DE3686646D1 - Herstellung eines igg-bindenden proteins zum erleichtern der weiterverarbeitung mittels "protein-engineering". - Google Patents
Herstellung eines igg-bindenden proteins zum erleichtern der weiterverarbeitung mittels "protein-engineering".Info
- Publication number
- DE3686646D1 DE3686646D1 DE8686850416T DE3686646T DE3686646D1 DE 3686646 D1 DE3686646 D1 DE 3686646D1 DE 8686850416 T DE8686850416 T DE 8686850416T DE 3686646 T DE3686646 T DE 3686646T DE 3686646 D1 DE3686646 D1 DE 3686646D1
- Authority
- DE
- Germany
- Prior art keywords
- recombinant dna
- protein
- sequence
- fragment
- dna molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 108020004511 Recombinant DNA Proteins 0.000 abstract 7
- 102000053602 DNA Human genes 0.000 abstract 4
- 239000012634 fragment Substances 0.000 abstract 4
- 108020004705 Codon Proteins 0.000 abstract 2
- OQCPATDFWYYDDX-HGNGGELXSA-N Ala-Gln-His Chemical compound C[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(O)=O OQCPATDFWYYDDX-HGNGGELXSA-N 0.000 abstract 1
- VAWNQIGQPUOPQW-ACZMJKKPSA-N Asp-Glu-Ala Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(O)=O VAWNQIGQPUOPQW-ACZMJKKPSA-N 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 108010088160 Staphylococcal Protein A Proteins 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 229940027941 immunoglobulin g Drugs 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000013600 plasmid vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8505922A SE8505922D0 (sv) | 1985-12-13 | 1985-12-13 | Construction of an igg binding protein to facilitate downstream processing using protein engineering |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3686646D1 true DE3686646D1 (de) | 1992-10-08 |
DE3686646T2 DE3686646T2 (de) | 1993-04-08 |
Family
ID=20362468
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686850416T Expired - Fee Related DE3686646T2 (de) | 1985-12-13 | 1986-12-02 | Herstellung eines igg-bindenden proteins zum erleichtern der weiterverarbeitung mittels "protein-engineering". |
Country Status (11)
Country | Link |
---|---|
US (1) | US5143844A (de) |
EP (1) | EP0230869B1 (de) |
JP (1) | JPH0811069B2 (de) |
AT (1) | ATE80180T1 (de) |
AU (1) | AU600244B2 (de) |
CA (1) | CA1311430C (de) |
DE (1) | DE3686646T2 (de) |
DK (1) | DK600486A (de) |
ES (1) | ES2046177T3 (de) |
GR (1) | GR3006178T3 (de) |
SE (1) | SE8505922D0 (de) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK528285D0 (da) * | 1985-11-15 | 1985-11-15 | Novo Industri As | Peptider samt praeparater indeholdende disse |
SE8505921D0 (sv) * | 1985-12-13 | 1985-12-13 | Kabigen Ab | A method to export gene products to the growth medium of gram negative bacteria |
SE8601940D0 (sv) * | 1986-04-25 | 1986-04-25 | Kabigen Ab | Preparation of fused proteins, antibodies and processes therefor |
US5985599A (en) * | 1986-05-29 | 1999-11-16 | The Austin Research Institute | FC receptor for immunoglobulin |
DE3856559T2 (de) * | 1987-05-21 | 2004-04-29 | Micromet Ag | Multifunktionelle Proteine mit vorbestimmter Zielsetzung |
ATE87007T1 (de) * | 1987-05-29 | 1993-04-15 | Sagami Chem Res | Fusionsprotein, enthaltend lymphotoxin. |
US5243040A (en) * | 1987-11-20 | 1993-09-07 | Creative Biomolecules | DNA encoding a protein which enables selective removal of immune complexes |
US5084398A (en) * | 1987-11-20 | 1992-01-28 | Creative Biomolecules | Selective removal of immune complexes |
