SE8505922D0 - Construction of an igg binding protein to facilitate downstream processing using protein engineering - Google Patents
Construction of an igg binding protein to facilitate downstream processing using protein engineeringInfo
- Publication number
- SE8505922D0 SE8505922D0 SE8505922A SE8505922A SE8505922D0 SE 8505922 D0 SE8505922 D0 SE 8505922D0 SE 8505922 A SE8505922 A SE 8505922A SE 8505922 A SE8505922 A SE 8505922A SE 8505922 D0 SE8505922 D0 SE 8505922D0
- Authority
- SE
- Sweden
- Prior art keywords
- recombinant dna
- protein
- sequence
- fragment
- dna molecule
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 238000010276 construction Methods 0.000 title 1
- 238000011143 downstream manufacturing Methods 0.000 title 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 7
- 102000053602 DNA Human genes 0.000 abstract 4
- 239000012634 fragment Substances 0.000 abstract 4
- 108020004705 Codon Proteins 0.000 abstract 2
- OQCPATDFWYYDDX-HGNGGELXSA-N Ala-Gln-His Chemical compound C[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(O)=O OQCPATDFWYYDDX-HGNGGELXSA-N 0.000 abstract 1
- VAWNQIGQPUOPQW-ACZMJKKPSA-N Asp-Glu-Ala Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(O)=O VAWNQIGQPUOPQW-ACZMJKKPSA-N 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 108010088160 Staphylococcal Protein A Proteins 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 229940027941 immunoglobulin g Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000013600 plasmid vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8505922A SE8505922D0 (sv) | 1985-12-13 | 1985-12-13 | Construction of an igg binding protein to facilitate downstream processing using protein engineering |
| DE8686850416T DE3686646T2 (de) | 1985-12-13 | 1986-12-02 | Herstellung eines igg-bindenden proteins zum erleichtern der weiterverarbeitung mittels "protein-engineering". |
| ES198686850416T ES2046177T3 (es) | 1985-12-13 | 1986-12-02 | Construccion de una proteina enlazante a igg para facilitar el tratamiento aguas abajo utilizando ingenieria de proteinas. |
| AT86850416T ATE80180T1 (de) | 1985-12-13 | 1986-12-02 | Herstellung eines igg-bindenden proteins zum erleichtern der weiterverarbeitung mittels ''protein-engineering''. |
| EP86850416A EP0230869B1 (en) | 1985-12-13 | 1986-12-02 | Construction of an igg binding protein to facilitate downstream processing using protein engineering |
| AU66331/86A AU600244B2 (en) | 1985-12-13 | 1986-12-09 | Construction of an IgG binding protein to facilitate downstream processing using protein engineering |
| CA000525167A CA1311430C (en) | 1985-12-13 | 1986-12-12 | Construction of an igg binding protein to facilitate downstream processing using protein engineering |
| DK600486A DK600486A (da) | 1985-12-13 | 1986-12-12 | Igg-bindingsprotein |
| JP61296509A JPH0811069B2 (ja) | 1985-12-13 | 1986-12-12 | 蛋白質工学を用いるダウンストリ−ムプロセツシングを促進するためのIgG結合性蛋白質の構成 |
| US07/594,564 US5143844A (en) | 1985-12-13 | 1990-10-09 | Construction of an igg binding protein to facilitate downstream processing using protein engineering |
| GR920402499T GR3006178T3 (en, 2012) | 1985-12-13 | 1992-11-05 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8505922A SE8505922D0 (sv) | 1985-12-13 | 1985-12-13 | Construction of an igg binding protein to facilitate downstream processing using protein engineering |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE8505922D0 true SE8505922D0 (sv) | 1985-12-13 |
Family
ID=20362468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8505922A SE8505922D0 (sv) | 1985-12-13 | 1985-12-13 | Construction of an igg binding protein to facilitate downstream processing using protein engineering |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5143844A (en, 2012) |
