NO943847L - Process for preparing macrocyclic chelating agents and forming chelates and conjugates thereof - Google Patents

Process for preparing macrocyclic chelating agents and forming chelates and conjugates thereof

Info

Publication number
NO943847L
NO943847L NO943847A NO943847A NO943847L NO 943847 L NO943847 L NO 943847L NO 943847 A NO943847 A NO 943847A NO 943847 A NO943847 A NO 943847A NO 943847 L NO943847 L NO 943847L
Authority
NO
Norway
Prior art keywords
chelating agents
conjugates
macrocyclic chelating
preparing macrocyclic
forming chelates
Prior art date
Application number
NO943847A
Other languages
Norwegian (no)
Other versions
NO943847D0 (en
Inventor
Roberta C Cheng
William A Fordyce
Jr William J Kruper
George R Litwinski
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of NO943847D0 publication Critical patent/NO943847D0/en
Publication of NO943847L publication Critical patent/NO943847L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Den foreliggende oppfinnelse vedrører en forbedret frem- gangsmåte for fremstilling av makrocykliske chelateringsmidler og for konjugering av de makrocykliske chelateringsmidler til biologiske molekyler.The present invention relates to an improved process for preparing macrocyclic chelating agents and for conjugating the macrocyclic chelating agents to biological molecules.

NO943847A 1992-04-13 1994-10-12 Process for preparing macrocyclic chelating agents and forming chelates and conjugates thereof NO943847L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86807892A 1992-04-13 1992-04-13
PCT/US1993/003483 WO1993020852A2 (en) 1992-04-13 1993-04-13 Macrocyclic chelating agents, chelates and conjugates thereof

Publications (2)

Publication Number Publication Date
NO943847D0 NO943847D0 (en) 1994-10-12
NO943847L true NO943847L (en) 1994-10-12

Family

ID=25351031

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943847A NO943847L (en) 1992-04-13 1994-10-12 Process for preparing macrocyclic chelating agents and forming chelates and conjugates thereof

Country Status (7)

Country Link
EP (1) EP0662842A1 (en)
JP (1) JPH07505886A (en)
AU (1) AU694074B2 (en)
CA (1) CA2117775A1 (en)
NO (1) NO943847L (en)
SG (1) SG52470A1 (en)
WO (1) WO1993020852A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10505357A (en) * 1994-09-07 1998-05-26 ザ ダウ ケミカル カンパニー Process for producing macrocyclic chelating agent, production of chelate and conjugate thereof
CA2522148C (en) * 2003-04-15 2010-07-13 Algeta As Thorium-227 for use in radiotherapy of soft tissue disease
US20090208421A1 (en) * 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
JP5376130B2 (en) * 2009-03-24 2013-12-25 独立行政法人日本原子力研究開発機構 Separation and purification of carrier-free 177Lu capable of antibody labeling
GB201002508D0 (en) 2010-02-12 2010-03-31 Algeta As Product

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US4994560A (en) * 1987-06-24 1991-02-19 The Dow Chemical Company Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
HU219485B (en) * 1988-06-24 2001-04-28 Dow Chemical Co. Process for producing 1,4,7,10-tetraazacyclododecane derivatives, complexes thereof, their antibody conjugates and pharmaceutical compositions containing them and diagnostic compositions containing the complexes and the conjugates
BR8907282A (en) * 1988-12-23 1991-03-12 Dow Chemical Co PROCESS TO PREPARE METAL COMPLEXES OPERATED WITH ISOTIOCIANATE

Also Published As

Publication number Publication date
AU694074B2 (en) 1998-07-09
CA2117775A1 (en) 1993-10-28
NO943847D0 (en) 1994-10-12
AU677006B2 (en) 1997-04-10
WO1993020852A3 (en) 1993-11-25
AU2856397A (en) 1997-10-30
JPH07505886A (en) 1995-06-29
WO1993020852A2 (en) 1993-10-28
SG52470A1 (en) 1998-09-28
EP0662842A1 (en) 1995-07-19
AU4285093A (en) 1993-11-18

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