DE3887750T2 (de) * | 1987-11-20 | 1994-09-15 | Creative Biomolecules Inc | Selektive entfernung von immunkomplexen. |
SE8800981A (sv) * | 1988-03-17 | 1988-10-14 | Lars Abrahamsen | A recombinant fusion protein, its use and a recombinant vector |
SE509359C2 (sv) * | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
GB8927008D0 (en) * | 1989-11-29 | 1990-01-17 | Ciba Geigy | Novel process for the production of unfused protein in e.coli |
US5681814A (en) * | 1990-06-07 | 1997-10-28 | Genentech, Inc. | Formulated IGF-I Composition |
US5595887A (en) * | 1990-07-16 | 1997-01-21 | Bionebraska, Inc. | Purification directed cloning of peptides using carbonic anhydrase as the affinity binding segment |
US6077694A (en) * | 1990-09-21 | 2000-06-20 | The United States Of America As Represented By The Department Of Health And Human Services | Method for over-expression and rapid purification of biosynthetic proteins |
US5863783A (en) * | 1991-03-27 | 1999-01-26 | Gist-Brocades, N.V. | Cloning and expression of DNA molecules encoding arabinan-degrading enzymes of fungal origin |
US5736363A (en) * | 1991-07-29 | 1998-04-07 | British Bio-Technology Limited | IGF-II analogues |
US5989887A (en) * | 1992-11-25 | 1999-11-23 | Dsm N.V. | Cloning and expression of DNA molecules incoding arabinan-degrading enzymes of fungal origin |
SE9504019D0 (sv) * | 1995-11-13 | 1995-11-13 | Pharmacia Ab | Method for production of proteins |
US5917026A (en) * | 1996-02-05 | 1999-06-29 | Loewenadler; Bjoern | Fusion proteins of immunopotentiating activity |
US5962270A (en) | 1996-02-06 | 1999-10-05 | Bionebraska, Inc. | Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs |
CA2265972A1 (en) * | 1996-09-16 | 1998-03-26 | Philip D. Acott | Use of igf-i for the treatment of polycystic kidney disease and related indications |
US6593290B1 (en) | 1996-11-01 | 2003-07-15 | Genentech, Inc. | Treatment of inner ear hair cells |
US6156728A (en) | 1996-11-01 | 2000-12-05 | Genentech, Inc. | Treatment of inner ear hair cells |
US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
IL143866A0 (en) | 1999-01-06 | 2002-04-21 | Genentech Inc | Insulin-like growth factor (igf) i mutant variants |
IL143834A0 (en) | 1999-01-06 | 2002-04-21 | Genentech Inc | Insulin-like growth factor (igf) i mutant variants |
DE60005806T2 (de) | 1999-04-08 | 2004-08-05 | Genentech, Inc., South San Francisco | Zusammensetzung auf basis gegensätzlich geladener polypeptide |
EP1282437B1 (de) | 2000-05-16 | 2008-03-19 | Genentech, Inc. | Behandlung von knorpelerkrankungen |
US20030157561A1 (en) * | 2001-11-19 | 2003-08-21 | Kolkman Joost A. | Combinatorial libraries of monomer domains |
SE0200943D0 (sv) | 2002-03-25 | 2002-03-25 | Amersham Biosciences Ab | Mutant protein |
US20050003548A1 (en) * | 2002-07-22 | 2005-01-06 | Nikolay Korokhov | Targeted adenoviral vector displaying immunoglobulin-binding domain and uses thereof |
AU2004291833B2 (en) | 2003-09-12 | 2010-08-26 | Ipsen Biopharmaceuticals, Inc. | Methods for treatment of insulin-like growth factor-1 (IGF-1) deficiency |
US7192738B2 (en) | 2003-10-03 | 2007-03-20 | Genentech, Inc. | IGF binding proteins |
DE05733048T1 (de) | 2004-04-06 | 2007-05-10 | Affibody Ab | Serumalbuminbindende peptidkonjugate zur arzneimittelherstellung |
US8679490B2 (en) | 2005-11-07 | 2014-03-25 | Genentech, Inc. | Binding polypeptides with diversified and consensus VH/VL hypervariable sequences |
KR101434682B1 (ko) | 2005-12-02 | 2014-08-27 | 제넨테크, 인크. | 결합 폴리펩티드 및 이들의 용도 |