| EP (1) | EP0230869B1 (en, 2012) |
| JP (1) | JPH0811069B2 (en, 2012) |
| AT (1) | ATE80180T1 (en, 2012) |
| AU (1) | AU600244B2 (en, 2012) |
| CA (1) | CA1311430C (en, 2012) |
| DE (1) | DE3686646T2 (en, 2012) |
| DK (1) | DK600486A (en, 2012) |
| ES (1) | ES2046177T3 (en, 2012) |
| GR (1) | GR3006178T3 (en, 2012) |
| SE (1) | SE8505922D0 (en, 2012) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK528285D0 (da) * | 1985-11-15 | 1985-11-15 | Novo Industri As | Peptider samt praeparater indeholdende disse |
| SE8505921D0 (sv) * | 1985-12-13 | 1985-12-13 | Kabigen Ab | A method to export gene products to the growth medium of gram negative bacteria |
| SE8601940D0 (sv) * | 1986-04-25 | 1986-04-25 | Kabigen Ab | Preparation of fused proteins, antibodies and processes therefor |
| US5985599A (en) * | 1986-05-29 | 1999-11-16 | The Austin Research Institute | FC receptor for immunoglobulin |
| WO1988009344A1 (en) * | 1987-05-21 | 1988-12-01 | Creative Biomolecules, Inc. | Targeted multifunctional proteins |
| US5095096A (en) * | 1987-05-29 | 1992-03-10 | Sagami Chemical Research Center | Fused protein comprising lymphotoxin |
| US5243040A (en) * | 1987-11-20 | 1993-09-07 | Creative Biomolecules | DNA encoding a protein which enables selective removal of immune complexes |
| AU623361B2 (en) * | 1987-11-20 | 1992-05-14 | Creative Biomolecules, Inc. | Selective removal of immune complexes |
| US5084398A (en) * | 1987-11-20 | 1992-01-28 | Creative Biomolecules | Selective removal of immune complexes |
| SE8800981D0 (sv) * | 1988-03-17 | 1988-03-17 | Nygren Per Ake | A recombinant fusion protein, its use and a recombinant vector |
| SE509359C2 (sv) * | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
| GB8927008D0 (en) * | 1989-11-29 | 1990-01-17 | Ciba Geigy | Novel process for the production of unfused protein in e.coli |
| US5681814A (en) * | 1990-06-07 | 1997-10-28 | Genentech, Inc. | Formulated IGF-I Composition |
| US5595887A (en) * | 1990-07-16 | 1997-01-21 | Bionebraska, Inc. | Purification directed cloning of peptides using carbonic anhydrase as the affinity binding segment |
| US6077694A (en) * | 1990-09-21 | 2000-06-20 | The United States Of America As Represented By The Department Of Health And Human Services | Method for over-expression and rapid purification of biosynthetic proteins |
| US5863783A (en) * | 1991-03-27 | 1999-01-26 | Gist-Brocades, N.V. | Cloning and expression of DNA molecules encoding arabinan-degrading enzymes of fungal origin |
| US5736363A (en) * | 1991-07-29 | 1998-04-07 | British Bio-Technology Limited | IGF-II analogues |
| US5989887A (en) * | 1992-11-25 | 1999-11-23 | Dsm N.V. | Cloning and expression of DNA molecules incoding arabinan-degrading enzymes of fungal origin |
| SE9504019D0 (sv) * | 1995-11-13 | 1995-11-13 | Pharmacia Ab | Method for production of proteins |
| US5917026A (en) * | 1996-02-05 | 1999-06-29 | Loewenadler; Bjoern | Fusion proteins of immunopotentiating activity |
| US5962270A (en) | 1996-02-06 | 1999-10-05 | Bionebraska, Inc. | Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs |
| CA2265972A1 (en) * | 1996-09-16 | 1998-03-26 | Philip D. Acott | Use of igf-i for the treatment of polycystic kidney disease and related indications |
| US6593290B1 (en) | 1996-11-01 | 2003-07-15 | Genentech, Inc. | Treatment of inner ear hair cells |
| US6156728A (en) * | 1996-11-01 | 2000-12-05 | Genentech, Inc. | Treatment of inner ear hair cells |
| US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
| US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
| CA2356257C (en) | 1999-01-06 | 2012-10-16 | Genentech, Inc. | Insulin-like growth factor (igf) i mutant variants |
| IL143866A0 (en) | 1999-01-06 | 2002-04-21 | Genentech Inc | Insulin-like growth factor (igf) i mutant variants |
