SE9002043D0 - Improved method for synthesis - Google Patents

Improved method for synthesis

Info

Publication number
SE9002043D0
SE9002043D0 SE9002043A SE9002043A SE9002043D0 SE 9002043 D0 SE9002043 D0 SE 9002043D0 SE 9002043 A SE9002043 A SE 9002043A SE 9002043 A SE9002043 A SE 9002043A SE 9002043 D0 SE9002043 D0 SE 9002043D0
Authority
SE
Sweden
Prior art keywords
synthesis
improved method
omeprazole
methoxy
aqueous phase
Prior art date
Application number
SE9002043A
Other languages
English (en)
Swedish (sv)
Inventor
A E Braendstroem
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9002043A priority Critical patent/SE9002043D0/xx
Publication of SE9002043D0 publication Critical patent/SE9002043D0/xx
Priority to ZA913779A priority patent/ZA913779B/xx
Priority to DZ910065A priority patent/DZ1504A1/fr
Priority to NZ238224A priority patent/NZ238224A/en
Priority to IL9827491A priority patent/IL98274A/en
Priority to IE184591A priority patent/IE911845A1/en
Priority to TNTNSN91042A priority patent/TNSN91042A1/fr
Priority to SG1996006672A priority patent/SG48053A1/en
Priority to DE69128832T priority patent/DE69128832T2/de
Priority to HK98102920.4A priority patent/HK1003831B/en
Priority to RO92-01512A priority patent/RO111366B1/ro
Priority to HU9203855A priority patent/HU214323B/hu
Priority to PCT/SE1991/000402 priority patent/WO1991018895A1/en
Priority to AT91910929T priority patent/ATE162790T1/de
Priority to AU80807/91A priority patent/AU640246B2/en
Priority to EP91910929A priority patent/EP0533752B1/en
Priority to PT97873A priority patent/PT97873B/pt
Priority to YU99291A priority patent/YU47570B/sh
Priority to UA93004176A priority patent/UA32524C2/uk
Priority to ES91910929T priority patent/ES2113378T3/es
Priority to RU9192016535A priority patent/RU2061693C1/ru
Priority to PL91297169A priority patent/PL165433B1/pl
Priority to CA002083605A priority patent/CA2083605C/en
Priority to JP3510790A priority patent/JP2993122B2/ja
Priority to DK91910929.8T priority patent/DK0533752T3/da
Priority to MA22445A priority patent/MA22171A1/fr
Priority to SK1726-91A priority patent/SK278505B6/sk
Priority to CS911726A priority patent/CZ279928B6/cs
Priority to EG35291A priority patent/EG19392A/xx
Priority to APAP/P/1991/000274A priority patent/AP216A/en
Priority to IS3711A priority patent/IS1752B/is
Priority to CN91103923A priority patent/CN1040536C/zh
Priority to SA91120027A priority patent/SA91120027B1/ar
Priority to KR1019910701379A priority patent/KR0178045B1/ko
Priority to HR920770A priority patent/HRP920770B1/xx
Priority to BG97146A priority patent/BG61265B1/bg
Priority to NO924682A priority patent/NO300541B1/no
Priority to FI925529A priority patent/FI102967B1/fi
Priority to US08/067,406 priority patent/US5386032A/en
Priority to LVP-93-1020A priority patent/LV10271B/xx
Priority to LTIP1711A priority patent/LT3584B/lt
Priority to GR980400843T priority patent/GR3026642T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
SE9002043A 1990-06-07 1990-06-07 Improved method for synthesis SE9002043D0 (sv)

Priority Applications (42)

