) * 1987-06-24 1988-12-28 The Dow Chemical Company Functionalized polyamine chelants and rhodium complexes thereof and process for their preparation
EP0353450A1 (en) * 1988-06-24 1990-02-07 The Dow Chemical Company Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates
EP0374947A1 (en) * 1988-12-23 1990-06-27 The Dow Chemical Company Process for preparing isothiocyanato functionalized metal complexes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0292689A2 (en) * 1987-04-24 1988-11-30 Bracco International B.V. Substituted 1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclo-dodecane and analogs
EP0296522A2 (en) * 1987-06-24 1988-12-28 The Dow Chemical Company Functionalized polyamine chelants and rhodium complexes thereof and process for their preparation
EP0353450A1 (en) * 1988-06-24 1990-02-07 The Dow Chemical Company Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates
EP0374947A1 (en) * 1988-12-23 1990-06-27 The Dow Chemical Company Process for preparing isothiocyanato functionalized metal complexes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOCONJUGATE CHEMISTRY vol. 2, MAY-JUNE 1991 pages 180 - 186 C. H. CUMMINS ET AL 'A convenient synthesis of bifunctional chelating agents based on DTPA and their coordination chemistry with Yttrium(iii)' See p. 180, general methods lines 1-2 *
CHEMICAL ABSTRACTS, vol. 113, no. 25 Columbus, Ohio, US; abstract no. 231345j, *

Also Published As

Publication number Publication date
CA2117775A1 (en) 1993-10-28
AU694074B2 (en) 1998-07-09
NO943847D0 (en) 1994-10-12
JPH07505886A (en) 1995-06-29
WO1993020852A2 (en) 1993-10-28
NO943847L (en) 1994-10-12
AU4285093A (en) 1993-11-18
AU677006B2 (en) 1997-04-10
EP0662842A1 (en) 1995-07-19
SG52470A1 (en) 1998-09-28
AU2856397A (en) 1997-10-30

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