JP2008048607A (ja) | 2006-08-22 | 2008-03-06 | Chisso Corp | Fc結合ドメインとカルシウム結合発光蛋白質との融合蛋白質、それをコードする遺伝子およびそれらの用途 |
GB2442118B (en) | 2006-09-19 | 2011-08-17 | Chisso Corp | Process for production of recombinant proteins as a soluble form |
CA2666053C (en) | 2006-12-06 | 2011-03-29 | Repligen Corporation | Nucleic acids encoding recombinant protein a |
US8198043B2 (en) | 2006-12-08 | 2012-06-12 | General Electric Company | Two helix binders |
US8592555B2 (en) | 2008-08-11 | 2013-11-26 | Emd Millipore Corporation | Immunoglobulin-binding proteins with improved specificity |
SG162687A1 (en) * | 2008-12-24 | 2010-07-29 | Millipore Corp | Caustic stable chromatography ligands |
CN102365361B (zh) | 2009-03-24 | 2015-09-02 | 株式会社钟化 | 对免疫球蛋白具有亲和性的蛋白质和免疫球蛋白结合性亲和配体 |
KR101431318B1 (ko) | 2009-04-02 | 2014-08-20 | 로슈 글리카트 아게 | 전장 항체 및 단일쇄 fab 단편을 포함하는 다중특이성 항체 |
CN104945509A (zh) | 2009-09-16 | 2015-09-30 | 弗·哈夫曼-拉罗切有限公司 | 包含卷曲螺旋和/或系链的蛋白质复合体及其用途 |
US9175067B2 (en) | 2010-03-08 | 2015-11-03 | Ge Healthcare Bio-Sciences Ab | Immunoglobulin G Fc region binding polypeptide |
CN102844432A (zh) | 2010-03-24 | 2012-12-26 | 株式会社钟化 | 特异性结合免疫球蛋白的蛋白质以及免疫球蛋白结合性亲和配体 |
TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
WO2011133886A2 (en) | 2010-04-23 | 2011-10-27 | Genentech, Inc. | Production of heteromultimeric proteins |
BR112013003279A2 (pt) | 2010-08-13 | 2016-06-14 | Genentech In | “métodos para tratar uma doença, método para neutralizar ou bloquear a atividade de il-1ß e/ou il-18, anticorpo, usos de um anticorpo e usos de um anticorpo monoclonal” |
CA2807278A1 (en) | 2010-08-24 | 2012-03-01 | F. Hoffmann - La Roche Ag | Bispecific antibodies comprising a disulfide stabilized - fv fragment |
EP2654914B1 (de) | 2010-12-20 | 2018-05-30 | GE Healthcare BioProcess R&D AB | Affinitätschromatographiematrix |
CN103269761B (zh) | 2010-12-20 | 2016-05-18 | 通用电气健康护理生物科学股份公司 | 亲和色谱基质 |
WO2012085111A1 (en) | 2010-12-23 | 2012-06-28 | F. Hoffmann-La Roche Ag | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
US10689447B2 (en) | 2011-02-04 | 2020-06-23 | Genentech, Inc. | Fc variants and methods for their production |
CN103649117B (zh) | 2011-02-04 | 2016-09-14 | 霍夫曼-拉罗奇有限公司 | Fc变体及其生成方法 |
US9284354B2 (en) | 2011-03-25 | 2016-03-15 | Kaneka Corporation | Immunoglobulin-binding polypeptide |
SG10201604559TA (en) | 2011-06-08 | 2016-07-28 | Emd Millipore Corp | Chromatography matrices including novel staphylococcus aureus protein a based ligands |
HRP20240230T1 (hr) | 2011-10-11 | 2024-04-26 | F. Hoffmann - La Roche Ag | Poboljšani sklop bispecifičnih protutijela |
RU2644341C2 (ru) | 2012-02-10 | 2018-02-08 | Дженентек, Инк. | Одноцепочечные антитела и другие гетеромультимеры |
WO2013147691A1 (en) | 2012-03-28 | 2013-10-03 | Ge Healthcare Bio-Sciences Ab | Affinity chromatography matrix |
MX2014014804A (es) | 2012-06-27 | 2015-02-12 | Hoffmann La Roche | Metodo para la elaboracion de conjugados de la region fc de anticuerpos que comprenden por lo menos una entidad de union que se une especificamente a un objetivo y usos del mismo. |
ES2597228T3 (es) | 2012-06-27 | 2017-01-17 | F. Hoffmann-La Roche Ag | Procedimiento para la selección y la producción de entidades de objetivación, como dianas, altamente selectivas y multiespecíficas, personalizadas, las cuales contienen por lo menos dos entidades de unión diferentes, y utilización de éstas |
WO2015005859A1 (en) | 2013-07-10 | 2015-01-15 | Ge Healthcare Bio-Sciences Ab | Mutated immunoglobulin-binding polypeptides |