| ES2208305T3 (es) | 1999-04-08 | 2004-06-16 | Genentech, Inc. | Composicion basada en polipeptidos de carga opuesta.. |
| ATE389416T1 (de) | 2000-05-16 | 2008-04-15 | Genentech Inc | Behandlung von knorpelerkrankungen |
| US20030157561A1 (en) * | 2001-11-19 | 2003-08-21 | Kolkman Joost A. | Combinatorial libraries of monomer domains |
| SE0200943D0 (sv) | 2002-03-25 | 2002-03-25 | Amersham Biosciences Ab | Mutant protein |
| US20050003548A1 (en) * | 2002-07-22 | 2005-01-06 | Nikolay Korokhov | Targeted adenoviral vector displaying immunoglobulin-binding domain and uses thereof |
| HUE027218T2 (en) | 2003-09-12 | 2016-10-28 | Ipsen Biopharmaceuticals Inc | Methods for Treatment of IGF-1 (Insulin-like Growth Factor 1) Deficiency |
| EP1670822A2 (en) | 2003-10-03 | 2006-06-21 | Genentech, Inc. | Igf binding proteins |
| EP2380594B1 (en) | 2004-04-06 | 2019-12-04 | Affibody AB | Use of a serum albumin binding peptide to reduce the immunogenicity of a protein |
| ES2577292T3 (es) | 2005-11-07 | 2016-07-14 | Genentech, Inc. | Polipéptidos de unión con secuencias hipervariables de VH/VL diversificadas y consenso |
| JP5808070B2 (ja) | 2005-12-02 | 2015-11-10 | ジェネンテック, インコーポレイテッド | 結合ポリペプチド及びその使用 |
| JP2008048607A (ja) | 2006-08-22 | 2008-03-06 | Chisso Corp | Fc結合ドメインとカルシウム結合発光蛋白質との融合蛋白質、それをコードする遺伝子およびそれらの用途 |
| GB2442118B (en) | 2006-09-19 | 2011-08-17 | Chisso Corp | Process for production of recombinant proteins as a soluble form |
| US7691608B2 (en) | 2006-12-06 | 2010-04-06 | Repligen Corporation | Nucleic acids encoding recombinant protein A |
| US8198043B2 (en) | 2006-12-08 | 2012-06-12 | General Electric Company | Two helix binders |
| US8592555B2 (en) | 2008-08-11 | 2013-11-26 | Emd Millipore Corporation | Immunoglobulin-binding proteins with improved specificity |
| SG162687A1 (en) | 2008-12-24 | 2010-07-29 | Millipore Corp | Caustic stable chromatography ligands |
| WO2010110288A1 (ja) | 2009-03-24 | 2010-09-30 | 株式会社カネカ | 免疫グロブリンに親和性を有するタンパク質および免疫グロブリン結合性アフィニティーリガンド |
| EP2414391B1 (en) | 2009-04-02 | 2018-11-28 | Roche Glycart AG | Multispecific antibodies comprising full length antibodies and single chain fab fragments |
| CA2781519A1 (en) | 2009-09-16 | 2011-03-24 | Genentech, Inc. | Coiled coil and/or tether containing protein complexes and uses thereof |
| CN107686513A (zh) * | 2010-03-08 | 2018-02-13 | 通用电气医疗集团生物工艺研发股份公司 | 免疫球蛋白G Fc区结合多肽 |
| SG184184A1 (en) | 2010-03-24 | 2012-10-30 | Kaneka Corp | Protein capable of binding specifically to immunoglobulin, and immunoglobulin-binding affinity ligand |
| AR080793A1 (es) | 2010-03-26 | 2012-05-09 | Roche Glycart Ag | Anticuerpos biespecificos |
| MX346731B (es) | 2010-04-23 | 2017-03-30 | Genentech Inc * | Producción de proteínas heteromultiméricas. |
| MX2013001267A (es) | 2010-08-13 | 2013-04-10 | Genentech Inc | ANTICUERPOS A IL-1ß E EIL-18 PARA TRATAMIENTO DE ENFERMEDAD. |
| CA2807278A1 (en) | 2010-08-24 | 2012-03-01 | F. Hoffmann - La Roche Ag | Bispecific antibodies comprising a disulfide stabilized - fv fragment |
| US9187555B2 (en) | 2010-12-20 | 2015-11-17 | Ge Healthcare Bio-Sciences Ab | Affinity chromatography matrix |
| JP5974342B2 (ja) | 2010-12-20 | 2016-08-23 | ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ | アフィニティークロマトグラフィーマトリックス |
| JP5766296B2 (ja) | 2010-12-23 | 2015-08-19 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用 |
| US10689447B2 (en) | 2011-02-04 | 2020-06-23 | Genentech, Inc. | Fc variants and methods for their production |
| AR085138A1 (es) | 2011-02-04 | 2013-09-11 | Genentech Inc | VARIANTES DE Fc Y METODOS PARA SU PRODUCCION |
| SG193950A1 (en) * | 2011-03-25 | 2013-11-29 | Kaneka Corp | Novel immunoglobulin-binding polypeptide |
