ATE46188T1 - Positionsspezifische proteolyse mittels renin. - Google Patents

Positionsspezifische proteolyse mittels renin.

Info

Publication number
ATE46188T1
ATE46188T1 AT85400985T AT85400985T ATE46188T1 AT E46188 T1 ATE46188 T1 AT E46188T1 AT 85400985 T AT85400985 T AT 85400985T AT 85400985 T AT85400985 T AT 85400985T AT E46188 T1 ATE46188 T1 AT E46188T1
Authority
AT
Austria
Prior art keywords
renin
fusion protein
cleaved
domains
nucleotide sequence
Prior art date
Application number
AT85400985T
Other languages
English (en)
Inventor
Joshua S Boger
Mary L Haffey
Edward M Scolnick
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE46188T1 publication Critical patent/ATE46188T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/14—Angiotensins: Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
    • C12N2710/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
AT85400985T 1984-05-24 1985-05-20 Positionsspezifische proteolyse mittels renin. ATE46188T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61408584A 1984-05-24 1984-05-24
EP85400985A EP0163573B1 (de) 1984-05-24 1985-05-20 Positionsspezifische Proteolyse mittels Renin

Publications (1)

Publication Number Publication Date
ATE46188T1 true ATE46188T1 (de) 1989-09-15

Family

ID=24459802

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85400985T ATE46188T1 (de) 1984-05-24 1985-05-20 Positionsspezifische proteolyse mittels renin.

Country Status (4)

Country Link
EP (1) EP0163573B1 (de)
JP (1) JPS60262595A (de)
AT (1) ATE46188T1 (de)
DE (1) DE3572843D1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707358A (en) * 1984-01-30 1987-11-17 The University Of Chicago Vaccine against Epstein-Barr Virus
EP0244147A3 (de) * 1986-04-28 1989-04-05 Merck & Co. Inc. Verfahren zur Reinigung hybrider Proteine
DE3752372T2 (de) * 1986-10-02 2004-06-24 Massachusetts Institute Of Technology, Cambridge Verfahren zur regulierung der metabolischen stabilität von proteinen
DE3706233A1 (de) * 1987-02-26 1988-09-08 Behringwerke Ag Immunogene fusionsproteine, die epstein-barr-virusproteine enthalten
US5013653A (en) 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
US5215896A (en) * 1987-03-20 1993-06-01 Creative Biomolecules, Inc. Leader sequences for the production of recombinant proteins
DE69101486T2 (de) * 1990-01-24 1994-08-04 Upjohn Co Verfahren zur reinigung rekombinanter polypeptide.
US5594115A (en) * 1990-04-09 1997-01-14 Pharmacia & Upjohn Company Process of purifying recombinant proteins and compounds useful in such process
AU5545696A (en) * 1995-04-17 1996-11-07 Dekalb Swine Breeders, Inc. Gene marker associated with swine proliferacy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1200773A (en) * 1980-02-29 1986-02-18 William J. Rutter Expression linkers
US4532207A (en) * 1982-03-19 1985-07-30 G. D. Searle & Co. Process for the preparation of polypeptides utilizing a charged amino acid polymer and exopeptidase

Also Published As

Publication number Publication date
JPS60262595A (ja) 1985-12-25
EP0163573B1 (de) 1989-09-06
EP0163573A1 (de) 1985-12-04
DE3572843D1 (en) 1989-10-12

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