Application Number Priority Date Filing Date Title
SE9002043A SE9002043D0 (sv) 1990-06-07 1990-06-07 Improved method for synthesis
ZA913779A ZA913779B (en) 1990-06-07 1991-05-17 Method for synthesis
DZ910065A DZ1504A1 (fr) 1990-06-07 1991-05-20 Méthode de synthèse améliorée.
NZ238224A NZ238224A (en) 1990-06-07 1991-05-22 Synthesis of omeprazole (5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulphinyl)-1h-benzimidazole)
IL9827491A IL98274A (en) 1990-06-07 1991-05-27 Method for synthesis of omeprazole
IE184591A IE911845A1 (en) 1990-06-07 1991-05-30 Improved method for synthesis
TNTNSN91042A TNSN91042A1 (fr) 1990-06-07 1991-06-04 Methode de synthese amelioree
MA22445A MA22171A1 (fr) 1990-06-07 1991-06-05 Methode de synthese amelioree
RU9192016535A RU2061693C1 (ru) 1990-06-07 1991-06-05 Способ получения омепразола
DK91910929.8T DK0533752T3 (da) 1990-06-07 1991-06-05 Forbedret syntesefremgangsmåde
HK98102920.4A HK1003831B (en) 1990-06-07 1991-06-05 Improved method for synthesis
RO92-01512A RO111366B1 (ro) 1990-06-07 1991-06-05 Procedeu de obtinere a omeprazolului
HU9203855A HU214323B (hu) 1990-06-07 1991-06-05 Eljárás omeprazol előállítására
PCT/SE1991/000402 WO1991018895A1 (en) 1990-06-07 1991-06-05 Improved method for synthesis
AT91910929T ATE162790T1 (de) 1990-06-07 1991-06-05 Verbesserte methode der synthese
AU80807/91A AU640246B2 (en) 1990-06-07 1991-06-05 Improved method for synthesis
EP91910929A EP0533752B1 (en) 1990-06-07 1991-06-05 Improved method for synthesis
PT97873A PT97873B (pt) 1990-06-07 1991-06-05 Processo aperfeicoado para a sintese do omeprazol
YU99291A YU47570B (sh) 1990-06-07 1991-06-05 Postupak za sintezu omeprazola
UA93004176A UA32524C2 (uk) 1990-06-07 1991-06-05 Спосіб одержання омепразолу
ES91910929T ES2113378T3 (es) 1990-06-07 1991-06-05 Metodo de sintesis mejorado.
SG1996006672A SG48053A1 (en) 1990-06-07 1991-06-05 Improved methods for synthesis
PL91297169A PL165433B1 (pl) 1990-06-07 1991-06-05 Sposób syntezy 5-metok3y-2-[(4--metoksy-3,5-dwumety]opirydynylo-2) metylo]sulflnylo1 H-benzim idazolu PL PL PL PL PL PL
CA002083605A CA2083605C (en) 1990-06-07 1991-06-05 Method for synthesis of omeprazole
JP3510790A JP2993122B2 (ja) 1990-06-07 1991-06-05 オメプラゾールの合成法
DE69128832T DE69128832T2 (de) 1990-06-07 1991-06-05 Verbesserte methode der synthese
SK1726-91A SK278505B6 (en) 1990-06-07 1991-06-06 Synthesis method of omeprazole
EG35291A EG19392A (en) 1990-06-07 1991-06-06 Improved method for omprazole symthesis
CS911726A CZ279928B6 (cs) 1990-06-07 1991-06-06 Zdokonalený způsob syntézy omeprazolu
APAP/P/1991/000274A AP216A (en) 1990-06-07 1991-06-07 Improved method for synthesis.
IS3711A IS1752B (is) 1990-06-07 1991-06-07 Bætt aðferð við tilurð omeprazole
CN91103923A CN1040536C (zh) 1990-06-07 1991-06-07 改进的合成奥美普拉唑的方法
SA91120027A SA91120027B1 (ar) 1990-06-07 1991-07-29 طريقة محسنة للتشييد
KR1019910701379A KR0178045B1 (en) 1990-06-07 1991-10-18 Improved method for synthesis
HR920770A HRP920770B1 (en) 1990-06-07 1992-10-01 Improved method for synthesis
BG97146A BG61265B1 (en) 1990-06-07 1992-12-04 Improved method for synthesis
FI925529A FI102967B1 (fi) 1990-06-07 1992-12-04 Parannettu synteesimenetelmä
NO924682A NO300541B1 (no) 1990-06-07 1992-12-04 Forbedret syntesefremgangsmåte ved fremstilling av omeprazol
US08/067,406 US5386032A (en) 1990-06-07 1993-05-25 Method of synthesis of 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl-1H-benzimidazole (omeprazole)
LVP-93-1020A LV10271B (en) 1990-06-07 1993-08-10 Improved method for synthesis
LTIP1711A LT3584B (en) 1990-06-07 1993-12-30 Improved method for omeprazole synthesis
GR980400843T GR3026642T3 (en) 1990-06-07 1998-04-14 Improved method for synthesis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9002043A SE9002043D0 (sv) 1990-06-07 1990-06-07 Improved method for synthesis

Publications (1)

Publication Number Publication Date
SE9002043D0 true SE9002043D0 (sv) 1990-06-07

Family

ID=20379708

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9002043A SE9002043D0 (sv) 1990-06-07 1990-06-07 Improved method for synthesis

Country Status (41)

Country Link
US (1) US5386032A (cs)
EP (1) EP0533752B1 (cs)
JP (1) JP2993122B2 (cs)
KR (1) KR0178045B1 (cs)
CN (1) CN1040536C (cs)
AP (1) AP216A (cs)
AT (1) ATE162790T1 (cs)
AU (1) AU640246B2 (cs)
BG (1) BG61265B1 (cs)
CA (1) CA2083605C (cs)
CZ (1) CZ279928B6 (cs)
DE (1) DE69128832T2 (cs)
DK (1) DK0533752T3 (cs)
DZ (1) DZ1504A1 (cs)
EG (1) EG19392A (cs)
ES (1) ES2113378T3 (cs)
FI (1) FI102967B1 (cs)
GR (1) GR3026642T3 (cs)
HR (1) HRP920770B1 (cs)
HU (1) HU214323B (cs)
IE (1) IE911845A1 (cs)
IL (1) IL98274A (cs)
IS (1) IS1752B (cs)
LT (1) LT3584B (cs)
LV (1) LV10271B (cs)
MA (1) MA22171A1 (cs)
NO (1) NO300541B1 (cs)
NZ (1) NZ238224A (cs)
PL (1) PL165433B1 (cs)
PT (1) PT97873B (cs)
RO (1) RO111366B1 (cs)
RU (1) RU2061693C1 (cs)
SA (1) SA91120027B1 (cs)
SE (1) SE9002043D0 (cs)
SG (1) SG48053A1 (cs)
SK (1) SK278505B6 (cs)
TN (1) TNSN91042A1 (cs)
UA (1) UA32524C2 (cs)
WO (1) WO1991018895A1 (cs)
YU (1) YU47570B (cs)
ZA (1) ZA913779B (cs)

