AU694074B2 - Process for purifying macrocyclic chelating agents - Google Patents

Process for purifying macrocyclic chelating agents

Info

Publication number
AU694074B2
AU694074B2 AU28563/97A AU2856397A AU694074B2 AU 694074 B2 AU694074 B2 AU 694074B2 AU 28563/97 A AU28563/97 A AU 28563/97A AU 2856397 A AU2856397 A AU 2856397A AU 694074 B2 AU694074 B2 AU 694074B2
Authority
AU
Australia
Prior art keywords
purifying
chelating agents
macrocyclic chelating
macrocyclic
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU28563/97A
Other versions
AU2856397A (en
Inventor
Roberta C. Cheng
William A. Fordyce
Willam J. Kruper Jr.
George R. Litwinski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Chemical Co
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of AU2856397A publication Critical patent/AU2856397A/en
Application granted granted Critical
Publication of AU694074B2 publication Critical patent/AU694074B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
AU28563/97A 1992-04-13 1997-07-09 Process for purifying macrocyclic chelating agents Ceased AU694074B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86807892A 1992-04-13 1992-04-13
US868078 1992-04-13

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU42850/93A Division AU677006C (en) 1992-04-13 1993-04-13 Process for preparing macrocyclic chelating agents and formation of chelates and conjugates thereof

Publications (2)

Publication Number Publication Date
AU2856397A AU2856397A (en) 1997-10-30
AU694074B2 true AU694074B2 (en) 1998-07-09

Family

ID=25351031

Family Applications (1)

Application Number Title Priority Date Filing Date
AU28563/97A Ceased AU694074B2 (en) 1992-04-13 1997-07-09 Process for purifying macrocyclic chelating agents

Country Status (7)

Country Link
EP (1) EP0662842A1 (en)
JP (1) JPH07505886A (en)
AU (1) AU694074B2 (en)
CA (1) CA2117775A1 (en)
NO (1) NO943847L (en)
SG (1) SG52470A1 (en)
WO (1) WO1993020852A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE258806T1 (en) * 1994-09-07 2004-02-15 Dow Chemical Co METHOD FOR PRODUCING MACROCYCLIC AGENTS AND THEIR CHELATES AND CONJUGATES
JP5006032B2 (en) * 2003-04-15 2012-08-22 アルゲッタ エイエス Use of thorium-227 in radiotherapy of soft tissue diseases
US20090208421A1 (en) 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
JP5376130B2 (en) * 2009-03-24 2013-12-25 独立行政法人日本原子力研究開発機構 Separation and purification of carrier-free 177Lu capable of antibody labeling
GB201002508D0 (en) 2010-02-12 2010-03-31 Algeta As Product

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US4994560A (en) * 1987-06-24 1991-02-19 The Dow Chemical Company Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
IL90730A0 (en) * 1988-06-24 1990-01-18 Dow Chemical Co Macrocyclic bifunctional chelants,complexes thereof and their antibody conjugates
JP2930708B2 (en) * 1988-12-23 1999-08-03 ザ ダウ ケミカル カンパニー Method for producing isothiocyanato-functionalized metal complex

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS 125 29606 120 49589 *

Also Published As

Publication number Publication date
JPH07505886A (en) 1995-06-29
NO943847D0 (en) 1994-10-12
WO1993020852A3 (en) 1993-11-25
NO943847L (en) 1994-10-12
SG52470A1 (en) 1998-09-28
WO1993020852A2 (en) 1993-10-28
CA2117775A1 (en) 1993-10-28
AU677006B2 (en) 1997-04-10
AU4285093A (en) 1993-11-18
EP0662842A1 (en) 1995-07-19
AU2856397A (en) 1997-10-30

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