JP6491600B2 (ja) | 2013-09-27 | 2019-03-27 | 株式会社カネカ | アルカリ水溶液を用いた多孔質セルロースビーズの製造方法 |
MX2016014409A (es) | 2014-05-06 | 2017-01-20 | Genentech Inc | Produccion de proteinas heteromultimericas usando celulas de mamifero. |
US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
WO2016087416A1 (en) | 2014-12-03 | 2016-06-09 | F. Hoffmann-La Roche Ag | Multispecific antibodies |
EP3252158A4 (de) | 2015-01-26 | 2018-07-18 | Kaneka Corporation | Mutantes immunglobulin-kappa-ketten-bindendes protein mit variabler region |
WO2016121701A1 (ja) | 2015-01-26 | 2016-08-04 | 株式会社カネカ | 免疫グロブリンκ鎖可変領域含有タンパク質精製用アフィニティー分離マトリックス |
JP6424101B2 (ja) * | 2015-01-30 | 2018-11-14 | Jnc株式会社 | Fc結合ドメインとカルシウム結合発光蛋白質との融合蛋白質、それをコードする遺伝子およびそれらの用途 |
CN107428807A (zh) | 2015-02-05 | 2017-12-01 | 三菱化学株式会社 | 对免疫球蛋白具有亲和性的蛋白质和使用它的亲和分离剂、液相色谱柱 |
WO2017195638A1 (ja) | 2016-05-09 | 2017-11-16 | 株式会社カネカ | 抗体またはκ鎖可変領域含有抗体断片の精製方法 |
US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
EP3455243B1 (de) | 2016-05-11 | 2021-03-24 | Cytiva BioProcess R&D AB | Trennmatrix |
US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
EP3455240A1 (de) | 2016-05-11 | 2019-03-20 | GE Healthcare BioProcess R&D AB | Verfahren zum speichern einer trennmatrix |
ES2909833T3 (es) | 2016-05-11 | 2022-05-10 | Cytiva Bioprocess R & D Ab | Método de limpieza y/o desinfección de una matriz de separación |
US11779860B2 (en) | 2017-08-07 | 2023-10-10 | Repligen Corporation | Fc binding proteins with cysteine in the C-terminal helical region |
GB202018588D0 (en) | 2020-11-26 | 2021-01-13 | Cytiva Bioprocess R & D Ab | Separation matrix |
GB202113626D0 (en) | 2021-09-24 | 2021-11-10 | Cytiva Bioprocess R & D Ab | FC binding polypeptides |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4769326A (en) * | 1980-02-29 | 1988-09-06 | The Regents Of The University Of California | Expression linkers |
SE8300693L (sv) * | 1983-02-09 | 1984-08-10 | Sven Lofdahl | Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta |
-
1985
- 1985-12-13 SE SE8505922A patent/SE8505922D0/xx unknown
-
1986
- 1986-12-02 AT AT86850416T patent/ATE80180T1/de not_active IP Right Cessation
- 1986-12-02 ES ES198686850416T patent/ES2046177T3/es not_active Expired - Lifetime
- 1986-12-02 EP EP86850416A patent/EP0230869B1/de not_active Expired
- 1986-12-02 DE DE8686850416T patent/DE3686646T2/de not_active Expired - Fee Related
- 1986-12-09 AU AU66331/86A patent/AU600244B2/en not_active Ceased
- 1986-12-12 CA CA000525167A patent/CA1311430C/en not_active Expired - Fee Related
- 1986-12-12 DK DK600486A patent/DK600486A/da not_active Application Discontinuation
- 1986-12-12 JP JP61296509A patent/JPH0811069B2/ja not_active Expired - Lifetime
-
1990
- 1990-10-09 US US07/594,564 patent/US5143844A/en not_active Expired - Lifetime
-
1992
- 1992-11-05 GR GR920402499T patent/GR3006178T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0230869A3 (en) | 1988-08-03 |
EP0230869B1 (de) | 1992-09-02 |
AU600244B2 (en) | 1990-08-09 |
ES2046177T3 (es) | 1994-02-01 |
JPS62190087A (ja) | 1987-08-20 |
JPH0811069B2 (ja) | 1996-02-07 |
DE3686646T2 (de) | 1993-04-08 |
GR3006178T3 (de) | 1993-06-21 |
DK600486D0 (da) | 1986-12-12 |
US5143844A (en) | 1992-09-01 |
EP0230869A2 (de) | 1987-08-05 |
AU6633186A (en) | 1987-06-18 |
SE8505922D0 (sv) | 1985-12-13 |
CA1311430C (en) | 1992-12-15 |
ATE80180T1 (de) | 1992-09-15 |
DK600486A (da) | 1987-06-14 |
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