| SG10201604554WA (en) | 2011-06-08 | 2016-07-28 | Emd Millipore Corp | Chromatography matrices including novel staphylococcus aureus protein a based ligands |
| MX359384B (es) | 2011-10-11 | 2018-09-25 | Genentech Inc | Conjunto mejorado de anticuerpos bisespecificos. |
| RU2644341C2 (ru) | 2012-02-10 | 2018-02-08 | Дженентек, Инк. | Одноцепочечные антитела и другие гетеромультимеры |
| WO2013147691A1 (en) | 2012-03-28 | 2013-10-03 | Ge Healthcare Bio-Sciences Ab | Affinity chromatography matrix |
| HK1207864A1 (en) | 2012-06-27 | 2016-02-12 | F. Hoffmann-La Roche Ag | Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof |
| WO2014001325A1 (en) | 2012-06-27 | 2014-01-03 | F. Hoffmann-La Roche Ag | Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof |
| CN105377880B (zh) | 2013-07-10 | 2020-08-07 | 通用电气医疗集团生物工艺研发股份公司 | 突变的免疫球蛋白结合多肽 |
| JP6491600B2 (ja) | 2013-09-27 | 2019-03-27 | 株式会社カネカ | アルカリ水溶液を用いた多孔質セルロースビーズの製造方法 |
| HRP20231139T1 (hr) | 2014-05-06 | 2024-01-05 | F. Hoffmann - La Roche Ag | Proizvodnja heteromultimernih proteina upotrebom stanica sisavaca |
| US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| JP6721590B2 (ja) | 2014-12-03 | 2020-07-15 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 多重特異性抗体 |
| WO2016121703A1 (ja) | 2015-01-26 | 2016-08-04 | 株式会社カネカ | 変異型免疫グロブリンκ鎖可変領域結合性ペプチド |
| WO2016121701A1 (ja) | 2015-01-26 | 2016-08-04 | 株式会社カネカ | 免疫グロブリンκ鎖可変領域含有タンパク質精製用アフィニティー分離マトリックス |
| JP6424101B2 (ja) * | 2015-01-30 | 2018-11-14 | Jnc株式会社 | Fc結合ドメインとカルシウム結合発光蛋白質との融合蛋白質、それをコードする遺伝子およびそれらの用途 |
| KR20170115535A (ko) | 2015-02-05 | 2017-10-17 | 미쯔비시 케미컬 주식회사 | 면역 글로불린에 친화성을 갖는 단백질, 및 그것을 사용한 친화성 분리제, 액체 크로마토그래피용 칼럼 |
| WO2017195638A1 (ja) | 2016-05-09 | 2017-11-16 | 株式会社カネカ | 抗体またはκ鎖可変領域含有抗体断片の精製方法 |
| US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| EP3455240B1 (en) | 2016-05-11 | 2025-01-01 | Cytiva BioProcess R&D AB | Method of storing a separation matrix |
| JP6987424B2 (ja) | 2016-05-11 | 2022-01-05 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックスを洗浄および/または消毒する方法 |
| US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| JP7031934B2 (ja) | 2016-05-11 | 2022-03-08 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックス |
| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| EP3455243B1 (en) | 2016-05-11 | 2021-03-24 | Cytiva BioProcess R&D AB | Separation matrix |
| US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
| US11779860B2 (en) | 2017-08-07 | 2023-10-10 | Repligen Corporation | Fc binding proteins with cysteine in the C-terminal helical region |
| EP4249097A3 (en) | 2018-02-01 | 2024-01-10 | Repligen Corporation | Fc binding proteins with cysteine in the c-terminal helical region |
| GB202018588D0 (en) | 2020-11-26 | 2021-01-13 | Cytiva Bioprocess R & D Ab | Separation matrix |
| GB202113626D0 (en) | 2021-09-24 | 2021-11-10 | Cytiva Bioprocess R & D Ab | FC binding polypeptides |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4769326A (en) * | 1980-02-29 | 1988-09-06 | The Regents Of The University Of California | Expression linkers |
| SE8300693L (sv) * | 1983-02-09 | 1984-08-10 | Sven Lofdahl | Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta |
-
1985
- 1985-12-13 SE SE8505922A patent/SE8505922D0/xx unknown
-
1986
- 1986-12-02 DE DE8686850416T patent/DE3686646T2/de not_active Expired - Fee Related
- 1986-12-02 ES ES198686850416T patent/ES2046177T3/es not_active Expired - Lifetime
- 1986-12-02 AT AT86850416T patent/ATE80180T1/de not_active IP Right Cessation
- 1986-12-02 EP EP86850416A patent/EP0230869B1/en not_active Expired
- 1986-12-09 AU AU66331/86A patent/AU600244B2/en not_active Ceased
- 1986-12-12 JP JP61296509A patent/JPH0811069B2/ja not_active Expired - Lifetime
- 1986-12-12 DK DK600486A patent/DK600486A/da not_active Application Discontinuation