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SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
SE508669C2 (sv) * 1996-04-26 1998-10-26 Astra Ab Nytt förfarande
SK283805B6 (sk) 1996-09-09 2004-02-03 Slovakofarma, A. S. Spôsob prípravy omeprazolu
SE510666C2 (sv) * 1996-12-20 1999-06-14 Astra Ab Nya Kristallmodifikationer
US6437139B1 (en) 1997-05-06 2002-08-20 Pdi-Research Laboratories, Inc. Synthesis of pharmaceutically useful pyridine derivatives
CA2204580A1 (en) * 1997-05-06 1998-11-06 Michel Zoghbi Synthesis of pharmaceutically useful pyridine derivatives
KR100463031B1 (ko) * 1997-05-26 2005-04-06 동아제약주식회사 5-메톡시-2-[3,5-디메틸-4-메톡시피리딜메틸)설피닐]-1h-벤즈이미다졸의신규제조방법
SE510650C2 (sv) * 1997-05-30 1999-06-14 Astra Ab Ny förening
SE510643C2 (sv) * 1997-06-27 1999-06-14 Astra Ab Termodynamiskt stabil omeprazol natrium form B
ES2137862B1 (es) * 1997-07-31 2000-09-16 Intexim S A Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion.
SE9704183D0 (sv) 1997-11-14 1997-11-14 Astra Ab New process
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US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
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Also Published As

Publication number Publication date
EP0533752A1 (en) 1993-03-31
EP0533752B1 (en) 1998-01-28
DZ1504A1 (fr) 2004-09-13
IS1752B (is) 2000-07-21
MA22171A1 (fr) 1991-12-31
YU99291A (sh) 1993-11-16
CN1058211A (zh) 1992-01-29
CA2083605C (en) 1998-12-08
PT97873A (pt) 1992-04-30
EG19392A (en) 1995-06-29
GR3026642T3 (en) 1998-07-31
HRP920770B1 (en) 2000-06-30
BG61265B1 (en) 1997-04-30
FI925529L (fi) 1992-12-04
WO1991018895A1 (en) 1991-12-12
TNSN91042A1 (fr) 1992-10-25
CA2083605A1 (en) 1991-12-08
NO924682L (no) 1992-12-04
SA91120027B1 (ar) 2002-06-03
UA32524C2 (uk) 2001-02-15
AU640246B2 (en) 1993-08-19
SK278505B6 (en) 1997-08-06
LV10271B (en) 1995-04-20
RU2061693C1 (ru) 1996-06-10
HU214323B (hu) 1998-03-02
JPH05507699A (ja) 1993-11-04
CN1040536C (zh) 1998-11-04
LT3584B (en) 1995-12-27
CS172691A3 (en) 1992-01-15
IE911845A1 (en) 1991-12-18
YU47570B (sh) 1995-10-03
IS3711A7 (is) 1991-12-08
PL165433B1 (pl) 1994-12-30
JP2993122B2 (ja) 1999-12-20
US5386032A (en) 1995-01-31
FI102967B (fi) 1999-03-31
HUT63408A (en) 1993-08-30
NZ238224A (en) 1993-11-25
SG48053A1 (en) 1998-04-17
ES2113378T3 (es) 1998-05-01
HK1003831A1 (en) 1998-11-06
HU9203855D0 (en) 1993-03-29
DE69128832T2 (de) 1998-05-28
HRP920770A2 (en) 1995-12-31
LTIP1711A (en) 1995-07-25
DK0533752T3 (da) 1998-06-02
DE69128832D1 (de) 1998-03-05
NO924682D0 (no) 1992-12-04
CZ279928B6 (cs) 1995-08-16
AP216A (en) 1992-09-02
FI102967B1 (fi) 1999-03-31
LV10271A (lv) 1994-10-20
AP9100274A0 (en) 1991-07-31
FI925529A0 (fi) 1992-12-04
BG97146A (bg) 1993-12-24
ZA913779B (en) 1992-02-26
IL98274A0 (en) 1992-06-21
IL98274A (en) 1995-03-30
RO111366B1 (ro) 1996-09-30
PT97873B (pt) 1998-10-30
ATE162790T1 (de) 1998-02-15
NO300541B1 (no) 1997-06-16
AU8080791A (en) 1991-12-31
KR0178045B1 (en) 1999-03-20

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