- 1986-12-12 CA CA000525167A patent/CA1311430C/en not_active Expired - Fee Related
-
1990
- 1990-10-09 US US07/594,564 patent/US5143844A/en not_active Expired - Lifetime
-
1992
- 1992-11-05 GR GR920402499T patent/GR3006178T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62190087A (ja) | 1987-08-20 |
| EP0230869A2 (en) | 1987-08-05 |
| AU6633186A (en) | 1987-06-18 |
| DE3686646T2 (de) | 1993-04-08 |
| EP0230869A3 (en) | 1988-08-03 |
| US5143844A (en) | 1992-09-01 |
| AU600244B2 (en) | 1990-08-09 |
| JPH0811069B2 (ja) | 1996-02-07 |
| CA1311430C (en) | 1992-12-15 |
| EP0230869B1 (en) | 1992-09-02 |
| DE3686646D1 (de) | 1992-10-08 |
| DK600486D0 (da) | 1986-12-12 |
| ATE80180T1 (de) | 1992-09-15 |
| GR3006178T3 (en, 2012) | 1993-06-21 |
| DK600486A (da) | 1987-06-14 |
| ES2046177T3 (es) | 1994-02-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE8505922D0 (sv) | Construction of an igg binding protein to facilitate downstream processing using protein engineering | |
| Gundelfinger et al. | The organization of the 7SL RNA in the signal recognition particle | |
| BR9610511A (pt) | Molécula de dna de forma circular útil em terapia gênica compreendendo ao menos uma sequência nucléica de interesse processo para sua produção célula recombinante composição farmacêutica utilização de uma molécula de dna e processo de produção de uma proteína recombinante | |
| IL57491A (en) | Recombinant dna,methods for the production thereof and proteins or polypeptides produced thereby | |
| ZA822855B (en) | Bacillus cloning vectors,recombinant dna molecules,bacillus hosts transformed with them and methods for expressing foreign dna sequences and producing polypeptides coded thereby | |
| WO1995016048A3 (en) | Recombinant protein production in bovine adenovirus expression vector system | |
| ATE242808T1 (de) | Cytoplasmatische expression von antikörpern, antikörperfragmenten und antikörperfragment- fusionsmolekülen in e. coli | |
| Johnson et al. | Identification of a plastid-specific ribosomal protein in the 30 S subunit of chloroplast ribosomes and isolation of the cDNA clone encoding its cytoplasmic precursor. | |
| JPS6420095A (en) | Polypeptide having anti-blood coagulating action | |
| HUT52551A (en) | Process for production of neutrophil-activizating factor | |
| IL99079A0 (en) | Protein structure of the plant toxin gelonin | |
| DK0805204T3 (da) | Bitestikel - specifikt receptorprotein og anvendelse heraf | |
| Roberts et al. | Different active sites of mammalian DNA ligases I and II. | |
| DE3572843D1 (en) | Site-specific proteolysis by renin | |
| Boyle et al. | All major regions of FtsK are required for resolution of chromosome dimers | |
| DE69634757D1 (de) | Vektor zur expression von n-terminal verlängerten proteinen in hefezellen | |
| Taylor et al. | Similarities in the heavy and light chains of tetanus toxin suggested by their amino acid compositions | |
| Bolyard et al. | Expression in Escherichia coli of the human fibrinogen B beta chain and its cleavage by thrombin | |
| Thomann et al. | Homologous expression and purification of mutants of an essential protein by reverse epitope-tagging | |
| Ikeuchi et al. | The enhancing of a cysteine proteinase activity at acidic pH by protein engineering, the role of glutamic 50 in the enzyme mechanism of caricain | |
| EP0688224A4 (en) | MUTANT PROTEIN, METHODS AND MATERIALS USED FOR ITS MANUFACTURE AND USE | |
| JPH07163379A (ja) | シグナル配列ペプチドをコードするdna断片の探索法及びそのためのベクター | |
| Troitskiĭ et al. | Purification, heterogeneity and some properties of T2 bacteriophage lysozyme | |
| Stefani | Mapping the Transcriptional Unit of the Human Epsilon Globin Gene | |
| TW287199B (en) | A method for genetically producing a protein exhibiting the activity of epstein-barr virus DNA polymerase |